LOCUS       NM_031911               4320 bp    mRNA    linear   PRI 06-APR-2024
DEFINITION  Homo sapiens C1q and TNF related 7 (C1QTNF7), transcript variant 3,
            mRNA.
ACCESSION   NM_031911
VERSION     NM_031911.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4320)
  AUTHORS   Zhang,Y., Liu,C., Liu,J., Guo,R., Yan,Z., Liu,W., Lau,W.B.,
            Jiao,X., Cao,J., Xu,K., Jia,Y., Ma,X. and Wang,Y.
  TITLE     Implications of C1q/TNF-related protein superfamily in patients
            with coronary artery disease
  JOURNAL   Sci Rep 10 (1), 878 (2020)
   PUBMED   31965030
  REMARK    GeneRIF: Implications of C1q/TNF-related protein superfamily in
            patients with coronary artery disease.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4320)
  AUTHORS   Deng,X., Sabino,E.C., Cunha-Neto,E., Ribeiro,A.L., Ianni,B.,
            Mady,C., Busch,M.P. and Seielstad,M.
  CONSRTM   REDSII Chagas Study Group from the NHLBI Retrovirus Epidemiology
            Donor Study-II Component International
  TITLE     Genome wide association study (GWAS) of Chagas cardiomyopathy in
            Trypanosoma cruzi seropositive subjects
  JOURNAL   PLoS One 8 (11), e79629 (2013)
   PUBMED   24324551
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4320)
  AUTHORS   Dick,D.M., Aliev,F., Krueger,R.F., Edwards,A., Agrawal,A.,
            Lynskey,M., Lin,P., Schuckit,M., Hesselbrock,V., Nurnberger,J. Jr.,
            Almasy,L., Porjesz,B., Edenberg,H.J., Bucholz,K., Kramer,J.,
            Kuperman,S. and Bierut,L.
  TITLE     Genome-wide association study of conduct disorder symptomatology
  JOURNAL   Mol Psychiatry 16 (8), 800-808 (2011)
   PUBMED   20585324
  REMARK    GeneRIF: found four markers that meet the criteria for genome-wide
            significance (P<5x10-8) with the CD symptom count, two of which are
            located in the gene C1QTNF7 (C1q and tumor necrosis factor-related
            protein 7).
            GeneRIF: Observational study and genome-wide association study of
            gene-disease association. (HuGE Navigator)
REFERENCE   4  (bases 1 to 4320)
  AUTHORS   Cerhan,J.R., Novak,A.J., Fredericksen,Z.S., Wang,A.H., Liebow,M.,
            Call,T.G., Dogan,A., Witzig,T.E., Ansell,S.M., Habermann,T.M.,
            Kay,N.E. and Slager,S.L.
  TITLE     Risk of non-Hodgkin lymphoma in association with germline variation
            in complement genes
  JOURNAL   Br J Haematol 145 (5), 614-623 (2009)
   PUBMED   19344414
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   5  (bases 1 to 4320)
  AUTHORS   Wong,G.W., Krawczyk,S.A., Kitidis-Mitrokostas,C., Revett,T.,
            Gimeno,R. and Lodish,H.F.
  TITLE     Molecular, biochemical and functional characterizations of C1q/TNF
            family members: adipose-tissue-selective expression patterns,
            regulation by PPAR-gamma agonist, cysteine-mediated
            oligomerizations, combinatorial associations and metabolic
            functions
  JOURNAL   Biochem J 416 (2), 161-177 (2008)
   PUBMED   18783346
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DB290077.1, AF329839.1, AC007016.5 and BE856929.1.
            
            On Jun 2, 2019 this sequence version replaced NM_031911.4.
            
            Transcript Variant: This variant (3) differs in the 5' UTR and uses
            a downstream translation initiation codon, compared to variant 1,
            resulting in an isoform (b) with a shorter N-terminus, compared to
            isoform a. Both variants 2 and 3 encode the same isoform.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The extent of this transcript is
            supported by transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803614.248911.1, AF329839.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1966682, SAMEA1968189
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000444304.3/ ENSP00000388914.2
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-18                DB290077.1         30-47
            19-1072             AF329839.1         22-1075
            1073-3974           AC007016.5         51340-54241
            3975-4320           BE856929.1         13-358              c
FEATURES             Location/Qualifiers
     source          1..4320
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="4"
                     /map="4p15.32"
     gene            1..4320
                     /gene="C1QTNF7"
                     /gene_synonym="CTRP7; ZACRP7"
                     /note="C1q and TNF related 7"
                     /db_xref="GeneID:114905"
                     /db_xref="HGNC:HGNC:14342"
     exon            1..74
                     /gene="C1QTNF7"
                     /gene_synonym="CTRP7; ZACRP7"
                     /inference="alignment:Splign:2.1.0"
     exon            75..320
                     /gene="C1QTNF7"
                     /gene_synonym="CTRP7; ZACRP7"
                     /inference="alignment:Splign:2.1.0"
     CDS             83..952
                     /gene="C1QTNF7"
                     /gene_synonym="CTRP7; ZACRP7"
                     /note="isoform b precursor is encoded by transcript
                     variant 3; complement-c1q tumor necrosis factor-related
                     protein 7; complement C1q tumor necrosis factor-related
                     protein 7; C1q and tumor necrosis factor related protein
                     7"
                     /codon_start=1
                     /product="complement C1q tumor necrosis factor-related
                     protein 7 isoform b precursor"
                     /protein_id="NP_114117.1"
                     /db_xref="CCDS:CCDS3414.1"
                     /db_xref="GeneID:114905"
                     /db_xref="HGNC:HGNC:14342"
                     /translation="MFVLLYVTSFAICASGQPRGNQLKGENYSPRYICSIPGLPGPPG
                     PPGANGSPGPHGRIGLPGRDGRDGRKGEKGEKGTAGLRGKTGPLGLAGEKGDQGETGK
                     KGPIGPEGEKGEVGPIGPPGPKGDRGEQGDPGLPGVCRCGSIVLKSAFSVGITTSYPE
                     ERLPIIFNKVLFNEGEHYNPATGKFICAFPGIYYFSYDITLANKHLAIGLVHNGQYRI
                     KTFDANTGNHDVASGSTVIYLQPEDEVWLEIFFTDQNGLFSDPGWADSLFSGFLLYVD
                     TDYLDSISEDDEL"
     exon            321..4320
                     /gene="C1QTNF7"
                     /gene_synonym="CTRP7; ZACRP7"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3779..3784
                     /regulatory_class="polyA_signal_sequence"
                     /gene="C1QTNF7"
                     /gene_synonym="CTRP7; ZACRP7"
                     /note="hexamer: AATAAA"
     polyA_site      3796
                     /gene="C1QTNF7"
                     /gene_synonym="CTRP7; ZACRP7"
                     /note="major polyA site"
     regulatory      4303..4308
                     /regulatory_class="polyA_signal_sequence"
                     /gene="C1QTNF7"
                     /gene_synonym="CTRP7; ZACRP7"
                     /note="hexamer: AATAAA"
     polyA_site      4320
                     /gene="C1QTNF7"
                     /gene_synonym="CTRP7; ZACRP7"
                     /note="major polyA site"
ORIGIN      
        1 actgagctct catgaaagat cctcagtctc ttgtggattt agaatcctgc agcagcccac
       61 catctaagag caagagccaa agatgtttgt cttgctctat gttacaagtt ttgccatttg
      121 tgccagtgga caaccccggg gtaatcagtt gaaaggagag aactactccc ccaggtatat
      181 ctgcagcatt cctggcttgc ctggacctcc agggccccct ggagcaaatg gttcccctgg
      241 gccccatggt cgcatcggcc ttccaggaag agatggtaga gacggcagga aaggagagaa
      301 aggtgaaaag ggaactgcag gtttgagagg taagactgga ccgctaggtc ttgccggtga
      361 gaaaggggac caaggagaga ctgggaagaa aggacccata ggaccagagg gagagaaagg
      421 agaagtaggt ccaattggtc ctcctggacc aaagggagac agaggagaac aaggggaccc
      481 ggggctgcct ggagtttgca gatgtggaag catcgtgctc aaatccgcct tttctgttgg
      541 catcacaacc agctacccag aagaaagact acctattata tttaacaagg tcctcttcaa
      601 cgagggagag cactacaacc ctgccacagg gaagttcatc tgtgctttcc cagggatcta
      661 ttacttttct tatgatatca cattggctaa taagcatctg gcaatcggac tggtacacaa
      721 tgggcaatac cggataaaga ccttcgacgc caacacagga aaccatgatg tggcttcggg
      781 gtccacagtc atctatctgc agccagaaga tgaagtctgg ctggagattt tcttcacaga
      841 ccagaatggc ctcttctcag acccaggttg ggcagacagc ttattctccg ggtttctctt
      901 atacgttgac acagattacc tagattccat atcagaagat gatgaattgt gatcaggacc
      961 aagatccctg tggtaaacac tctgattgaa tctggggttc cagaaggtgg aacaagcagg
     1021 aatgggatcc aaagagactc ccactcagat tctaaagcat ttaaagacaa ttctagcaga
     1081 atttatcaaa acaagatgaa acacagaaaa gttgaaacca caacaaaatg aattctatta
     1141 aagaatagcc ccagatataa attctcttga aagcaatgtt cataaatatt taagcaaatt
     1201 aaagacaatg ttaacaaatt ttctattaaa tgccctgagt gataaaacca gttggcaata
     1261 atattgcctt attaaatctt caaaaaatat attttagtct gttatttaag aaaaacataa
     1321 catcccaaaa tctttgacaa ttctcgaaag gctatatagt aagtcaaaaa ccaaaggtaa
     1381 gagatgctaa ctatttttca agcaagctac agagaaatga taaatgtttt ttgttttatt
     1441 atttattcct tcatgtttgt atatattcac tcaacaaccc tttaatgagc ctgtaaggac
     1501 cagacactgt ggcgctgaat cagatttaat aatgagttaa gacaaagccc ctacctatgg
     1561 gctagtgtgt ggtgatcaaa ctatcacaat tcagtgtgat gagcagcata gcaaacagat
     1621 ggatttgaag ctaaaagcac acagggtctg ctattcctga ggctgggggc cagagaagct
     1681 tttacgcatg gaaaaacact aatcatgcca aggtgtatgt gtttaagggg gtgtgatgga
     1741 tgcaaaggga atgaggaatt cagcactgca ttctctttgc accctcaatg catgattggt
     1801 attctcaaca gcaaaggggt gaaaaatcta gagacagagg aggcctggca ggggtgataa
     1861 aaatggagat tgaaatgaag agaaatagcc agcaggtgat tcttctgaat cctttagtgt
     1921 gatggtttcc caagacaaac atttgtccta atagctttct cataaatatg ggcaccactt
     1981 tacattgtgg taagacattg cttctcatgg atctgctagg tatttatttc aaataaagca
     2041 aggcatatgt tcactgattt acgagtaagc tgatgagagc aatgaacagg agaaggaggg
     2101 agagagccaa atgtctgagt aaacagatat cccttccaag tctcacacct cccttagtcc
     2161 cactcttgct tgtgtcagca ccttgttctt cactgaactg caattcttca attattctct
     2221 tccatgattt tgtctgatct accatttcta tggtttatgg taatagtatt ccctttatcc
     2281 ctcccttttg gtaacttcca atcctccttc tatgtattcc tttctctgct cattgactta
     2341 taaatagttt tcatacctct tatgtttgaa tcaccatgct agattctgtg aagacagaag
     2401 agtatcaaga ttaatatatt aatagtatag ctctgactgg taaatttctt ttttttaatc
     2461 ttccccaatt taaatttttt aatttaaaag taaattttac tgtcgaaaat gcaaacttgg
     2521 ggagggcgga aacatcacac acaaggtttc cacttcacac ttggagggtt gcatggcggc
     2581 tgggcaaagg tgctccccac ttcccagatg gtgcggcggc tggccagagg cactcttcac
     2641 ttcccagaca gaggggcggc cgggcagagg tgctcctcac ttcccagagg gtgcaggagc
     2701 cagctctgac tagtaaattt ctaaggatac cagaaaggaa atggcatgca cacacacaaa
     2761 aaatacctaa attttggatg agaaaatgat aaaatatgct aagttctagg ctggaaataa
     2821 gggcaaaatg ctgtgaaaga agaggaaatg tttacttcca aattaggatg tgacagagaa
     2881 gggataggga aatcctctct gctcattggg ccttacatga tgggtgacac ttggagtggc
     2941 acaagttggg ggaaagcgca cttgagacag aggtaatgat ggggacgaag tgagaacaga
     3001 gacccagaag gagaatcaat ggaccatatt tgtaagagct ttgaaagcca gcctgagaat
     3061 tggaggattt attcataaga aagtgtagag accctgtgta tttcagagct ggatactgcc
     3121 attaccacag atgaaagttg caatgatcta gcagttgtgt gcaaaggcaa ggcttgcttt
     3181 tcctgtcttt caaccctatc ttgcttttcc tgtctttcaa ccctatcttg ctttcattgt
     3241 cttcatcttc ctgccatact ttgtgcactt attgctctcc ttctgagtca ggacatgtgt
     3301 acaggagacc aagaacaatg agtattagaa aaaaaggaga cagcaaaggt ggtttgaggt
     3361 agtcacctgc ttacagataa cagccaaaga tagaattcca agttataaag cataaaaaag
     3421 agccaacaga agtaactaat ccgggaaaag tgaacatatg ggccctttaa agactacaag
     3481 atttgctaga taaactggaa atggagaagt tattgcagac agtcatgaac cacaaatcac
     3541 tgtgattaaa attttcttct gatcgtaatc cacgaatgca ttcatttttt ggacattgct
     3601 tacttatctt ttaaatgttt cttttattac aaagcctatt ttgagtagct tttaaaactg
     3661 aatttccttt aattggtttg aagcctagag atgaatttcg ttttcaaata tctggtggga
     3721 tggtaatggg gattagagaa ctgacatgag aaaagaggag ctgttttggt attaaacgaa
     3781 taaaatctta agcaaatata ggtgtctttt attcttaaaa aatagcagat acagtttatc
     3841 cacatttgta aatatttgta taaagaaagt agcaaaacag ttttggttta aaaagttcca
     3901 agtctcattg caatcattct ttgtaaaggc tgacttgtaa tgaatatgta ttaagcaata
     3961 tttattgact atacaccatc ttgttctaga agagtttaaa gccacttaag aagataaata
     4021 agatataaaa agaaaacagc agtcaaaagc agatgagaag aaatgggaaa aacaaaaaaa
     4081 aaagaaaata atgaggctaa tataatgctg tgtgtacatg aacatgaatg tgcctgtgtt
     4141 acacattttc aggccacaaa tgtttctttg tgcccctgca tgcacaaggg tatttccagg
     4201 tcatttatca ttgtgaacag tgttgcttat gataaaaaat agattctata aactctaaat
     4261 atactttttt tctaccactc tgtgtaaaag atcatgaacg taaataaatt ttagatatga
//
