LOCUS       NM_152379               1430 bp    mRNA    linear   PRI 16-FEB-2025
DEFINITION  Homo sapiens 40S small subunit processome assembly factor 1
            (FSAF1), transcript variant 1, mRNA.
ACCESSION   NM_152379
VERSION     NM_152379.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1430)
  AUTHORS   Wei,Z., Zhao,Y., Cai,J. and Xie,Y.
  TITLE     The Nucleolar Protein C1orf131 Is a Novel Gene Involved in the
            Progression of Lung Adenocarcinoma Cells through the AKT Signalling
            Pathway
  JOURNAL   Int J Mol Sci 25 (12), 6381 (2024)
   PUBMED   38928092
  REMARK    GeneRIF: The Nucleolar Protein C1orf131 Is a Novel Gene Involved in
            the Progression of Lung Adenocarcinoma Cells through the AKT
            Signalling Pathway.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1430)
  AUTHORS   Singh,S., Vanden Broeck,A., Miller,L., Chaker-Margot,M. and
            Klinge,S.
  TITLE     Nucleolar maturation of the human small subunit processome
  JOURNAL   Science 373 (6560), eabj5338 (2021)
   PUBMED   34516797
REFERENCE   3  (bases 1 to 1430)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   4  (bases 1 to 1430)
  AUTHORS   Baltz,A.G., Munschauer,M., Schwanhausser,B., Vasile,A.,
            Murakawa,Y., Schueler,M., Youngs,N., Penfold-Brown,D., Drew,K.,
            Milek,M., Wyler,E., Bonneau,R., Selbach,M., Dieterich,C. and
            Landthaler,M.
  TITLE     The mRNA-bound proteome and its global occupancy profile on
            protein-coding transcripts
  JOURNAL   Mol Cell 46 (5), 674-690 (2012)
   PUBMED   22681889
REFERENCE   5  (bases 1 to 1430)
  AUTHORS   Castello,A., Fischer,B., Eichelbaum,K., Horos,R., Beckmann,B.M.,
            Strein,C., Davey,N.E., Humphreys,D.T., Preiss,T., Steinmetz,L.M.,
            Krijgsveld,J. and Hentze,M.W.
  TITLE     Insights into RNA biology from an atlas of mammalian mRNA-binding
            proteins
  JOURNAL   Cell 149 (6), 1393-1406 (2012)
   PUBMED   22658674
REFERENCE   6  (bases 1 to 1430)
  AUTHORS   Ohta,S., Bukowski-Wills,J.C., Sanchez-Pulido,L., Alves Fde,L.,
            Wood,L., Chen,Z.A., Platani,M., Fischer,L., Hudson,D.F.,
            Ponting,C.P., Fukagawa,T., Earnshaw,W.C. and Rappsilber,J.
  TITLE     The protein composition of mitotic chromosomes determined using
            multiclassifier combinatorial proteomics
  JOURNAL   Cell 142 (5), 810-821 (2010)
   PUBMED   20813266
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK055124.1 and BC053609.1.
            
            On Nov 23, 2018 this sequence version replaced NM_152379.3.
            
            Transcript Variant: This variant (1) represnts the longer
            transcript and encodes the longer isoform (a).
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR5189667.123929.1,
                                           SRR5189661.11373.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000366649.7/ ENSP00000355609.2
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-115               AK055124.1         13-127
            116-1430            BC053609.1         77-1391
FEATURES             Location/Qualifiers
     source          1..1430
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1q42.2"
     gene            1..1430
                     /gene="FSAF1"
                     /gene_synonym="C1orf131"
                     /note="40S small subunit processome assembly factor 1"
                     /db_xref="GeneID:128061"
                     /db_xref="HGNC:HGNC:25332"
     exon            1..152
                     /gene="FSAF1"
                     /gene_synonym="C1orf131"
                     /inference="alignment:Splign:2.1.0"
     CDS             35..916
                     /gene="FSAF1"
                     /gene_synonym="C1orf131"
                     /note="isoform a is encoded by transcript variant 1;
                     uncharacterized protein C1orf131"
                     /codon_start=1
                     /product="40S small subunit processome assembly factor 1
                     isoform a"
                     /protein_id="NP_689592.2"
                     /db_xref="CCDS:CCDS1591.2"
                     /db_xref="GeneID:128061"
                     /db_xref="HGNC:HGNC:25332"
                     /translation="MRVDSSADPTMSQEQGPGSSTPPSSPTLLDALLQNLYDFGGTEG
                     ETEQKKIIKKRENKKRDVMASAALAAEPSPLPGSLIRGQRKSASSFFKELREERHCAP
                     SGTPTGPEILAAAVPPSSLKNNREQVEVVEFHSNKKRKLTPDHNKNTKQANPSVLERD
                     VDTQEFNLEKARLEVHRFGITGYGKGKERILEQERAIMLGAKPPKKSYVNYKVLQEQI
                     KEKKAAKEEEKRLAQETDIFKKKKRKGQEDRKSKKKSAPSILSNGRIGQVGKFKNGTL
                     ILSPVDIKKINSSRVAK"
     exon            153..484
                     /gene="FSAF1"
                     /gene_synonym="C1orf131"
                     /inference="alignment:Splign:2.1.0"
     exon            485..544
                     /gene="FSAF1"
                     /gene_synonym="C1orf131"
                     /inference="alignment:Splign:2.1.0"
     exon            545..640
                     /gene="FSAF1"
                     /gene_synonym="C1orf131"
                     /inference="alignment:Splign:2.1.0"
     exon            641..727
                     /gene="FSAF1"
                     /gene_synonym="C1orf131"
                     /inference="alignment:Splign:2.1.0"
     exon            728..780
                     /gene="FSAF1"
                     /gene_synonym="C1orf131"
                     /inference="alignment:Splign:2.1.0"
     exon            781..1430
                     /gene="FSAF1"
                     /gene_synonym="C1orf131"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1411..1416
                     /regulatory_class="polyA_signal_sequence"
                     /gene="FSAF1"
                     /gene_synonym="C1orf131"
                     /note="hexamer: AATAAA"
     polyA_site      1430
                     /gene="FSAF1"
                     /gene_synonym="C1orf131"
                     /note="major polyA site"
ORIGIN      
        1 gcggaacccg gaagcggggg tgcagcgcgg cagaatgagg gttgattcct cggctgaccc
       61 cacaatgtcg caggagcaag ggccggggtc ctccacgcct cccagttctc cgacacttct
      121 tgacgctctg ctccagaacc tttacgactt tggaggtaca gaaggtgaaa cagaacagaa
      181 gaagatcata aagaaaaggg aaaacaagaa gagagatgtg atggcttcag cggccttggc
      241 agcagagcca tctcccctac ctggttctct cataagaggc cagaggaaga gcgcttcgag
      301 cttcttcaag gaacttagag aagagcggca ttgtgctcct tctgggaccc ccacaggacc
      361 agagatcctt gctgctgcag ttcctccctc ttccctaaag aacaataggg aacaagtaga
      421 agtggtagaa tttcacagca ataaaaaaag aaaattgacg ccagatcata acaagaacac
      481 aaagcaggct aatcctagtg ttttggagag agatgtggat acacaagaat ttaacctaga
      541 aaaagctcgt ttagaagtgc accggtttgg tatcacgggt tatggaaaag gaaaggagag
      601 aatcctggaa caggaacgtg ccattatgct gggcgctaag cctcctaaaa agagttatgt
      661 gaattacaag gttttacagg agcaaattaa agaaaaaaag gcagcaaagg aagaagaaaa
      721 gagactggcc caagaaacag atattttcaa gaaaaagaag aggaaaggac aggaggacag
      781 gaaatccaaa aagaagtccg ctcccagtat tttgtcaaat ggacggattg gacaggttgg
      841 aaaattcaaa aatggaacac tgattctgag cccagttgat atcaagaaaa taaattcttc
      901 cagagtggcc aaatgaagta ctttgtcaaa taaaacgagg atgggaacaa ctgagtcaac
      961 tgcagcggcc ctggaccctg tgcgactcta gatagatcgt tcttaacacg catttcacag
     1021 actgcttttt cattttagaa aaaaagtcaa acagaagtaa catttctagt tgccgaagtg
     1081 tctgcttcat ggtgctgaac gtgtcaggcc cagtgcagca tgaatgtgaa gtgaacccac
     1141 tgaaaagtga tttttaatgt tctccagcaa acttcactcc tgtttcatgt tcactggtat
     1201 ttggtgcatt tgcttgtaat acagtttttt ataactttac tgttttgtaa atgctagtag
     1261 tttacattaa attgccttat atttttaatg atttaatgtt atgatatcat gaaagaacca
     1321 agaatctagt aatttatcag ttttgtggaa aagcagtttt aatttttagc ctaccatgtg
     1381 tacaaaatct acttcataag aagttatata aataaaatag gtttgtagta
//
