LOCUS       NM_001330306            2432 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens chromosome 1 open reading frame 159 (C1orf159),
            transcript variant 1, mRNA.
ACCESSION   NM_001330306 XM_011541663
VERSION     NM_001330306.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2432)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   2  (bases 1 to 2432)
  AUTHORS   Clark,H.F., Gurney,A.L., Abaya,E., Baker,K., Baldwin,D., Brush,J.,
            Chen,J., Chow,B., Chui,C., Crowley,C., Currell,B., Deuel,B.,
            Dowd,P., Eaton,D., Foster,J., Grimaldi,C., Gu,Q., Hass,P.E.,
            Heldens,S., Huang,A., Kim,H.S., Klimowski,L., Jin,Y., Johnson,S.,
            Lee,J., Lewis,L., Liao,D., Mark,M., Robbie,E., Sanchez,C.,
            Schoenfeld,J., Seshagiri,S., Simmons,L., Singh,J., Smith,V.,
            Stinson,J., Vagts,A., Vandlen,R., Watanabe,C., Wieand,D., Woods,K.,
            Xie,M.H., Yansura,D., Yi,S., Yu,G., Yuan,J., Zhang,M., Zhang,Z.,
            Goddard,A., Wood,W.I., Godowski,P. and Gray,A.
  TITLE     The secreted protein discovery initiative (SPDI), a large-scale
            effort to identify novel human secreted and transmembrane proteins:
            a bioinformatics assessment
  JOURNAL   Genome Res 13 (10), 2265-2270 (2003)
   PUBMED   12975309
  REMARK    Erratum:[Genome Res. 2003 Dec;13(12):2759]
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL390719.47.
            
            On Jun 2, 2019 this sequence version replaced NM_001330306.1.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            RNAseq introns :: mixed sample support SAMEA1965299, SAMEA1966682
                              [ECO:0006172]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-30                AL390719.47        55151-55180         c
            31-84               AL390719.47        54113-54166         c
            85-197              AL390719.47        31082-31194         c
            198-291             AL390719.47        30563-30656         c
            292-399             AL390719.47        29967-30074         c
            400-475             AL390719.47        29444-29519         c
            476-571             AL390719.47        26593-26688         c
            572-637             AL390719.47        26230-26295         c
            638-772             AL390719.47        24969-25103         c
            773-798             AL390719.47        23572-23597         c
            799-1267            AL390719.47        23006-23474         c
            1268-2432           AL390719.47        20914-22078         c
FEATURES             Location/Qualifiers
     source          1..2432
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1p36.33"
     gene            1..2432
                     /gene="C1orf159"
                     /note="chromosome 1 open reading frame 159"
                     /db_xref="GeneID:54991"
                     /db_xref="HGNC:HGNC:26062"
     exon            1..30
                     /gene="C1orf159"
                     /inference="alignment:Splign:2.1.0"
     exon            31..84
                     /gene="C1orf159"
                     /inference="alignment:Splign:2.1.0"
     exon            85..197
                     /gene="C1orf159"
                     /inference="alignment:Splign:2.1.0"
     exon            198..291
                     /gene="C1orf159"
                     /inference="alignment:Splign:2.1.0"
     CDS             220..1362
                     /gene="C1orf159"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; uncharacterized protein C1orf159"
                     /codon_start=1
                     /product="uncharacterized protein C1orf159 isoform 1
                     precursor"
                     /protein_id="NP_001317235.1"
                     /db_xref="CCDS:CCDS81250.1"
                     /db_xref="GeneID:54991"
                     /db_xref="HGNC:HGNC:26062"
                     /translation="MALRHLALLAGLLVGVASKSMENTVTRNSTAVINTQAEGTLSPP
                     GLSSLPVVREWALTHTAQLPECCVDVVGVNASCPGASLCGPGCYRRWNADGSASCVRC
                     GNGTLPAYNGSECRSFAGPGAPFPMNRSSGTPGRPHPGAPRVAASLFLGTFFISSGLI
                     LSVAGFFYLKRSSKLPRACYRRNKAPALQPGEAAAMIPPPQSSGNSSCRIPLWGFPSL
                     GQSQGALWVCPQTGLPGSGSRPPLPGSPGDPPTRQGQGRIWLVPPALDLSWIWPAPPA
                     RPPLIPVTSMLFPVPETWGLQERRTHHDRADPQYLLLLEVQLHPRTDAAGLRQALLSS
                     HRFSGAGSGGPKSQPVRKPRYVRRERPLDRATDPAAFPGEARISNV"
     exon            292..399
                     /gene="C1orf159"
                     /inference="alignment:Splign:2.1.0"
     exon            400..475
                     /gene="C1orf159"
                     /inference="alignment:Splign:2.1.0"
     exon            476..571
                     /gene="C1orf159"
                     /inference="alignment:Splign:2.1.0"
     exon            572..637
                     /gene="C1orf159"
                     /inference="alignment:Splign:2.1.0"
     exon            638..772
                     /gene="C1orf159"
                     /inference="alignment:Splign:2.1.0"
     exon            773..798
                     /gene="C1orf159"
                     /inference="alignment:Splign:2.1.0"
     exon            799..1267
                     /gene="C1orf159"
                     /inference="alignment:Splign:2.1.0"
     exon            1268..2432
                     /gene="C1orf159"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2412..2417
                     /regulatory_class="polyA_signal_sequence"
                     /gene="C1orf159"
                     /note="hexamer: TATAAA"
     polyA_site      2432
                     /gene="C1orf159"
                     /note="major polyA site"
ORIGIN      
        1 gtacgaaaga gaaacccgga gggcgccggg tattaccagg gtgtgcagag aaggcagagc
       61 tgcgtcttcc tcttttattt ttccgactgg gccggggtct gcagggctca gctgagccca
      121 tgagctccca gagctaaccc ctgaacaccc aggcgggcaa agggctgatg tcggtagtcc
      181 ccatcctgga ggggcaggct ctgcgcatct gctcctggca tggcgctgcg gcacctcgcc
      241 ctcctggctg gccttctcgt gggagtcgcc agcaagtcca tggagaacac ggtcacgaga
      301 aacagcacag ctgtgatcaa cacacaagct gagggtaccc tgagcccccc aggcctgtcc
      361 agtctgcctg tggtcaggga atgggccctc acacacaccg cccagctgcc cgagtgctgt
      421 gtggatgtgg tgggcgtcaa cgccagctgc ccaggcgcaa gtctgtgtgg tccaggctgt
      481 tacaggcgct ggaacgcgga cgggagcgcc agctgcgtcc gctgtgggaa cggaaccctc
      541 ccagcctaca acggctccga gtgtagaagc tttgctggcc cgggtgcgcc attccccatg
      601 aacagaagct cagggacccc cgggcggcca catcctgggg ctccgcgcgt ggccgcctcc
      661 ctcttcctgg gcacgttctt cattagctcc ggcctcatcc tctccgtagc tgggttcttc
      721 tacctcaagc gctccagtaa actccccagg gcctgctaca gaagaaacaa agctccggcc
      781 ctgcagcctg gcgaagccgc tgcaatgatc cccccgccac agtcctcagg taacagcagc
      841 tgtcgcatcc ccctgtgggg tttcccatct ctgggccagt cccagggtgc tctgtgggtt
      901 tgtccccaaa cgggtttgcc tggctctgga tctcggccac ccctgcccgg gtccccagga
      961 gacccaccca caaggcaggg ccagggccgg atttggctgg tgccccctgc tctggatctc
     1021 agctggattt ggccggcgcc ccctgcccgc ccccctttaa tccccgtgac ttccatgctc
     1081 tttcctgttc ccgagacgtg gggtctgcag gaaaggagga cccaccacga cagggcagac
     1141 ccccaatacc tgctcctcct tgaagtccag ctccacccga ggacagacgc agccggcctc
     1201 cgccaggccc tcctgagcag ccatcgcttc agtggtgctg ggtcaggcgg acccaagagt
     1261 cagcccgtac ggaagccgcg ctacgtcagg cgggagcggc ccctggacag ggccacggat
     1321 cccgctgcct tcccggggga ggcccgtatc agcaatgtct gacctggagg ccgagaccac
     1381 gccacgcact tggcggcagg gacccggagg ccgacccctt ggcgggaacc agcacaaagt
     1441 gttggcatcg cccggcgccc gggacagtcc tgggcacagc ctcggctctg agtccctccg
     1501 cctcccagcg acggacgcca aagggtcccg ggccgcctga ggctcctccc caccacagcc
     1561 atctcgttta tcggaccagg agcaggcatc catgagacct cagagcttca gatcgaggcc
     1621 ttggggggtc cgggcccccc caggaaacac ggtgaggccc cagcgcctgc agccaaagct
     1681 ggcacgatct atggggcagg tgccgctctg cctagaaaag ccaggggctc tgctgccgtg
     1741 ccctccagag cccacagcgg gcaggactcc tccagcacca ccacacccag tggcccgaga
     1801 cccctctgag aacagtgagg ctggtcctcg tgccgttcca gccggtgccc ggccagtggg
     1861 gaggacacag cctaggaacc agctgcctga gaccagggtg cctctgggct gtcctcccgc
     1921 gtggcggaga ccccaagcac gcagccaccc atttccggag ctgcaggata gagcttcctc
     1981 ttgatctctg tttttaagca gaaattcatt gtgcagaaaa gtcctccaga gctctgtggc
     2041 cccgctcgga tccgctggac ccccatgcct ggctgatccc tgcccacgtg gggcaggccc
     2101 acatctaacc cccacaagtc actgcctcac tgcacctgcc aaggctgccc tggcgctgag
     2161 tcctggggtc cctcccggag ttcctgggag aaaggcgccg tcgtggccgc ctcccgcacg
     2221 ccaggcccgg gctccaccgt gggtctcaga cgccctgcgg caccggcacc gtctgcttta
     2281 gcatgggacc cccctctgag gggtggcctg gccttcgggg tccccacgct cctttgcgaa
     2341 gtccactgtg ggtgccatca tggtctccgg gacctgggcc agcgggaacg tgggggcact
     2401 gggtgtgctg atataaagtc ggcattactc aa
//
