LOCUS       NM_139240                988 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens chromosome 1 open reading frame 105 (C1orf105),
            transcript variant 1, mRNA.
ACCESSION   NM_139240
VERSION     NM_139240.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 988)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   2  (bases 1 to 988)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 988)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Paulo,J.A., Cannon,J.R., Ting,L.,
            Baltier,K., Colby,G., Gebreab,F., Gygi,M.P., Parzen,H., Szpyt,J.,
            Tam,S., Zarraga,G., Pontano-Vaites,L., Swarup,S., White,A.E.,
            Schweppe,D.K., Rad,R., Erickson,B.K., Obar,R.A., Guruharsha,K.G.,
            Li,K., Artavanis-Tsakonas,S., Gygi,S.P. and Harper,J.W.
  TITLE     Architecture of the human interactome defines protein communities
            and disease networks
  JOURNAL   Nature 545 (7655), 505-509 (2017)
   PUBMED   28514442
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            Z97195.1 and AL035295.1.
            
            On Nov 23, 2018 this sequence version replaced NM_139240.3.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: AL035295.1, SRR5189667.374634.1
                                           [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000367727.9/ ENSP00000356700.4
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-3                 Z97195.1           109156-109158       c
            4-988               AL035295.1         1-985
FEATURES             Location/Qualifiers
     source          1..988
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1q24.3"
     gene            1..988
                     /gene="C1orf105"
                     /note="chromosome 1 open reading frame 105"
                     /db_xref="GeneID:92346"
                     /db_xref="HGNC:HGNC:29591"
     exon            1..222
                     /gene="C1orf105"
                     /inference="alignment:Splign:2.1.0"
     CDS             202..753
                     /gene="C1orf105"
                     /note="isoform 1 is encoded by transcript variant 1;
                     uncharacterized protein C1orf105"
                     /codon_start=1
                     /product="uncharacterized protein C1orf105 isoform 1"
                     /protein_id="NP_640333.3"
                     /db_xref="CCDS:CCDS1301.1"
                     /db_xref="GeneID:92346"
                     /db_xref="HGNC:HGNC:29591"
                     /translation="MEKRELKASVPKFDKIPWLSEASLVNKPLVLSLPRRYPHTSATF
                     LTSSKKNMNLPILFQVPDVLSKARRNQCDSMLLRNQQLCSTCQEMKMVQPRTMKIPDD
                     PKASFENCMSYRMSLHQPKFQTTPEPFHDDIPTESIHYRLPILGPRTAVFHGLLTEAY
                     KTLKERQRSSLPRKEPIGKTTRQ"
     exon            223..308
                     /gene="C1orf105"
                     /inference="alignment:Splign:2.1.0"
     exon            309..399
                     /gene="C1orf105"
                     /inference="alignment:Splign:2.1.0"
     exon            400..474
                     /gene="C1orf105"
                     /inference="alignment:Splign:2.1.0"
     exon            475..542
                     /gene="C1orf105"
                     /inference="alignment:Splign:2.1.0"
     exon            543..607
                     /gene="C1orf105"
                     /inference="alignment:Splign:2.1.0"
     exon            608..988
                     /gene="C1orf105"
                     /inference="alignment:Splign:2.1.0"
     regulatory      962..967
                     /regulatory_class="polyA_signal_sequence"
                     /gene="C1orf105"
                     /note="hexamer: TATAAA"
     polyA_site      988
                     /gene="C1orf105"
                     /note="major polyA site"
ORIGIN      
        1 aagatgtaaa tcacacagat gttggtagag aaaaaggcat actggtattg aaactgtaaa
       61 ctggcctgtt tacttcgtct cctaacaaaa aacactttgg attcaggttc tccacagcag
      121 tcttccactg gccacagtga ggggagctag gtttccccag tctccagcta gaaaaactca
      181 gaacatctaa agatctgaaa gatggaaaaa agagaactaa aggcttctgt tccaaaattt
      241 gacaagattc cttggcttag tgaggccagc cttgtaaaca agccattagt gctcagcctt
      301 cccagaagat atcctcatac ctctgcgact tttctgactt catccaagaa gaatatgaat
      361 ttgccaattt tgtttcaagt tccagatgtt ttatctaagg ccaggaggaa ccagtgtgac
      421 tccatgctgc tcagaaacca acagctgtgc tccacatgtc aagaaatgaa aatggtacaa
      481 ccaagaacaa tgaaaatccc agatgatcca aaagcatcct ttgagaattg tatgagttat
      541 agaatgagtc ttcatcaacc caaattccag actacacctg agcctttcca tgatgacatc
      601 ccaacagaaa gcattcacta cagactgccc attctgggcc ccaggacagc tgtcttccac
      661 ggattactga cagaggccta caaaactcta aaagagagac aacgttcttc cttgcccaga
      721 aaggaaccaa taggcaagac aacgaggcag tgagcggtag gagctcatca cctcccagac
      781 tcccagagag aaaataacct cgccaagcca atctttgaca ctggcacctt ctcctcacaa
      841 ttttctctct tctcccaaaa gatgatttaa ttttgccttc ctaagattgc tggtattcta
      901 gctcttacct ctatgttctt tctcacgtct cctaaagaca aaattgttta atttacatga
      961 ttataaagat ctgtttatga aaatggaa
//
