LOCUS       NM_001010881            4672 bp    mRNA    linear   PRI 04-AUG-2024
DEFINITION  Homo sapiens chromosome 1 open reading frame 167 (C1orf167), mRNA.
ACCESSION   NM_001010881
VERSION     NM_001010881.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4672)
  AUTHORS   Mo,X.B., Lei,S.F., Zhang,Y.H. and Zhang,H.
  TITLE     Examination of the associations between m6A-associated
            single-nucleotide polymorphisms and blood pressure
  JOURNAL   Hypertens Res 42 (10), 1582-1589 (2019)
   PUBMED   31175347
REFERENCE   2  (bases 1 to 4672)
  AUTHORS   Genno,P.G., Nemer,G.M., Zein Eddine,S.B., Macari,A.T. and
            Ghafari,J.G.
  TITLE     Three novel genes tied to mandibular prognathism in eastern
            Mediterranean families
  JOURNAL   Am J Orthod Dentofacial Orthop 156 (1), 104-112 (2019)
   PUBMED   31256822
REFERENCE   3  (bases 1 to 4672)
  AUTHORS   van Meurs,J.B., Pare,G., Schwartz,S.M., Hazra,A., Tanaka,T.,
            Vermeulen,S.H., Cotlarciuc,I., Yuan,X., Malarstig,A.,
            Bandinelli,S., Bis,J.C., Blom,H., Brown,M.J., Chen,C., Chen,Y.D.,
            Clarke,R.J., Dehghan,A., Erdmann,J., Ferrucci,L., Hamsten,A.,
            Hofman,A., Hunter,D.J., Goel,A., Johnson,A.D., Kathiresan,S.,
            Kampman,E., Kiel,D.P., Kiemeney,L.A., Chambers,J.C., Kraft,P.,
            Lindemans,J., McKnight,B., Nelson,C.P., O'Donnell,C.J., Psaty,B.M.,
            Ridker,P.M., Rivadeneira,F., Rose,L.M., Seedorf,U., Siscovick,D.S.,
            Schunkert,H., Selhub,J., Ueland,P.M., Vollenweider,P., Waeber,G.,
            Waterworth,D.M., Watkins,H., Witteman,J.C., den Heijer,M.,
            Jacques,P., Uitterlinden,A.G., Kooner,J.S., Rader,D.J.,
            Reilly,M.P., Mooser,V., Chasman,D.I., Samani,N.J. and Ahmadi,K.R.
  TITLE     Common genetic loci influencing plasma homocysteine concentrations
            and their effect on risk of coronary artery disease
  JOURNAL   Am J Clin Nutr 98 (3), 668-676 (2013)
   PUBMED   23824729
REFERENCE   4  (bases 1 to 4672)
  AUTHORS   Ban,H.J., Heo,J.Y., Oh,K.S. and Park,K.J.
  TITLE     Identification of type 2 diabetes-associated combination of SNPs
            using support vector machine
  JOURNAL   BMC Genet 11, 26 (2010)
   PUBMED   20416077
  REMARK    GeneRIF: Observational study of gene-disease association and
            gene-gene interaction. (HuGE Navigator)
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 4672)
  AUTHORS   Matarin,M., Brown,W.M., Dena,H., Britton,A., De Vrieze,F.W.,
            Brott,T.G., Brown,R.D. Jr., Worrall,B.B., Case,L.D., Chanock,S.J.,
            Metter,E.J., Ferrucci,L., Gamble,D., Hardy,J.A., Rich,S.S.,
            Singleton,A. and Meschia,J.F.
  TITLE     Candidate gene polymorphisms for ischemic stroke
  JOURNAL   Stroke 40 (11), 3436-3442 (2009)
   PUBMED   19729601
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   6  (bases 1 to 4672)
  AUTHORS   Tran,P., Leclerc,D., Chan,M., Pai,A., Hiou-Tim,F., Wu,Q.,
            Goyette,P., Artigas,C., Milos,R. and Rozen,R.
  TITLE     Multiple transcription start sites and alternative splicing in the
            methylenetetrahydrofolate reductase gene result in two enzyme
            isoforms
  JOURNAL   Mamm Genome 13 (9), 483-492 (2002)
   PUBMED   12370778
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            HY031308.1, HY056181.1, BC128091.1, AL953897.6, AL833920.1,
            AL834308.1, AL833926.1 and AF398935.1.
            
            On Jun 2, 2019 this sequence version replaced NM_001010881.1.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMEA1968968,
                              SAMEA2148093 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            inferred exon combination :: based on alignments, homology
            MANE Ensembl match        :: ENST00000688073.1/ ENSP00000510540.1
            RefSeq Select criteria    :: based on manual assertion, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-34                HY031308.1         2-35
            35-492              HY056181.1         1-458
            493-913             BC128091.1         306-726
            914-1138            AL953897.6         52541-52765
            1139-1508           AL833920.1         1-370
            1509-1509           AL953897.6         53271-53271
            1510-1630           AL833920.1         372-492
            1631-1712           AL953897.6         54205-54286
            1713-1914           AL833920.1         575-776
            1915-1915           AL953897.6         57582-57582
            1916-2165           AL833920.1         778-1027
            2166-2166           AL953897.6         58278-58278
            2167-2454           AL833920.1         1029-1316
            2455-2509           AL953897.6         62595-62649
            2510-2653           AL834308.1         477-620
            2654-2654           AL953897.6         64815-64815
            2655-2941           AL834308.1         622-908
            2942-2974           AL953897.6         65933-65965
            2975-3287           AL834308.1         942-1254
            3288-3288           AL953897.6         70297-70297
            3289-4476           AL833926.1         605-1792
            4477-4477           AL953897.6         75414-75414
            4478-4672           AF398935.1         589-783
FEATURES             Location/Qualifiers
     source          1..4672
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1p36.22"
     gene            1..4672
                     /gene="C1orf167"
                     /note="chromosome 1 open reading frame 167"
                     /db_xref="GeneID:284498"
                     /db_xref="HGNC:HGNC:25262"
     exon            1..113
                     /gene="C1orf167"
                     /inference="alignment:Splign:2.1.0"
     exon            114..253
                     /gene="C1orf167"
                     /inference="alignment:Splign:2.1.0"
     CDS             184..4533
                     /gene="C1orf167"
                     /codon_start=1
                     /product="uncharacterized protein C1orf167"
                     /protein_id="NP_001010881.1"
                     /db_xref="CCDS:CCDS90862.1"
                     /db_xref="GeneID:284498"
                     /db_xref="HGNC:HGNC:25262"
                     /translation="MELRSDASHKENVSPKPAALPKPEQRRFRRSLGIGLSGRHDQWV
                     PGCQVERGGPAATPSPGAVLDQEPCRVQTNLASPGPRLGLALKDTTGQLVNSSFWQQS
                     NLQSLARRRQGKAREFAIQQSNLSINETSSPHLCPEPGGSSGPHKLPWGPLLSQEPLA
                     RPSSCLRQSGLPAPGTPSGDFRPTEAFAPLDGHTQPGLRSWGGLGSWRSRLVGEPLTL
                     EDLAVPSQNQTQAPSRAAVHQLLASVHCLAQEAARLRCQAPQEPPGAVQQDLWTGGGQ
                     PFSAHPQPSQPVLASSDGRRRRLRGHRETAAFLETPASLSDSWAQSKLMSPETTLGTR
                     TKDSLNPEQGLPPAHPLGSGDSCSPWSQDGRAQRGDPSLPRGVGSRGTDPCSSAFSNT
                     AWGVSPKQKGEEGAPRERVHREEERTAFHLSDTVPASSASKNKAQNITAPESEAICWQ
                     LLSRCFRSWRHLVKRQREPAAAAVALGRWQLLRKCLQALWLREAQLEAAWGQYTKVLL
                     VRSFREWRNLALQQKQVQPHMQAGPGSPPSRRAQGKGLSLGRSTVVDPAQRSRLEHTS
                     PGSLREEEIAQRLLSHPRQRTDSRHERVQILQALQLAVFFLWCQQKKRARQERETLRK
                     ATRATQRTGSFPQAWHSTAAGVAWVAPLSPQHQRAWLCRCFGAWQQFVQRGSRYRDHL
                     ADRRTGTLRKCLEQWVRMKQLRESDGAKVTQLSLCRQKAGREAVYTAGPGACGLGAVG
                     QAQGQQEQGRGSLQDACWTLALCWALLLWKMRLFQRQWANSFFQGLQQRMLQRSLRWW
                     HLRALGPDATSSCTKTPSALEPLSSSTLQDSLEKVPRAPTLPDTLQGSLLWAAGQRQQ
                     GQCLLLWQARAQQFQGTARWYQHTRQRRIFLSWSRWATAQWAWRELASHRAWDRTCRA
                     VLGLWRQRLLQSRLVEWWAQERGWRLARDALCHWHSCWQGQQFLHEKCQTWVQVHLQG
                     LQKVVFRSWQQAAAHQRCTVTRPEQLLLQSYFQAWCEVVRDTGVLRAQHQAFQDGLRR
                     RALGAVFATWREAQEVAAGAQEQRVAQASLARWRSCGQQGQEDGQQKKARAPQAFPAW
                     PVAPGMHHEAQQQAGESAGAQAAQCWTWCWALWVHESCRGQVSRAHASWKPRAWVLEA
                     SVQSAVRGGVQRAILTQLRPAELRRFLRTVQLRVRLGLPGAGKTRSCWTQATELVPPA
                     PSLQCSLGGRRKPRGTAWAQRCREHSLCPAFQLWPQWPGQSSWVPGLPLWTRDQGPRA
                     HSSPEPRACKAQSKAHKRRLRARSCRILEKQAQAHGSALLLALKGHDALGHQEEVPAA
                     PVPRGTASRAAGFPAGQVPGSGMAALGGCPRGRAAGADPAQGVAPEMGLADVVAADPA
                     TASGSAVTAAGRWAFKKWHQRLAARSPRRGAASSPRPWSKPGPKGPESGQEAARAPRG
                     WGLGAEHGAQLQL"
     exon            254..1482
                     /gene="C1orf167"
                     /inference="alignment:Splign:2.1.0"
     exon            1483..1526
                     /gene="C1orf167"
                     /inference="alignment:Splign:2.1.0"
     exon            1527..1725
                     /gene="C1orf167"
                     /inference="alignment:Splign:2.1.0"
     exon            1726..1880
                     /gene="C1orf167"
                     /inference="alignment:Splign:2.1.0"
     exon            1881..1993
                     /gene="C1orf167"
                     /inference="alignment:Splign:2.1.0"
     exon            1994..2171
                     /gene="C1orf167"
                     /inference="alignment:Splign:2.1.0"
     exon            2172..2347
                     /gene="C1orf167"
                     /inference="alignment:Splign:2.1.0"
     exon            2348..2522
                     /gene="C1orf167"
                     /inference="alignment:Splign:2.1.0"
     exon            2523..2679
                     /gene="C1orf167"
                     /inference="alignment:Splign:2.1.0"
     exon            2680..2834
                     /gene="C1orf167"
                     /inference="alignment:Splign:2.1.0"
     exon            2835..3043
                     /gene="C1orf167"
                     /inference="alignment:Splign:2.1.0"
     exon            3044..3188
                     /gene="C1orf167"
                     /inference="alignment:Splign:2.1.0"
     exon            3189..3608
                     /gene="C1orf167"
                     /inference="alignment:Splign:2.1.0"
     exon            3609..3750
                     /gene="C1orf167"
                     /inference="alignment:Splign:2.1.0"
     exon            3751..3856
                     /gene="C1orf167"
                     /inference="alignment:Splign:2.1.0"
     exon            3857..4031
                     /gene="C1orf167"
                     /inference="alignment:Splign:2.1.0"
     exon            4032..4261
                     /gene="C1orf167"
                     /inference="alignment:Splign:2.1.0"
     exon            4262..4356
                     /gene="C1orf167"
                     /inference="alignment:Splign:2.1.0"
     exon            4357..4672
                     /gene="C1orf167"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4547..4552
                     /regulatory_class="polyA_signal_sequence"
                     /gene="C1orf167"
                     /note="hexamer: AATAAA"
     polyA_site      4565
                     /gene="C1orf167"
     regulatory      4649..4654
                     /regulatory_class="polyA_signal_sequence"
                     /gene="C1orf167"
                     /note="hexamer: AATAAA"
     polyA_site      4672
                     /gene="C1orf167"
                     /note="major polyA site"
ORIGIN      
        1 gacgtcccct cccgcccgcg acctgccgac ctgcggggat cgttagcggt cccagccccc
       61 gtctagattc aaatccgact gggtgaagga ggacccgagg aggacccacg cacggcccat
      121 ctgattaaac agaccaggcc actcactgtg gagtggacca aggatactcc tgtccctgag
      181 cccatggagc taaggtctga tgccagccac aaggagaatg tgtccccaaa gcctgcagcg
      241 ctcccgaagc cagagcaacg aagattccgg aggagcctgg gcatcggcct gagtggtaga
      301 catgaccagt gggtgcccgg gtgccaggtg gagaggggag ggcctgctgc cacaccctcc
      361 ccaggggcag tgctagacca ggagccctgc cgagtccaga ccaacctggc cagccctggt
      421 ccccgcctgg gcctagctct gaaggacacg actggccaac tggtcaattc aagcttctgg
      481 caacagagca acctgcagtc cctggccagg aggcgccaag ggaaggcccg agagtttgcc
      541 atccagcaga gcaacctgag catcaacgag accagcagcc cccacctctg cccagagcct
      601 gggggaagct ctgggcccca caagcttccc tggggtcctc tcctatccca agagccactg
      661 gctcgcccat cttcctgcct gaggcagtcc gggctgccgg ccccaggcac ccctagcggg
      721 gacttcaggc ccactgaagc ctttgcccct ctcgatgggc atacacagcc aggcctcaga
      781 tcctggggtg gtctggggag ctggaggtcc aggctggtgg gggaacctct caccctggag
      841 gacctggctg tccccagtca gaaccagact caggccccat cccgtgctgc cgtccaccag
      901 ctgctggctt ctgtacattg cctggcgcag gaggcagccc gactcaggtg ccaggctccc
      961 caggaacccc ccggtgctgt gcagcaggac ctctggaccg gcggcggcca gccattctcc
     1021 gcccaccccc agcccagcca gcctgtcctt gcttcctcgg atgggaggag gagacgcctt
     1081 cgaggccaca gggaaactgc ggctttcttg gagaccccgg ctagtctctc agactcttgg
     1141 gcacaaagca agctaatgtc acctgagacc actttgggga cacggaccaa ggattccctt
     1201 aatcctgagc aggggctccc tcctgcccac cccctagggt caggggacag ctgctccccc
     1261 tggtctcaag atggcagggc acagaggggt gaccccagtc tccctcgagg ggtgggaagc
     1321 agggggaccg acccctgttc ctcagccttc tccaacacag cctggggagt ctcacccaag
     1381 cagaaaggag aggagggggc cccgagggag cgggtccaca gggaggagga gaggacagct
     1441 ttccatctgt cagacacagt cccagcgagc agtgcgtcga agaacaaggc acaaaacatc
     1501 acagccccag agtctgaggc aatctgctgg cagctgttgt ccagatgttt tcgatcctgg
     1561 aggcacttgg tgaagaggca gcgggagcca gcggcggcgg cagtggcact gggccgctgg
     1621 cagctgttgc gaaagtgcct tcaggccttg tggctccggg aggctcagct ggaggcagca
     1681 tgggggcagt acacaaaggt tctgctggtc cggagcttcc gagagtggag aaacctggct
     1741 ttacagcaga aacaagtaca gccccacatg caggctgggc cagggtcccc gccctccagg
     1801 agagcccagg gcaaaggcct ctccttggga agaagcacag tggtggaccc cgcccagaga
     1861 agcaggctgg aacacaccag tccaggaagt ctgagggagg aggagattgc tcagcggctt
     1921 ctgtcacatc ctaggcagag aacagacagc agacacgaga gagtccagat cctgcaggcc
     1981 ctgcaactgg ctgtgttctt cctgtggtgc caacagaaga aacgggccag acaggagagg
     2041 gagactctgc ggaaggccac cagggccaca cagaggacag ggagcttccc ccaggcctgg
     2101 cactctactg ctgcaggtgt agcctgggtg gccccactga gcccccagca ccagagagct
     2161 tggctgtgca ggtgcttcgg ggcgtggcag cagttcgtgc aaagagggtc ccggtaccga
     2221 gaccacctgg ctgaccgccg gacggggacc ctgaggaaat gcctggaaca gtgggtgcgg
     2281 atgaagcagc tccgggaatc agatggggca aaggtgaccc agctgtccct ctgccggcag
     2341 aaagcaggac gtgaggctgt ctacaccgca ggccctggag cctgtggcct gggtgcagtg
     2401 ggccaggccc aggggcagca ggagcaaggc cggggctccc tgcaggatgc ctgctggaca
     2461 ctggccctct gctgggcgct gctgctgtgg aagatgcggc ttttccagcg ccagtgggcc
     2521 aactccttct tccagggcct gcagcagcgg atgctgcagc gcagcctgag atggtggcac
     2581 ttgagggcac tgggcccaga tgccacatca agctgcacca agaccccctc ggctctggag
     2641 ccactgagca gcagcacact ccaagactct ctggagaagg ttcccagggc ccccaccctc
     2701 ccggacactc tccaggggag ccttctgtgg gcagctgggc agcggcagca ggggcagtgc
     2761 cttctgctct ggcaggcacg ggcccagcag ttccagggca cagccaggtg gtaccagcat
     2821 acccgccaga ggcgcatctt cctcagctgg agccgctggg caacagccca atgggcctgg
     2881 agagagctgg cttcccaccg ggcctgggat cggacctgca gggctgtgct gggcctgtgg
     2941 cgtcagcggc tgctgcagtc acggctggtg gagtggtggg cccaggagcg gggctggcgg
     3001 ctggcacgag atgccctatg ccactggcac tcctgttggc aggggcagca gttcctgcat
     3061 gaaaagtgcc agacatgggt gcaggtccac ctccagggcc tgcagaaggt ggtgttccgg
     3121 agctggcagc aggcagcagc tcatcagaga tgcacagtga cccggccaga gcagctgcta
     3181 ctgcagagct acttccaggc ctggtgtgag gttgtaagag acacgggggt gctccgggcc
     3241 cagcatcaag cctttcagga tggcctgagg agaagagcac tgggggccgt gtttgccaca
     3301 tggcgggaag cccaggaagt ggcagccggg gcacaggagc agcgtgtggc ccaggcctcc
     3361 cttgcccgct ggagaagctg cgggcagcaa ggccaggaag atgggcagca gaagaaggcc
     3421 cgggccccac aggccttccc agcatggcca gtggccccgg gcatgcacca tgaggcccag
     3481 cagcaggcag gagagagcgc tggggcccag gcagcccagt gctggacttg gtgctgggct
     3541 ctgtgggtgc atgagtcctg tcggggccag gtcagccgag cccatgcttc ctggaagccg
     3601 cgagcctggg tcctagaggc ctcggtgcag tcggcggtgc gcggcggtgt ccagcgagcc
     3661 atcctcaccc agctccggcc ggctgagctc aggcgcttcc tgcggacagt gcagctcagg
     3721 gtgcggctgg gactgccagg ggccggcaag acccgcagct gctggacaca ggccacagag
     3781 ctggtgcctc ccgcgccatc actgcagtgc agcctgggtg gacggaggaa gccaagggga
     3841 acggcctggg ctcagaggtg cagggaacat tccctctgcc ctgccttcca gctctggcca
     3901 cagtggcctg gacagagtag ctgggtccca ggcctgcccc tgtggacgag ggaccaggga
     3961 ccaagagcgc actccagccc tgagcccaga gcctgcaaag cccaaagcaa ggcccataaa
     4021 cggaggctac gtgctcgttc ctgcaggatc ctggaaaagc aggcccaggc ccatggctct
     4081 gccctccttc tggccctgaa gggtcacgat gctcttggcc atcaggagga agtacctgca
     4141 gcgccggtgc ctcgaggcac tgcttcacgg gctgcggggt tcccagcagg ccaggtgcct
     4201 ggcagtggca tggcagcact gggtggatgc ccaaggggca gagcagctgg tgcggaccct
     4261 gctcagggag tggcacctga gatgggcctg gcagacgtgg tggcagcgga tcctgcgact
     4321 gcgagtggct cagcagttac agcagcagga agatgggcct ttaagaagtg gcaccaacgc
     4381 ctggcagcca ggagcccaag gagaggagct gccagtagcc caagaccctg gagcaagcca
     4441 ggccccaagg gccccgagag tggacaggaa gccgccagag caccgcgggg ttgggggctt
     4501 ggggcagagc atggggccca gctgcagctg tgacttgttc tcatagaata aaaaacagaa
     4561 ctgaacttag ccttcccagg gaaggaacca tgccccacac atccagggag tgatgacaga
     4621 ggggacagct tgaagagctc tgaaggacaa taaaacccac tcctcagtcc ta
//
