LOCUS       NM_016546               3335 bp    mRNA    linear   PRI 05-APR-2024
DEFINITION  Homo sapiens complement C1r subcomponent like (C1RL), transcript
            variant 1, mRNA.
ACCESSION   NM_016546
VERSION     NM_016546.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3335)
  AUTHORS   Wang,J., Tong,L., Lin,G., Wang,H., Zhang,L. and Yang,X.
  TITLE     Immunological and clinicopathological characteristics of C1RL in
            2120 glioma patients
  JOURNAL   BMC Cancer 20 (1), 931 (2020)
   PUBMED   32993564
  REMARK    GeneRIF: Immunological and clinicopathological characteristics of
            C1RL in 2120 glioma patients.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3335)
  AUTHORS   Han,S., Lan,Q., Park,A.K., Lee,K.M., Park,S.K., Ahn,H.S.,
            Shin,H.Y., Kang,H.J., Koo,H.H., Seo,J.J., Choi,J.E., Ahn,Y.O.,
            Chanock,S.J., Kim,H., Rothman,N. and Kang,D.
  TITLE     Polymorphisms in innate immunity genes and risk of childhood
            leukemia
  JOURNAL   Hum Immunol 71 (7), 727-730 (2010)
   PUBMED   20438785
  REMARK    GeneRIF: Observational study of gene-disease association and
            gene-gene interaction. (HuGE Navigator)
REFERENCE   3  (bases 1 to 3335)
  AUTHORS   Rajaraman,P., Brenner,A.V., Neta,G., Pfeiffer,R., Wang,S.S.,
            Yeager,M., Thomas,G., Fine,H.A., Linet,M.S., Rothman,N.,
            Chanock,S.J. and Inskip,P.D.
  TITLE     Risk of meningioma and common variation in genes related to innate
            immunity
  JOURNAL   Cancer Epidemiol Biomarkers Prev 19 (5), 1356-1361 (2010)
   PUBMED   20406964
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   4  (bases 1 to 3335)
  AUTHORS   Cerhan,J.R., Novak,A.J., Fredericksen,Z.S., Wang,A.H., Liebow,M.,
            Call,T.G., Dogan,A., Witzig,T.E., Ansell,S.M., Habermann,T.M.,
            Kay,N.E. and Slager,S.L.
  TITLE     Risk of non-Hodgkin lymphoma in association with germline variation
            in complement genes
  JOURNAL   Br J Haematol 145 (5), 614-623 (2009)
   PUBMED   19344414
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   5  (bases 1 to 3335)
  AUTHORS   Rajaraman,P., Brenner,A.V., Butler,M.A., Wang,S.S., Pfeiffer,R.M.,
            Ruder,A.M., Linet,M.S., Yeager,M., Wang,Z., Orr,N., Fine,H.A.,
            Kwon,D., Thomas,G., Rothman,N., Inskip,P.D. and Chanock,S.J.
  TITLE     Common variation in genes related to innate immunity and risk of
            adult glioma
  JOURNAL   Cancer Epidemiol Biomarkers Prev 18 (5), 1651-1658 (2009)
   PUBMED   19423540
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   6  (bases 1 to 3335)
  AUTHORS   Palmer,D.J., Kelly,V.C., Smit,A.M., Kuy,S., Knight,C.G. and
            Cooper,G.J.
  TITLE     Human colostrum: identification of minor proteins in the aqueous
            phase by proteomics
  JOURNAL   Proteomics 6 (7), 2208-2216 (2006)
   PUBMED   16502470
REFERENCE   7  (bases 1 to 3335)
  AUTHORS   Wicher,K.B. and Fries,E.
  TITLE     Prohaptoglobin is proteolytically cleaved in the endoplasmic
            reticulum by the complement C1r-like protein
  JOURNAL   Proc Natl Acad Sci U S A 101 (40), 14390-14395 (2004)
   PUBMED   15385675
  REMARK    GeneRIF: coexpression of the proform of Hp (proHp) and C1r-LP
            effected cleavage of proHp in the endoplasmic reticulum
REFERENCE   8  (bases 1 to 3335)
  AUTHORS   Lin,N., Liu,S., Li,N., Wu,P., An,H., Yu,Y., Wan,T. and Cao,X.
  TITLE     A novel human dendritic cell-derived C1r-like serine protease
            analog inhibits complement-mediated cytotoxicity
  JOURNAL   Biochem Biophys Res Commun 321 (2), 329-336 (2004)
   PUBMED   15358180
  REMARK    GeneRIF: CLSPa itself possesses little protease activity, but it
            plays an inhibitory role in other active protease catalytic
            processes
REFERENCE   9  (bases 1 to 3335)
  AUTHORS   Puente,X.S., Sanchez,L.M., Overall,C.M. and Lopez-Otin,C.
  TITLE     Human and mouse proteases: a comparative genomic approach
  JOURNAL   Nat Rev Genet 4 (7), 544-558 (2003)
   PUBMED   12838346
  REMARK    Review article
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            HY062376.1, AK222802.1 and AC233309.2.
            
            On Nov 23, 2018 this sequence version replaced NM_016546.3.
            
            Transcript Variant: This variant (1) encodes the longest isoform
            (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF178985.1, AK222802.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968540, SAMN04284274
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000266542.9/ ENSP00000266542.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-9                 HY062376.1         65-73
            10-313              AK222802.1         1-304
            314-330             AC233309.2         20975-20991         c
            331-1080            AK222802.1         322-1071
            1081-1081           AC233309.2         9528-9528           c
            1082-1927           AK222802.1         1073-1918
            1928-3335           AC233309.2         7274-8681           c
FEATURES             Location/Qualifiers
     source          1..3335
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /map="12p13.31"
     gene            1..3335
                     /gene="C1RL"
                     /gene_synonym="C1r-LP; C1RL1; C1RLP; CLSPa"
                     /note="complement C1r subcomponent like"
                     /db_xref="GeneID:51279"
                     /db_xref="HGNC:HGNC:21265"
                     /db_xref="MIM:608974"
     exon            1..105
                     /gene="C1RL"
                     /gene_synonym="C1r-LP; C1RL1; C1RLP; CLSPa"
                     /inference="alignment:Splign:2.1.0"
     CDS             35..1498
                     /gene="C1RL"
                     /gene_synonym="C1r-LP; C1RL1; C1RLP; CLSPa"
                     /EC_number="3.4.21.41"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; complement C1r-like proteinase; complement C1r
                     subcomponent-like protein; C1r-like serine protease analog
                     protein; complement component 1, r subcomponent-like"
                     /codon_start=1
                     /product="complement C1r subcomponent-like protein isoform
                     1 precursor"
                     /protein_id="NP_057630.2"
                     /db_xref="CCDS:CCDS8573.1"
                     /db_xref="GeneID:51279"
                     /db_xref="HGNC:HGNC:21265"
                     /db_xref="MIM:608974"
                     /translation="MPGPRVWGKYLWRSPHSKGCPGAMWWLLLWGVLQACPTRGSVLL
                     AQELPQQLTSPGYPEPYGKGQESSTDIKAPEGFAVRLVFQDFDLEPSQDCAGDSVTIS
                     FVGSDPSQFCGQQGSPLGRPPGQREFVSSGRSLRLTFRTQPSSENKTAHLHKGFLALY
                     QTVAVNYSQPISEASRGSEAINAPGDNPAKVQNHCQEPYYQAAAAGALTCATPGTWKD
                     RQDGEEVLQCMPVCGRPVTPIAQNQTTLGSSRAKLGNFPWQAFTSIHGRGGGALLGDR
                     WILTAAHTIYPKDSVSLRKNQSVNVFLGHTAIDEMLKLGNHPVHRVVVHPDYRQNESH
                     NFSGDIALLELQHSIPLGPNVLPVCLPDNETLYRSGLLGYVSGFGMEMGWLTTELKYS
                     RLPVAPREACNAWLQKRQRPEVFSDNMFCVGDETQRHSVCQGDSGSVYVVWDNHAHHW
                     VATGIVSWGIGCGEGYDFYTKVLSYVDWIKGVMNGKN"
     exon            106..334
                     /gene="C1RL"
                     /gene_synonym="C1r-LP; C1RL1; C1RLP; CLSPa"
                     /inference="alignment:Splign:2.1.0"
     exon            335..524
                     /gene="C1RL"
                     /gene_synonym="C1r-LP; C1RL1; C1RLP; CLSPa"
                     /inference="alignment:Splign:2.1.0"
     exon            525..650
                     /gene="C1RL"
                     /gene_synonym="C1r-LP; C1RL1; C1RLP; CLSPa"
                     /inference="alignment:Splign:2.1.0"
     exon            651..725
                     /gene="C1RL"
                     /gene_synonym="C1r-LP; C1RL1; C1RLP; CLSPa"
                     /inference="alignment:Splign:2.1.0"
     exon            726..3335
                     /gene="C1RL"
                     /gene_synonym="C1r-LP; C1RL1; C1RLP; CLSPa"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2830..2835
                     /regulatory_class="polyA_signal_sequence"
                     /gene="C1RL"
                     /gene_synonym="C1r-LP; C1RL1; C1RLP; CLSPa"
                     /note="hexamer: AATAAA"
     polyA_site      2849
                     /gene="C1RL"
                     /gene_synonym="C1r-LP; C1RL1; C1RLP; CLSPa"
                     /note="major polyA site"
     regulatory      3318..3323
                     /regulatory_class="polyA_signal_sequence"
                     /gene="C1RL"
                     /gene_synonym="C1r-LP; C1RL1; C1RLP; CLSPa"
                     /note="hexamer: AATATA"
     polyA_site      3335
                     /gene="C1RL"
                     /gene_synonym="C1r-LP; C1RL1; C1RLP; CLSPa"
                     /note="major polyA site"
ORIGIN      
        1 agttctctcg caggtcccag atgtccagtt ccagatgcct ggacccagag tgtgggggaa
       61 atatctctgg agaagccctc actccaaagg ctgtccaggc gcaatgtggt ggctgcttct
      121 ctggggagtc ctccaggctt gcccaacccg gggctccgtc ctcttggccc aagagctacc
      181 ccagcagctg acatcccccg ggtacccaga gccgtatggc aaaggccaag agagcagcac
      241 ggacatcaag gctccagagg gctttgctgt gaggctcgtc ttccaggact tcgacctgga
      301 gccgtcccag gactgtgcag gggactctgt cacaatctca ttcgtcggtt cggatccaag
      361 ccagttctgt ggtcagcaag gctcccctct gggcaggccc cctggtcaga gggagtttgt
      421 atcctcaggg aggagtttgc ggctgacctt ccgcacacag ccttcctcgg agaacaagac
      481 tgcccacctc cacaagggct tcctggccct ctaccaaacc gtggctgtga actatagtca
      541 gcccatcagc gaggccagca ggggctctga ggccatcaac gcacctggag acaaccctgc
      601 caaggtccag aaccactgcc aggagcccta ttatcaggcc gcggcagcag gggcactcac
      661 ctgtgcaacc ccagggacct ggaaagacag acaggatggg gaggaggttc ttcagtgtat
      721 gcctgtctgc ggacggccag tcacccccat tgcccagaat cagacgaccc tcggttcttc
      781 cagagccaag ctgggcaact tcccctggca agccttcacc agtatccacg gccgtggggg
      841 cggggccctg ctgggggaca gatggatcct cactgctgcc cacaccatct accccaagga
      901 cagtgtttct ctcaggaaga accagagtgt gaatgtgttc ttgggccaca cagccataga
      961 tgagatgctg aaactgggga accaccctgt ccaccgtgtc gttgtgcacc ccgactaccg
     1021 tcagaatgag tcccataact ttagcgggga catcgccctc ctggagctgc agcacagcat
     1081 ccccctgggc cccaacgtcc tcccggtctg tctgcccgat aatgagaccc tctaccgcag
     1141 cggcttgttg ggctacgtca gtgggtttgg catggagatg ggctggctaa ctactgagct
     1201 gaagtactcg aggctgcctg tagctcccag ggaggcctgc aacgcctggc tccaaaagag
     1261 acagagaccc gaggtgtttt ctgacaatat gttctgtgtt ggggatgaga cgcaaaggca
     1321 cagtgtctgc cagggggaca gtggcagcgt ctatgtggta tgggacaatc atgcccatca
     1381 ctgggtggcc acgggcattg tgtcctgggg catagggtgt ggcgaagggt atgacttcta
     1441 caccaaggtg ctcagctatg tggactggat caagggagtg atgaatggca agaattgacc
     1501 ctgggggctt gaacagggac tgaccagcac agtggaggcc ccaggcaaca gagggcctgg
     1561 agtgaggact gaacactggg gtaggggttg ggggtggggg gttgggggag gcagggaaat
     1621 cctattcaca tcactgttgc accaagccac tgcaagagaa acccccaccc ggcaagcccg
     1681 ccccatccca gacaggaagc agagtcccac agaccgctcc tcctcaccct ctacctccct
     1741 gtgctcatgc actaggcccc gggaagcctg tacatctcaa caactttcgc cttgaatgtc
     1801 cttagaaccg ccttccccta cttcatctgt tgacacagct tttatactca cctgtggaag
     1861 agtcagctac tcacccgcta ttagagtatg gaggaagggg ttttcattgc attgcatttc
     1921 tgaaacattc ctaagaccct ttagttgacc ttcaaatatt caagctattc tgcagctcca
     1981 agatgcaatt atagaaacag ctcctttttt attttatgtc ctctatatgc caggtgcttc
     2041 acctgttatt tcacttaatc ctcataccat atttgcaaag gatgtgttat tatctatgtg
     2101 tgacaaatga ggaaactgag gctcagggga taaagggact tgcccaagtc ccacagctgg
     2161 tgtgtgactg cagagactgt gctcttccca gtgtgctgca atacttctca accctcctct
     2221 aacctgctgt gtcacccgct ttccctccca gcccccacat ccttaccatt ttccctccct
     2281 gggaattcct gcttctgcga aaatggtatc ctctagctca cactttccta atggccccat
     2341 ctcctgcaga agccaggtga gcccagcact ggactgaagt tcttgcagac accccacctg
     2401 tgcccctatc atcaggggaa ctgctccacc tgagaggacc aactctttaa tttttagtaa
     2461 aacctggagg tgatgggccg ggcgcagtgg ctcacgcctg taatcccaac accttaggag
     2521 tccgaggtgg gtggatcacg aggtcaggag atccagccca tcctggccaa catggtgaaa
     2581 ccccatctct actaaaaata caaaaattag ccgggcgtgg tgacacgtgc ctgtagtccc
     2641 agctactcgg gaggctgagg caggagaatc acttgaacct gggaggcgga ggttgcagtg
     2701 agctaagatc acgccactgc actccagcct gcggacagac caagacttca tcccccccaa
     2761 aaaaaaaaga ttggaggtga tttacagtga aagacacaaa taaaatacaa ctgttcaatg
     2821 gaaatagaaa ataaacacca taaaagagag aagagaggta atttgttagc atcaagagtc
     2881 aagttgctat atggtcaaag gttaaattta tctctaaaaa atggcaggat tcaaagttgt
     2941 acatacatgt gattacttct gttttttaca cccacataca gtacaaaaga ttattaaaaa
     3001 tattcccaaa aggcaggtgc aatgatgcac acttataccc ccagccactc aggaggctga
     3061 tgcaagagga tcgcttgagc ccaggagttg aagtccagcc taagcaacat agtgaaaccc
     3121 catcgccaaa aatataataa taattctctc aaaatactaa acagaggtgg ttttattgat
     3181 aagattttgg ctgtttggtt ttccactatt ctctattggc taaaatttgt ttaatgagca
     3241 tgaaatgttt ttattttatt ttgcttattt ttatgattgc aaaaaatgat atgagtttct
     3301 ccctgccaag gcaaaaaaat atatatatac ctata
//
