LOCUS       NM_001085375            4122 bp    mRNA    linear   PRI 09-FEB-2025
DEFINITION  Homo sapiens chromosome 1 open reading frame 226 (C1orf226),
            transcript variant 2, mRNA.
ACCESSION   NM_001085375
VERSION     NM_001085375.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4122)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   2  (bases 1 to 4122)
  AUTHORS   Buljan,M., Ciuffa,R., van Drogen,A., Vichalkovski,A., Mehnert,M.,
            Rosenberger,G., Lee,S., Varjosalo,M., Pernas,L.E., Spegg,V.,
            Snijder,B., Aebersold,R. and Gstaiger,M.
  TITLE     Kinase Interaction Network Expands Functional and Disease Roles of
            Human Kinases
  JOURNAL   Mol Cell 79 (3), 504-520 (2020)
   PUBMED   32707033
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL512785.7, AK125122.1 and AI480219.1.
            
            On Nov 22, 2018 this sequence version replaced NM_001085375.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK125122.1, BC127743.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000458626.4/ ENSP00000437071.1
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2                 AL512785.7         68963-68964
            3-68                AK125122.1         1-66
            69-69               AL512785.7         69031-69031
            70-1715             AK125122.1         68-1713
            1716-3844           AL512785.7         71641-73769
            3845-4122           AI480219.1         27-304              c
FEATURES             Location/Qualifiers
     source          1..4122
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1q23.3"
     gene            1..4122
                     /gene="C1orf226"
                     /note="chromosome 1 open reading frame 226"
                     /db_xref="GeneID:400793"
                     /db_xref="HGNC:HGNC:34351"
     exon            1..491
                     /gene="C1orf226"
                     /inference="alignment:Splign:2.1.0"
     CDS             175..993
                     /gene="C1orf226"
                     /codon_start=1
                     /product="uncharacterized protein C1orf226"
                     /protein_id="NP_001078844.1"
                     /db_xref="CCDS:CCDS53422.1"
                     /db_xref="GeneID:400793"
                     /db_xref="HGNC:HGNC:34351"
                     /translation="MFENLNTALTPKLQASRSFPHLSKPVAPGSAPLGSGEPGGPGLW
                     VGSSQHLKNLGKAMGAKVNDFLRRKEPSSLGSVGVTEINKTAGAQLASGTDAAPEAWL
                     EDERSVLQETFPRLDPPPPITRKRTPRALKTTQDMLISSQPVLSSLEYGTEPSPGQAQ
                     DSAPTAQPDVPADASQPEATMEREERGKVLPNGEVSLSVPDLIHKDSQDESKLKMTEC
                     RRASSPSLIERNGFKLSLSPISLAESWEDGSPPPQARTSSLDNEGPHPDLLSFE"
     exon            492..4122
                     /gene="C1orf226"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4103..4108
                     /regulatory_class="polyA_signal_sequence"
                     /gene="C1orf226"
                     /note="hexamer: AATAAA"
     polyA_site      4122
                     /gene="C1orf226"
                     /note="major polyA site"
ORIGIN      
        1 acactggaaa gttcaagagt gtctttgctg gctctttctt gaatatttcc aaagccttgg
       61 aagttacagg ttttgggtgt gggataagga aaaactgaat gatagagcac aggtaccgct
      121 cccctttcct catcatgcct ctctgtcgcc tctttgttca tagttgacca cggcatgttt
      181 gagaatttga acacagccct cactccaaag ctccaggcca gccgctcctt cccccacttg
      241 tccaagcccg tggcccccgg ctctgcccct ctgggctctg gtgagcctgg ggggccagga
      301 ctctgggtgg gcagcagcca gcacctcaag aacctgggca aagccatggg ggccaaagtg
      361 aatgacttcc tgaggagaaa ggagccctcc agcctgggca gtgtgggtgt gacagagatc
      421 aacaagactg caggagcaca gctggccagt gggactgacg cggctccaga ggcttggcta
      481 gaggatgaaa ggtcagtcct gcaagaaaca tttcctcggc tggatcctcc acctcccata
      541 accagaaagc gaacccctcg ggccctgaag accacccagg acatgctgat ttcatcacag
      601 cctgtcctca gcagtctgga gtatgggaca gagccatcac ctgggcaggc ccaggactcc
      661 gctcccactg cccagcctga cgtcccagca gacgcttcac agccagaggc caccatggaa
      721 agagaagaga gaggcaaagt tctgcccaat ggagaggttt ccctgtcagt acctgaccta
      781 atccacaagg atagccagga cgaatccaag ctaaagatga ctgagtgcag aagggcctcc
      841 tcccccagcc ttatcgagag gaatggcttc aaactcagct tgagccccat cagcctggct
      901 gagtcctggg aggatggcag cccccctcct caggcacgga cctccagcct cgacaatgag
      961 ggccctcacc cagacctgct gtcctttgaa tagagcctct gctctttcct gctgagctct
     1021 gcccttgtct tcctgctgct ttctcctcca ctgcgcacac tggccctggc ctcaactccg
     1081 ctgtgccctt tgtcttcctt gtatgaggca ccagcagaga gccagtcgtc catcatggga
     1141 ttttgcagga ctggaagtcc ttgagtagtt ctagttaaag agtctatccg cagaatggct
     1201 gaaggacttg atgccgtttt gagcctaatt ttctgtaacc tcctctgagt gggctgcagc
     1261 ccttggacat tagagctctt ccactcttga gcttgtcctg tcttctcagt gaattgcagg
     1321 gccaccagct caggacaatg gatcttacag gaattctttt tgcctgtccc ctacatgcgc
     1381 ctcctcccct gctgttctcc ctcccacacc cctgtccctt ctctctcctc cttgatgggt
     1441 ccgatgcccc tggcctcagc gggaggaagg ctggatgagg aatgatgtgt ttggcttgat
     1501 gacaggccat ggcctagaaa gccacacacc ctgaccacag cccagccata gctcctcttg
     1561 gtcccaggac agtgcaggcc cctggttgcc atgtttgctc tgcccctggg gtggaggcca
     1621 gaggagatgc ttaccaggcc tgagaccttg agagttcacc cagggtttga acgctgccac
     1681 ccagggttcc caaggtttct cccatctggt cagatgtcga acacaaaatg tgggcattct
     1741 gcacggaagg aaagatcagg cttctcttgc tgagtgtgtg aagacaggga gagccaggcc
     1801 ccagcagatg cggcctagca cactctgatt tggttttgtg gggagggccc aggaacttgg
     1861 gggtggtctt ggcattcaga gctggtgcta aaaacccaga gcagaagcag ggagaaggga
     1921 gtgaggatgg gacagagaag agcgaccact ggggatcaga acagcttttc aggggccacc
     1981 ttgcagccta aaataatgcc gtttcagggc ctgggcctgc tgtgagagcc agaatgaagc
     2041 atgtacaaga ttggaatgtg agaagaactg tggggggaaa ccagttttaa ttaagtggaa
     2101 gtgctttgtg cttgtgctga agttgcctgg gcctcctgca gctctggacc tcactggagc
     2161 ggccccgccc tgcccttgcc tgcctttctt ttatgctgat gctggtgggc tttttcctgc
     2221 ttcaggatcc atgtaaggga ctgaccaggt tcatccagcc ttaactggtt cctgcaaccc
     2281 acttttaggt ctcccaccag gggcctattg tgctgtcttc ctgtgaccag cagatcctgt
     2341 aagggggtga tcctaattct ggggctcttt gcagcaagag gagaacgttc tttttcttga
     2401 acaaggtggc cggttccctg ggagaaggct gggaatggca cgtccggcca gggcaggcgg
     2461 tgcggcatcc tcctcctggg attcctgtgg cctcccctgt tctattcatt gtttggcttc
     2521 ccacccataa gctctgggat acccagggct tgcttcccag ctcttctcat ctccaagcct
     2581 ctgctcccct tcccaccacc actgccatat aaaatggcca tgctaactcc tacacaacta
     2641 ggagcctcag caggattgct aggatgtggg ttccttcctg catgcttgct tctgcagctg
     2701 tgtggccttg ccatggccct cccaccactt tcccttctac cttgccttcc attgtcttcc
     2761 ttctcccaga aagccaggtt tcaccacgtg ctcaccacaa actgtctccc ctccctcgta
     2821 ggagtcactg cagtagggca cctgcaggcc ctggtagagt gagcagggct tacgtgtaca
     2881 ttctttctca ctctaaggat gtgatatctg accctgatgt cagagaggag gtctcaggac
     2941 tagcattcgg ggtcctttga gtgttcccag aatggtttgg ggtatcacac aaaacaccag
     3001 agctgaggat agggatagag tccccaaaca cacatcctgg gagcaagcca cttcatctga
     3061 gcttcccata ccaggagcat ggtttgtgct ttgatgggaa acctagcaag cccctgcact
     3121 ctggggcttc tcctctcctg gagcccaggg cggctctggc ccgatgatat ggcagccata
     3181 ggtacaggta ttgcaggtgc agcctttctt aagtaccctg cctccactct atagcccagc
     3241 tgctgctgga gtccaggacc ttagacccag gatgagcaaa aggatcccac caggttgtcc
     3301 aggaccattg ccagggtgac cccagagttc ttcagacctg tgtctgatac tgaatacagt
     3361 gccatgggac cctgctccaa tctaactgcc tacaacctgc ccgtccccct gctgcaggga
     3421 tgttgctgct acctcgggag gctctctgag actggtgtct ggtcttagat gctgcacata
     3481 gtacctggtg ctagggtcta ggggctgccc aaagcccagc aggaacagct actactcatc
     3541 ctgcagaggc cttggcccag accagctttc catccaaagc ctcacctggt ttccatgtcc
     3601 atctcaacag tctggccttc ctgtgactgt agcctggcag ccacaccctc agtaatcccg
     3661 cacagtgagt ccagcttctc tgggagcttg gccttcagtt agcccagtcc atgagagggc
     3721 agggtaatga ggaggagtaa aggacctatc ttctctgtcc acataaggaa gttgggacca
     3781 caaggtcttt tatctccttg ttactcccca accccaccat aacctcctac tcagcacaca
     3841 gctgtatcct ggtagattat aaggtgagct tccagaacct ggcaggaggc tggtgtatcc
     3901 ccctgcacag agggaagtgt atctgaatgt tgtgtatgtg gctgatatgg aagacataca
     3961 tgtatgcaat ccatcagcgt ttaaagaaga agattggctc cagttcggag gaggaggagg
     4021 aagattacag atctattctg agtatttttt agagagttaa tatttatatt tttagtaatt
     4081 ttctggtaga aggaaattgc acaataaaat gatttggttt gg
//
