LOCUS       NM_001136508             921 bp    mRNA    linear   PRI 01-AUG-2024
DEFINITION  Homo sapiens chromosome 1 open reading frame 185 (C1orf185),
            transcript variant 1, mRNA.
ACCESSION   NM_001136508 XM_209252
VERSION     NM_001136508.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 921)
  AUTHORS   Cazin,C., Neirijnck,Y., Loeuillet,C., Wehrli,L., Kuhne,F.,
            Lordey,I., Mustapha,S.F.B., Bouker,A., Zouari,R., Thierry-Mieg,N.,
            Nef,S., Arnoult,C., Ray,P.F. and Kherraf,Z.E.
  TITLE     Combined Use of Whole Exome Sequencing and CRISPR/Cas9 to Study the
            Etiology of Non-Obstructive Azoospermia: Demonstration of the
            Dispensable Role of the Testis-Specific Genes C1orf185 and CCT6B
  JOURNAL   Cells 11 (1), 118 (2021)
   PUBMED   35011680
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 921)
  AUTHORS   Sotoodehnia,N., Isaacs,A., de Bakker,P.I., Dorr,M., Newton-Cheh,C.,
            Nolte,I.M., van der Harst,P., Muller,M., Eijgelsheim,M., Alonso,A.,
            Hicks,A.A., Padmanabhan,S., Hayward,C., Smith,A.V., Polasek,O.,
            Giovannone,S., Fu,J., Magnani,J.W., Marciante,K.D., Pfeufer,A.,
            Gharib,S.A., Teumer,A., Li,M., Bis,J.C., Rivadeneira,F.,
            Aspelund,T., Kottgen,A., Johnson,T., Rice,K., Sie,M.P., Wang,Y.A.,
            Klopp,N., Fuchsberger,C., Wild,S.H., Mateo Leach,I., Estrada,K.,
            Volker,U., Wright,A.F., Asselbergs,F.W., Qu,J., Chakravarti,A.,
            Sinner,M.F., Kors,J.A., Petersmann,A., Harris,T.B., Soliman,E.Z.,
            Munroe,P.B., Psaty,B.M., Oostra,B.A., Cupples,L.A., Perz,S., de
            Boer,R.A., Uitterlinden,A.G., Volzke,H., Spector,T.D., Liu,F.Y.,
            Boerwinkle,E., Dominiczak,A.F., Rotter,J.I., van Herpen,G.,
            Levy,D., Wichmann,H.E., van Gilst,W.H., Witteman,J.C.,
            Kroemer,H.K., Kao,W.H., Heckbert,S.R., Meitinger,T., Hofman,A.,
            Campbell,H., Folsom,A.R., van Veldhuisen,D.J., Schwienbacher,C.,
            O'Donnell,C.J., Volpato,C.B., Caulfield,M.J., Connell,J.M.,
            Launer,L., Lu,X., Franke,L., Fehrmann,R.S., te Meerman,G.,
            Groen,H.J., Weersma,R.K., van den Berg,L.H., Wijmenga,C.,
            Ophoff,R.A., Navis,G., Rudan,I., Snieder,H., Wilson,J.F.,
            Pramstaller,P.P., Siscovick,D.S., Wang,T.J., Gudnason,V., van
            Duijn,C.M., Felix,S.B., Fishman,G.I., Jamshidi,Y., Stricker,B.H.,
            Samani,N.J., Kaab,S. and Arking,D.E.
  TITLE     Common variants in 22 loci are associated with QRS duration and
            cardiac ventricular conduction
  JOURNAL   Nat Genet 42 (12), 1068-1076 (2010)
   PUBMED   21076409
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK130995.1 and AL162430.15.
            
            On Jul 7, 2017 this sequence version replaced NM_001136508.1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK130995.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968968, SAMEA2148093
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000371759.7/ ENSP00000360824.2
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-682               AK130995.1         1-682
            683-921             AL162430.15        51724-51962
FEATURES             Location/Qualifiers
     source          1..921
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1p32.3"
     gene            1..921
                     /gene="C1orf185"
                     /note="chromosome 1 open reading frame 185"
                     /db_xref="GeneID:284546"
                     /db_xref="HGNC:HGNC:28096"
     exon            1..22
                     /gene="C1orf185"
                     /inference="alignment:Splign:2.1.0"
     CDS             7..606
                     /gene="C1orf185"
                     /note="isoform 1 is encoded by transcript variant 1;
                     uncharacterized protein C1orf185"
                     /codon_start=1
                     /product="uncharacterized protein C1orf185 isoform 1"
                     /protein_id="NP_001129980.1"
                     /db_xref="CCDS:CCDS44142.1"
                     /db_xref="GeneID:284546"
                     /db_xref="HGNC:HGNC:28096"
                     /translation="MASPKGFFNYLTYFLAAGAVTLGIGFFALASALWFLICKRREIF
                     QNSKFKAIDERCRQRPSMAKIKSHSQCVFISRNFHTGRFQLQEEQRKKEAAHIKAIKD
                     HSKDEPQLATKNIICDPSETSSTTNRSSVTLSLSTLPSDSYYSQSIEAADDWFSDDSL
                     VKRNSPMPSLGEPLMEKVFSYLSTISLEEGTESVLNDTL"
     exon            23..128
                     /gene="C1orf185"
                     /inference="alignment:Splign:2.1.0"
     exon            129..264
                     /gene="C1orf185"
                     /inference="alignment:Splign:2.1.0"
     exon            265..301
                     /gene="C1orf185"
                     /inference="alignment:Splign:2.1.0"
     exon            302..921
                     /gene="C1orf185"
                     /inference="alignment:Splign:2.1.0"
     regulatory      666..671
                     /regulatory_class="polyA_signal_sequence"
                     /gene="C1orf185"
                     /note="hexamer: TATAAA"
     polyA_site      684
                     /gene="C1orf185"
                     /note="major polyA site"
     regulatory      897..902
                     /regulatory_class="polyA_signal_sequence"
                     /gene="C1orf185"
                     /note="hexamer: AATAAA"
     polyA_site      921
                     /gene="C1orf185"
ORIGIN      
        1 agtcatatgg cttcacctaa aggttttttt aattacttga cctattttct tgctgctggt
       61 gctgtcactt tgggaattgg tttctttgct ttggcatcag ctttgtggtt cctgatttgc
      121 aaacgaagag aaatatttca aaattccaaa tttaaagcaa ttgatgagag atgcaggcaa
      181 agaccatcaa tggcgaagat taaatctcat tctcagtgtg tttttatttc tcgaaatttt
      241 catactggga gattccaatt acaggaggag caaagaaaaa aggaagcagc acatataaaa
      301 gcaattaaag atcattctaa agatgaaccc caacttgcaa caaaaaatat catttgtgat
      361 ccctcagaga ccagctccac aacaaatcgc agcagtgtta cattaagctt atcaacatta
      421 ccatctgatt cttattacag ccaaagtata gaagcagctg atgactggtt ttctgatgat
      481 tctctagtga aaaggaactc tccaatgcct tctctcgggg aacctctaat ggaaaaagta
      541 ttttcatacc tgtcaaccat ttcattagaa gagggtactg aaagtgtact gaatgacact
      601 ttatgaccat caaaaagatg actacattaa gggaaaatgt tcatgaagaa acacagaggt
      661 tgaaatataa aaccttcaac ataatactga atgacttttt tcttttgaaa ccttgtatac
      721 aatcagcttc tgagtctctt aacatgtcca tgctaatatt gctttttttg ttctttacca
      781 tagagcggct ctacttccct tgctggttct tatttctaga aacaaaatta ggaagaacta
      841 gagtgatgtc atgaacatta agcttaactt attgtatctc atccaaagac atattaaata
      901 aaatgagtgt atgtcaacaa a
//
