LOCUS       NM_001276351            2187 bp    mRNA    linear   PRI 04-AUG-2024
DEFINITION  Homo sapiens chromosome 1 open reading frame 141 (C1orf141),
            transcript variant 1, mRNA.
ACCESSION   NM_001276351
VERSION     NM_001276351.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2187)
  AUTHORS   Liu,H., Irwanto,A., Fu,X., Yu,G., Yu,Y., Sun,Y., Wang,C., Wang,Z.,
            Okada,Y., Low,H., Li,Y., Liany,H., Chen,M., Bao,F., Li,J., You,J.,
            Zhang,Q., Liu,J., Chu,T., Andiappan,A.K., Wang,N., Niu,G., Liu,D.,
            Yu,X., Zhang,L., Tian,H., Zhou,G., Rotzschke,O., Chen,S., Zhang,X.,
            Liu,J. and Zhang,F.
  TITLE     Discovery of six new susceptibility loci and analysis of
            pleiotropic effects in leprosy
  JOURNAL   Nat Genet 47 (3), 267-271 (2015)
   PUBMED   25642632
REFERENCE   2  (bases 1 to 2187)
  AUTHORS   Hou,S., Du,L., Lei,B., Pang,C.P., Zhang,M., Zhuang,W., Zhang,M.,
            Huang,L., Gong,B., Wang,M., Zhang,Q., Hu,K., Zhou,Q., Qi,J.,
            Wang,C., Tian,Y., Ye,Z., Liang,L., Yu,H., Li,H., Zhou,Y., Cao,Q.,
            Liu,Y., Bai,L., Liao,D., Kijlstra,A., Xu,J., Yang,Z. and Yang,P.
  TITLE     Genome-wide association analysis of Vogt-Koyanagi-Harada syndrome
            identifies two new susceptibility loci at 1p31.2 and 10q21.3
  JOURNAL   Nat Genet 46 (9), 1007-1011 (2014)
   PUBMED   25108386
REFERENCE   3  (bases 1 to 2187)
  AUTHORS   Deng,X., Sabino,E.C., Cunha-Neto,E., Ribeiro,A.L., Ianni,B.,
            Mady,C., Busch,M.P. and Seielstad,M.
  CONSRTM   REDSII Chagas Study Group from the NHLBI Retrovirus Epidemiology
            Donor Study-II Component International
  TITLE     Genome wide association study (GWAS) of Chagas cardiomyopathy in
            Trypanosoma cruzi seropositive subjects
  JOURNAL   PLoS One 8 (11), e79629 (2013)
   PUBMED   24324551
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2187)
  AUTHORS   Kenny,E.E., Pe'er,I., Karban,A., Ozelius,L., Mitchell,A.A.,
            Ng,S.M., Erazo,M., Ostrer,H., Abraham,C., Abreu,M.T., Atzmon,G.,
            Barzilai,N., Brant,S.R., Bressman,S., Burns,E.R., Chowers,Y.,
            Clark,L.N., Darvasi,A., Doheny,D., Duerr,R.H., Eliakim,R.,
            Giladi,N., Gregersen,P.K., Hakonarson,H., Jones,M.R., Marder,K.,
            McGovern,D.P., Mulle,J., Orr-Urtreger,A., Proctor,D.D., Pulver,A.,
            Rotter,J.I., Silverberg,M.S., Ullman,T., Warren,S.T., Waterman,M.,
            Zhang,W., Bergman,A., Mayer,L., Katz,S., Desnick,R.J., Cho,J.H. and
            Peter,I.
  TITLE     A genome-wide scan of Ashkenazi Jewish Crohn's disease suggests
            novel susceptibility loci
  JOURNAL   PLoS Genet 8 (3), e1002559 (2012)
   PUBMED   22412388
REFERENCE   5  (bases 1 to 2187)
  AUTHORS   Zhang,F., Liu,H., Chen,S., Low,H., Sun,L., Cui,Y., Chu,T., Li,Y.,
            Fu,X., Yu,Y., Yu,G., Shi,B., Tian,H., Liu,D., Yu,X., Li,J., Lu,N.,
            Bao,F., Yuan,C., Liu,J., Liu,H., Zhang,L., Sun,Y., Chen,M.,
            Yang,Q., Yang,H., Yang,R., Zhang,L., Wang,Q., Liu,H., Zuo,F.,
            Zhang,H., Khor,C.C., Hibberd,M.L., Yang,S., Liu,J. and Zhang,X.
  TITLE     Identification of two new loci at IL23R and RAB32 that influence
            susceptibility to leprosy
  JOURNAL   Nat Genet 43 (12), 1247-1251 (2011)
   PUBMED   22019778
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2187)
  AUTHORS   Raelson,J.V., Little,R.D., Ruether,A., Fournier,H., Paquin,B., Van
            Eerdewegh,P., Bradley,W.E., Croteau,P., Nguyen-Huu,Q., Segal,J.,
            Debrus,S., Allard,R., Rosenstiel,P., Franke,A., Jacobs,G.,
            Nikolaus,S., Vidal,J.M., Szego,P., Laplante,N., Clark,H.F.,
            Paulussen,R.J., Hooper,J.W., Keith,T.P., Belouchi,A. and
            Schreiber,S.
  TITLE     Genome-wide association study for Crohn's disease in the Quebec
            Founder Population identifies multiple validated disease loci
  JOURNAL   Proc Natl Acad Sci U S A 104 (37), 14747-14752 (2007)
   PUBMED   17804789
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BG772061.1, BC090886.1 and AL133320.8.
            
            On Jun 2, 2019 this sequence version replaced NM_001276351.1.
            
            Transcript Variant: This variant (1) encodes the longer isoform
            (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC090886.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1968540 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000684719.1/ ENSP00000507487.1
            RefSeq Select criteria :: based on computational evidence
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-27                BG772061.1         11-37
            28-708              BC090886.1         1-681
            709-709             AL133320.8         94041-94041         c
            710-1295            BC090886.1         683-1268
            1296-2187           AL133320.8         90933-91824         c
FEATURES             Location/Qualifiers
     source          1..2187
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1p31.3"
     gene            1..2187
                     /gene="C1orf141"
                     /note="chromosome 1 open reading frame 141"
                     /db_xref="GeneID:400757"
                     /db_xref="HGNC:HGNC:32044"
     exon            1..41
                     /gene="C1orf141"
                     /inference="alignment:Splign:2.1.0"
     exon            42..127
                     /gene="C1orf141"
                     /inference="alignment:Splign:2.1.0"
     exon            128..219
                     /gene="C1orf141"
                     /inference="alignment:Splign:2.1.0"
     CDS             145..1347
                     /gene="C1orf141"
                     /note="isoform 1 is encoded by transcript variant 1;
                     uncharacterized protein C1orf141"
                     /codon_start=1
                     /product="uncharacterized protein C1orf141 isoform 1"
                     /protein_id="NP_001263280.1"
                     /db_xref="CCDS:CCDS30745.1"
                     /db_xref="GeneID:400757"
                     /db_xref="HGNC:HGNC:32044"
                     /translation="MAEKILEKLDVLDKQAEIILARRTKINRLQSEGRKTTMAIPLTF
                     DFQLEFEEALATSASKAISKIKEDKSCSITKSKMHVSFKCEPEPRKSNFEKSNLRPFF
                     IQTNVKNKESESTAQIEKKPRKPLDSVGLLEGDRNKRKKSPQMNDFNIKENKSVRNYQ
                     LSKYRSVRKKSLLPLCFEDELKNPHAKIVNVSPTKTVTSHMEQKDTNPIIFHDTEYVR
                     MLLLTKNRFSSHPLENENIYPHKRTNFILERNCEILKSIIGNQSISLFKPQKTMPTVQ
                     RKDIQIPMSFKAGHTTVDDKLKKKTNKQTLENRSWNTLYNFSQNFSSLTKQFVGYLDK
                     AVIHEMSAQTGKFERMFSAGKPTSIPTSSALPVKCYSKPFKYIYELNNVTPLDNLLNL
                     SNEILNAS"
     exon            220..377
                     /gene="C1orf141"
                     /inference="alignment:Splign:2.1.0"
     exon            378..490
                     /gene="C1orf141"
                     /inference="alignment:Splign:2.1.0"
     exon            491..560
                     /gene="C1orf141"
                     /inference="alignment:Splign:2.1.0"
     exon            561..747
                     /gene="C1orf141"
                     /inference="alignment:Splign:2.1.0"
     exon            748..2187
                     /gene="C1orf141"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1825..1830
                     /regulatory_class="polyA_signal_sequence"
                     /gene="C1orf141"
                     /note="hexamer: ATTAAA"
     polyA_site      1851
                     /gene="C1orf141"
                     /note="major polyA site"
     regulatory      1935..1940
                     /regulatory_class="polyA_signal_sequence"
                     /gene="C1orf141"
                     /note="hexamer: AATAAA"
     polyA_site      1963
                     /gene="C1orf141"
     regulatory      2161..2166
                     /regulatory_class="polyA_signal_sequence"
                     /gene="C1orf141"
                     /note="hexamer: AATAAA"
     polyA_site      2187
                     /gene="C1orf141"
ORIGIN      
        1 gagtaacccg cggagccaga agagggagga aaggagatga gatttcatca tgttggccag
       61 cctggtctca aactcctgac ctcaagtgac ccgcctgcct cagcctccca aagtgctggg
      121 attacaggaa tttagtgatt gacaatggca gaaaaaatcc tagagaagtt ggatgtcctt
      181 gataagcaag cagagataat cttggccaga agaacaaaga taaacaggct tcagagtgaa
      241 ggaagaaaaa caactatggc tatacccctg acatttgatt ttcagttgga atttgaagaa
      301 gctcttgcta catccgcgtc taaggcaata tcaaagatca aagaagacaa gtcatgcagc
      361 attacaaaat caaaaatgca tgtctctttc aaatgtgagc ctgaacctag aaagagtaat
      421 tttgaaaagt caaatttaag accattcttt attcaaacaa atgtaaaaaa taaagaaagt
      481 gagtcaacag ctcaaattga aaaaaaacct aggaaaccat tggattctgt tggtctctta
      541 gaaggtgata gaaataaaag aaaaaaatct ccacagatga acgattttaa tataaaagaa
      601 aacaaatcgg tcagaaatta tcaattaagt aagtataggt cagtaagaaa gaaaagcttg
      661 ctcccgttgt gctttgagga tgaattgaaa aatccacatg ccaagatagt caacgttagt
      721 ccaacaaaga cagtaacttc tcacatggaa caaaaggaca caaatcccat aattttccat
      781 gacacagaat atgtacgaat gttacttttg acaaaaaata gattttcttc tcatcctttg
      841 gaaaatgaaa acatttaccc acataaaaga acaaatttca ttttagaaag aaattgtgaa
      901 atcctcaaat ctataattgg caatcaatct atttctcttt tcaaacccca aaaaactatg
      961 cctacagtac agagaaaaga tatacagatc cctatgtctt ttaaagcggg ccacacaact
     1021 gtagatgata aactaaagaa gaaaactaat aagcagacac tagaaaacag atcttggaat
     1081 acactctata atttctcaca gaatttttct agcctaacaa aacaatttgt gggttacctt
     1141 gataaagctg ttattcatga aatgagtgcc caaactggaa aatttgaaag aatgttttct
     1201 gcaggaaaac caacgagcat acccacatcc agtgccttac ctgtcaaatg ttactcaaag
     1261 ccttttaaat atatatatga actaaataat gtaacgccac tggataattt gttaaactta
     1321 tcaaatgaaa ttttaaatgc ctcataaaat attatgtatg cagcaatatt tgagtaacaa
     1381 gaagcaaata tccaagttcc aaaattataa aagaaattct tatccaaata gtaatgttct
     1441 aattgatcat ataagaaagc aaagcataga cattagaatt ataagtcagc agtggtctgt
     1501 tcaagaacaa tcaacatttt tagaaaatag taggacaaaa ttaggaaata attatcacca
     1561 agaggatcta gttcatgact ttctattatc tcaattagat tgctcaatca tcagccttcc
     1621 tatactaaac tctgattcag gaccaagaaa ggcatagtct gactctggaa atgcgctgtt
     1681 ggaagccaaa taacatcaat actcttgttc tataattgaa tatcaaataa gacaaattac
     1741 cattaattta atgactgtgg agttaattgt ataccagcat ttcagcaaat catcatcaat
     1801 agtattacat tagcaattta tgcaattaaa agggctttgt aaaactttga atagatttta
     1861 ttgtcattag tagctgttgg aacttcatta ttatataatg tttttgcaaa ctttaacttt
     1921 tttctaaatt gttaaataaa agaataacta tccttaatct aaataatttt ggtagcaaat
     1981 cctataaggt attaaacatt ttaaggtata ttattacatt gctattttac tgtttctcat
     2041 taacccaaac agtttaaagg cagaattcca cttagaaaca agttgcattt tgaaagttta
     2101 tttgtaatcc atttgtttgg aattcagaaa tgtatttcac ataaaaataa tcttggaagt
     2161 aataaattcc aaaattaact aacaaaa
//
