LOCUS       NM_198446               1329 bp    mRNA    linear   PRI 09-FEB-2024
DEFINITION  Homo sapiens chromosome 1 open reading frame 122 (C1orf122),
            transcript variant 1, mRNA.
ACCESSION   NM_198446 XM_059173
VERSION     NM_198446.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1329)
  AUTHORS   Yoshida,T., Kato,K., Yokoi,K., Oguri,M., Watanabe,S., Metoki,N.,
            Yoshida,H., Satoh,K., Aoyagi,Y., Nishigaki,Y., Nozawa,Y. and
            Yamada,Y.
  TITLE     Association of genetic variants with chronic kidney disease in
            individuals with different lipid profiles
  JOURNAL   Int J Mol Med 24 (2), 233-246 (2009)
   PUBMED   19578796
  REMARK    GeneRIF: Observational study of gene-disease association and
            gene-environment interaction. (HuGE Navigator)
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL929472.21, CX788342.1 and AY517499.1.
            
            On Nov 22, 2018 this sequence version replaced NM_198446.2.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY517499.1, BC057819.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968540, SAMEA1970526
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000373042.5/ ENSP00000362133.4
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-11                AL929472.21        36516-36526
            12-356              CX788342.1         1-345
            357-1329            AY517499.1         1-973
FEATURES             Location/Qualifiers
     source          1..1329
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1p34.3"
     gene            1..1329
                     /gene="C1orf122"
                     /gene_synonym="ALAESM"
                     /note="chromosome 1 open reading frame 122"
                     /db_xref="GeneID:127687"
                     /db_xref="HGNC:HGNC:24789"
     exon            1..650
                     /gene="C1orf122"
                     /gene_synonym="ALAESM"
                     /inference="alignment:Splign:2.1.0"
     CDS             616..948
                     /gene="C1orf122"
                     /gene_synonym="ALAESM"
                     /note="isoform 1 is encoded by transcript variant 1;
                     uncharacterized protein C1orf122"
                     /codon_start=1
                     /product="uncharacterized protein C1orf122 isoform 1"
                     /protein_id="NP_940848.2"
                     /db_xref="CCDS:CCDS427.2"
                     /db_xref="GeneID:127687"
                     /db_xref="HGNC:HGNC:24789"
                     /translation="MEWGPGSDWSRGEAAGVDRGKAGLGLGGRPPPQPPREERAQQLL
                     DAVEQRQRQLLDTIAACEEMLRQLGRRRPEPAGGGNVSAKPGAPPQPAVSARGGFPKD
                     AGDGAAEP"
     exon            651..852
                     /gene="C1orf122"
                     /gene_synonym="ALAESM"
                     /inference="alignment:Splign:2.1.0"
     exon            853..1329
                     /gene="C1orf122"
                     /gene_synonym="ALAESM"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1305..1310
                     /regulatory_class="polyA_signal_sequence"
                     /gene="C1orf122"
                     /gene_synonym="ALAESM"
                     /note="hexamer: ATTAAA"
     polyA_site      1329
                     /gene="C1orf122"
                     /gene_synonym="ALAESM"
                     /note="major polyA site"
ORIGIN      
        1 acctgtagac gtcggccacg cggccgaggc atacggccag aggcttggcc tcgctgcgac
       61 ccttgaggcg gtacacagcg cgcagagccg ccgagcagct cgccgcgcag gccaggccgt
      121 acagcgtatc ggtggggacg gccaccacgg cgccggcgcg cagctcggcc acggcggccc
      181 gcagcgcctc ggtccagccg gcgcgctccg ggctcgcggc ctgcacggcc ccgctccccg
      241 ggagccgcaa cagccgggcg ccgggggccg ccggagcggg actcggcggg cggaagaggc
      301 gaccgctccg ggagccagca ggcccctcgc tcaaccccac gctggcagcc accgcggccc
      361 tcatccccct gcaccgacgc gccggagaca tccgcccagg cccgcttccg ggaggaagtg
      421 acgctcccag ccagcttccg gtccaggaga ctcggccccg cctctgcgcc gggcagctta
      481 aagggaccac gacccccagg aggattgaag gagaccggtg gggacggggc ggggcgcagc
      541 cttgcgaagc cctaacgcag cgctggggag gggggcggcc gaaagggggg cggtggtcgg
      601 gccgcgcaag cggagatgga atggggcccg ggctcagact ggtcacgggg ggaggctgcc
      661 ggcgtggacc gcgggaaggc ggggctgggg ctcggcggga ggccaccccc acagccgccc
      721 cgggaggagc gcgcccagca gctgctggac gcggtggagc agcggcagcg gcagctcctg
      781 gacaccatcg cagcctgcga ggagatgtta cggcagctgg gccgccggcg cccggagccg
      841 gctggtggcg ggaacgtctc agccaaacct ggagcgcccc cccagccggc tgtctccgcc
      901 agaggcggct ttccaaagga tgctggcgat ggagctgcgg agccctgacc atccccgagc
      961 agaataccct gacttctctc cctccccagg gccggtggct ggactctgaa caactccctt
     1021 cagtaaaggg gccagtcttc actggcagtg gctggtactt ggctctcagc ctggagtggc
     1081 agctctgcta gcagctgggt tcactcccac ttcatcctgg ctgaaagcag tgctgtgctt
     1141 tgaaatgcag ccaatgaata cccagtctga ttacccagat ttgggcagac cagcagtgct
     1201 cgccagagtg gtctggcctg ctatggggga tccaggtggt gttacatgtc catttcatgt
     1261 tttgggggct tttagcccca caaaacacct tcagtagagc cttgattaaa aggaaacctg
     1321 cagactctc
//
