LOCUS       NM_001297640            3209 bp    mRNA    linear   PRI 06-APR-2024
DEFINITION  Homo sapiens complement C1r subcomponent like (C1RL), transcript
            variant 2, mRNA.
ACCESSION   NM_001297640
VERSION     NM_001297640.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3209)
  AUTHORS   Wang,J., Tong,L., Lin,G., Wang,H., Zhang,L. and Yang,X.
  TITLE     Immunological and clinicopathological characteristics of C1RL in
            2120 glioma patients
  JOURNAL   BMC Cancer 20 (1), 931 (2020)
   PUBMED   32993564
  REMARK    GeneRIF: Immunological and clinicopathological characteristics of
            C1RL in 2120 glioma patients.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3209)
  AUTHORS   Han,S., Lan,Q., Park,A.K., Lee,K.M., Park,S.K., Ahn,H.S.,
            Shin,H.Y., Kang,H.J., Koo,H.H., Seo,J.J., Choi,J.E., Ahn,Y.O.,
            Chanock,S.J., Kim,H., Rothman,N. and Kang,D.
  TITLE     Polymorphisms in innate immunity genes and risk of childhood
            leukemia
  JOURNAL   Hum Immunol 71 (7), 727-730 (2010)
   PUBMED   20438785
  REMARK    GeneRIF: Observational study of gene-disease association and
            gene-gene interaction. (HuGE Navigator)
REFERENCE   3  (bases 1 to 3209)
  AUTHORS   Rajaraman,P., Brenner,A.V., Neta,G., Pfeiffer,R., Wang,S.S.,
            Yeager,M., Thomas,G., Fine,H.A., Linet,M.S., Rothman,N.,
            Chanock,S.J. and Inskip,P.D.
  TITLE     Risk of meningioma and common variation in genes related to innate
            immunity
  JOURNAL   Cancer Epidemiol Biomarkers Prev 19 (5), 1356-1361 (2010)
   PUBMED   20406964
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   4  (bases 1 to 3209)
  AUTHORS   Cerhan,J.R., Novak,A.J., Fredericksen,Z.S., Wang,A.H., Liebow,M.,
            Call,T.G., Dogan,A., Witzig,T.E., Ansell,S.M., Habermann,T.M.,
            Kay,N.E. and Slager,S.L.
  TITLE     Risk of non-Hodgkin lymphoma in association with germline variation
            in complement genes
  JOURNAL   Br J Haematol 145 (5), 614-623 (2009)
   PUBMED   19344414
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   5  (bases 1 to 3209)
  AUTHORS   Rajaraman,P., Brenner,A.V., Butler,M.A., Wang,S.S., Pfeiffer,R.M.,
            Ruder,A.M., Linet,M.S., Yeager,M., Wang,Z., Orr,N., Fine,H.A.,
            Kwon,D., Thomas,G., Rothman,N., Inskip,P.D. and Chanock,S.J.
  TITLE     Common variation in genes related to innate immunity and risk of
            adult glioma
  JOURNAL   Cancer Epidemiol Biomarkers Prev 18 (5), 1651-1658 (2009)
   PUBMED   19423540
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   6  (bases 1 to 3209)
  AUTHORS   Palmer,D.J., Kelly,V.C., Smit,A.M., Kuy,S., Knight,C.G. and
            Cooper,G.J.
  TITLE     Human colostrum: identification of minor proteins in the aqueous
            phase by proteomics
  JOURNAL   Proteomics 6 (7), 2208-2216 (2006)
   PUBMED   16502470
REFERENCE   7  (bases 1 to 3209)
  AUTHORS   Wicher,K.B. and Fries,E.
  TITLE     Prohaptoglobin is proteolytically cleaved in the endoplasmic
            reticulum by the complement C1r-like protein
  JOURNAL   Proc Natl Acad Sci U S A 101 (40), 14390-14395 (2004)
   PUBMED   15385675
  REMARK    GeneRIF: coexpression of the proform of Hp (proHp) and C1r-LP
            effected cleavage of proHp in the endoplasmic reticulum
REFERENCE   8  (bases 1 to 3209)
  AUTHORS   Lin,N., Liu,S., Li,N., Wu,P., An,H., Yu,Y., Wan,T. and Cao,X.
  TITLE     A novel human dendritic cell-derived C1r-like serine protease
            analog inhibits complement-mediated cytotoxicity
  JOURNAL   Biochem Biophys Res Commun 321 (2), 329-336 (2004)
   PUBMED   15358180
  REMARK    GeneRIF: CLSPa itself possesses little protease activity, but it
            plays an inhibitory role in other active protease catalytic
            processes
REFERENCE   9  (bases 1 to 3209)
  AUTHORS   Puente,X.S., Sanchez,L.M., Overall,C.M. and Lopez-Otin,C.
  TITLE     Human and mouse proteases: a comparative genomic approach
  JOURNAL   Nat Rev Genet 4 (7), 544-558 (2003)
   PUBMED   12838346
  REMARK    Review article
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            HY062376.1, DR004214.1, AC233309.2 and AK222802.1.
            
            On May 31, 2019 this sequence version replaced NM_001297640.1.
            
            Transcript Variant: This variant (2) lacks an alternate in-frame
            exon compared to variant 1. The encoded isoform (2) is shorter than
            isoform 1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: DR004214.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968540, SAMN04284274
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-55                HY062376.1         65-119
            56-186              DR004214.1         46-176
            187-187             AC233309.2         21118-21118         c
            188-385             DR004214.1         178-375
            386-430             AC233309.2         14712-14756         c
            431-544             DR004214.1         421-534
            545-577             AC233309.2         12428-12460         c
            578-609             DR004214.1         568-599
            610-954             AK222802.1         727-1071
            955-955             AC233309.2         9528-9528           c
            956-1801            AK222802.1         1073-1918
            1802-3209           AC233309.2         7274-8681           c
FEATURES             Location/Qualifiers
     source          1..3209
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /map="12p13.31"
     gene            1..3209
                     /gene="C1RL"
                     /gene_synonym="C1r-LP; C1RL1; C1RLP; CLSPa"
                     /note="complement C1r subcomponent like"
                     /db_xref="GeneID:51279"
                     /db_xref="HGNC:HGNC:21265"
                     /db_xref="MIM:608974"
     exon            1..105
                     /gene="C1RL"
                     /gene_synonym="C1r-LP; C1RL1; C1RLP; CLSPa"
                     /inference="alignment:Splign:2.1.0"
     CDS             35..1372
                     /gene="C1RL"
                     /gene_synonym="C1r-LP; C1RL1; C1RLP; CLSPa"
                     /EC_number="3.4.21.41"
                     /note="isoform 2 precursor is encoded by transcript
                     variant 2; complement C1r-like proteinase; complement C1r
                     subcomponent-like protein; C1r-like serine protease analog
                     protein; complement component 1, r subcomponent-like"
                     /codon_start=1
                     /product="complement C1r subcomponent-like protein isoform
                     2 precursor"
                     /protein_id="NP_001284569.1"
                     /db_xref="GeneID:51279"
                     /db_xref="HGNC:HGNC:21265"
                     /db_xref="MIM:608974"
                     /translation="MPGPRVWGKYLWRSPHSKGCPGAMWWLLLWGVLQACPTRGSVLL
                     AQELPQQLTSPGYPEPYGKGQESSTDIKAPEGFAVRLVFQDFDLEPSQDCAGDSVTIS
                     FVGSDPSQFCGQQGSPLGRPPGQREFVSSGRSLRLTFRTQPSSENKTAHLHKGFLALY
                     QTVGALTCATPGTWKDRQDGEEVLQCMPVCGRPVTPIAQNQTTLGSSRAKLGNFPWQA
                     FTSIHGRGGGALLGDRWILTAAHTIYPKDSVSLRKNQSVNVFLGHTAIDEMLKLGNHP
                     VHRVVVHPDYRQNESHNFSGDIALLELQHSIPLGPNVLPVCLPDNETLYRSGLLGYVS
                     GFGMEMGWLTTELKYSRLPVAPREACNAWLQKRQRPEVFSDNMFCVGDETQRHSVCQG
                     DSGSVYVVWDNHAHHWVATGIVSWGIGCGEGYDFYTKVLSYVDWIKGVMNGKN"
     exon            106..334
                     /gene="C1RL"
                     /gene_synonym="C1r-LP; C1RL1; C1RLP; CLSPa"
                     /inference="alignment:Splign:2.1.0"
     exon            335..524
                     /gene="C1RL"
                     /gene_synonym="C1r-LP; C1RL1; C1RLP; CLSPa"
                     /inference="alignment:Splign:2.1.0"
     exon            525..599
                     /gene="C1RL"
                     /gene_synonym="C1r-LP; C1RL1; C1RLP; CLSPa"
                     /inference="alignment:Splign:2.1.0"
     exon            600..3209
                     /gene="C1RL"
                     /gene_synonym="C1r-LP; C1RL1; C1RLP; CLSPa"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2704..2709
                     /regulatory_class="polyA_signal_sequence"
                     /gene="C1RL"
                     /gene_synonym="C1r-LP; C1RL1; C1RLP; CLSPa"
                     /note="hexamer: AATAAA"
     polyA_site      2723
                     /gene="C1RL"
                     /gene_synonym="C1r-LP; C1RL1; C1RLP; CLSPa"
                     /note="major polyA site"
     regulatory      3192..3197
                     /regulatory_class="polyA_signal_sequence"
                     /gene="C1RL"
                     /gene_synonym="C1r-LP; C1RL1; C1RLP; CLSPa"
                     /note="hexamer: AATATA"
     polyA_site      3209
                     /gene="C1RL"
                     /gene_synonym="C1r-LP; C1RL1; C1RLP; CLSPa"
                     /note="major polyA site"
ORIGIN      
        1 agttctctcg caggtcccag atgtccagtt ccagatgcct ggacccagag tgtgggggaa
       61 atatctctgg agaagccctc actccaaagg ctgtccaggc gcaatgtggt ggctgcttct
      121 ctggggagtc ctccaggctt gcccaacccg gggctccgtc ctcttggccc aagagctacc
      181 ccagcagctg acatcccccg ggtacccaga gccgtatggc aaaggccaag agagcagcac
      241 ggacatcaag gctccagagg gctttgctgt gaggctcgtc ttccaggact tcgacctgga
      301 gccgtcccag gactgtgcag gggactctgt cacaatctca ttcgtcggtt cggatccaag
      361 ccagttctgt ggtcagcaag gctcccctct gggcaggccc cctggtcaga gggagtttgt
      421 atcctcaggg aggagtttgc ggctgacctt ccgcacacag ccttcctcgg agaacaagac
      481 tgcccacctc cacaagggct tcctggccct ctaccaaacc gtgggggcac tcacctgtgc
      541 aaccccaggg acctggaaag acagacagga tggggaggag gttcttcagt gtatgcctgt
      601 ctgcggacgg ccagtcaccc ccattgccca gaatcagacg accctcggtt cttccagagc
      661 caagctgggc aacttcccct ggcaagcctt caccagtatc cacggccgtg ggggcggggc
      721 cctgctgggg gacagatgga tcctcactgc tgcccacacc atctacccca aggacagtgt
      781 ttctctcagg aagaaccaga gtgtgaatgt gttcttgggc cacacagcca tagatgagat
      841 gctgaaactg gggaaccacc ctgtccaccg tgtcgttgtg caccccgact accgtcagaa
      901 tgagtcccat aactttagcg gggacatcgc cctcctggag ctgcagcaca gcatccccct
      961 gggccccaac gtcctcccgg tctgtctgcc cgataatgag accctctacc gcagcggctt
     1021 gttgggctac gtcagtgggt ttggcatgga gatgggctgg ctaactactg agctgaagta
     1081 ctcgaggctg cctgtagctc ccagggaggc ctgcaacgcc tggctccaaa agagacagag
     1141 acccgaggtg ttttctgaca atatgttctg tgttggggat gagacgcaaa ggcacagtgt
     1201 ctgccagggg gacagtggca gcgtctatgt ggtatgggac aatcatgccc atcactgggt
     1261 ggccacgggc attgtgtcct ggggcatagg gtgtggcgaa gggtatgact tctacaccaa
     1321 ggtgctcagc tatgtggact ggatcaaggg agtgatgaat ggcaagaatt gaccctgggg
     1381 gcttgaacag ggactgacca gcacagtgga ggccccaggc aacagagggc ctggagtgag
     1441 gactgaacac tggggtaggg gttgggggtg gggggttggg ggaggcaggg aaatcctatt
     1501 cacatcactg ttgcaccaag ccactgcaag agaaaccccc acccggcaag cccgccccat
     1561 cccagacagg aagcagagtc ccacagaccg ctcctcctca ccctctacct ccctgtgctc
     1621 atgcactagg ccccgggaag cctgtacatc tcaacaactt tcgccttgaa tgtccttaga
     1681 accgccttcc cctacttcat ctgttgacac agcttttata ctcacctgtg gaagagtcag
     1741 ctactcaccc gctattagag tatggaggaa ggggttttca ttgcattgca tttctgaaac
     1801 attcctaaga ccctttagtt gaccttcaaa tattcaagct attctgcagc tccaagatgc
     1861 aattatagaa acagctcctt ttttatttta tgtcctctat atgccaggtg cttcacctgt
     1921 tatttcactt aatcctcata ccatatttgc aaaggatgtg ttattatcta tgtgtgacaa
     1981 atgaggaaac tgaggctcag gggataaagg gacttgccca agtcccacag ctggtgtgtg
     2041 actgcagaga ctgtgctctt cccagtgtgc tgcaatactt ctcaaccctc ctctaacctg
     2101 ctgtgtcacc cgctttccct cccagccccc acatccttac cattttccct ccctgggaat
     2161 tcctgcttct gcgaaaatgg tatcctctag ctcacacttt cctaatggcc ccatctcctg
     2221 cagaagccag gtgagcccag cactggactg aagttcttgc agacacccca cctgtgcccc
     2281 tatcatcagg ggaactgctc cacctgagag gaccaactct ttaattttta gtaaaacctg
     2341 gaggtgatgg gccgggcgca gtggctcacg cctgtaatcc caacacctta ggagtccgag
     2401 gtgggtggat cacgaggtca ggagatccag cccatcctgg ccaacatggt gaaaccccat
     2461 ctctactaaa aatacaaaaa ttagccgggc gtggtgacac gtgcctgtag tcccagctac
     2521 tcgggaggct gaggcaggag aatcacttga acctgggagg cggaggttgc agtgagctaa
     2581 gatcacgcca ctgcactcca gcctgcggac agaccaagac ttcatccccc ccaaaaaaaa
     2641 aagattggag gtgatttaca gtgaaagaca caaataaaat acaactgttc aatggaaata
     2701 gaaaataaac accataaaag agagaagaga ggtaatttgt tagcatcaag agtcaagttg
     2761 ctatatggtc aaaggttaaa tttatctcta aaaaatggca ggattcaaag ttgtacatac
     2821 atgtgattac ttctgttttt tacacccaca tacagtacaa aagattatta aaaatattcc
     2881 caaaaggcag gtgcaatgat gcacacttat acccccagcc actcaggagg ctgatgcaag
     2941 aggatcgctt gagcccagga gttgaagtcc agcctaagca acatagtgaa accccatcgc
     3001 caaaaatata ataataattc tctcaaaata ctaaacagag gtggttttat tgataagatt
     3061 ttggctgttt ggttttccac tattctctat tggctaaaat ttgtttaatg agcatgaaat
     3121 gtttttattt tattttgctt atttttatga ttgcaaaaaa tgatatgagt ttctccctgc
     3181 caaggcaaaa aaatatatat atacctata
//
