LOCUS       NM_024097               4760 bp    mRNA    linear   PRI 04-DEC-2024
DEFINITION  Homo sapiens chromosome 1 open reading frame 50 (C1orf50),
            transcript variant 1, mRNA.
ACCESSION   NM_024097
VERSION     NM_024097.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4760)
  AUTHORS   Otani,Y., Tanaka,A., Maekawa,M., Pena,T., Rogachevskaya,A.,
            Ando,T., Itano,T., Katayama,H., Nakata,E., Ozaki,T., Toyooka,S.,
            Doihara,H., Roehrl,M.H. and Fujimura,A.
  TITLE     The role of C1orf50 in breast cancer progression and prognosis
  JOURNAL   Breast Cancer (2024) In press
   PUBMED   39604563
  REMARK    Publication Status: Available-Online prior to print
REFERENCE   2  (bases 1 to 4760)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   3  (bases 1 to 4760)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   4  (bases 1 to 4760)
  AUTHORS   Fragoza,R., Das,J., Wierbowski,S.D., Liang,J., Tran,T.N., Liang,S.,
            Beltran,J.F., Rivera-Erick,C.A., Ye,K., Wang,T.Y., Yao,L., Mort,M.,
            Stenson,P.D., Cooper,D.N., Wei,X., Keinan,A., Schimenti,J.C.,
            Clark,A.G. and Yu,H.
  TITLE     Extensive disruption of protein interactions by genetic variants
            across the allele frequency spectrum in human populations
  JOURNAL   Nat Commun 10 (1), 4141 (2019)
   PUBMED   31515488
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 4760)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Paulo,J.A., Cannon,J.R., Ting,L.,
            Baltier,K., Colby,G., Gebreab,F., Gygi,M.P., Parzen,H., Szpyt,J.,
            Tam,S., Zarraga,G., Pontano-Vaites,L., Swarup,S., White,A.E.,
            Schweppe,D.K., Rad,R., Erickson,B.K., Obar,R.A., Guruharsha,K.G.,
            Li,K., Artavanis-Tsakonas,S., Gygi,S.P. and Harper,J.W.
  TITLE     Architecture of the human interactome defines protein communities
            and disease networks
  JOURNAL   Nature 545 (7655), 505-509 (2017)
   PUBMED   28514442
REFERENCE   6  (bases 1 to 4760)
  AUTHORS   Zhong,Q., Pevzner,S.J., Hao,T., Wang,Y., Mosca,R., Menche,J.,
            Taipale,M., Tasan,M., Fan,C., Yang,X., Haley,P., Murray,R.R.,
            Mer,F., Gebreab,F., Tam,S., MacWilliams,A., Dricot,A., Reichert,P.,
            Santhanam,B., Ghamsari,L., Calderwood,M.A., Rolland,T.,
            Charloteaux,B., Lindquist,S., Barabasi,A.L., Hill,D.E., Aloy,P.,
            Cusick,M.E., Xia,Y., Roth,F.P. and Vidal,M.
  TITLE     An inter-species protein-protein interaction network across vast
            evolutionary distance
  JOURNAL   Mol Syst Biol 12 (4), 865 (2016)
   PUBMED   27107014
  REMARK    Publication Status: Online-Only
REFERENCE   7  (bases 1 to 4760)
  AUTHORS   Yachie,N., Petsalaki,E., Mellor,J.C., Weile,J., Jacob,Y., Verby,M.,
            Ozturk,S.B., Li,S., Cote,A.G., Mosca,R., Knapp,J.J., Ko,M., Yu,A.,
            Gebbia,M., Sahni,N., Yi,S., Tyagi,T., Sheykhkarimli,D., Roth,J.F.,
            Wong,C., Musa,L., Snider,J., Liu,Y.C., Yu,H., Braun,P.,
            Stagljar,I., Hao,T., Calderwood,M.A., Pelletier,L., Aloy,P.,
            Hill,D.E., Vidal,M. and Roth,F.P.
  TITLE     Pooled-matrix protein interaction screens using Barcode Fusion
            Genetics
  JOURNAL   Mol Syst Biol 12 (4), 863 (2016)
   PUBMED   27107012
  REMARK    Publication Status: Online-Only
REFERENCE   8  (bases 1 to 4760)
  AUTHORS   Sahni,N., Yi,S., Taipale,M., Fuxman Bass,J.I.,
            Coulombe-Huntington,J., Yang,F., Peng,J., Weile,J., Karras,G.I.,
            Wang,Y., Kovacs,I.A., Kamburov,A., Krykbaeva,I., Lam,M.H.,
            Tucker,G., Khurana,V., Sharma,A., Liu,Y.Y., Yachie,N., Zhong,Q.,
            Shen,Y., Palagi,A., San-Miguel,A., Fan,C., Balcha,D., Dricot,A.,
            Jordan,D.M., Walsh,J.M., Shah,A.A., Yang,X., Stoyanova,A.K.,
            Leighton,A., Calderwood,M.A., Jacob,Y., Cusick,M.E.,
            Salehi-Ashtiani,K., Whitesell,L.J., Sunyaev,S., Berger,B.,
            Barabasi,A.L., Charloteaux,B., Hill,D.E., Hao,T., Roth,F.P.,
            Xia,Y., Walhout,A.J.M., Lindquist,S. and Vidal,M.
  TITLE     Widespread macromolecular interaction perturbations in human
            genetic disorders
  JOURNAL   Cell 161 (3), 647-660 (2015)
   PUBMED   25910212
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DA684965.1, CN256666.1, BC001508.2, AA741374.1 and AC098484.2.
            
            On Nov 23, 2018 this sequence version replaced NM_024097.3.
            
            Transcript Variant: This variant (1) represents the longer,
            protein-coding variant.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660807.301955.1,
                                           SRR1803612.484071.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000372525.7/ ENSP00000361603.4
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-345               DA684965.1         5-349
            346-867             CN256666.1         134-655
            868-1009            BC001508.2         848-989
            1010-1011           AA741374.1         25-26               c
            1012-4760           AC098484.2         123721-127469
FEATURES             Location/Qualifiers
     source          1..4760
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1p34.2"
     gene            1..4760
                     /gene="C1orf50"
                     /note="chromosome 1 open reading frame 50"
                     /db_xref="GeneID:79078"
                     /db_xref="HGNC:HGNC:28795"
     exon            1..142
                     /gene="C1orf50"
                     /inference="alignment:Splign:2.1.0"
     CDS             64..663
                     /gene="C1orf50"
                     /codon_start=1
                     /product="uncharacterized protein C1orf50"
                     /protein_id="NP_077002.2"
                     /db_xref="CCDS:CCDS473.1"
                     /db_xref="GeneID:79078"
                     /db_xref="HGNC:HGNC:28795"
                     /translation="MEDAAAPGRTEGVLERQGAPPAAGQGGALVELTPTPGGLALVSP
                     YHTHRAGDPLDLVALAEQVQKADEFIRANATNKLTVIAEQIQHLQEQARKVLEDAHRD
                     ANLHHVACNIVKKPGNIYYLYKRESGQQYFSIISPKEWGTSCPHDFLGAYKLQHDLSW
                     TPYEDIEKQDAKISMMDTLLSQSVALPPCTEPNFQGLTH"
     exon            143..258
                     /gene="C1orf50"
                     /inference="alignment:Splign:2.1.0"
     exon            259..345
                     /gene="C1orf50"
                     /inference="alignment:Splign:2.1.0"
     exon            346..477
                     /gene="C1orf50"
                     /inference="alignment:Splign:2.1.0"
     exon            478..4760
                     /gene="C1orf50"
                     /inference="alignment:Splign:2.1.0"
     polyA_site      796
                     /gene="C1orf50"
                     /note="major polyA site"
     regulatory      982..987
                     /regulatory_class="polyA_signal_sequence"
                     /gene="C1orf50"
                     /note="hexamer: CATAAA"
     polyA_site      1013
                     /gene="C1orf50"
     polyA_site      1783
                     /gene="C1orf50"
     regulatory      1853..1858
                     /regulatory_class="polyA_signal_sequence"
                     /gene="C1orf50"
                     /note="hexamer: CATAAA"
     polyA_site      1880
                     /gene="C1orf50"
     regulatory      2143..2148
                     /regulatory_class="polyA_signal_sequence"
                     /gene="C1orf50"
                     /note="hexamer: AACAAA"
     polyA_site      2163
                     /gene="C1orf50"
     regulatory      4733..4738
                     /regulatory_class="polyA_signal_sequence"
                     /gene="C1orf50"
                     /note="hexamer: AATAAA"
     polyA_site      4760
                     /gene="C1orf50"
ORIGIN      
        1 gcctttatgc gcaggctctt cctactcgca cagcccaggg agtggggagg ataaggcgct
       61 gtcatggagg acgccgccgc gccggggcgg accgaggggg tccttgaaag gcaaggagcg
      121 ccgccagctg caggccaggg aggagccctg gtggagctca ccccgacccc cggcggcctg
      181 gccctggtga gcccctacca cacccaccgg gccggggacc ccttagacct cgtggcgctc
      241 gcagagcagg tgcagaaggc tgatgaattc atccgagcaa atgccaccaa caagctgaca
      301 gtcatagctg agcaaatcca acatttgcaa gaacaagcca ggaaggtact ggaagatgct
      361 cacagagatg ccaacctgca ccatgtagct tgtaatatag tgaaaaaacc tggcaacatt
      421 tactatctct ataaacggga gagtggtcag cagtattttt ccatcatttc tccaaaggaa
      481 tgggggacaa gttgtccaca tgacttcctt ggtgcctaca aactacagca tgacttgtcc
      541 tggactccgt atgaggacat tgagaagcaa gatgctaaaa tcagcatgat ggacacgttg
      601 ctaagccagt cagtggccct gcctccgtgc actgaaccca acttccaggg actgactcac
      661 tgagagtggg ctttgacaaa cagctctcac aggacctggc tgtcaacctc cttgttgccc
      721 ccactgttgc cttgagaatt gaagacatgt aggtgactca caaacttctt ggaaagagac
      781 cctgtgtgaa tgtaaatgct gtcattatga cttttaattg ggatgggaat aatcattgag
      841 acagagtcac tgtctttcgg gatcctcttt ggaccacaga tacccaagtc agtcagtttc
      901 agagtattgg ccagtgtact ttccttcttc ctctccatca cttcttccct taagttaaag
      961 tgttagagaa gaccttcttc ccataaaaag gttggtggat cgttttccag agagaactgt
     1021 tttcagtctt ttatatatat atatatatat atataactgg tagtatttaa cattggggtt
     1081 gaggctgtct cacagttggt gcaactccag tttaaaattc atctgggaac gagaatgttg
     1141 agtaatggag ggtgatttaa aaaacaacaa caacaacaaa aaaaaaaaca cttggcttgg
     1201 ctggaccaga gagtgtgtga ttctgggatt tctgtgctgt tgatgaggtt tgtcttgccc
     1261 cttttgctct ctctgccttg ctagagtgac agaatctgag gcagcaaagg ccaggtttgg
     1321 ggagagtcaa ctttgaaact cacaaatttt agacttggaa gagacattgg atgctgccac
     1381 taatcattat agagtccact gtgtagtctc ccaagttgga aatcccaggc tcagccacct
     1441 gcagcagaac aaacccattt aaatggctac ttaacactgt ggaagagagt aaggcagtag
     1501 agtgagaagc aagaaaaaca gccaaattgt tgactgtgag ttaactcaga ttgaaatcca
     1561 ttttgaccag aattattcaa gaacttaaca gggttttggc aaaattactg tagttcttat
     1621 tctgactagg ctcttgtagg actctacctt ctttcctatc tgtttggtgg aattagctaa
     1681 gtttatggat tatttcgcat ggctataatc tattgcaata tgctgtaaaa ggagggagag
     1741 atgtgtactt gaactgacaa ttggccaaat ttctctctgg gaatgatgtt cctgatgctg
     1801 atctgtttgg taataccctc cccgggccgc cccccgattc atggtctttc ctcataaact
     1861 gcatttcttg tgagctgtaa gaggtctacc taaggcctag cacaggatgg ggctagaatc
     1921 taacaaactc actccgatga tacttggttg ctcggttcac atgggaatgc tctttggact
     1981 cagctgcaga ggtcttttgc tcaggtgctg cagagccgga tggaagagac attagtggta
     2041 gagtagtgga ttctgactac agaaagtttc ccaggttttc agaaggttct gacctgcatg
     2101 atgatgacac attttgaata ggtgctttat tagttacaga taaacaaatt actgcaaact
     2161 taatggttta aagcaacacc tatttatttc agagcttaca ggttaggagt tcaggcacca
     2221 tttcattgag tcctctgctt cacagtttct ctgaaaccct ggaaggctga aatcaagtta
     2281 ttggtcaggg ctgttcttat ctgaaggcct gagtggggaa ggatctgctt ccaagctcac
     2341 ttaaattgtt agcagaattt cttttctttc ctttcttttt ttttgagaca gagtctcgct
     2401 gtattgccag gcctgagtac agtggctcaa tctcagctta ccgcaacctc cgcctcctgg
     2461 ttcaagtgat tctcctgcct cagcctcctc agtagctgag attacaggcg cacgccacca
     2521 tgcccagcta atttttttat ttttagtaga gacagggttt caccatgttg gccaggaggg
     2581 tctctatctc ttgacctcat gatccacctg cctcagcctc ccacagtgct ggcgtttgag
     2641 ccaccatacc tggcctgttg gcagaatttc aattccacaa gggttgctgg cttccggggt
     2701 tccactagct gactgttggc tggaggttgc cctcacttcc ttgccacacg agcctctata
     2761 acatggcagc tttcttaagc aaagtaaaca aggattagag tctgctagcc agatggaagt
     2821 tacagtctca tgtagtctga tcacagaagt gacatttcat cacctttgcc gtaatctttt
     2881 ggttggaagc aagtcactag gctagcccat attcaaggga gggagttata caaaggcatg
     2941 tataccagaa ggcagacatc attgaatcat tgaacagatc ctagaatcta tctgccacag
     3001 tgctcagttg agaagaagaa aggaaaattc taggtaaaaa aggcaatatt actaagtggt
     3061 taagtgtgat gatgtcaaag tcacagatct gcacttgact gtcaactctg acaagacagc
     3121 ctcccagctg gcatccctgc ttccccctct gtcccctctc caatccattc tgcatgcagt
     3181 catcagcttg atcatttgaa aatgccaaat ctccctcact cttgacattt cctaacctaa
     3241 agagtgggag agtagtgatt gaaaagagag aaactgcctt ctgttcagta agatgtactc
     3301 cctgcactga ccaccaaggg gtgtcattgc tctttcctgg ttaagccagt taccacactt
     3361 gggaagggct agtggcaatg tgaggtgatt tggggcacct cagaatggga aactaggacc
     3421 cagtgattat atacagtaat cacttttcat ttacccatcc atctgttcac ctgataattt
     3481 cattagtgtt aagtgccttc taggttccag gttctggtga ataatggagc tgaataagaa
     3541 atcacaattt ccagggagct cacagtatag tagggaagga aacaagttaa caattacaag
     3601 atgctctaag aaggggtgtg atagaggtac gcatggaata ctatggagct ccggggaggg
     3661 gttccttact gagcttggag aatttgggaa gacacttgga ggagctgatg cctgcttggt
     3721 gttgaaaacc atacaagtta gaactttctg gaggctccaa ttgccctttc ataggaagtt
     3781 tgtcttttgg gggttggggt agggttcatt tttggatgga gtttatttgt gaatgaagaa
     3841 agtgacaacc atttaagcca tatcaaccaa agcagtcctg gcaatgagga ggggtggagt
     3901 gagatatgtc ctggctagaa aatccttgtg tttaaaagct aggagatagt tgaagacagg
     3961 gaggaaaaaa cattccagac aaaaaataac atggaaggga cattgaccag aattgacacg
     4021 acatttgggg aatcgcagcc agttaaacag gagaatatgg actggggaat atgagagaag
     4081 aactaatgga aggatttggg gaggctggta atattggcag cagagtttgg gtagagggaa
     4141 gacaggagat tccatcccta atcaaggcaa gggatgatgg gagtctgaat taagcagtag
     4201 tagaatgaga gggcctgtat ttcaccaatt acaaggtgta cttccccccc cccccccccc
     4261 acattttggt gtctgtcaaa cttggacact tctaaaagtc aatggcatgt cacagtttaa
     4321 gtggcatttt ttctttctta gagctacata aaagaatcat aacaagctgg gcgcagtggc
     4381 tcacgcctgt aatcccagca ctttgggcgg ctgaggcggg cggatcacga ggtcaggaga
     4441 ttgagaccat tctggctaac atagtgaaat cctgtctcta ctaaaaatac aaaaaattag
     4501 ccgggcgtgg tggcgggcgc ctgtaatccc agctactcgg gaggctgagg caggagaatg
     4561 tcgtgaacct gggaggcgaa gcttgcagtg agccgagatt gcaccactgc actccaactt
     4621 gggcaacaga gcaagactcc atctcaaaaa aaaaaaaaaa agaatcataa catagcatct
     4681 tacatttgat gaagcatggc acattgaaag tacaatcgat tgccatcttg ttaataaaat
     4741 gtcagaggga ttagaggaaa
//
