LOCUS       NM_017891               1832 bp    mRNA    linear   PRI 21-SEP-2024
DEFINITION  Homo sapiens chromosome 1 open reading frame 159 (C1orf159),
            transcript variant 2, mRNA.
ACCESSION   NM_017891 NM_001114103
VERSION     NM_017891.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1832)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   2  (bases 1 to 1832)
  AUTHORS   Clark,H.F., Gurney,A.L., Abaya,E., Baker,K., Baldwin,D., Brush,J.,
            Chen,J., Chow,B., Chui,C., Crowley,C., Currell,B., Deuel,B.,
            Dowd,P., Eaton,D., Foster,J., Grimaldi,C., Gu,Q., Hass,P.E.,
            Heldens,S., Huang,A., Kim,H.S., Klimowski,L., Jin,Y., Johnson,S.,
            Lee,J., Lewis,L., Liao,D., Mark,M., Robbie,E., Sanchez,C.,
            Schoenfeld,J., Seshagiri,S., Simmons,L., Singh,J., Smith,V.,
            Stinson,J., Vagts,A., Vandlen,R., Watanabe,C., Wieand,D., Woods,K.,
            Xie,M.H., Yansura,D., Yi,S., Yu,G., Yuan,J., Zhang,M., Zhang,Z.,
            Goddard,A., Wood,W.I., Godowski,P. and Gray,A.
  TITLE     The secreted protein discovery initiative (SPDI), a large-scale
            effort to identify novel human secreted and transmembrane proteins:
            a bioinformatics assessment
  JOURNAL   Genome Res 13 (10), 2265-2270 (2003)
   PUBMED   12975309
  REMARK    Erratum:[Genome Res. 2003 Dec;13(12):2759]
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK000591.1, BE280321.1 and BM974309.1.
            
            On Jun 2, 2019 this sequence version replaced NM_017891.4.
            
            Transcript Variant: This variant (2) differs in the 5' UTR, lacks
            an alternate in-frame exon, and uses an alternate in-frame splice
            junction compared to variant 1. The resulting isoform (2) has the
            same N- and C-termini but is shorter compared to isoform 1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK000591.1, SRR3476690.754151.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000421241.7/ ENSP00000400736.2
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-890               AK000591.1         3-892
            891-957             BE280321.1         348-414
            958-1414            AK000591.1         960-1416
            1415-1832           BM974309.1         17-434              c
FEATURES             Location/Qualifiers
     source          1..1832
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1p36.33"
     gene            1..1832
                     /gene="C1orf159"
                     /note="chromosome 1 open reading frame 159"
                     /db_xref="GeneID:54991"
                     /db_xref="HGNC:HGNC:26062"
     exon            1..30
                     /gene="C1orf159"
                     /inference="alignment:Splign:2.1.0"
     exon            31..143
                     /gene="C1orf159"
                     /inference="alignment:Splign:2.1.0"
     exon            144..237
                     /gene="C1orf159"
                     /inference="alignment:Splign:2.1.0"
     CDS             166..762
                     /gene="C1orf159"
                     /note="isoform 2 precursor is encoded by transcript
                     variant 2; uncharacterized protein C1orf159"
                     /codon_start=1
                     /product="uncharacterized protein C1orf159 isoform 2
                     precursor"
                     /protein_id="NP_060361.4"
                     /db_xref="CCDS:CCDS7.2"
                     /db_xref="GeneID:54991"
                     /db_xref="HGNC:HGNC:26062"
                     /translation="MALRHLALLAGLLVGVASKSMENTAQLPECCVDVVGVNASCPGA
                     SLCGPGCYRRWNADGSASCVRCGNGTLPAYNGSECRSFAGPGAPFPMNRSSGTPGRPH
                     PGAPRVAASLFLGTFFISSGLILSVAGFFYLKRSSKLPRACYRRNKAPALQPGEAAAM
                     IPPPQSSVRKPRYVRRERPLDRATDPAAFPGEARISNV"
     exon            238..313
                     /gene="C1orf159"
                     /inference="alignment:Splign:2.1.0"
     exon            314..409
                     /gene="C1orf159"
                     /inference="alignment:Splign:2.1.0"
     exon            410..475
                     /gene="C1orf159"
                     /inference="alignment:Splign:2.1.0"
     exon            476..610
                     /gene="C1orf159"
                     /inference="alignment:Splign:2.1.0"
     exon            611..636
                     /gene="C1orf159"
                     /inference="alignment:Splign:2.1.0"
     exon            637..667
                     /gene="C1orf159"
                     /inference="alignment:Splign:2.1.0"
     exon            668..1832
                     /gene="C1orf159"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1812..1817
                     /regulatory_class="polyA_signal_sequence"
                     /gene="C1orf159"
                     /note="hexamer: TATAAA"
     polyA_site      1832
                     /gene="C1orf159"
                     /note="major polyA site"
ORIGIN      
        1 gtacgaaaga gaaacccgga gggcgccggg gactgggccg gggtctgcag ggctcagctg
       61 agcccatgag ctcccagagc taacccctga acacccaggc gggcaaaggg ctgatgtcgg
      121 tagtccccat cctggagggg caggctctgc gcatctgctc ctggcatggc gctgcggcac
      181 ctcgccctcc tggctggcct tctcgtggga gtcgccagca agtccatgga gaacacggcc
      241 cagctgcccg agtgctgtgt ggatgtggtg ggcgtcaacg ccagctgccc aggcgcaagt
      301 ctgtgtggtc caggctgtta caggcgctgg aacgcggacg ggagcgccag ctgcgtccgc
      361 tgtgggaacg gaaccctccc agcctacaac ggctccgagt gtagaagctt tgctggcccg
      421 ggtgcgccat tccccatgaa cagaagctca gggacccccg ggcggccaca tcctggggct
      481 ccgcgcgtgg ccgcctccct cttcctgggc acgttcttca ttagctccgg cctcatcctc
      541 tccgtagctg ggttcttcta cctcaagcgc tccagtaaac tccccagggc ctgctacaga
      601 agaaacaaag ctccggccct gcagcctggc gaagccgctg caatgatccc cccgccacag
      661 tcctcagtac ggaagccgcg ctacgtcagg cgggagcggc ccctggacag ggccacggat
      721 cccgctgcct tcccggggga ggcccgtatc agcaatgtct gacctggagg ccgagaccac
      781 gccacgcact tggcggcagg gacccggagg ccgacccctt ggcgggaacc agcacaaagt
      841 gttggcatcg cccggcgccc gggacagtcc tgggcacagc ctcggctctg agtccctccg
      901 cctcccagcg acggacgcca aagggtcccg ggccgcctga ggctcctccc caccacagcc
      961 atctcgttta tcggaccagg agcaggcatc catgagacct cagagcttca gatcgaggcc
     1021 ttggggggtc cgggcccccc caggaaacac ggtgaggccc cagcgcctgc agccaaagct
     1081 ggcacgatct atggggcagg tgccgctctg cctagaaaag ccaggggctc tgctgccgtg
     1141 ccctccagag cccacagcgg gcaggactcc tccagcacca ccacacccag tggcccgaga
     1201 cccctctgag aacagtgagg ctggtcctcg tgccgttcca gccggtgccc ggccagtggg
     1261 gaggacacag cctaggaacc agctgcctga gaccagggtg cctctgggct gtcctcccgc
     1321 gtggcggaga ccccaagcac gcagccaccc atttccggag ctgcaggata gagcttcctc
     1381 ttgatctctg tttttaagca gaaattcatt gtgcagaaaa gtcctccaga gctctgtggc
     1441 cccgctcgga tccgctggac ccccatgcct ggctgatccc tgcccacgtg gggcaggccc
     1501 acatctaacc cccacaagtc actgcctcac tgcacctgcc aaggctgccc tggcgctgag
     1561 tcctggggtc cctcccggag ttcctgggag aaaggcgccg tcgtggccgc ctcccgcacg
     1621 ccaggcccgg gctccaccgt gggtctcaga cgccctgcgg caccggcacc gtctgcttta
     1681 gcatgggacc cccctctgag gggtggcctg gccttcgggg tccccacgct cctttgcgaa
     1741 gtccactgtg ggtgccatca tggtctccgg gacctgggcc agcgggaacg tgggggcact
     1801 gggtgtgctg atataaagtc ggcattactc aa
//
