LOCUS       NM_023938               5501 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens chromosome 1 open reading frame 116 (C1orf116),
            transcript variant 1, mRNA.
ACCESSION   NM_023938 NM_024115
VERSION     NM_023938.6
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5501)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   2  (bases 1 to 5501)
  AUTHORS   Parsana,P., Amend,S.R., Hernandez,J., Pienta,K.J. and Battle,A.
  TITLE     Identifying global expression patterns and key regulators in
            epithelial to mesenchymal transition through multi-study
            integration
  JOURNAL   BMC Cancer 17 (1), 447 (2017)
   PUBMED   28651527
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 5501)
  AUTHORS   Xin,X., Rual,J.F., Hirozane-Kishikawa,T., Hill,D.E., Vidal,M.,
            Boone,C. and Thierry-Mieg,N.
  TITLE     Shifted Transversal Design smart-pooling for high coverage
            interactome mapping
  JOURNAL   Genome Res 19 (7), 1262-1269 (2009)
   PUBMED   19447967
REFERENCE   4  (bases 1 to 5501)
  AUTHORS   Gonzales,P.A., Pisitkun,T., Hoffert,J.D., Tchapyjnikov,D.,
            Star,R.A., Kleta,R., Wang,N.S. and Knepper,M.A.
  TITLE     Large-scale proteomics and phosphoproteomics of urinary exosomes
  JOURNAL   J Am Soc Nephrol 20 (2), 363-379 (2009)
   PUBMED   19056867
REFERENCE   5  (bases 1 to 5501)
  AUTHORS   Steketee,K., Ziel-van der Made,A.C., van der Korput,H.A.,
            Houtsmuller,A.B. and Trapman,J.
  TITLE     A bioinformatics-based functional analysis shows that the
            specifically androgen-regulated gene SARG contains an active direct
            repeat androgen response element in the first intron
  JOURNAL   J Mol Endocrinol 33 (2), 477-491 (2004)
   PUBMED   15525603
  REMARK    GeneRIF: SARG mRNA expression is high in prostate tissue. SARG is
            composed of four exons and spans a region of 14.5 kbp on chromosome
            1q32.2.
REFERENCE   6  (bases 1 to 5501)
  AUTHORS   Cleutjens,C.B., Steketee,K., van Eekelen,C.C., van der Korput,J.A.,
            Brinkmann,A.O. and Trapman,J.
  TITLE     Both androgen receptor and glucocorticoid receptor are able to
            induce prostate-specific antigen expression, but differ in their
            growth-stimulating properties of LNCaP cells
  JOURNAL   Endocrinology 138 (12), 5293-5300 (1997)
   PUBMED   9389513
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DA859157.1, BC000765.2, AC098935.2 and BG150416.1.
            
            On Nov 23, 2018 this sequence version replaced NM_023938.5.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY352640.1, BC000765.2 [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000359470.6/ ENSP00000352447.5
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-104               DA859157.1         2-105
            105-1588            BC000765.2         1-1484
            1589-5258           AC098935.2         170794-174463       c
            5259-5501           BG150416.1         6-248               c
FEATURES             Location/Qualifiers
     source          1..5501
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1q32.1"
     gene            1..5501
                     /gene="C1orf116"
                     /gene_synonym="SARG"
                     /note="chromosome 1 open reading frame 116"
                     /db_xref="GeneID:79098"
                     /db_xref="HGNC:HGNC:28667"
                     /db_xref="MIM:611680"
     exon            1..178
                     /gene="C1orf116"
                     /gene_synonym="SARG"
                     /inference="alignment:Splign:2.1.0"
     exon            179..364
                     /gene="C1orf116"
                     /gene_synonym="SARG"
                     /inference="alignment:Splign:2.1.0"
     CDS             260..2065
                     /gene="C1orf116"
                     /gene_synonym="SARG"
                     /note="isoform 1 is encoded by transcript variant 1;
                     specifically androgen-regulated protein; specifically
                     androgen-regulated gene protein"
                     /codon_start=1
                     /product="specifically androgen-regulated gene protein
                     isoform 1"
                     /protein_id="NP_076427.2"
                     /db_xref="CCDS:CCDS1475.1"
                     /db_xref="GeneID:79098"
                     /db_xref="HGNC:HGNC:28667"
                     /db_xref="MIM:611680"
                     /translation="MPERELWPAGTGSEPVTRVGSCDSMMSSTSTRSGSSDSSYDFLS
                     TEEKECLLFLEETIGSLDTEADSGLSTDESEPATTPRGFRALPITQPTPRGGPEETIT
                     QQGRTPRTVTESSSSHPPEPQGLGLRSGSYSLPRNIHIARSQNFRKSTTQASSHNPGE
                     PGRLAPEPEKEQVSQSSQPRQAPASPQEAALDLDVVLIPPPEAFRDTQPEQCREASLP
                     EGPGQQGHTPQLHTPSSSQEREQTPSEAMSQKAKETVSTRYTQPQPPPAGLPQNARAE
                     DAPLSSGEDPNSRLAPLTTPKPRKLPPNIVLKSSRSSFHSDPQHWLSRHTEAAPGDSG
                     LISCSLQEQRKARKEALEKLGLPQDQDEPGLHLSKPTSSIRPKETRAQHLSPAPGLAQ
                     PAAPAQASAAIPAAGKALAQAPAPAPGPAQGPLPMKSPAPGNVAASKSMPISIPKAPR
                     ANSALTPPKPESGLTLQESNTPGLRQMNFKSNTLERSGVGLSSYLSTEKDASPKTSTS
                     LGKGSFLDKISPSVLRNSRPRPASLGTGKDFAGIQVGKLADLEQEQSSKRLSYQGQSR
                     DKLPRPPCVSVKISPKGVPNEHRREALKKLGLLKE"
     exon            365..542
                     /gene="C1orf116"
                     /gene_synonym="SARG"
                     /inference="alignment:Splign:2.1.0"
     exon            543..5501
                     /gene="C1orf116"
                     /gene_synonym="SARG"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3308..3313
                     /regulatory_class="polyA_signal_sequence"
                     /gene="C1orf116"
                     /gene_synonym="SARG"
                     /note="hexamer: ATTAAA"
     polyA_site      3328
                     /gene="C1orf116"
                     /gene_synonym="SARG"
                     /note="major polyA site"
     regulatory      5484..5489
                     /regulatory_class="polyA_signal_sequence"
                     /gene="C1orf116"
                     /gene_synonym="SARG"
                     /note="hexamer: AATAAA"
     polyA_site      5501
                     /gene="C1orf116"
                     /gene_synonym="SARG"
ORIGIN      
        1 agtggcaggg tgggggccag gcagcacaga tgaagcattt acctatctag gtaagtcagg
       61 aggagctcaa aaggagaaga aaacagtagg aggcagggga agcagcctct gtctccatct
      121 ctgccctttg aaacaaaagg gtatttcttt tctctcttca gcccccaacc cagtggaggc
      181 ccggcttggg acattgttca cttcccctcg cttcccctct agaagccccc tttgccatcc
      241 ctgcaccttg tttcgggtga tgcccgagag ggagctgtgg ccagcgggga ctggctcaga
      301 acccgtgacc cgtgtcggca gctgtgacag catgatgagc agcacctcca cccgctctgg
      361 atctagtgat agcagctacg acttcctgtc cactgaagag aaggagtgtc tgctcttcct
      421 ggaggagacc attggctcac tggacacgga ggctgacagc ggactgtcca ctgacgagtc
      481 tgagccagcc acaactccca gaggtttccg agcactgccc ataacccaac ccactccccg
      541 gggaggtcca gaggagacca tcactcagca aggacgaacg ccaaggacag taactgagtc
      601 cagctcatcc caccctcctg agccccaggg cctaggcctc aggtctggct cctacagcct
      661 ccctaggaat atccacattg ccagaagcca gaacttcagg aaaagcacca cccaggctag
      721 cagtcacaac cctggagaac cggggaggct tgcgccagag cctgagaaag aacaggtcag
      781 ccagagcagc caacccaggc aggcacctgc cagcccccag gaggctgccc ttgacttgga
      841 cgtggtgctc atccctccgc cagaagcttt ccgggacacc cagccagagc agtgtaggga
      901 agccagcctg cccgaggggc caggacagca gggccacaca ccccagctcc acacaccatc
      961 cagctcccag gaaagagagc agactccttc agaagccatg tcccaaaaag ccaaggaaac
     1021 agtctcaacc aggtacacac aaccccagcc tcctcctgca gggttgcctc agaatgcaag
     1081 agctgaagat gctcccctct catcagggga ggacccaaac agccgactag ctcccctcac
     1141 aacccctaag ccccggaagc tgccacctaa tattgttctg aagagcagcc gaagcagttt
     1201 ccacagtgac ccccagcact ggctgtcccg ccacactgag gctgcccctg gagattctgg
     1261 cctgatctcc tgttcactgc aagagcagag aaaagcacgt aaagaagctc tagagaagct
     1321 ggggctaccc caggatcaag atgagcctgg actccactta agtaagccca ccagctccat
     1381 cagacccaag gagacacggg cccagcatct gtccccagct ccaggtctgg ctcagcctgc
     1441 agctccagcc caggcctcag cagctattcc tgctgctggg aaggctctgg ctcaagctcc
     1501 ggctccagct ccaggtccag ctcagggacc tttgccaatg aagtctccag ctccaggcaa
     1561 tgttgcagct agcaaatcta tgccaatttc tatccctaag gccccaaggg caaacagtgc
     1621 cctgactcca ccgaagccag agtcagggct gactctccag gagagcaaca cccctggcct
     1681 gagacagatg aacttcaagt ccaacactct ggagcgctca ggcgtgggac tgagcagcta
     1741 cctttcaact gagaaagatg ccagccccaa aaccagcact tctctgggaa agggctcctt
     1801 cttggacaag atctcgccca gtgtcttacg taattctcgg ccccgcccgg cctccctggg
     1861 cacggggaaa gattttgcag gtatccaggt aggcaagctg gctgacctgg agcaggagca
     1921 gagctccaag cgcctgtcct accaaggaca gagccgtgac aagcttcctc gccccccctg
     1981 tgtcagtgtc aagatctccc caaagggtgt ccccaatgaa cacagaaggg aggccctgaa
     2041 gaagctggga ctgttgaagg agtagactct gcgaccagta cagaccctgt cctggctgaa
     2101 caagaagaga cacatgctcc acttgggagc ctttgccacc acgcaactca gggctcaaga
     2161 tgaatgggag ggagagattt gagtccaagc atacatttat attcagtgtt gtgccattga
     2221 gttcccatgt ggatcattct gaaggtgatc tccacaagag ggtgtgtgtg tgtgtgtttg
     2281 gtgtgtgtgt ggaggggggg ccgctggata catcactgaa gctattgata taacacaatg
     2341 agtcactgtt cagaattttg ctcttgttag atgttttctt acattgggta gagtccagcc
     2401 tagtgagagc tgagtgaagg ggctggccat gcctgagaca aaaagtcaaa tgagacaatg
     2461 gacgtgtcaa tgacttgaaa aaaagtcaca tccagcaaat gcagggtcac atgaaatatg
     2521 ggcctcctgg aatccctaca gtggatggag actggctcat accttgccag atccctctct
     2581 cagttccagc cttctggaca aggcctgggc taagaggagc tgattcgtta tctcttcacc
     2641 cactgccctc tcagtatcac cagtcccaaa gacaggatac gtccctgtaa cccaatctct
     2701 cggttgattg atagcagaac agctcttgtt ggtctgagaa ggcaggataa gtgaccacat
     2761 atttatgcca ctacctccac cagggagagt ccttctccac aggcttgata aattcaatca
     2821 ccaactgtgc tgtcgtccct gactctgcta ctcccgttct tcctgctttc ctgctccgta
     2881 tctcagtctg cactgacccc agggctgggc tgacatcaag atgggagccc agcccacggg
     2941 ctttataaac acccaagaac cgtttcagat cttctctgtg ctgatgcagg tagttttaaa
     3001 tttttctcag ttccagtgat agaaaaccca cacaatacat cctctgccag tcttaataga
     3061 atatcagagg taagaggggc ctcagagaag ctctgacgca gtgctgctgg ggaagggaag
     3121 tgactaaccc cgggtcagcc tgccatttag ggaaagagct gaggttctta cccttgttgc
     3181 atgctgccac ctctccttag ccagtgctct tgtacatcca cacagcaccc taaggagcca
     3241 tagtcaccat caaagactca accctaaggc ccttcaagat ctcaaagtgc cttctgaagc
     3301 atcagagatt aaatattgtt caaactaata gttattgctg tggcttttaa ttttatcttt
     3361 ggaagatagc tatatggtaa ctcatcatta accagaacac ctctcccctc aaattccgtg
     3421 accaagttgt gcagcttgag caaatgccga aagagggtat tatgggtggg tggtgtgggc
     3481 ttgcaaatac aagcttggag gtgagacatg gccagacatg actcctgctt ccccttagga
     3541 agtaaatctt acttatggtt gtgaactgct tggagtccag gatgcccaga tgtgaggggc
     3601 agatgaaggg aatgttgctg gaaaggtgcc ttttaaggct gctgagaatt tctggactgt
     3661 gtcctgatgg acgcagcacc atcaaagccc agaatttctg aaaacggtga caaggttaac
     3721 ataaggacaa caaatactcc accctgtcat ggtatgtgag gtgtgggtgt ggcggtttct
     3781 gtgtacgttt gctcatacac gcacatccaa aagcctgtgc ctcattcctg gccatgggtg
     3841 aggacttggt ctgtcacggc tgatgaggac tcccacaacc ggccaagtta tgtcttatta
     3901 tacaccccca gaaagagaga aagctgcctt ctggaggact gattccacat gctatattca
     3961 gctgagttga tttctgtgtc tatttcaacc cataacctga agaatgatca ccttattcct
     4021 tattcattaa ttttcttgat taatagggaa acttgggaat agctataaag taaaacttgg
     4081 gtggaacctg gggccctggc atcacacaag tgtgattagg atggtcaagg tcatcaggag
     4141 tacagcctat tatattccca catcctgaga aaggtcattt ctcccacaca cgacaaagtc
     4201 acagacatcc tgcacctgcc actaggcatc ctcatcctac tgacatgccc atttctccag
     4261 ttttcttaat ctgagactcc cttcccttgt tttttaaaga taccgtgctt ctccacatcc
     4321 tcatccttca aggagcatat tttgctctta ggatggtctt tgggattcaa gaatagaata
     4381 ataaatccaa acttggtcat tcccattttg aagagatgca agagggccca gtgaggacat
     4441 ccgcctccct gaaagtggtg ctagacagag ctgaggtcat tgtatctgtg tatccacata
     4501 ggatttctct taattcagct tgaattgatg gggagggagg taagagtagg gtcagagtta
     4561 ctcatccctt ttcaaagaat tgtgggtgga agtttgtaaa ggccattcat ttgattttca
     4621 aaatcaaagc gacagctcta cttccacttg gccttagatc tctgctatac cctgccatag
     4681 ccttgatgcc actgggcaca agccacctgc caaatacagg agtggcctct cccagcctgg
     4741 catgataggg gggtctgtgc cctcagatgt gttgacagct gctcttctga attgccacac
     4801 ctgtgctaca cttggaattc tgtgctctga ctctgcaggg taggaccacg tgccatctca
     4861 cacagaggtc aaccgatgag cccactcact cgtacatgcc ttcttccaca gtgggaagca
     4921 tgatctggca ggggccgccc tgtaggctgg ggatgggctg ctgtgtgaat gttgacgttc
     4981 gtttcatgga gaaaggggag gtgaaagatt gaagagcagg ttcctgtcaa tgttctgagt
     5041 tcgagctgga ggtgtagatt gaatagtcta catggtctgt gagtgtgtga gatgaaccct
     5101 tccatccttt gacacctggt tgtatgtgta ggctaagaag gaaggaccct cctgtcagtg
     5161 tgcaaagctg taatctcatg gactagagga gagggggcca aggggatgga caggagaagt
     5221 catgcagaat ctaagcagga atgcagatag aacacatcta ggctcttttc cccaggagag
     5281 tgatgatgga gcatatagat ctggctcaaa ttcagcctcc atcacttacc agtcaggaac
     5341 cctggcgata tcactttaac tttctgaacc tcagagtctt cacctataag acggggaaaa
     5401 taataccacc ctttcaagat tgttgagata aataagtgat ataaaacatg taaagcttag
     5461 ttctggccac agtgtagcta ctcaataaat gataatacta c
//
