LOCUS       NM_024319               1290 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens chromosome 1 open reading frame 35 (C1orf35),
            transcript variant 1, mRNA.
ACCESSION   NM_024319
VERSION     NM_024319.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1290)
  AUTHORS   Buljan,M., Ciuffa,R., van Drogen,A., Vichalkovski,A., Mehnert,M.,
            Rosenberger,G., Lee,S., Varjosalo,M., Pernas,L.E., Spegg,V.,
            Snijder,B., Aebersold,R. and Gstaiger,M.
  TITLE     Kinase Interaction Network Expands Functional and Disease Roles of
            Human Kinases
  JOURNAL   Mol Cell 79 (3), 504-520 (2020)
   PUBMED   32707033
REFERENCE   2  (bases 1 to 1290)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 1290)
  AUTHORS   Luo,S.Q., Xiong,D.H., Li,J., Li,G., Wang,Y., Zhang,J.M., Bu,X.F.,
            Hu,W.X. and Hu,J.
  TITLE     C1orf35 contributes to tumorigenesis by activating c-MYC
            transcription in multiple myeloma
  JOURNAL   Oncogene 39 (16), 3354-3366 (2020)
   PUBMED   32103167
  REMARK    GeneRIF: C1orf35 contributes to tumorigenesis by activating c-MYC
            transcription in multiple myeloma.
REFERENCE   4  (bases 1 to 1290)
  AUTHORS   Melton,P.E., Johnson,M.P., Gokhale-Agashe,D., Rea,A.J., Ariff,A.,
            Cadby,G., Peralta,J.M., McNab,T.J., Allcock,R.J., Abraham,L.J.,
            Blangero,J., Brennecke,S.P. and Moses,E.K.
  TITLE     Whole-exome sequencing in multiplex preeclampsia families
            identifies novel candidate susceptibility genes
  JOURNAL   J Hypertens 37 (5), 997-1011 (2019)
   PUBMED   30633125
  REMARK    GeneRIF: The study represents the first to use WES in multiplex
            families for preeclampsia and identifies two novel genes (QRFPR and
            C1orf35) not previously associated with preeclampsia and find
            nominal association of rs34270076 with protein levels.
REFERENCE   5  (bases 1 to 1290)
  AUTHORS   Jefferson,M., Donaszi-Ivanov,A., Pollen,S., Dalmay,T., Saalbach,G.
            and Powell,P.P.
  TITLE     Host factors that interact with the pestivirus N-terminal protease,
            Npro, are components of the ribonucleoprotein complex
  JOURNAL   J Virol 88 (18), 10340-10353 (2014)
   PUBMED   24965446
REFERENCE   6  (bases 1 to 1290)
  AUTHORS   Yu,H., Tardivo,L., Tam,S., Weiner,E., Gebreab,F., Fan,C.,
            Svrzikapa,N., Hirozane-Kishikawa,T., Rietman,E., Yang,X.,
            Sahalie,J., Salehi-Ashtiani,K., Hao,T., Cusick,M.E., Hill,D.E.,
            Roth,F.P., Braun,P. and Vidal,M.
  TITLE     Next-generation sequencing to generate interactome datasets
  JOURNAL   Nat Methods 8 (6), 478-480 (2011)
   PUBMED   21516116
REFERENCE   7  (bases 1 to 1290)
  AUTHORS   Lee,O.H., Kim,H., He,Q., Baek,H.J., Yang,D., Chen,L.Y., Liang,J.,
            Chae,H.K., Safari,A., Liu,D. and Songyang,Z.
  TITLE     Genome-wide YFP fluorescence complementation screen identifies new
            regulators for telomere signaling in human cells
  JOURNAL   Mol Cell Proteomics 10 (2), M110.001628 (2011)
   PUBMED   21044950
REFERENCE   8  (bases 1 to 1290)
  AUTHORS   Venkatesan,K., Rual,J.F., Vazquez,A., Stelzl,U., Lemmens,I.,
            Hirozane-Kishikawa,T., Hao,T., Zenkner,M., Xin,X., Goh,K.I.,
            Yildirim,M.A., Simonis,N., Heinzmann,K., Gebreab,F., Sahalie,J.M.,
            Cevik,S., Simon,C., de Smet,A.S., Dann,E., Smolyar,A.,
            Vinayagam,A., Yu,H., Szeto,D., Borick,H., Dricot,A., Klitgord,N.,
            Murray,R.R., Lin,C., Lalowski,M., Timm,J., Rau,K., Boone,C.,
            Braun,P., Cusick,M.E., Roth,F.P., Hill,D.E., Tavernier,J.,
            Wanker,E.E., Barabasi,A.L. and Vidal,M.
  TITLE     An empirical framework for binary interactome mapping
  JOURNAL   Nat Methods 6 (1), 83-90 (2009)
   PUBMED   19060904
REFERENCE   9  (bases 1 to 1290)
  AUTHORS   Andersen,J.S., Lam,Y.W., Leung,A.K., Ong,S.E., Lyon,C.E.,
            Lamond,A.I. and Mann,M.
  TITLE     Nucleolar proteome dynamics
  JOURNAL   Nature 433 (7021), 77-83 (2005)
   PUBMED   15635413
REFERENCE   10 (bases 1 to 1290)
  AUTHORS   Tian,J.Y., Hu,W.X., Tian,E.M., Shi,Y.W., Shen,Q.X., Tang,L.J. and
            Jiang,Y.S.
  TITLE     Cloning and sequence analysis of tumor-associated gene hMMTAG2 from
            human multiple myeloma cell line ARH-77
  JOURNAL   Sheng Wu Hua Xue Yu Sheng Wu Wu Li Xue Bao (Shanghai) 35 (2),
            143-148 (2003)
   PUBMED   12545221
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK126087.1 and BC002843.2.
            
            On Nov 22, 2018 this sequence version replaced NM_024319.3.
            
            Transcript Variant: This variant (1) represents the shorter
            transcript and encodes the protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY137773.1, BC002843.2 [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000272139.5/ ENSP00000272139.4
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-4                 AK126087.1         2087-2090
            5-1290              BC002843.2         1-1286
FEATURES             Location/Qualifiers
     source          1..1290
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1q42.13"
     gene            1..1290
                     /gene="C1orf35"
                     /gene_synonym="MMTAG2"
                     /note="chromosome 1 open reading frame 35"
                     /db_xref="GeneID:79169"
                     /db_xref="HGNC:HGNC:19032"
     exon            1..192
                     /gene="C1orf35"
                     /gene_synonym="MMTAG2"
                     /inference="alignment:Splign:2.1.0"
     CDS             99..890
                     /gene="C1orf35"
                     /gene_synonym="MMTAG2"
                     /note="multiple myeloma transforming 2"
                     /codon_start=1
                     /product="multiple myeloma tumor-associated protein 2"
                     /protein_id="NP_077295.1"
                     /db_xref="CCDS:CCDS1566.1"
                     /db_xref="GeneID:79169"
                     /db_xref="HGNC:HGNC:19032"
                     /translation="MFGSSRGGVRGGQDQFNWEDVKTDKQRENYLGNSLMAPVGRWQK
                     GRDLTWYAKGRAPCAGPSREEELAAVREAEREALLAALGYKNVKKQPTGLSKEDFAEV
                     CKREGGDPEEKGVDRLLGLGSASGSVGRVAMSREDKEAAKLGLSVFTHHRVESGGPGT
                     SAASARRKPRAEDQTESSCESHRKSKKEKKKKKKRKHKKEKKKKDKEHRRPAEATSSP
                     TSPERPRHHHHDSDSNSPCCKRRKRGHSGDRRSPSRRWHDRGSEA"
     exon            193..343
                     /gene="C1orf35"
                     /gene_synonym="MMTAG2"
                     /inference="alignment:Splign:2.1.0"
     exon            344..389
                     /gene="C1orf35"
                     /gene_synonym="MMTAG2"
                     /inference="alignment:Splign:2.1.0"
     exon            390..472
                     /gene="C1orf35"
                     /gene_synonym="MMTAG2"
                     /inference="alignment:Splign:2.1.0"
     exon            473..545
                     /gene="C1orf35"
                     /gene_synonym="MMTAG2"
                     /inference="alignment:Splign:2.1.0"
     exon            546..631
                     /gene="C1orf35"
                     /gene_synonym="MMTAG2"
                     /inference="alignment:Splign:2.1.0"
     exon            632..766
                     /gene="C1orf35"
                     /gene_synonym="MMTAG2"
                     /inference="alignment:Splign:2.1.0"
     exon            767..1290
                     /gene="C1orf35"
                     /gene_synonym="MMTAG2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1273..1278
                     /regulatory_class="polyA_signal_sequence"
                     /gene="C1orf35"
                     /gene_synonym="MMTAG2"
                     /note="hexamer: AATATA"
     polyA_site      1290
                     /gene="C1orf35"
                     /gene_synonym="MMTAG2"
                     /note="major polyA site"
ORIGIN      
        1 ggggtcgggc ctgggtccga cggtagtggg tagcgggtct cgggttgcgg gttgcaggtt
       61 gcaagccgca ggccccaggc aactgccttc ccggcgccat gttcggctcc agtcgtggag
      121 gcgtgcgcgg cgggcaggac cagttcaact gggaggacgt gaagactgac aagcagcggg
      181 agaactacct gggcaactcg ctgatggcgc cggtaggccg ctggcagaag ggccgcgacc
      241 tcacctggta cgccaagggc cgggcgccat gcgcgggccc gagccgcgag gaggaactgg
      301 cagccgtgcg ggaggcggag cgcgaggcgc tgctggccgc ccttggctac aagaacgtga
      361 agaagcagcc cacgggcctg agcaaggagg acttcgcgga ggtctgcaag cgggaaggag
      421 gcgaccccga ggagaagggc gtggaccggc tgctggggct ggggagcgca agtggctccg
      481 tgggccgcgt ggcgatgtcc cgagaggaca aggaggccgc caaactgggg ctgtctgtgt
      541 tcacgcatca ccgcgtagag agcggcgggc ccgggacctc ggcagcctcg gccaggagga
      601 agccgcgggc ggaggatcag acggaaagca gttgtgagag ccacaggaaa agcaagaagg
      661 agaagaagaa aaagaaaaag aggaaacaca agaaagagaa gaagaagaaa gacaaagagc
      721 acaggcggcc agctgaggcc acctcctctc ccacatctcc tgagaggccc aggcaccacc
      781 accatgactc cgactccaac tccccctgct gtaagaggag gaagcgggga cacagtgggg
      841 acaggaggag cccgtctcgc aggtggcatg acagaggctc tgaggcctga tggctggacc
      901 ctgctcactg ctgttgtggg accctgaacc ctcccttcac cttgcttgcc tcctgcctcg
      961 gaagctcctt gggtgtgggt gaagcccgag gctgctcctg tggaagtggc tctgggcacc
     1021 agcctgtggg gctaaagact tgacagctag ctctggagca gccggcttcc tggaaaacct
     1081 ccaggtttcg cataccaggg atggcccctg gcttggcctg cgaaggtgaa cctgcccaga
     1141 tttatcagta gaggctggac tccctctgtg tcctgcccat ggttgcagca gccatgggcc
     1201 tatgagcggt ctaactgtgg ccaagtatgg tgacctctat ttttctttat attgactctt
     1261 tgtatttcaa taaatatatt ttaaaaggaa
//
