LOCUS       NM_001098616            1678 bp    mRNA    linear   PRI 06-APR-2024
DEFINITION  Homo sapiens chromosome 1 open reading frame 43 (C1orf43),
            transcript variant 3, mRNA.
ACCESSION   NM_001098616
VERSION     NM_001098616.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1678)
  AUTHORS   Jeng,E.E., Bhadkamkar,V., Ibe,N.U., Gause,H., Jiang,L., Chan,J.,
            Jian,R., Jimenez-Morales,D., Stevenson,E., Krogan,N.J.,
            Swaney,D.L., Snyder,M.P., Mukherjee,S. and Bassik,M.C.
  TITLE     Systematic Identification of Host Cell Regulators of Legionella
            pneumophila Pathogenesis Using a Genome-wide CRISPR Screen
  JOURNAL   Cell Host Microbe 26 (4), 551-563 (2019)
   PUBMED   31540829
REFERENCE   2  (bases 1 to 1678)
  AUTHORS   Wei,Y.J., Hu,Q.Q., Gu,C.Y., Wang,Y.P., Han,Z.G. and Cai,B.
  TITLE     Up-regulation of NICE-3 as a novel EDC gene could contribute to
            human hepatocellular carcinoma
  JOURNAL   Asian Pac J Cancer Prev 13 (9), 4363-4368 (2012)
   PUBMED   23167344
  REMARK    GeneRIF: our findings indicate that NICE-3 may contribute to human
            hepatocellular carcinoma by promoting cell proliferation.
REFERENCE   3  (bases 1 to 1678)
  AUTHORS   Marenholz,I., Zirra,M., Fischer,D.F., Backendorf,C., Ziegler,A. and
            Mischke,D.
  TITLE     Identification of human epidermal differentiation complex
            (EDC)-encoded genes by subtractive hybridization of entire YACs to
            a gridded keratinocyte cDNA library
  JOURNAL   Genome Res 11 (3), 341-355 (2001)
   PUBMED   11230159
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC000152.2 and BU072807.1.
            
            On Jun 2, 2019 this sequence version replaced NM_001098616.2.
            
            Transcript Variant: This variant (3) contains an alternate in-frame
            exon, compared to variant 1. The encoded isoform (3) is longer than
            isoform 1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC000152.2, AF109185.1 [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000368521.10/ ENSP00000357507.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1194              BC000152.2         17-1210
            1195-1678           BU072807.1         95-578
FEATURES             Location/Qualifiers
     source          1..1678
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1q21.3"
     gene            1..1678
                     /gene="C1orf43"
                     /gene_synonym="HSPC012; NICE-3; NICE3; NS5ATP4; S863-3"
                     /note="chromosome 1 open reading frame 43"
                     /db_xref="GeneID:25912"
                     /db_xref="HGNC:HGNC:29876"
                     /db_xref="MIM:617428"
     exon            1..249
                     /gene="C1orf43"
                     /gene_synonym="HSPC012; NICE-3; NICE3; NS5ATP4; S863-3"
                     /inference="alignment:Splign:2.1.0"
     CDS             184..945
                     /gene="C1orf43"
                     /gene_synonym="HSPC012; NICE-3; NICE3; NS5ATP4; S863-3"
                     /note="isoform 3 is encoded by transcript variant 3; HCV
                     NS5A-transactivated protein 4; hepatitis C virus
                     NS5A-transactivated protein 4; uncharacterized protein
                     C1orf43"
                     /codon_start=1
                     /product="protein C1orf43 isoform 3"
                     /protein_id="NP_001092086.1"
                     /db_xref="CCDS:CCDS41404.1"
                     /db_xref="GeneID:25912"
                     /db_xref="HGNC:HGNC:29876"
                     /db_xref="MIM:617428"
                     /translation="MASGSNWLSGVNVVLVMAYGSLVFVLLFIFVKRQIMRFAMKSRR
                     GPHVPVGHNAPKDLKEEIDIRLSRVQDIKYEPQLLADDDARLLQLETQGNQSCYNYLY
                     RMKALDAIRTSEIPFHSEGRHPRSLMGKNFRSYLLDLRNTSTPFKGVRKALIDTLLDG
                     YETARYGTGVFGQNEYLRYQEALSELATAVKARIGSSQRHHQSAAKDLTQSPEVSPTT
                     IQVTYLPSSQKSKRAKHFLELKSFKDNYNTLESTL"
     exon            250..351
                     /gene="C1orf43"
                     /gene_synonym="HSPC012; NICE-3; NICE3; NS5ATP4; S863-3"
                     /inference="alignment:Splign:2.1.0"
     exon            352..469
                     /gene="C1orf43"
                     /gene_synonym="HSPC012; NICE-3; NICE3; NS5ATP4; S863-3"
                     /inference="alignment:Splign:2.1.0"
     exon            470..523
                     /gene="C1orf43"
                     /gene_synonym="HSPC012; NICE-3; NICE3; NS5ATP4; S863-3"
                     /inference="alignment:Splign:2.1.0"
     exon            524..690
                     /gene="C1orf43"
                     /gene_synonym="HSPC012; NICE-3; NICE3; NS5ATP4; S863-3"
                     /inference="alignment:Splign:2.1.0"
     exon            691..749
                     /gene="C1orf43"
                     /gene_synonym="HSPC012; NICE-3; NICE3; NS5ATP4; S863-3"
                     /inference="alignment:Splign:2.1.0"
     exon            750..1678
                     /gene="C1orf43"
                     /gene_synonym="HSPC012; NICE-3; NICE3; NS5ATP4; S863-3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1672..1677
                     /regulatory_class="polyA_signal_sequence"
                     /gene="C1orf43"
                     /gene_synonym="HSPC012; NICE-3; NICE3; NS5ATP4; S863-3"
                     /note="hexamer: AATAAA"
     polyA_site      1678
                     /gene="C1orf43"
                     /gene_synonym="HSPC012; NICE-3; NICE3; NS5ATP4; S863-3"
                     /note="major polyA site"
ORIGIN      
        1 ctcctttccc agctctcctg cctgtccgcc atgttttcag gccgggtctg gcttggtctt
       61 cccccgtaag gaaatggccg gggagctcca ggggacccag gcgccgtcgc ttcggcggag
      121 cctgggctga ccagccagga cagcggggta aacccgaaca attctgcgcg aggtagggag
      181 gccatggcgt ccggcagtaa ctggctctcc ggggtgaatg tcgtgctggt gatggcctac
      241 gggagcctgg tgtttgtact gctatttatt tttgtgaaga ggcaaatcat gcgctttgca
      301 atgaaatctc gaaggggacc tcatgtccct gtgggacaca atgcccccaa ggacttgaaa
      361 gaggagattg atattcgact ctccagggtt caggatatca agtatgagcc ccagctcctt
      421 gcagatgatg atgctagact actacaactg gaaacccagg gaaatcaaag ttgctacaac
      481 tatctgtata ggatgaaagc tctggatgcc attcgtacct ctgagatccc atttcattct
      541 gaaggccggc atccccgttc cttaatgggc aagaatttcc gctcctacct gctggatctg
      601 cgaaacacta gtacgccttt caagggtgta cgcaaagcac tcattgatac ccttttggat
      661 ggctatgaaa cagcccgcta tgggacaggg gtctttggcc agaatgagta cctacgctat
      721 caggaggccc tgagtgagct ggccactgcg gttaaagcac gaattgggag ctctcagcga
      781 catcaccagt cagcagccaa agacctaact cagtcccctg aggtctcccc aacaaccatc
      841 caggtgacat acctcccctc cagtcagaag agtaaacgtg ccaagcactt ccttgaattg
      901 aagagcttta aggataacta taacacattg gagagtactc tgtgacggag ctgaaggact
      961 cttgccgtag attaagccag tcagttgcaa tgtgcaagac aggctgcttg ccgggccgcc
     1021 ctcggaacat ctggcccagc aggcccagac tgtatccatc caagttcccg ttgtatccag
     1081 agttcttaga gcttgtgtct aaagggtaat tccccaaccc ttccttatga gcatttttag
     1141 aacattggct aagactattt tcccccagta gcgctttttt ctggatttgc attcaggtgt
     1201 tattcttaat gtttctgtca aagcttctta aaaatcttca cttggtttca gccatagttc
     1261 accttccctg ttccaggttt atttaattcc aaaggtgaga gttggagtga gatgtcttcc
     1321 atatctatac ctttgtgcac agttgaatgg gaactgtttg ggtttagggc atcttagagt
     1381 tgattgatgg aaaaagcaga caggaactgg tgggaggtca agtggggaag ttggtgaatg
     1441 tggaataact tacctttgtg ctccacttaa accagatgtg ttgcagcttt cctgacatgc
     1501 aaggatctac tttaattcca cactctcatt aataaattga ataaaaggga atgttttggc
     1561 acctgatata atctgccagg ctatgtgaca gtaggaagga atggtttccc ctaacaagcc
     1621 caatgcactg gtctgacttt ataaattatt taataaaatg aactattatc aaataaaa
//
