LOCUS       NM_024709               2891 bp    mRNA    linear   PRI 11-FEB-2025
DEFINITION  Homo sapiens chromosome 1 open reading frame 115 (C1orf115), mRNA.
ACCESSION   NM_024709
VERSION     NM_024709.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2891)
  AUTHORS   Masud,S.N., Chandrashekhar,M., Aregger,M., Tan,G., Zhang,X.,
            Mero,P., Pirman,D.A., Zaslaver,O., Smolen,G.A., Lin,Z.Y.,
            Wong,C.J., Boone,C., Gingras,A.C., Montenegro-Burke,J.R. and
            Moffat,J.
  TITLE     Chemical genomics with pyrvinium identifies C1orf115 as a regulator
            of drug efflux
  JOURNAL   Nat Chem Biol 18 (12), 1370-1379 (2022)
   PUBMED   35970996
  REMARK    Erratum:[Nat Chem Biol. 2022 Oct;18(10):1162. doi:
            10.1038/s41589-022-01146-9.. PMID: 36002506]
REFERENCE   2  (bases 1 to 2891)
  AUTHORS   Lau,M.T., Ghazanfar,S., Parkin,A., Chou,A., Rouaen,J.R.,
            Littleboy,J.B., Nessem,D., Khuong,T.M., Nevoltris,D., Schofield,P.,
            Langley,D., Christ,D., Yang,J., Pajic,M. and Neely,G.G.
  TITLE     Systematic functional identification of cancer multi-drug
            resistance genes
  JOURNAL   Genome Biol 21 (1), 27 (2020)
   PUBMED   32028983
  REMARK    GeneRIF: Systematic functional identification of cancer multi-drug
            resistance genes.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2891)
  AUTHORS   Sigg,M.A., Menchen,T., Lee,C., Johnson,J., Jungnickel,M.K.,
            Choksi,S.P., Garcia,G. 3rd, Busengdal,H., Dougherty,G.W.,
            Pennekamp,P., Werner,C., Rentzsch,F., Florman,H.M., Krogan,N.,
            Wallingford,J.B., Omran,H. and Reiter,J.F.
  TITLE     Evolutionary Proteomics Uncovers Ancient Associations of Cilia with
            Signaling Pathways
  JOURNAL   Dev Cell 43 (6), 744-762 (2017)
   PUBMED   29257953
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC036067.1, AK091937.1 and BU728891.1.
            
            On Nov 22, 2018 this sequence version replaced NM_024709.4.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC036067.1, SRR1660805.146380.1
                                           [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000294889.6/ ENSP00000294889.5
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1518              BC036067.1         44-1561
            1519-2889           AK091937.1         1530-2900
            2890-2891           BU728891.1         23-24               c
FEATURES             Location/Qualifiers
     source          1..2891
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1q41"
     gene            1..2891
                     /gene="C1orf115"
                     /gene_synonym="RDD1"
                     /note="chromosome 1 open reading frame 115"
                     /db_xref="GeneID:79762"
                     /db_xref="HGNC:HGNC:25873"
     exon            1..349
                     /gene="C1orf115"
                     /gene_synonym="RDD1"
                     /inference="alignment:Splign:2.1.0"
     CDS             41..469
                     /gene="C1orf115"
                     /gene_synonym="RDD1"
                     /note="uncharacterized protein C1orf115; Required for
                     Drug-induced Death 1"
                     /codon_start=1
                     /product="required for drug-induced death protein 1"
                     /protein_id="NP_078985.3"
                     /db_xref="CCDS:CCDS1524.1"
                     /db_xref="GeneID:79762"
                     /db_xref="HGNC:HGNC:25873"
                     /translation="MTVGARLRSKAESSLLRRGPRGRGRTEGDEEAAAILEHLEYADE
                     AEAAAESGTSAADERGPGTRGARRVHFALLPERYEPLEEPAPSEQPRKRYRRKLKKYG
                     KNVGKVIIKGCRYVVIGLQGFAAAYSAPFAVATSVVSFVR"
     exon            350..2891
                     /gene="C1orf115"
                     /gene_synonym="RDD1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2869..2874
                     /regulatory_class="polyA_signal_sequence"
                     /gene="C1orf115"
                     /gene_synonym="RDD1"
                     /note="hexamer: AATAAA"
     polyA_site      2891
                     /gene="C1orf115"
                     /gene_synonym="RDD1"
                     /note="major polyA site"
ORIGIN      
        1 gtctttgcgc tcggaccttc gccagagggg ccgggacatc atgacggtgg gagccaggct
       61 ccgaagcaag gcggagagca gcctcctgcg ccgcgggccc cgagggcgag ggcgaaccga
      121 gggggacgag gaggcggccg ccatcctgga gcacctggag tacgcggacg aggcggaggc
      181 ggcggccgag agcgggacga gcgcggcgga cgagcggggc ccggggaccc ggggcgcgcg
      241 gagggtgcac ttcgccctcc tgcccgagcg ctacgagcca ctggaggagc cggcgccgag
      301 cgagcagccc aggaagaggt accggaggaa gctgaagaag tacggcaaga atgtcgggaa
      361 ggtcatcatc aaaggatgcc gctacgtggt catcggcctg caaggcttcg ctgcagccta
      421 ctccgccccg tttgcggtag ccaccagcgt ggtatccttc gtgcgctaat gggagctgct
      481 gtggcaggtg cccccagagt gaacgggagc ccctgctgtg ggaactttgt gaatcctgga
      541 gcatctcaga cttgaacaca cagcatattt ggaagagaaa acatgccttt ctttgttgaa
      601 tcacattagt atgatgagtg agtcatccct gcccatctgc tgagcttctc acatctctca
      661 gtcacacgtg gacccagtgg tcaatcctgc agagaattcg gcggaggtta ggtttgggag
      721 tggagctagc gtgctaaagc cagagccttc acgtgaaggt ggcaggcact ggggcggaag
      781 ccaacactca acagatgcaa gcagtgtggg tgtgcagcag aacagtgatc ttgggggagg
      841 aagaggatgt tactagagtc agatgatttg ctgtattctc ctgaaaggtc gtaggctgac
      901 aggcgctcac attccttggc tgcctcggtt ctgagggcag ctaaggagct gtttattcct
      961 caagtcatgc tccccgatct ccttcctcta ccactctgtc accaggagtt taattacagg
     1021 cttgaggaga agaaaggaag aaaagatatc ttgatgcttt gaaaactgtg ttggcagtgt
     1081 ggcatgactg tttaaagtag ataaaacctt gtcattttac cccatccctg catgactgtg
     1141 aagctggcga ggaaggagga agaagggcaa gttcagatgc aggctgggtg gctgggacag
     1201 gttggctaag ggactactct ggagggctct tctgcctggc attgcccact tcggcccagc
     1261 cacgtgtttg cagcgaccag agtccctgca aaggtgtggc tggctgtggt cagggtgcta
     1321 ctagcaccat cagcgcactc ccgccattgg ctcagctcct ctctgccagt ccaactaaga
     1381 gtgctttgtc ctgggtggga cataggggct gagagagatg gggggagaca taacacccag
     1441 gaatgaaaat acagatttag agaaggaacc agtaagtagg agacagatgt gaaggaaatg
     1501 gaaatgaggc aagaggacat tggaagagag aagtttgctg tccaggagcc aggtctggag
     1561 catcagtgtg agggagttca ggtaggctgg gcctgtgcct ctaggtaggg acaagggagg
     1621 ctgggtagcc agggctggtg cttaaaaccc ctgaggccat gagctcattg gctgcctttg
     1681 tagcatcctg tcttcttctg tgctgcctgg tttgatctca tctcacctgg attcaaaggg
     1741 taaggtgggc atgggtcttg ggcctgacac ccaccaagga tgacctgtgg actgccatcg
     1801 gatgctgaac agggagatga aaggaggtcc tcttaccata cccctctgcc aaccccccag
     1861 taggccactg ttctgacttt gtttccagaa tatccagaaa tccaaagggg ctgttgctga
     1921 acagtctgca ggaccagtga cagcacctac ctgttgtccc aaggcataca aaggaggcct
     1981 caacgctcat gcttctctaa tcaagcccta ccaagacaga cagaaagaca gacagaaaaa
     2041 aggaaggggt agaggagaag gttgaagctg tggagctaga ctctgcttca cttcctgaag
     2101 cttcaacttc atgtcgaaga ttcactggga cccaattcct gcattgttaa tatttgtgag
     2161 gaaaagtgaa acaagtgatc tggttttagc ccagatgatg aaagtggata tggcacattt
     2221 tcacacacgt gagataatta cagcttgccc cacaacactg ggtgttggag aaagggagag
     2281 atagtcataa gtggaagaaa aagccaagca tagtgagtgg gaaagagagt gagagcctgt
     2341 gcaggctgct gacgagcccc aggcagccca caagtttctc gtggggagat ggaggcagag
     2401 cccagggtag gggacagagc tgctggggcc tttccttgcc tgggaatctg tcccaggaag
     2461 agcttcccca ctcccatccc ccaaattgga aaaaccgtac attcaagcct gtttggccct
     2521 gaaattctta agaatctggt taagaattaa ctcactaatg tcaaaagtca aaacctccta
     2581 ggggttgtcc tgggagtcag gttcacgggt acagaagatg aatctcagat gtcactcaac
     2641 ctgagccgtc attctctgtg gcagggctgc cctgggtttc tcttactcaa tccctggagt
     2701 gtaagcattt ggattgtgtc acagattacc tttttacctt ttctttcttt ttttttcttt
     2761 ttttcaatat cagtgcccac accttactga gtattgagtt ttagagcttt cgcttgatgt
     2821 gcttgaccaa gagacttctt ttgtatcctt ttcttgtcct atgatgtaaa taaaagcctc
     2881 gatttatgta a
//
