LOCUS       NM_178540               1824 bp    mRNA    linear   PRI 23-APR-2024
DEFINITION  Homo sapiens C1q and TNF related 9 (C1QTNF9), transcript variant 2,
            mRNA.
ACCESSION   NM_178540
VERSION     NM_178540.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1824)
  AUTHORS   Peng,Y.L., Li,H., Sun,P., Zhang,H.D., Li,D., Wang,H.B. and Zhang,L.
  TITLE     Causal association between complement system FHR-5, CTRP9, and
            breast carcinoma in situ: a Mendelian randomization study
  JOURNAL   Eur Rev Med Pharmacol Sci 28 (6), 2363-2371 (2024)
   PUBMED   38567599
  REMARK    GeneRIF: Causal association between complement system FHR-5, CTRP9,
            and breast carcinoma in situ: a Mendelian randomization study.
REFERENCE   2  (bases 1 to 1824)
  AUTHORS   Zhu,L., Chen,S. and Dai,X.
  TITLE     CTRP9 alleviates hypoxia/reoxygenation-induced human placental
            vascular endothelial cells impairment and mitochondrial dysfunction
            through activating AMPK/Nrf2 signaling
  JOURNAL   Tissue Cell 85, 102217 (2023)
   PUBMED   37774521
  REMARK    GeneRIF: CTRP9 alleviates hypoxia/reoxygenation-induced human
            placental vascular endothelial cells impairment and mitochondrial
            dysfunction through activating AMPK/Nrf2 signaling.
REFERENCE   3  (bases 1 to 1824)
  AUTHORS   Song,R., Hu,W., Cheng,R., Zhao,Y., Qin,W., Li,X., Zhu,Y., Gan,L.
            and Liu,J.
  TITLE     Association Between Circulating Levels of C1q/TNF-Related Protein-9
            and Type 2 Diabetes Mellitus: A Systematic Review and Meta-analysis
  JOURNAL   J Clin Endocrinol Metab 108 (10), 2728-2738 (2023)
   PUBMED   37029975
  REMARK    GeneRIF: Association Between Circulating Levels of C1q/TNF-Related
            Protein-9 and Type 2 Diabetes Mellitus: A Systematic Review and
            Meta-analysis.
REFERENCE   4  (bases 1 to 1824)
  AUTHORS   Wang,J., Ren,B., Yang,Y. and Li,Y.
  TITLE     C1q/tumor necrosis factor-related protein-9 exerts antioxidant and
            anti-inflammatory effects on oxygen-glucose
            deprivation/reoxygenation-stimulated neurons by modulating the
            Akt-GSK-3beta-Nrf2 cascade via AdipoR1
  JOURNAL   Int Immunopharmacol 118, 110045 (2023)
   PUBMED   36996742
  REMARK    GeneRIF: C1q/tumor necrosis factor-related protein-9 exerts
            antioxidant and anti-inflammatory effects on oxygen-glucose
            deprivation/reoxygenation-stimulated neurons by modulating the
            Akt-GSK-3beta-Nrf2 cascade via AdipoR1.
REFERENCE   5  (bases 1 to 1824)
  AUTHORS   Zhang,Y.Q., Zhang,Y.W., Dai,J.L., Li,C., Wang,W.Q., Zhang,H.F.,
            Lau,W.B., Wang,X.M., Liu,X.G. and Li,R.
  TITLE     Serum CTRP9 and high-molecular weight adiponectin are associated
            with ischemic stroke
  JOURNAL   BMC Neurol 22 (1), 429 (2022)
   PUBMED   36380279
  REMARK    GeneRIF: Serum CTRP9 and high-molecular weight adiponectin are
            associated with ischemic stroke.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1824)
  AUTHORS   Jung,C.H., Lee,M.J., Kang,Y.M., Jang,J.E., Leem,J., Lee,Y.L.,
            Seol,S.M., Yoon,H.K., Lee,W.J. and Park,J.Y.
  TITLE     Association of serum C1q/TNF-related protein-9 concentration with
            arterial stiffness in subjects with type 2 diabetes
  JOURNAL   J Clin Endocrinol Metab 99 (12), E2477-E2484 (2014)
   PUBMED   25105737
  REMARK    GeneRIF: Serum CTRP9 concentration was significantly and positively
            associated with arterial stiffness in patients with type 2 diabetes
REFERENCE   7  (bases 1 to 1824)
  AUTHORS   Hwang,Y.C., Woo Oh,S., Park,S.W. and Park,C.Y.
  TITLE     Association of serum C1q/TNF-Related Protein-9 (CTRP9)
            concentration with visceral adiposity and metabolic syndrome in
            humans
  JOURNAL   Int J Obes (Lond) 38 (9), 1207-1212 (2014)
   PUBMED   24357853
  REMARK    GeneRIF: Serum CTRP9 concentrations were positively associated with
            favorable glucose or metabolic phenotypes and absence of metabolic
            syndrome, independent of serum total adiponectin concentrations.
REFERENCE   8  (bases 1 to 1824)
  AUTHORS   Peterson,J.M., Wei,Z. and Wong,G.W.
  TITLE     CTRP8 and CTRP9B are novel proteins that hetero-oligomerize with
            C1q/TNF family members
  JOURNAL   Biochem Biophys Res Commun 388 (2), 360-365 (2009)
   PUBMED   19666007
REFERENCE   9  (bases 1 to 1824)
  AUTHORS   Wong,G.W., Krawczyk,S.A., Kitidis-Mitrokostas,C., Ge,G.,
            Spooner,E., Hug,C., Gimeno,R. and Lodish,H.F.
  TITLE     Identification and characterization of CTRP9, a novel secreted
            glycoprotein, from adipose tissue that reduces serum glucose in
            mice and forms heterotrimers with adiponectin
  JOURNAL   FASEB J 23 (1), 241-258 (2009)
   PUBMED   18787108
REFERENCE   10 (bases 1 to 1824)
  AUTHORS   Clark,H.F., Gurney,A.L., Abaya,E., Baker,K., Baldwin,D., Brush,J.,
            Chen,J., Chow,B., Chui,C., Crowley,C., Currell,B., Deuel,B.,
            Dowd,P., Eaton,D., Foster,J., Grimaldi,C., Gu,Q., Hass,P.E.,
            Heldens,S., Huang,A., Kim,H.S., Klimowski,L., Jin,Y., Johnson,S.,
            Lee,J., Lewis,L., Liao,D., Mark,M., Robbie,E., Sanchez,C.,
            Schoenfeld,J., Seshagiri,S., Simmons,L., Singh,J., Smith,V.,
            Stinson,J., Vagts,A., Vandlen,R., Watanabe,C., Wieand,D., Woods,K.,
            Xie,M.H., Yansura,D., Yi,S., Yu,G., Yuan,J., Zhang,M., Zhang,Z.,
            Goddard,A., Wood,W.I., Godowski,P. and Gray,A.
  TITLE     The secreted protein discovery initiative (SPDI), a large-scale
            effort to identify novel human secreted and transmembrane proteins:
            a bioinformatics assessment
  JOURNAL   Genome Res 13 (10), 2265-2270 (2003)
   PUBMED   12975309
  REMARK    Erratum:[Genome Res. 2003 Dec;13(12):2759]
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC040438.1, BI767787.1 and AL359736.19.
            
            On Jun 2, 2019 this sequence version replaced NM_178540.4.
            
            Transcript Variant: This variant (2) lacks an alternate exon in the
            5' UTR compared to variant 1. Variants 1, 2, and 3 all encode the
            same protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC040438.1, AY358145.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968540, SAMEA2142670
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000332018.5/ ENSP00000333737.4
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-394               BC040438.1         3-396
            395-523             BI767787.1         419-547
            524-576             BI767787.1         549-601
            577-713             BC040438.1         579-715
            714-778             BI767787.1         738-802
            779-838             BC040438.1         781-840
            839-839             AL359736.19        166726-166726
            840-1824            BC040438.1         842-1826
FEATURES             Location/Qualifiers
     source          1..1824
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="13"
                     /map="13q12.12"
     gene            1..1824
                     /gene="C1QTNF9"
                     /gene_synonym="AQL1; C1QTNF9A; CTRP9"
                     /note="C1q and TNF related 9"
                     /db_xref="GeneID:338872"
                     /db_xref="HGNC:HGNC:28732"
                     /db_xref="MIM:614285"
     exon            1..37
                     /gene="C1QTNF9"
                     /gene_synonym="AQL1; C1QTNF9A; CTRP9"
                     /inference="alignment:Splign:2.1.0"
     exon            38..225
                     /gene="C1QTNF9"
                     /gene_synonym="AQL1; C1QTNF9A; CTRP9"
                     /inference="alignment:Splign:2.1.0"
     CDS             60..1061
                     /gene="C1QTNF9"
                     /gene_synonym="AQL1; C1QTNF9A; CTRP9"
                     /note="complement C1q tumor necrosis factor-related
                     protein 9A; C1q and tumor necrosis factor related protein
                     9; complement C1q and tumor necrosis factor-related
                     protein 9; complement C1q and tumor necrosis
                     factor-related protein 9A"
                     /codon_start=1
                     /product="complement C1q and tumor necrosis factor-related
                     protein 9A precursor"
                     /protein_id="NP_848635.2"
                     /db_xref="CCDS:CCDS9306.1"
                     /db_xref="GeneID:338872"
                     /db_xref="HGNC:HGNC:28732"
                     /db_xref="MIM:614285"
                     /translation="MRIWWLLLAIEICTGNINSQDTCRQGHPGIPGNPGHNGLPGRDG
                     RDGAKGDKGDAGEPGRPGSPGKDGTSGEKGERGADGKVEAKGIKGDQGSRGSPGKHGP
                     KGLAGPMGEKGLRGETGPQGQKGNKGDVGPTGPEGPRGNIGPLGPTGLPGPMGPIGKP
                     GPKGEAGPTGPQGEPGVRGIRGWKGDRGEKGKIGETLVLPKSAFTVGLTVLSKFPSSD
                     MPIKFDKILYNEFNHYDTAAGKFTCHIAGVYYFTYHITVFSRNVQVSLVKNGVKILHT
                     KDAYMSSEDQASGGIVLQLKLGDEVWLQVTGGERFNGLFADEDDDTTFTGFLLFSSP"
     exon            226..288
                     /gene="C1QTNF9"
                     /gene_synonym="AQL1; C1QTNF9A; CTRP9"
                     /inference="alignment:Splign:2.1.0"
     exon            289..1824
                     /gene="C1QTNF9"
                     /gene_synonym="AQL1; C1QTNF9A; CTRP9"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1233..1238
                     /regulatory_class="polyA_signal_sequence"
                     /gene="C1QTNF9"
                     /gene_synonym="AQL1; C1QTNF9A; CTRP9"
                     /note="hexamer: AGTAAA"
     polyA_site      1251
                     /gene="C1QTNF9"
                     /gene_synonym="AQL1; C1QTNF9A; CTRP9"
     regulatory      1790..1795
                     /regulatory_class="polyA_signal_sequence"
                     /gene="C1QTNF9"
                     /gene_synonym="AQL1; C1QTNF9A; CTRP9"
                     /note="hexamer: AATAAA"
     polyA_site      1824
                     /gene="C1QTNF9"
                     /gene_synonym="AQL1; C1QTNF9A; CTRP9"
                     /note="major polyA site"
ORIGIN      
        1 acagtatctg ggtccagcct gcagccctag ggtccagttc agagtctgtc atctgaacca
       61 tgaggatctg gtggcttctg cttgccattg aaatctgcac agggaacata aactcacagg
      121 acacctgcag gcaagggcac cctggaatcc ctgggaaccc cggtcacaat ggtctgcctg
      181 gaagagatgg acgagacgga gcgaagggtg acaaaggcga tgcaggagaa ccaggacgtc
      241 ctggcagccc ggggaaggat gggacgagtg gagagaaggg agaacgagga gcagatggaa
      301 aagttgaagc aaaaggcatc aaaggtgatc aaggctcaag aggatcccca ggaaaacatg
      361 gccccaaggg gcttgcaggg cccatgggag agaagggcct ccgaggagag actgggcctc
      421 aggggcagaa ggggaataag ggtgacgtgg gtcccactgg tcctgagggg ccaaggggca
      481 acattgggcc tttgggccca actggtttac cgggccccat gggccctatt ggaaagcctg
      541 gtcccaaagg agaagctgga cccacggggc cccagggtga gccaggagtc cggggaataa
      601 gaggctggaa aggagatcga ggagagaaag ggaaaatcgg tgagactcta gtcttgccaa
      661 aaagtgcttt cactgtgggg ctcacggtgc tgagcaagtt tccttcttca gatatgccca
      721 ttaaatttga taagatcctg tataacgaat tcaaccatta tgatacagca gcggggaaat
      781 tcacgtgcca cattgctggg gtctattact tcacctacca catcactgtt ttctccagaa
      841 atgttcaggt gtctttggtc aaaaatggag taaaaatact gcacaccaaa gatgcttaca
      901 tgagctctga ggaccaggcc tctggcggca ttgtcctgca gctgaagctc ggggatgagg
      961 tgtggctgca ggtgacagga ggagagaggt tcaatggctt gtttgctgat gaggacgatg
     1021 acacaacttt cacagggttc cttctgttca gcagcccgtg acagaggaga gtttaaaaat
     1081 ccgccacacc atccatcaga atcagcttgg gatgaactta ttcagatggt tttactttat
     1141 taattcctcc aattattaca ataatcataa aaaggtgaaa atggaaaagt tattcccaaa
     1201 actgattctg tgtaacttac tatttttcca ggagtaaata tttaaaatag ctgcatggtt
     1261 tattctaatt tatttcacat ttcttattcc tattatctga agaatccctc gtctgtgcgt
     1321 ttcttgtggg aagagtgttt taatatcatt ttagtgctct gaggagtcat atgaagatgt
     1381 atccctcatc tgtgtttctg aggacattaa ggggaaatta gagggaaatg tttattcaat
     1441 ttagtactag caacagcttt aagctggtga tgctgtcata ctccagaaag ctgtagacac
     1501 tgctcatttt gtcttttaaa aaaattttat tttattttaa gttctgggat acatatgcaa
     1561 aacatgcatg tttgttacat aggtaaacat gtgctgtggt ggtttgctgt atctatcaac
     1621 ccatcaccta ggtattaagc cctgcatgca ttagctattt gtcctggtgc tctccctccc
     1681 actttgctca ttttctaacc taggttttaa tcaccatttt acccaacaaa tcattgttcg
     1741 atcattattt gccagacttg aatctctatg tgttttctag gactgctcta ataaagtaca
     1801 caaactggga gtctttaaac aaca
//
