LOCUS       NM_207419               3406 bp    mRNA    linear   PRI 03-APR-2024
DEFINITION  Homo sapiens C1q and TNF related 8 (C1QTNF8), mRNA.
ACCESSION   NM_207419
VERSION     NM_207419.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3406)
  AUTHORS   Krishnan,S.N., Thanasupawat,T., Arreza,L., Wong,G.W., Sfanos,K.,
            Trock,B., Arock,M., Shah,G.G., Glogowska,A., Ghavami,S.,
            Hombach-Klonisch,S. and Klonisch,T.
  TITLE     Human C1q Tumor Necrosis Factor 8 (CTRP8) defines a novel tryptase+
            mast cell subpopulation in the prostate cancer microenvironment
  JOURNAL   Biochim Biophys Acta Mol Basis Dis 1869 (5), 166681 (2023)
   PUBMED   36921737
  REMARK    GeneRIF: Human C1q Tumor Necrosis Factor 8 (CTRP8) defines a novel
            tryptase+ mast cell subpopulation in the prostate cancer
            microenvironment.
REFERENCE   2  (bases 1 to 3406)
  AUTHORS   Thanasupawat,T., Glogowska,A., Burg,M., Krcek,J., Beiko,J.,
            Pitz,M., Zhang,G.J., Hombach-Klonisch,S. and Klonisch,T.
  TITLE     C1q/TNF-related peptide 8 (CTRP8) promotes temozolomide resistance
            in human glioblastoma
  JOURNAL   Mol Oncol 12 (9), 1464-1479 (2018)
   PUBMED   29949238
  REMARK    GeneRIF: This study demonstrates a novel role for CTRP8 in
            protecting human glioblastoma cells against the DNA alkylating
            damage of temozolomide, the standard chemotherapy drug used to
            treat glioblastoma. This DNA protective role of CTRP8 required a
            functional RXFP1-STAT3 signaling cascade in glioblastoma cells.
            CTRP8-RXFP1-STAT3 axis is an emerging new drug target for improved
            treatment of human glioblastoma.
REFERENCE   3  (bases 1 to 3406)
  AUTHORS   Glogowska,A., Kunanuvat,U., Stetefeld,J., Patel,T.R.,
            Thanasupawat,T., Krcek,J., Weber,E., Wong,G.W., Del Bigio,M.R.,
            Hoang-Vu,C., Hombach-Klonisch,S. and Klonisch,T.
  TITLE     C1q-tumour necrosis factor-related protein 8 (CTRP8) is a novel
            interaction partner of relaxin receptor RXFP1 in human brain cancer
            cells
  JOURNAL   J Pathol 231 (4), 466-479 (2013)
   PUBMED   24014093
  REMARK    GeneRIF: direct interaction of human CTRP8 with RXFP1
REFERENCE   4  (bases 1 to 3406)
  AUTHORS   Peterson,J.M., Wei,Z. and Wong,G.W.
  TITLE     CTRP8 and CTRP9B are novel proteins that hetero-oligomerize with
            C1q/TNF family members
  JOURNAL   Biochem Biophys Res Commun 388 (2), 360-365 (2009)
   PUBMED   19666007
  REMARK    GeneRIF: two novel human C1q/TNF family members, designated as
            CTRP8 and CTRP9B were described.
REFERENCE   5  (bases 1 to 3406)
  AUTHORS   Clark,H.F., Gurney,A.L., Abaya,E., Baker,K., Baldwin,D., Brush,J.,
            Chen,J., Chow,B., Chui,C., Crowley,C., Currell,B., Deuel,B.,
            Dowd,P., Eaton,D., Foster,J., Grimaldi,C., Gu,Q., Hass,P.E.,
            Heldens,S., Huang,A., Kim,H.S., Klimowski,L., Jin,Y., Johnson,S.,
            Lee,J., Lewis,L., Liao,D., Mark,M., Robbie,E., Sanchez,C.,
            Schoenfeld,J., Seshagiri,S., Simmons,L., Singh,J., Smith,V.,
            Stinson,J., Vagts,A., Vandlen,R., Watanabe,C., Wieand,D., Woods,K.,
            Xie,M.H., Yansura,D., Yi,S., Yu,G., Yuan,J., Zhang,M., Zhang,Z.,
            Goddard,A., Wood,W.I., Godowski,P. and Gray,A.
  TITLE     The secreted protein discovery initiative (SPDI), a large-scale
            effort to identify novel human secreted and transmembrane proteins:
            a bioinformatics assessment
  JOURNAL   Genome Res 13 (10), 2265-2270 (2003)
   PUBMED   12975309
  REMARK    Erratum:[Genome Res. 2003 Dec;13(12):2759]
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL031713.8 and AC009041.10.
            
            On Jun 26, 2009 this sequence version replaced NM_207419.2.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000328449.6/ ENSP00000330426.5
            RefSeq Select criteria :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-89                AL031713.8         17422-17510         c
            90-263              AL031713.8         16881-17054         c
            264-482             AL031713.8         15981-16199         c
            483-1037            AL031713.8         14763-15317         c
            1038-3406           AC009041.10        158577-160945       c
FEATURES             Location/Qualifiers
     source          1..3406
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="16"
                     /map="16p13.3"
     gene            1..3406
                     /gene="C1QTNF8"
                     /gene_synonym="CTRP8; UNQ5829"
                     /note="C1q and TNF related 8"
                     /db_xref="GeneID:390664"
                     /db_xref="HGNC:HGNC:31374"
                     /db_xref="MIM:614147"
     exon            1..89
                     /gene="C1QTNF8"
                     /gene_synonym="CTRP8; UNQ5829"
                     /inference="alignment:Splign:2.1.0"
     exon            90..263
                     /gene="C1QTNF8"
                     /gene_synonym="CTRP8; UNQ5829"
                     /inference="alignment:Splign:2.1.0"
     exon            264..482
                     /gene="C1QTNF8"
                     /gene_synonym="CTRP8; UNQ5829"
                     /inference="alignment:Splign:2.1.0"
     CDS             275..1033
                     /gene="C1QTNF8"
                     /gene_synonym="CTRP8; UNQ5829"
                     /note="complement C1q tumor necrosis factor-related
                     protein 8; C1q/TNF-related protein 8; C1q and tumor
                     necrosis factor related protein 8"
                     /codon_start=1
                     /product="complement C1q tumor necrosis factor-related
                     protein 8 precursor"
                     /protein_id="NP_997302.2"
                     /db_xref="CCDS:CCDS32358.1"
                     /db_xref="GeneID:390664"
                     /db_xref="HGNC:HGNC:31374"
                     /db_xref="MIM:614147"
                     /translation="MAAPALLLLALLLPVGAWPGLPRRPCVHCCRPAWPPGPYARVSD
                     RDLWRGDLWRGLPRVRPTIDIEILKGEKGEAGVRGRAGRSGKEGPPGARGLQGRRGQK
                     GQVGPPGAACRRAYAAFSVGRREGLHSSDHFQAVPFDTELVNLDGAFDLAAGRFLCTV
                     PGVYFLSLNVHTWNYKETYLHIMLNRRPAAVLYAQPSERSVMQAQSLMLLLAAGDAVW
                     VRMFQRDRDNAIYGEHGDLYITFSGHLVKPAAEL"
     exon            483..1037
                     /gene="C1QTNF8"
                     /gene_synonym="CTRP8; UNQ5829"
                     /inference="alignment:Splign:2.1.0"
     exon            1038..3406
                     /gene="C1QTNF8"
                     /gene_synonym="CTRP8; UNQ5829"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gcccagagga agccacgggc gcccaggcgg gcatgaaagg gctctttgac ggctgggttg
       61 ctgggacagt aacacagacg gccggccagg aggaaggacc ttgccctgtg ctacaatccc
      121 agagggcttc ctgaaggagg cagcctagat ctttgtccag cagagcccat cttcagggaa
      181 tattgaggat cccgacccgt gcacctgccc tagcggaaga cactcctggc caagcctcca
      241 gatgtggctg tgaggggagt gggccctggc caagatggca gcccccgccc tgctgctcct
      301 agcactgctg ctgcccgtgg gggcctggcc cgggctgccc aggaggccct gtgtgcactg
      361 ctgccgcccg gcctggcccc ctggacccta tgcccgggtg agtgacaggg acctgtggag
      421 gggggacctg tggagggggc tgcctcgagt acggcccact atagacatcg aaatcctcaa
      481 aggtgagaag ggtgaggccg gcgtccgagg tcgggccggc aggagcggga aagaggggcc
      541 gccaggcgcc cggggcctgc agggccgcag aggccagaag gggcaggtgg ggccgccggg
      601 cgccgcgtgc cgacgtgcct acgccgcctt ctccgtgggc cggcgcgagg gcctgcacag
      661 ctccgaccac ttccaggcgg tgcccttcga cacggagctg gtgaacctgg acggcgcctt
      721 cgacctggcc gcgggccgct tcctctgcac ggtgcccggc gtctacttcc tcagcctcaa
      781 cgtgcacacc tggaactaca aggagaccta cctgcacatc atgctgaacc ggcggcccgc
      841 ggccgtgctc tacgcgcagc ccagcgagcg cagcgtcatg caggcccaga gcctgatgct
      901 gctgctggcg gcgggcgacg ccgtctgggt gcgcatgttc cagcgcgacc gggacaacgc
      961 catctacggc gagcacggag acctctacat caccttcagc ggccacctgg tcaagccggc
     1021 cgccgagctg tagccggaca gacgtccgcc tgtggggact ctgggagccc cggctggcgc
     1081 gcccgcctct ccacttcgcc tcactcctgt cctgggacag agggtgccct gcccttggga
     1141 gatggtgctc tgaggcccgg ccagagtctg cagaacccgc gtgtgtgtgc tggagccact
     1201 ccccaggcag gcgggggaac aagcgtggcc cccaacagcg caggacagga ggaggggcgg
     1261 ctacaggggc ccgccatttg ctgtgcacac atggcccctc tgcagggaga ggggctctgt
     1321 cccggctgcg ccacccccac ccactgccca agcctgctgc ctcccaagtc gcccggcatc
     1381 cacctctttc cctgaggctg tccctggggc caggctgccc ctcagcaccc ccaagtggcc
     1441 ccgtactcaa gtcccacctt gtgtgtctgt gggggggcgg tagcagggct tctggaagtg
     1501 tggtgacaac caaggacagg aggggctggg gccggtggcc gtggctggtg aaccctggcc
     1561 ctgctagaga caggaggggc actggcgctg gggctggacc cggaaccttc cctctccttc
     1621 gccccacact gaggtgggcg gggcctcagg ctgcactttg gcccagggcc tgagtctgct
     1681 cctggctggg atagcgggac acacccaggg cgcccggcaa ccggcagggg tcggagccat
     1741 ctccgggcac tcacggggcc ttggcacaga ggcttccgcc ttagagagaa aggcgcccga
     1801 acaggaaggg gtgggccgag gggagattgg cagaccccag gcctcccacc ccgaccggga
     1861 cacccccagc cctaccccgt gtgctgacgg ccggtggcgc taagaggtgc caggagagaa
     1921 gcccacagcc tggtcctggc tgcagcagca gggcgcctgg tcagcactct ggggagcctt
     1981 gtgctcactc agcccgttcc caagtgagga cacccagtgc cacgcaggca gagccaggct
     2041 gcagccacgt cccgcccacc ccacacagag cccgtgtccc tgccagctct gcctgtcgcc
     2101 tcagcttccc gtgcagcagg gggtgcgcaa aggcctctgt cggggacccc agagcagctg
     2161 tgaggggccc tgggcttgca ggtcccaagt gggcactgcc cagagccgag cccttggtgt
     2221 ccaggccccg gaggacagct gcacggctcc aggggttcct gcttgggggg atccccagga
     2281 ggagcctgtt ggggtcaagt gtggcaggtg cttgaagaac cagaggtggg gggtatgggc
     2341 tgctgggggt gggggtcccg gctggccatg cagaggttct tggccccggt gagagagcag
     2401 ggctggatgg gagatgggag ccaggggtcc ggaccacccc agggccaggg aggacatctc
     2461 ctctcgcagg ctgcctgttc tgtgctgggg aagcacccca gaatcccaga caaccgttcc
     2521 tttccctggc cctggccctg gcccggctgc cctggggtct ccagcctctg tgattccagt
     2581 gagcctgtgc tgccagggtg gcaggtggtc ctgaggaaga gagtcccggg aagacgccag
     2641 cccctgcacc agggagctca gaaagtgccc gtcaccaggc ccagccaagg acccagacgt
     2701 gaccacagca gccccgaagc caggcgctta ttccgaggga caggctggac ctccccgcac
     2761 agacgtcgcc gtggcctata ggtagttgca gctgcggata ctaagaagca gcaggggtca
     2821 ggcgggcagg ggtcgggctg cagcaggggt caggcgggca ggggtgcaag gtctcttgga
     2881 agctggcggg ggtgtctaat gaatgccagt ggcgaccctg gttctcagag aaccggggtg
     2941 gggagatgcc tgtgagagcc tcagacagca ggacctgcat cccgccaacc ttccaggttt
     3001 atttgtttaa aaaacaatga ctgagaactg aaagtgagat aagatacggt cacgattctc
     3061 tgccaagtga taaaagcctg agggacgctg ccagtgccag gtgggagcgg aaagagggat
     3121 gcttggtaga ggccagagac acgaaaagca gcgacagcct cgtgctgccc tggccactta
     3181 ggagacaagg gggagccacc ccatcagaac cgcaccgggc acccccgtgg tcggcccgtg
     3241 ctggctttaa tcatgagtca accgcacagg aagggactgg ggaacgcggc ttcccgcggg
     3301 gacatccctg tgacattcca ggcaagcatc gggctgggga ggcagcttat cccatgtaac
     3361 tttatccgtt tagtggaatt ccagtaaaaa tccaatttta aatgtt
//
