LOCUS       NM_207356               1645 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens chromosome 1 open reading frame 174 (C1orf174), mRNA.
ACCESSION   NM_207356
VERSION     NM_207356.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1645)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   2  (bases 1 to 1645)
  AUTHORS   Buljan,M., Ciuffa,R., van Drogen,A., Vichalkovski,A., Mehnert,M.,
            Rosenberger,G., Lee,S., Varjosalo,M., Pernas,L.E., Spegg,V.,
            Snijder,B., Aebersold,R. and Gstaiger,M.
  TITLE     Kinase Interaction Network Expands Functional and Disease Roles of
            Human Kinases
  JOURNAL   Mol Cell 79 (3), 504-520 (2020)
   PUBMED   32707033
REFERENCE   3  (bases 1 to 1645)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   4  (bases 1 to 1645)
  AUTHORS   Ingham,N.J., Rook,V., Di Domenico,F., James,E., Lewis,M.A.,
            Girotto,G., Buniello,A. and Steel,K.P.
  TITLE     Functional analysis of candidate genes from genome-wide association
            studies of hearing
  JOURNAL   Hear Res 387, 107879 (2020)
   PUBMED   31927188
REFERENCE   5  (bases 1 to 1645)
  AUTHORS   Fragoza,R., Das,J., Wierbowski,S.D., Liang,J., Tran,T.N., Liang,S.,
            Beltran,J.F., Rivera-Erick,C.A., Ye,K., Wang,T.Y., Yao,L., Mort,M.,
            Stenson,P.D., Cooper,D.N., Wei,X., Keinan,A., Schimenti,J.C.,
            Clark,A.G. and Yu,H.
  TITLE     Extensive disruption of protein interactions by genetic variants
            across the allele frequency spectrum in human populations
  JOURNAL   Nat Commun 10 (1), 4141 (2019)
   PUBMED   31515488
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1645)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Paulo,J.A., Cannon,J.R., Ting,L.,
            Baltier,K., Colby,G., Gebreab,F., Gygi,M.P., Parzen,H., Szpyt,J.,
            Tam,S., Zarraga,G., Pontano-Vaites,L., Swarup,S., White,A.E.,
            Schweppe,D.K., Rad,R., Erickson,B.K., Obar,R.A., Guruharsha,K.G.,
            Li,K., Artavanis-Tsakonas,S., Gygi,S.P. and Harper,J.W.
  TITLE     Architecture of the human interactome defines protein communities
            and disease networks
  JOURNAL   Nature 545 (7655), 505-509 (2017)
   PUBMED   28514442
REFERENCE   7  (bases 1 to 1645)
  AUTHORS   Lee,O.H., Kim,H., He,Q., Baek,H.J., Yang,D., Chen,L.Y., Liang,J.,
            Chae,H.K., Safari,A., Liu,D. and Songyang,Z.
  TITLE     Genome-wide YFP fluorescence complementation screen identifies new
            regulators for telomere signaling in human cells
  JOURNAL   Mol Cell Proteomics 10 (2), M110.001628 (2011)
   PUBMED   21044950
REFERENCE   8  (bases 1 to 1645)
  AUTHORS   Stelzl,U., Worm,U., Lalowski,M., Haenig,C., Brembeck,F.H.,
            Goehler,H., Stroedicke,M., Zenkner,M., Schoenherr,A., Koeppen,S.,
            Timm,J., Mintzlaff,S., Abraham,C., Bock,N., Kietzmann,S.,
            Goedde,A., Toksoz,E., Droege,A., Krobitsch,S., Korn,B.,
            Birchmeier,W., Lehrach,H. and Wanker,E.E.
  TITLE     A human protein-protein interaction network: a resource for
            annotating the proteome
  JOURNAL   Cell 122 (6), 957-968 (2005)
   PUBMED   16169070
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC067302.1 and AL691523.6.
            
            On Nov 23, 2018 this sequence version replaced NM_207356.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC067302.1, SRR5189658.90011.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000361605.4/ ENSP00000355306.3
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-243               BC067302.1         14-256
            244-704             AL691523.6         61200-61660         c
            705-1633            AL691523.6         59776-60704         c
            1634-1645           BC067302.1         1647-1658
FEATURES             Location/Qualifiers
     source          1..1645
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1p36.32"
     gene            1..1645
                     /gene="C1orf174"
                     /note="chromosome 1 open reading frame 174"
                     /db_xref="GeneID:339448"
                     /db_xref="HGNC:HGNC:27915"
     exon            1..101
                     /gene="C1orf174"
                     /inference="alignment:Splign:2.1.0"
     CDS             87..818
                     /gene="C1orf174"
                     /note="RP13-531C17.2"
                     /codon_start=1
                     /product="UPF0688 protein C1orf174"
                     /protein_id="NP_997239.2"
                     /db_xref="CCDS:CCDS53.1"
                     /db_xref="GeneID:339448"
                     /db_xref="HGNC:HGNC:27915"
                     /translation="MRSRKLTGAVRSSARLKARSCSAARLASAQEVAGSTSAKTACLT
                     SSSHKATDTRTSKKFKCDKGHLVKSELQKLVPKNDSASLPKVTPETPCENEFAEGSAL
                     LPGSEAGVSVQQGAASLPLGGCRVVSDSRLAKTRDGLSVPKHSAGSGAEESNSSSTVQ
                     KQNEPGLQTEDVQKPPLQMDNSVFLDDDSNQPMPVSRFFGNVELMQDLPPASSSCPSM
                     SRREFRKMHFRAKDDDDDDDDDAEM"
     exon            102..215
                     /gene="C1orf174"
                     /inference="alignment:Splign:2.1.0"
     exon            216..704
                     /gene="C1orf174"
                     /inference="alignment:Splign:2.1.0"
     exon            705..1645
                     /gene="C1orf174"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1624..1629
                     /regulatory_class="polyA_signal_sequence"
                     /gene="C1orf174"
                     /note="hexamer: AATAAA"
     polyA_site      1645
                     /gene="C1orf174"
                     /note="major polyA site"
ORIGIN      
        1 gcggcgcgct ctgcagactc cgggtcgccg ctccgccggg acgcgttggc cggggcgcgc
       61 ggtgcttggc tgcggtgctc acactcatga ggagccggaa gctcacaggt gcagtgcggt
      121 cttcagcgcg cttgaaagca cgaagttgtt cggcagccag gttggcctct gcccaggaag
      181 ttgctggttc cacgtctgcc aagacagcat gtctgacttc ctcatcccac aaagccacag
      241 acacgcgaac gtccaagaag ttcaaatgtg acaaaggaca tcttgtgaag tcagaattac
      301 agaagcttgt ccctaagaat gacagcgctt ctttgccaaa agtgacacct gagacccctt
      361 gtgaaaatga gtttgctgaa ggcagtgcct tgcttccagg cagcgaggct ggcgtttctg
      421 tgcagcaggg ggctgcaagt cttcctctcg gtggctgcag agttgtgagt gactctcgct
      481 tagcaaagac tagagatggc ctgtccgtgc caaaacacag tgccgggtcc ggagcagaag
      541 aatccaacag cagctccact gtgcagaagc agaatgagcc agggctacag acagaggatg
      601 tgcagaagcc accacttcag atggacaaca gcgtctttct agatgacgac agcaatcagc
      661 caatgcccgt gagccggttc tttggaaacg ttgagctcat gcaggacctc ccacctgcgt
      721 cttcatcttg tccttcaatg agcagacgag agttcagaaa aatgcatttc agagccaaag
      781 atgatgatga tgacgacgac gatgatgcag aaatgtaggg gccatacaaa ataatgtcct
      841 tgagtattta gtaccattaa caatttgaca atttagcaca ttacaagatt tatataaaat
      901 gtatctccaa gagaatgtct taatcaaact tcagaactga cccatctaag tcaatagtgc
      961 aaagcaccca atacctgtgg aggatgtact catgggaact aaaactcaaa ccatctttga
     1021 ggttgcaaag ctgctgtact gtgccaatgt cctttctttt tttttttttt tttttttcct
     1081 tggagacaga gtttctctct tgtcgcccag gctggagtgc aatggcgcaa tctcggctca
     1141 ctgcaacctc cacctcctgg gttcaagtga ttctcctgcc tcagcctcct gagtagctgg
     1201 gattacaggc atacaccacc acacccagct agtttttgta ttattagtag acacgggggt
     1261 ttctccacgt tggccaggct ggtctcaaac tcctgacctc gtgatacgcc cgcctcagcc
     1321 tcccaaagtg ctgggattac aggcgcgagc caccatgccc ggccagtgtc ctttcttata
     1381 cacgtacata catgatgatg gcttgagtca gctgcagggc agtgggctta atgagaggga
     1441 tctttgtaaa gacagctctt cacttcagct cagtagcttt ggtcataggc aagtttgttt
     1501 tccattatca taatttgatg attcttgtga tgaattcaat gctagttctt aaagaactct
     1561 tttatttctg tatgtggagc taatgtttac cttggaaatt ttgcaaaata catgtaagaa
     1621 agaaataaaa tatattttga aaata
//
