LOCUS       NM_001024594             600 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens chromosome 1 open reading frame 53 (C1orf53), mRNA.
ACCESSION   NM_001024594 XM_371331
VERSION     NM_001024594.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 600)
  AUTHORS   Morgenstern,M., Peikert,C.D., Lubbert,P., Suppanz,I., Klemm,C.,
            Alka,O., Steiert,C., Naumenko,N., Schendzielorz,A., Melchionda,L.,
            Muhlhauser,W.W.D., Knapp,B., Busch,J.D., Stiller,S.B.,
            Dannenmaier,S., Lindau,C., Licheva,M., Eickhorst,C., Galbusera,R.,
            Zerbes,R.M., Ryan,M.T., Kraft,C., Kozjak-Pavlovic,V., Drepper,F.,
            Dennerlein,S., Oeljeklaus,S., Pfanner,N., Wiedemann,N. and
            Warscheid,B.
  TITLE     Quantitative high-confidence human mitochondrial proteome and its
            dynamics in cellular context
  JOURNAL   Cell Metab 33 (12), 2464-2483 (2021)
   PUBMED   34800366
REFERENCE   2  (bases 1 to 600)
  AUTHORS   Jostins,L., Ripke,S., Weersma,R.K., Duerr,R.H., McGovern,D.P.,
            Hui,K.Y., Lee,J.C., Schumm,L.P., Sharma,Y., Anderson,C.A.,
            Essers,J., Mitrovic,M., Ning,K., Cleynen,I., Theatre,E.,
            Spain,S.L., Raychaudhuri,S., Goyette,P., Wei,Z., Abraham,C.,
            Achkar,J.P., Ahmad,T., Amininejad,L., Ananthakrishnan,A.N.,
            Andersen,V., Andrews,J.M., Baidoo,L., Balschun,T., Bampton,P.A.,
            Bitton,A., Boucher,G., Brand,S., Buning,C., Cohain,A., Cichon,S.,
            D'Amato,M., De Jong,D., Devaney,K.L., Dubinsky,M., Edwards,C.,
            Ellinghaus,D., Ferguson,L.R., Franchimont,D., Fransen,K.,
            Gearry,R., Georges,M., Gieger,C., Glas,J., Haritunians,T., Hart,A.,
            Hawkey,C., Hedl,M., Hu,X., Karlsen,T.H., Kupcinskas,L.,
            Kugathasan,S., Latiano,A., Laukens,D., Lawrance,I.C., Lees,C.W.,
            Louis,E., Mahy,G., Mansfield,J., Morgan,A.R., Mowat,C., Newman,W.,
            Palmieri,O., Ponsioen,C.Y., Potocnik,U., Prescott,N.J.,
            Regueiro,M., Rotter,J.I., Russell,R.K., Sanderson,J.D., Sans,M.,
            Satsangi,J., Schreiber,S., Simms,L.A., Sventoraityte,J.,
            Targan,S.R., Taylor,K.D., Tremelling,M., Verspaget,H.W., De Vos,M.,
            Wijmenga,C., Wilson,D.C., Winkelmann,J., Xavier,R.J., Zeissig,S.,
            Zhang,B., Zhang,C.K., Zhao,H., Silverberg,M.S., Annese,V.,
            Hakonarson,H., Brant,S.R., Radford-Smith,G., Mathew,C.G.,
            Rioux,J.D., Schadt,E.E., Daly,M.J., Franke,A., Parkes,M.,
            Vermeire,S., Barrett,J.C. and Cho,J.H.
  CONSRTM   International IBD Genetics Consortium (IIBDGC)
  TITLE     Host-microbe interactions have shaped the genetic architecture of
            inflammatory bowel disease
  JOURNAL   Nature 491 (7422), 119-124 (2012)
   PUBMED   23128233
REFERENCE   3  (bases 1 to 600)
  AUTHORS   Corson,T.W., Huang,A., Tsao,M.S. and Gallie,B.L.
  TITLE     KIF14 is a candidate oncogene in the 1q minimal region of genomic
            gain in multiple cancers
  JOURNAL   Oncogene 24 (30), 4741-4753 (2005)
   PUBMED   15897902
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC130634.1 and BC038214.1.
            
            On Nov 22, 2018 this sequence version replaced NM_001024594.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR5189655.138974.1,
                                           SRR1163657.9682.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1968540
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000367393.8/ ENSP00000356363.3
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-492               BC130634.1         79-570
            493-600             BC038214.1         470-577
FEATURES             Location/Qualifiers
     source          1..600
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1q31.3"
     gene            1..600
                     /gene="C1orf53"
                     /note="chromosome 1 open reading frame 53"
                     /db_xref="GeneID:388722"
                     /db_xref="HGNC:HGNC:30003"
     exon            1..284
                     /gene="C1orf53"
                     /inference="alignment:Splign:2.1.0"
     CDS             21..458
                     /gene="C1orf53"
                     /codon_start=1
                     /product="uncharacterized protein C1orf53"
                     /protein_id="NP_001019765.1"
                     /db_xref="CCDS:CCDS44290.1"
                     /db_xref="GeneID:388722"
                     /db_xref="HGNC:HGNC:30003"
                     /translation="MAARQIWARTGAALCRQPSAAPPPAPLWVRAGFRQQLSLTLCPA
                     NEGNCGGSAPSTPGRPERAARPSVSEELTAAERQIAELHAAACAAGQLNYVDPATGYV
                     VLTQIAHLQRGECCGSACRHCPYGQVNVKDPSKKKQFNSYFYV"
     exon            285..386
                     /gene="C1orf53"
                     /inference="alignment:Splign:2.1.0"
     exon            387..600
                     /gene="C1orf53"
                     /inference="alignment:Splign:2.1.0"
     regulatory      573..578
                     /regulatory_class="polyA_signal_sequence"
                     /gene="C1orf53"
                     /note="hexamer: ATTAAA"
     polyA_site      600
                     /gene="C1orf53"
                     /note="major polyA site"
ORIGIN      
        1 ctcccaaggc cggcggcggc atggcggcca ggcagatctg ggcacggacg ggtgccgcgc
       61 tctgcaggca accttccgcc gccccgccgc cagcacctct ctgggtaaga gctgggttcc
      121 gacagcagct cagcttaacc ctctgccctg ctaacgaggg aaactgcggc ggctccgcgc
      181 ccagcacgcc cggtaggccg gagagagcgg cgaggccttc ggtgagcgaa gagttaaccg
      241 cggcggagcg acagatcgcg gagctgcacg ctgccgcctg cgcggctggc cagctaaact
      301 atgtggatcc agctactggc tatgtggtgc tcacacagat tgcccacttg caaagaggtg
      361 aatgttgtgg ctctgcgtgc agacattgtc catatggtca agtcaatgtt aaagatccat
      421 ctaaaaagaa gcaattcaat tcatattttt atgtttgaca agaatttcat ctctgttccc
      481 taactgtgct tgtatttttt aaaaaataaa gccccaattc agaattgctg gattattagt
      541 acttgaacac tagtttaatc ctaaatacat atattaaaag aacatcaata aaatgaaaaa
//
