LOCUS       NM_198077               3254 bp    mRNA    linear   PRI 05-APR-2024
DEFINITION  Homo sapiens chromosome 1 open reading frame 52 (C1orf52),
            transcript variant 1, mRNA.
ACCESSION   NM_198077 XM_086187
VERSION     NM_198077.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3254)
  AUTHORS   Castello,A., Fischer,B., Eichelbaum,K., Horos,R., Beckmann,B.M.,
            Strein,C., Davey,N.E., Humphreys,D.T., Preiss,T., Steinmetz,L.M.,
            Krijgsveld,J. and Hentze,M.W.
  TITLE     Insights into RNA biology from an atlas of mammalian mRNA-binding
            proteins
  JOURNAL   Cell 149 (6), 1393-1406 (2012)
   PUBMED   22658674
REFERENCE   2  (bases 1 to 3254)
  AUTHORS   Hosgood,H.D. 3rd, Zhang,L., Shen,M., Berndt,S.I., Vermeulen,R.,
            Li,G., Yin,S., Yeager,M., Yuenger,J., Rothman,N., Chanock,S.,
            Smith,M. and Lan,Q.
  TITLE     Association between genetic variants in VEGF, ERCC3 and
            occupational benzene haematotoxicity
  JOURNAL   Occup Environ Med 66 (12), 848-853 (2009)
   PUBMED   19773279
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   3  (bases 1 to 3254)
  AUTHORS   Rush,J., Moritz,A., Lee,K.A., Guo,A., Goss,V.L., Spek,E.J.,
            Zhang,H., Zha,X.M., Polakiewicz,R.D. and Comb,M.J.
  TITLE     Immunoaffinity profiling of tyrosine phosphorylation in cancer
            cells
  JOURNAL   Nat Biotechnol 23 (1), 94-101 (2005)
   PUBMED   15592455
REFERENCE   4  (bases 1 to 3254)
  AUTHORS   Makalowska,I., Sood,R., Faruque,M.U., Hu,P., Robbins,C.M.,
            Eddings,E.M., Mestre,J.D., Baxevanis,A.D. and Carpten,J.D.
  TITLE     Identification of six novel genes by experimental validation of
            GeneMachine predicted genes
  JOURNAL   Gene 284 (1-2), 203-213 (2002)
   PUBMED   11891061
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK126929.1, AY486331.1, AL590113.8 and BX118798.1.
            
            On Nov 22, 2018 this sequence version replaced NM_198077.3.
            
            Transcript Variant: This variant (1) represents the more frequently
            occurring transcript. It encodes a 182 aa protein.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            transcript and genomic sequence to make the sequence consistent
            with the reference genome assembly. The genomic coordinates used
            for the transcript record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR11853561.1104.1,
                                           SRR11853562.1356.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1968968,
                                           SAMEA2151358 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000471115.6/ ENSP00000419417.1
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-20                AK126929.1         11-30
            21-1234             AY486331.1         1-1214
            1235-2719           AL590113.8         40005-41489         c
            2720-3254           BX118798.1         12-546              c
FEATURES             Location/Qualifiers
     source          1..3254
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1p22.3"
     gene            1..3254
                     /gene="C1orf52"
                     /gene_synonym="gm117"
                     /note="chromosome 1 open reading frame 52"
                     /db_xref="GeneID:148423"
                     /db_xref="HGNC:HGNC:24871"
     exon            1..305
                     /gene="C1orf52"
                     /gene_synonym="gm117"
                     /inference="alignment:Splign:2.1.0"
     CDS             30..578
                     /gene="C1orf52"
                     /gene_synonym="gm117"
                     /note="BCL10-associated gene protein"
                     /codon_start=1
                     /product="UPF0690 protein C1orf52"
                     /protein_id="NP_932343.1"
                     /db_xref="CCDS:CCDS703.1"
                     /db_xref="GeneID:148423"
                     /db_xref="HGNC:HGNC:24871"
                     /translation="MAAEEKDPLSYFAAYGSSSSGSSDEEDNIEPEETSRRTPDPAKS
                     AGGCRNKAEKRLPGPDELFRSVTRPAFLYNPLNKQIDWERHVVKAPEEPPKEFKIWKS
                     NYVPPPETYTTEKKPPPPELDMAIKWSNIYEDNGDDAPQNAKKARLLPEGEETLESDD
                     EKDEHTSKKRKVEPGEPAKKKK"
     exon            306..504
                     /gene="C1orf52"
                     /gene_synonym="gm117"
                     /inference="alignment:Splign:2.1.0"
     exon            505..3254
                     /gene="C1orf52"
                     /gene_synonym="gm117"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1206..1211
                     /regulatory_class="polyA_signal_sequence"
                     /gene="C1orf52"
                     /gene_synonym="gm117"
                     /note="hexamer: AATAAA"
     polyA_site      1239
                     /gene="C1orf52"
                     /gene_synonym="gm117"
                     /note="major polyA site"
     regulatory      3234..3239
                     /regulatory_class="polyA_signal_sequence"
                     /gene="C1orf52"
                     /gene_synonym="gm117"
                     /note="hexamer: ATTAAA"
     polyA_site      3254
                     /gene="C1orf52"
                     /gene_synonym="gm117"
ORIGIN      
        1 ggagtgctgg gttgtcgctc gcagccgtca tggcagcgga ggagaaggac cctctgagct
       61 attttgcggc atacgggagc agcagctcag gctcctcgga cgaggaggat aacatcgagc
      121 cggaggagac gagtcgcaga accccggatc cggcgaagtc ggcgggcggc tgtaggaaca
      181 aggcggagaa gcggctcccg ggacctgacg agctgtttag gagcgtgact cgcccggcct
      241 ttctctacaa tccgctcaac aaacagatag actgggagag gcacgtcgtc aaggcgcctg
      301 aggagcctcc aaaggaattc aaaatatgga agtcaaatta tgtaccacct cctgagacct
      361 acaccactga gaagaagcct ccgcctccag agcttgacat ggcaataaaa tggtctaaca
      421 tatatgagga caatggtgat gatgctccac agaatgctaa gaaagctagg cttctaccag
      481 aaggggagga gacgttggaa tcagatgatg aaaaagatga gcatacttct aaaaagcgca
      541 aagtagagcc aggagaacca gcaaagaaga aaaagtagaa acaaatgacc agaatttctg
      601 tactgctaaa cttgttgaaa tgtttctttg gacagattaa gttgatattg tgggttatta
      661 tgccacatct ccatgaaaat gcatacgtta atgaactaat aagtattgcc tcaagaactt
      721 tccactatag aattcttttt ttatttaaaa catgtatgta tttaaaactc aactggtgac
      781 ttgtgattgt gaaattgata acacttggat gcattcttgc tctcacagaa ttggtgacat
      841 gctttgagag ttttgtcaca tgttgacatg ccaatgttct tataaacctt ttataaagga
      901 atatattttt aaagtaaata tattgtaatg tactgtgaac ttgtagggtg cttttcaaca
      961 gtctttgtac agtgtaaata gatcatggaa ataaaattac ttattcaata ttactattac
     1021 tgtataacat taacatttga atgtttgtct gtgacaagta ccctatttgt cgtgtgacat
     1081 tttaagttgt aataagaagt attaccattt aaagagtgcc tcctgtgttc caggtgcttt
     1141 gtgcatatat tttctctgat ccttaaacaa cctagcgcaa ggtattatta gtattctcat
     1201 tttataataa agagtgcttg agtagcttgt ctgatgttac acagctagtg agtggttcat
     1261 ttggaattta acttgggaca cttgaacctc aaaatcatca cattaaacca cctgtccacc
     1321 agtcaaaatt tagtcatctt tcaggaatga catcaattgt catctcttcc aggtactttt
     1381 ttctgttgta cctggagatc cgttagtaga gatcttttcc tctcctgatt ggatgactgt
     1441 acttgtcatc tgtgctttat ggttattcat taatttcttt attaaattgt aagtttacag
     1501 gacattcagt taaatttgaa tttcagataa ataatgtttt agtatattta atattcagga
     1561 catatacaaa aaatgtgttt atctgaaatt caaatttaac tgaacatctt ttatctggta
     1621 accctacttc tacatgtttt ctctacccag cttctatttt aatgctttgc gtatagtaat
     1681 aataaaatga acaagaagta gttgggaagg tgtgatcgtt gagttccaaa atgcagttat
     1741 ttgtagcatt ttgaacaata aaaaggttac actctgcatc aatctttcca tgaatctgaa
     1801 gcccttaaga gataagaatt acagaacagt gcacattcag tgtataagaa caagacagcc
     1861 aagcatggtg gcttatgctt gtaatcccag cactttggga ggccaaggtg ggaggatagc
     1921 ttgaggccaa gagttggaga ccagcctaga caacatgata agacctcatc tttacaaaaa
     1981 ataatttaga aagaaaaaga cataatctaa gtattttttt ttaaatctgt ttttccccat
     2041 tgtggaagat aaaatttgaa caattacgcg agatttgttt acctaggcat gtgtatcaag
     2101 tagattaaaa ttcataaaag tcattaagag tgattgcatc agccatggtg ctttgtggaa
     2161 tgaaggtcca taacagcatg atggcttcca gtatatcatc gagtttagaa aaaccaattc
     2221 tatagctgcc catcctccag gtttgcaaat atatgaatcc caaaattgaa gtaattgcta
     2281 aagcaagaat atgttttttt aagattgtag tctttgtaat gaatttggaa atctgtggta
     2341 tcatatacta aggagtggca tcaagtgaca aagcaagacc atagtatgta catgacacca
     2401 aacacaacca aatcaagtta tatttgtgaa gttgtgattc ccaagctctg gagaaatcta
     2461 aaatttggat gcatgtgttg gtggagcaaa tatctcagaa gttactgaaa tattgcaagg
     2521 ttcttaagtt agcatgaaag caaacttttt tctctctttc ctgggagatg tgcagagtat
     2581 gttgtatgag gaggaagaca ggacttaggg aagaggctaa atattttgga gcaagtctga
     2641 ctcagccatt tgtatctcct ggttggaaaa cggactgtca tatcactcta cattcatcat
     2701 cacattagag aatagattat tttccccttt agagatgtcc tgggaacgtg tttgcacaag
     2761 tgtccatgtg ggtactgagg tgaagtttgg ttgagctagt ggaaacctag tggggaaaag
     2821 tcttaaaaat ccatatacat aagaaaaatc atctgtccaa gtatctttca ttttagagaa
     2881 tcgagtcact tgatacttct gattgtttcc tgcactttaa gttaagcctg ggcaacatgt
     2941 tgagatcctg atctggtttg gctgtgtccc caaccaaatc tcacttgaat tgtaattccc
     3001 acaattccca cgtgtcatgg gtggtgactg aattatgggg gtgggtcttt ccggtgctgt
     3061 tcttatgata gtgaatgagt cttacgagat ctgatggttt taaaaaccat cagtgcaggg
     3121 agttgccctg cacaagctct ctgcctgctg ccctccacat aagatgtgtc ttgctcctct
     3181 tgccttctgc catgattgtg aggcttcctc agccatgtgg aactgtaagt ccaattaaac
     3241 ctgtttcttg caaa
//
