LOCUS       NM_152374               2628 bp    mRNA    linear   PRI 05-APR-2024
DEFINITION  Homo sapiens chromosome 1 open reading frame 216 (C1orf216),
            transcript variant 1, mRNA.
ACCESSION   NM_152374
VERSION     NM_152374.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2628)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   2  (bases 1 to 2628)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 2628)
  AUTHORS   Yu,H., Tardivo,L., Tam,S., Weiner,E., Gebreab,F., Fan,C.,
            Svrzikapa,N., Hirozane-Kishikawa,T., Rietman,E., Yang,X.,
            Sahalie,J., Salehi-Ashtiani,K., Hao,T., Cusick,M.E., Hill,D.E.,
            Roth,F.P., Braun,P. and Vidal,M.
  TITLE     Next-generation sequencing to generate interactome datasets
  JOURNAL   Nat Methods 8 (6), 478-480 (2011)
   PUBMED   21516116
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK096303.1.
            
            On Nov 23, 2018 this sequence version replaced NM_152374.1.
            
            Transcript Variant: This variant (1) represents the longer
            transcript. Variants 1 and 2 both encode the same protein.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR3476690.837537.1, AK096303.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000270815.5/ ENSP00000425166.1
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2628              AK096303.1         306-2933
FEATURES             Location/Qualifiers
     source          1..2628
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1p34.3"
     gene            1..2628
                     /gene="C1orf216"
                     /note="chromosome 1 open reading frame 216"
                     /db_xref="GeneID:127703"
                     /db_xref="HGNC:HGNC:26800"
     exon            1..178
                     /gene="C1orf216"
                     /inference="alignment:Splign:2.1.0"
     exon            179..2628
                     /gene="C1orf216"
                     /inference="alignment:Splign:2.1.0"
     CDS             184..873
                     /gene="C1orf216"
                     /codon_start=1
                     /product="UPF0500 protein C1orf216"
                     /protein_id="NP_689587.1"
                     /db_xref="CCDS:CCDS395.1"
                     /db_xref="GeneID:127703"
                     /db_xref="HGNC:HGNC:26800"
                     /translation="MFAIQPGLAEGGQFLGDPPPGLCQPELQPDSNSNFMASAKDANE
                     NWHGMPGRVEPILRRSSSESPSDNQAFQAPGSPEEGVRSPPEGAEIPGAEPEKMGGAG
                     TVCSPLEDNGYASSSLSIDSRSSSPEPACGTPRGPGPPDPLLPSVAQAVQHLQVQERY
                     KEQEKEKHHVHLVMYRRLALLQWIRGLQHQLIDQQARLQESFDTILDNRKELIRCLQQ
                     RAAPSRPQDQA"
     regulatory      2607..2612
                     /regulatory_class="polyA_signal_sequence"
                     /gene="C1orf216"
                     /note="hexamer: AATAAA"
     polyA_site      2628
                     /gene="C1orf216"
                     /note="major polyA site"
ORIGIN      
        1 gcagacgccg cctgactccg cagtccggga ctggggctgg gcgcgctgcc cgggagcccc
       61 gcacccacgc ctggaccgcg gagacgccca ggccgaggaa cccccagccc agggactaga
      121 caccaccagg gccgggcgga gccagagcca gacgcgccgg agcgggcgcc tctacgccgc
      181 tagatgttcg ccatccagcc agggctagct gaggggggcc aattcctggg ggacccacct
      241 cctggattat gtcagcccga gctccaacca gacagcaact ccaacttcat ggcaagtgcc
      301 aaggatgcta acgagaattg gcatgggatg ccaggcagag tggaacctat cctgaggagg
      361 agctcctctg agtcaccctc tgacaaccaa gccttccagg cccctggatc ccctgaggaa
      421 ggggtgcgca gccccccaga gggggcagag attcccgggg ctgagcctga gaagatgggt
      481 ggtgctggca cagtctgctc ccctctggag gacaacggct atgccagcag ttccctgagc
      541 attgacagcc gtagcagcag tcctgagcct gcctgtggga ccccgcgagg ccctggccct
      601 cccgatcccc ttctgccctc agtggcccag gctgtgcagc acttacaagt ccaggagcgc
      661 tacaaagagc aggagaagga aaagcaccac gtgcacttgg tgatgtaccg tcgcctggca
      721 ctgctccagt ggatccgggg cctgcagcat cagttgattg accagcaggc ccgactgcag
      781 gagagcttcg acaccatcct agacaaccgg aaggagctta ttcgctgtct ccagcagagg
      841 gcagcaccat ccaggcccca ggaccaggcc taagggtgtg cctccacaag tgtgcaaggg
      901 tatatgtata tatttgcagg catgtgtgag gcgcactagt aagtacataa tttgctggca
      961 tgattgcagg taggcatgag tgtgtatgtg ctaacatgta ggctggtgtg tgtaggcatg
     1021 tgtgaataag catgtataaa tgagcttaag tgtgctgtgt gcacatgtgt acacacagct
     1081 aatttatctg cagacctata tgtgagcatg taagagtgaa catatgtgtg tgtgtgtagt
     1141 atgtaagaat gaggaactcg gtatgtgcat gtgtagacag gtacccagca gtgtgtgtat
     1201 atgcgcatga gtgaggatgt ataggcagaa gatgtgtgtg tctatgagtg agtttgagtg
     1261 tgcaggcttg tattaggtgt atgtgaggaa gcccttgtgt gtgcaggggt gcacatgttt
     1321 ggccacaggc atgggaggtg tatgttagga gcatgtgtgt ttgtaggcag actcatgagc
     1381 aggtgtgtgc aaatacatat ccagctgcac tgtgggtgtc cacccacacc ttgtgttcct
     1441 catggcctac cccagccttt cttctccact gggtcccact gttccctgga gacagagggc
     1501 tagcatgctg tcatttatct gaaggttgtg gctgacccat tctcctggga tttcccaggc
     1561 cacctctcct ttccctttcc ctcacttaac ccagacttgc tcagctgagg ctattgtccc
     1621 tgatgttggc tttacttgta ggaggtttag tggctgctct ggcctgccat ggaattttgg
     1681 ctgcaatttt ggcagtgtgt ggagaactgg tatcaggaaa gggaaccagg agtagtgatg
     1741 aagatgatgg tggggatggg gacagaggac ataggggact gtccctcttg aactctgcct
     1801 ttgggcacat gggagatggg gacaggaaag atgataacag tggaaccctg tgaagaatag
     1861 gagaatggga attctaaaat accagttccc aaacaaacca tctctccatt ggaaaaggag
     1921 ctgttgcaaa ccgtgttcat ttaagcttct gatgaaaagc aatgtatgtt tataagcttg
     1981 caagtaacag acaagatgtt ccaaggccga tgaggaaaat atcgcttccc tgtctctgcc
     2041 tctaccttgc tgtgcctctc tggctttagc agcattggat gttgaattgg tttggttcat
     2101 ttctctgaag tcggactgtc aggaggagcc agaggttggc tttctgggat gtgaagggga
     2161 cagtgtcagc ctaagcctct ggagatgctt aggatgctga attttaaccc cttctttcac
     2221 tgcatggccc ttcaaacagg gattggcagg ctccgcgagt tacagagtgg gtgagtcttg
     2281 gagagaacca acgactaagg tagcttagct ctctgctttg ttcttgggag ccaagagaat
     2341 gcaagatcct ggtgggtgag cagtggtatg aagaggggac actggtgggt gaacagtggc
     2401 atggaagtca ctgatgcagc ctctggccct cagtctccct atcggcaaag tggggggctc
     2461 ttcctatctc taaagagttt catccctgac aggtggatgg gtgaaagatc cagagagtgg
     2521 gggtgagggg tgggccctga agactttttg tctgtagctc ttgcatattg agtgtataaa
     2581 cccggcttct ggaccaaccc aagatgaata aactggggca gaaaatta
//
