LOCUS       NP_057630                487 aa            linear   PRI 28-APR-2025
DEFINITION  complement C1r subcomponent-like protein isoform 1 precursor [Homo
            sapiens].
ACCESSION   NP_057630
VERSION     NP_057630.2
DBSOURCE    REFSEQ: accession NM_016546.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (residues 1 to 487)
  AUTHORS   Wang,J., Tong,L., Lin,G., Wang,H., Zhang,L. and Yang,X.
  TITLE     Immunological and clinicopathological characteristics of C1RL in
            2120 glioma patients
  JOURNAL   BMC Cancer 20 (1), 931 (2020)
   PUBMED   32993564
  REMARK    GeneRIF: Immunological and clinicopathological characteristics of
            C1RL in 2120 glioma patients.
            Publication Status: Online-Only
REFERENCE   2  (residues 1 to 487)
  AUTHORS   Han,S., Lan,Q., Park,A.K., Lee,K.M., Park,S.K., Ahn,H.S.,
            Shin,H.Y., Kang,H.J., Koo,H.H., Seo,J.J., Choi,J.E., Ahn,Y.O.,
            Chanock,S.J., Kim,H., Rothman,N. and Kang,D.
  TITLE     Polymorphisms in innate immunity genes and risk of childhood
            leukemia
  JOURNAL   Hum Immunol 71 (7), 727-730 (2010)
   PUBMED   20438785
  REMARK    GeneRIF: Observational study of gene-disease association and
            gene-gene interaction. (HuGE Navigator)
REFERENCE   3  (residues 1 to 487)
  AUTHORS   Rajaraman,P., Brenner,A.V., Neta,G., Pfeiffer,R., Wang,S.S.,
            Yeager,M., Thomas,G., Fine,H.A., Linet,M.S., Rothman,N.,
            Chanock,S.J. and Inskip,P.D.
  TITLE     Risk of meningioma and common variation in genes related to innate
            immunity
  JOURNAL   Cancer Epidemiol Biomarkers Prev 19 (5), 1356-1361 (2010)
   PUBMED   20406964
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   4  (residues 1 to 487)
  AUTHORS   Cerhan,J.R., Novak,A.J., Fredericksen,Z.S., Wang,A.H., Liebow,M.,
            Call,T.G., Dogan,A., Witzig,T.E., Ansell,S.M., Habermann,T.M.,
            Kay,N.E. and Slager,S.L.
  TITLE     Risk of non-Hodgkin lymphoma in association with germline variation
            in complement genes
  JOURNAL   Br J Haematol 145 (5), 614-623 (2009)
   PUBMED   19344414
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   5  (residues 1 to 487)
  AUTHORS   Rajaraman,P., Brenner,A.V., Butler,M.A., Wang,S.S., Pfeiffer,R.M.,
            Ruder,A.M., Linet,M.S., Yeager,M., Wang,Z., Orr,N., Fine,H.A.,
            Kwon,D., Thomas,G., Rothman,N., Inskip,P.D. and Chanock,S.J.
  TITLE     Common variation in genes related to innate immunity and risk of
            adult glioma
  JOURNAL   Cancer Epidemiol Biomarkers Prev 18 (5), 1651-1658 (2009)
   PUBMED   19423540
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   6  (residues 1 to 487)
  AUTHORS   Palmer,D.J., Kelly,V.C., Smit,A.M., Kuy,S., Knight,C.G. and
            Cooper,G.J.
  TITLE     Human colostrum: identification of minor proteins in the aqueous
            phase by proteomics
  JOURNAL   Proteomics 6 (7), 2208-2216 (2006)
   PUBMED   16502470
REFERENCE   7  (residues 1 to 487)
  AUTHORS   Wicher,K.B. and Fries,E.
  TITLE     Prohaptoglobin is proteolytically cleaved in the endoplasmic
            reticulum by the complement C1r-like protein
  JOURNAL   Proc Natl Acad Sci U S A 101 (40), 14390-14395 (2004)
   PUBMED   15385675
  REMARK    GeneRIF: coexpression of the proform of Hp (proHp) and C1r-LP
            effected cleavage of proHp in the endoplasmic reticulum
REFERENCE   8  (residues 1 to 487)
  AUTHORS   Lin,N., Liu,S., Li,N., Wu,P., An,H., Yu,Y., Wan,T. and Cao,X.
  TITLE     A novel human dendritic cell-derived C1r-like serine protease
            analog inhibits complement-mediated cytotoxicity
  JOURNAL   Biochem Biophys Res Commun 321 (2), 329-336 (2004)
   PUBMED   15358180
  REMARK    GeneRIF: CLSPa itself possesses little protease activity, but it
            plays an inhibitory role in other active protease catalytic
            processes
REFERENCE   9  (residues 1 to 487)
  AUTHORS   Puente,X.S., Sanchez,L.M., Overall,C.M. and Lopez-Otin,C.
  TITLE     Human and mouse proteases: a comparative genomic approach
  JOURNAL   Nat Rev Genet 4 (7), 544-558 (2003)
   PUBMED   12838346
  REMARK    Review article
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            HY062376.1, AK222802.1 and AC233309.2.
            
            On Feb 24, 2010 this sequence version replaced NP_057630.1.
            
            Transcript Variant: This variant (1) encodes the longest isoform
            (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF178985.1, AK222802.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968540, SAMN04284274
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000266542.9/ ENSP00000266542.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..487
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /map="12p13.31"
     Protein         1..487
                     /product="complement C1r subcomponent-like protein isoform
                     1 precursor"
                     /EC_number="3.4.21.41"
                     /note="complement C1r-like proteinase; complement C1r
                     subcomponent-like protein; C1r-like serine protease analog
                     protein; complement component 1, r subcomponent-like"
                     /calculated_mol_wt=49451
     sig_peptide     1..35
                     /note="/evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q9NZP8.2)"
                     /calculated_mol_wt=4066
     mat_peptide     36..487
                     /product="Complement C1r subcomponent-like protein.
                     /id=PRO_0000318678"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9NZP8.2)"
                     /calculated_mol_wt=49451
     Region          40..162
                     /region_name="CUB"
                     /note="CUB domain; extracellular domain; present in
                     proteins mostly known to be involved in development; not
                     found in prokaryotes, plants and yeast; cd00041"
                     /db_xref="CDD:238001"
     Site            order(49,51,53,80,85,127,157,159,161..162)
                     /site_type="other"
                     /note="heterodimerization interface [polypeptide binding]"
                     /db_xref="CDD:238001"
     Site            147
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000269|PubMed:19159218; propagated from
                     UniProtKB/Swiss-Prot (Q9NZP8.2)"
     Site            166
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000269|PubMed:16335952; propagated from
                     UniProtKB/Swiss-Prot (Q9NZP8.2)"
     Site            242
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) (complex) asparagine.
                     /evidence=ECO:0000269|PubMed:16335952,
                     ECO:0000269|PubMed:19139490, ECO:0000269|PubMed:19159218;
                     propagated from UniProtKB/Swiss-Prot (Q9NZP8.2)"
     Region          247..480
                     /region_name="Tryp_SPc"
                     /note="Trypsin-like serine protease; Many of these are
                     synthesized as inactive precursor zymogens that are
                     cleaved during limited proteolysis to generate their
                     active forms. Alignment contains also inactive enzymes
                     that have substitutions of the catalytic triad...;
                     cd00190"
                     /db_xref="CDD:238113"
     Site            order(283,339,436)
                     /site_type="active"
                     /db_xref="CDD:238113"
     Site            296
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000269|PubMed:16335952,
                     ECO:0000269|PubMed:19159218; propagated from
                     UniProtKB/Swiss-Prot (Q9NZP8.2)"
     Site            363
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q9NZP8.2)"
     Site            order(430,457,459)
                     /site_type="other"
                     /note="substrate binding sites [chemical binding]"
                     /db_xref="CDD:238113"
     CDS             1..487
                     /gene="C1RL"
                     /gene_synonym="C1r-LP; C1RL1; C1RLP; CLSPa"
                     /coded_by="NM_016546.4:35..1498"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1"
                     /db_xref="CCDS:CCDS8573.1"
                     /db_xref="GeneID:51279"
                     /db_xref="HGNC:HGNC:21265"
                     /db_xref="MIM:608974"
ORIGIN      
        1 mpgprvwgky lwrsphskgc pgamwwlllw gvlqacptrg svllaqelpq qltspgypep
       61 ygkgqesstd ikapegfavr lvfqdfdlep sqdcagdsvt isfvgsdpsq fcgqqgsplg
      121 rppgqrefvs sgrslrltfr tqpssenkta hlhkgflaly qtvavnysqp iseasrgsea
      181 inapgdnpak vqnhcqepyy qaaaagaltc atpgtwkdrq dgeevlqcmp vcgrpvtpia
      241 qnqttlgssr aklgnfpwqa ftsihgrggg allgdrwilt aahtiypkds vslrknqsvn
      301 vflghtaide mlklgnhpvh rvvvhpdyrq neshnfsgdi allelqhsip lgpnvlpvcl
      361 pdnetlyrsg llgyvsgfgm emgwlttelk ysrlpvapre acnawlqkrq rpevfsdnmf
      421 cvgdetqrhs vcqgdsgsvy vvwdnhahhw vatgivswgi gcgegydfyt kvlsyvdwik
      481 gvmngkn
//
