LOCUS       NM_001276352            2213 bp    mRNA    linear   PRI 04-AUG-2024
DEFINITION  Homo sapiens chromosome 1 open reading frame 141 (C1orf141),
            transcript variant 2, mRNA.
ACCESSION   NM_001276352
VERSION     NM_001276352.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2213)
  AUTHORS   Liu,H., Irwanto,A., Fu,X., Yu,G., Yu,Y., Sun,Y., Wang,C., Wang,Z.,
            Okada,Y., Low,H., Li,Y., Liany,H., Chen,M., Bao,F., Li,J., You,J.,
            Zhang,Q., Liu,J., Chu,T., Andiappan,A.K., Wang,N., Niu,G., Liu,D.,
            Yu,X., Zhang,L., Tian,H., Zhou,G., Rotzschke,O., Chen,S., Zhang,X.,
            Liu,J. and Zhang,F.
  TITLE     Discovery of six new susceptibility loci and analysis of
            pleiotropic effects in leprosy
  JOURNAL   Nat Genet 47 (3), 267-271 (2015)
   PUBMED   25642632
REFERENCE   2  (bases 1 to 2213)
  AUTHORS   Hou,S., Du,L., Lei,B., Pang,C.P., Zhang,M., Zhuang,W., Zhang,M.,
            Huang,L., Gong,B., Wang,M., Zhang,Q., Hu,K., Zhou,Q., Qi,J.,
            Wang,C., Tian,Y., Ye,Z., Liang,L., Yu,H., Li,H., Zhou,Y., Cao,Q.,
            Liu,Y., Bai,L., Liao,D., Kijlstra,A., Xu,J., Yang,Z. and Yang,P.
  TITLE     Genome-wide association analysis of Vogt-Koyanagi-Harada syndrome
            identifies two new susceptibility loci at 1p31.2 and 10q21.3
  JOURNAL   Nat Genet 46 (9), 1007-1011 (2014)
   PUBMED   25108386
REFERENCE   3  (bases 1 to 2213)
  AUTHORS   Deng,X., Sabino,E.C., Cunha-Neto,E., Ribeiro,A.L., Ianni,B.,
            Mady,C., Busch,M.P. and Seielstad,M.
  CONSRTM   REDSII Chagas Study Group from the NHLBI Retrovirus Epidemiology
            Donor Study-II Component International
  TITLE     Genome wide association study (GWAS) of Chagas cardiomyopathy in
            Trypanosoma cruzi seropositive subjects
  JOURNAL   PLoS One 8 (11), e79629 (2013)
   PUBMED   24324551
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2213)
  AUTHORS   Kenny,E.E., Pe'er,I., Karban,A., Ozelius,L., Mitchell,A.A.,
            Ng,S.M., Erazo,M., Ostrer,H., Abraham,C., Abreu,M.T., Atzmon,G.,
            Barzilai,N., Brant,S.R., Bressman,S., Burns,E.R., Chowers,Y.,
            Clark,L.N., Darvasi,A., Doheny,D., Duerr,R.H., Eliakim,R.,
            Giladi,N., Gregersen,P.K., Hakonarson,H., Jones,M.R., Marder,K.,
            McGovern,D.P., Mulle,J., Orr-Urtreger,A., Proctor,D.D., Pulver,A.,
            Rotter,J.I., Silverberg,M.S., Ullman,T., Warren,S.T., Waterman,M.,
            Zhang,W., Bergman,A., Mayer,L., Katz,S., Desnick,R.J., Cho,J.H. and
            Peter,I.
  TITLE     A genome-wide scan of Ashkenazi Jewish Crohn's disease suggests
            novel susceptibility loci
  JOURNAL   PLoS Genet 8 (3), e1002559 (2012)
   PUBMED   22412388
REFERENCE   5  (bases 1 to 2213)
  AUTHORS   Zhang,F., Liu,H., Chen,S., Low,H., Sun,L., Cui,Y., Chu,T., Li,Y.,
            Fu,X., Yu,Y., Yu,G., Shi,B., Tian,H., Liu,D., Yu,X., Li,J., Lu,N.,
            Bao,F., Yuan,C., Liu,J., Liu,H., Zhang,L., Sun,Y., Chen,M.,
            Yang,Q., Yang,H., Yang,R., Zhang,L., Wang,Q., Liu,H., Zuo,F.,
            Zhang,H., Khor,C.C., Hibberd,M.L., Yang,S., Liu,J. and Zhang,X.
  TITLE     Identification of two new loci at IL23R and RAB32 that influence
            susceptibility to leprosy
  JOURNAL   Nat Genet 43 (12), 1247-1251 (2011)
   PUBMED   22019778
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2213)
  AUTHORS   Raelson,J.V., Little,R.D., Ruether,A., Fournier,H., Paquin,B., Van
            Eerdewegh,P., Bradley,W.E., Croteau,P., Nguyen-Huu,Q., Segal,J.,
            Debrus,S., Allard,R., Rosenstiel,P., Franke,A., Jacobs,G.,
            Nikolaus,S., Vidal,J.M., Szego,P., Laplante,N., Clark,H.F.,
            Paulussen,R.J., Hooper,J.W., Keith,T.P., Belouchi,A. and
            Schreiber,S.
  TITLE     Genome-wide association study for Crohn's disease in the Quebec
            Founder Population identifies multiple validated disease loci
  JOURNAL   Proc Natl Acad Sci U S A 104 (37), 14747-14752 (2007)
   PUBMED   17804789
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BG772061.1, BC062728.1 and AL133320.8.
            
            On Jun 2, 2019 this sequence version replaced NM_001276352.1.
            
            Transcript Variant: This variant (2) contains two alternate
            in-frame exons but lacks another alternate coding exon in the 3'
            end, that causes a frameshift. The resulting isoform (2) contains
            an alternate internal segment but has a shorter and distinct
            C-terminus compared to isoform 1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMEA2148874
                              [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-53                BG772061.1         11-63
            54-490              BC062728.1         43-479
            491-612             BG772061.1         500-621
            613-1349            BC062728.1         745-1481
            1350-2213           AL133320.8         90933-91796         c
FEATURES             Location/Qualifiers
     source          1..2213
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1p31.3"
     gene            1..2213
                     /gene="C1orf141"
                     /note="chromosome 1 open reading frame 141"
                     /db_xref="GeneID:400757"
                     /db_xref="HGNC:HGNC:32044"
     exon            1..41
                     /gene="C1orf141"
                     /inference="alignment:Splign:2.1.0"
     exon            42..127
                     /gene="C1orf141"
                     /inference="alignment:Splign:2.1.0"
     exon            128..219
                     /gene="C1orf141"
                     /inference="alignment:Splign:2.1.0"
     CDS             145..798
                     /gene="C1orf141"
                     /note="isoform 2 is encoded by transcript variant 2;
                     uncharacterized protein C1orf141"
                     /codon_start=1
                     /product="uncharacterized protein C1orf141 isoform 2"
                     /protein_id="NP_001263281.1"
                     /db_xref="CCDS:CCDS72804.1"
                     /db_xref="GeneID:400757"
                     /db_xref="HGNC:HGNC:32044"
                     /translation="MAEKILEKLDVLDKQAEIILARRTKINRLQSEGRKTTMAIPLTF
                     DFQLEFEEALATSASKAISKIKEDKSCSITKSKMHVSFKCEPEPRKSNFEKSNLRPFF
                     IQTNVKNKESESTEPVEEHLKSRSIRPYLYLKDTTEMENAGPLNVLYSQHRQACRRSL
                     GSTDFSPMFNIQSNAHKKEKDSTLFTAQIEKKPRKPLDSVGLLEGDRNKRNKRTQIP"
     exon            220..377
                     /gene="C1orf141"
                     /inference="alignment:Splign:2.1.0"
     exon            378..490
                     /gene="C1orf141"
                     /inference="alignment:Splign:2.1.0"
     exon            491..558
                     /gene="C1orf141"
                     /inference="alignment:Splign:2.1.0"
     exon            559..703
                     /gene="C1orf141"
                     /inference="alignment:Splign:2.1.0"
     exon            704..773
                     /gene="C1orf141"
                     /inference="alignment:Splign:2.1.0"
     exon            774..2213
                     /gene="C1orf141"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1851..1856
                     /regulatory_class="polyA_signal_sequence"
                     /gene="C1orf141"
                     /note="hexamer: ATTAAA"
     polyA_site      1877
                     /gene="C1orf141"
                     /note="major polyA site"
     regulatory      1961..1966
                     /regulatory_class="polyA_signal_sequence"
                     /gene="C1orf141"
                     /note="hexamer: AATAAA"
     polyA_site      1989
                     /gene="C1orf141"
     regulatory      2187..2192
                     /regulatory_class="polyA_signal_sequence"
                     /gene="C1orf141"
                     /note="hexamer: AATAAA"
     polyA_site      2213
                     /gene="C1orf141"
ORIGIN      
        1 gagtaacccg cggagccaga agagggagga aaggagatga gatttcatca tgttggccag
       61 cctggtctca aactcctgac ctcaagtgac ccgcctgcct cagcctccca aagtgctggg
      121 attacaggaa tttagtgatt gacaatggca gaaaaaatcc tagagaagtt ggatgtcctt
      181 gataagcaag cagagataat cttggccaga agaacaaaga taaacaggct tcagagtgaa
      241 ggaagaaaaa caactatggc tatacccctg acatttgatt ttcagttgga atttgaagaa
      301 gctcttgcta catccgcgtc taaggcaata tcaaagatca aagaagacaa gtcatgcagc
      361 attacaaaat caaaaatgca tgtctctttc aaatgtgagc ctgaacctag aaagagtaat
      421 tttgaaaagt caaatttaag accattcttt attcaaacaa atgtaaaaaa taaagaaagt
      481 gagtcaacag agccagtaga agaacatcta aaatcaagat ctattagacc ctatctttat
      541 cttaaggata caactgagat ggaaaatgca gggcctttga atgttctata ttcacagcat
      601 agacaagcat gtagaagatc actgggttct acagactttt ctcctatgtt caacattcag
      661 tctaatgctc ataaaaagga aaaagactct actttattta cagctcaaat tgaaaaaaaa
      721 cctaggaaac cattggattc tgttggtctc ttagaaggtg atagaaataa aaggaacaaa
      781 aggacacaaa tcccataatt ttccatgaca cagaatatgt acgaatgtta cttttgacaa
      841 aaaatagatt ttcttctcat cctttggaaa atgaaaacat ttacccacat aaaagaacaa
      901 atttcatttt agaaagaaat tgtgaaatcc tcaaatctat aattggcaat caatctattt
      961 ctcttttcaa accccaaaaa actatgccta cagtacagag aaaagatata cagatcccta
     1021 tgtcttttaa agcgggccac acaactgtag atgataaact aaagaagaaa actaataagc
     1081 agacactaga aaacagatct tggaatacac tctataattt ctcacagaat ttttctagcc
     1141 taacaaaaca atttgtgggt taccttgata aagctgttat tcatgaaatg agtgcccaaa
     1201 ctggaaaatt tgaaagaatg ttttctgcag gaaaaccaac gagcataccc acatccagtg
     1261 ccttacctgt caaatgttac tcaaagcctt ttaaatatat atatgaacta aataatgtaa
     1321 cgccactgga taatttgtta aacttatcaa atgaaatttt aaatgcctca taaaatatta
     1381 tgtatgcagc aatatttgag taacaagaag caaatatcca agttccaaaa ttataaaaga
     1441 aattcttatc caaatagtaa tgttctaatt gatcatataa gaaagcaaag catagacatt
     1501 agaattataa gtcagcagtg gtctgttcaa gaacaatcaa catttttaga aaatagtagg
     1561 acaaaattag gaaataatta tcaccaagag gatctagttc atgactttct attatctcaa
     1621 ttagattgct caatcatcag ccttcctata ctaaactctg attcaggacc aagaaaggca
     1681 tagtctgact ctggaaatgc gctgttggaa gccaaataac atcaatactc ttgttctata
     1741 attgaatatc aaataagaca aattaccatt aatttaatga ctgtggagtt aattgtatac
     1801 cagcatttca gcaaatcatc atcaatagta ttacattagc aatttatgca attaaaaggg
     1861 ctttgtaaaa ctttgaatag attttattgt cattagtagc tgttggaact tcattattat
     1921 ataatgtttt tgcaaacttt aacttttttc taaattgtta aataaaagaa taactatcct
     1981 taatctaaat aattttggta gcaaatccta taaggtatta aacattttaa ggtatattat
     2041 tacattgcta ttttactgtt tctcattaac ccaaacagtt taaaggcaga attccactta
     2101 gaaacaagtt gcattttgaa agtttatttg taatccattt gtttggaatt cagaaatgta
     2161 tttcacataa aaataatctt ggaagtaata aattccaaaa ttaactaaca aaa
//
