LOCUS       NM_031910               2893 bp    mRNA    linear   PRI 28-AUG-2024
DEFINITION  Homo sapiens C1q and TNF related 6 (C1QTNF6), transcript variant 1,
            mRNA.
ACCESSION   NM_031910
VERSION     NM_031910.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2893)
  AUTHORS   Yan,S., Ding,J., Wang,Z., Zhang,Y., Xu,Y., Jia,Y., Yang,J. and
            Qiu,H.
  TITLE     CTRP6 alleviates endometrial fibrosis by regulating Smad3 pathway
            in intrauterine adhesiondagger
  JOURNAL   Biol Reprod 111 (2), 322-331 (2024)
   PUBMED   38984926
  REMARK    GeneRIF: CTRP6 alleviates endometrial fibrosis by regulating Smad3
            pathway in intrauterine adhesiondagger.
REFERENCE   2  (bases 1 to 2893)
  AUTHORS   Hamed,S.F., Hassan,N.A., Shouman,S.A., Tohamy,T.A., Fakhry,H. and
            Radwan,E.
  TITLE     Down regulation of C1q tumor necrosis factor-related protein 6 is
            associated with increased risk of breast cancer
  JOURNAL   Arch Biochem Biophys 757, 110039 (2024)
   PUBMED   38750921
  REMARK    GeneRIF: Down regulation of C1q tumor necrosis factor-related
            protein 6 is associated with increased risk of breast cancer.
REFERENCE   3  (bases 1 to 2893)
  AUTHORS   Cai,S., Zhang,B., Huang,C., Deng,Y., Wang,C., Yang,Y., Xiang,Z.,
            Ni,Y., Wang,Z., Wang,L., Zhang,B., Guo,X., He,J., Ma,K. and Yu,Z.
  TITLE     CTRP6 protects against ferroptosis to drive lung cancer progression
            and metastasis by destabilizing SOCS2 and augmenting the xCT/GPX4
            pathway
  JOURNAL   Cancer Lett 579, 216465 (2023)
   PUBMED   38084702
  REMARK    GeneRIF: CTRP6 protects against ferroptosis to drive lung cancer
            progression and metastasis by destabilizing SOCS2 and augmenting
            the xCT/GPX4 pathway.
REFERENCE   4  (bases 1 to 2893)
  AUTHORS   Huang,F. and Qi,H.
  TITLE     MiR-29c-3p/C1QTNF6 Restrains the Angiogenesis and Cell
            Proliferation, Migration and Invasion in Head and Neck Squamous
            Cell Carcinoma
  JOURNAL   Mol Biotechnol 65 (6), 913-921 (2023)
   PUBMED   36348139
  REMARK    GeneRIF: MiR-29c-3p/C1QTNF6 Restrains the Angiogenesis and Cell
            Proliferation, Migration and Invasion in Head and Neck Squamous
            Cell Carcinoma.
REFERENCE   5  (bases 1 to 2893)
  AUTHORS   Kim,D.K., Weller,B., Lin,C.W., Sheykhkarimli,D., Knapp,J.J.,
            Dugied,G., Zanzoni,A., Pons,C., Tofaute,M.J., Maseko,S.B.,
            Spirohn,K., Laval,F., Lambourne,L., Kishore,N., Rayhan,A.,
            Sauer,M., Young,V., Halder,H., la Rosa,N.M., Pogoutse,O.,
            Strobel,A., Schwehn,P., Li,R., Rothballer,S.T., Altmann,M.,
            Cassonnet,P., Cote,A.G., Vergara,L.E., Hazelwood,I., Liu,B.B.,
            Nguyen,M., Pandiarajan,R., Dohai,B., Coloma,P.A.R., Poirson,J.,
            Giuliana,P., Willems,L., Taipale,M., Jacob,Y., Hao,T., Hill,D.E.,
            Brun,C., Twizere,J.C., Krappmann,D., Heinig,M., Falter,C., Aloy,P.,
            Demeret,C., Vidal,M., Calderwood,M.A., Roth,F.P. and
            Falter-Braun,P.
  TITLE     A proteome-scale map of the SARS-CoV-2-human contactome
  JOURNAL   Nat Biotechnol 41 (1), 140-149 (2023)
   PUBMED   36217029
REFERENCE   6  (bases 1 to 2893)
  AUTHORS   Smyth,D.J., Plagnol,V., Walker,N.M., Cooper,J.D., Downes,K.,
            Yang,J.H., Howson,J.M., Stevens,H., McManus,R., Wijmenga,C.,
            Heap,G.A., Dubois,P.C., Clayton,D.G., Hunt,K.A., van Heel,D.A. and
            Todd,J.A.
  TITLE     Shared and distinct genetic variants in type 1 diabetes and celiac
            disease
  JOURNAL   N Engl J Med 359 (26), 2767-2777 (2008)
   PUBMED   19073967
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   7  (bases 1 to 2893)
  AUTHORS   Cooper,J.D., Smyth,D.J., Smiles,A.M., Plagnol,V., Walker,N.M.,
            Allen,J.E., Downes,K., Barrett,J.C., Healy,B.C., Mychaleckyj,J.C.,
            Warram,J.H. and Todd,J.A.
  TITLE     Meta-analysis of genome-wide association study data identifies
            additional type 1 diabetes risk loci
  JOURNAL   Nat Genet 40 (12), 1399-1401 (2008)
   PUBMED   18978792
REFERENCE   8  (bases 1 to 2893)
  AUTHORS   Zhang,Z. and Henzel,W.J.
  TITLE     Signal peptide prediction based on analysis of experimentally
            verified cleavage sites
  JOURNAL   Protein Sci 13 (10), 2819-2824 (2004)
   PUBMED   15340161
REFERENCE   9  (bases 1 to 2893)
  AUTHORS   Collins,J.E., Wright,C.L., Edwards,C.A., Davis,M.P., Grinham,J.A.,
            Cole,C.G., Goward,M.E., Aguado,B., Mallya,M., Mokrab,Y.,
            Huckle,E.J., Beare,D.M. and Dunham,I.
  TITLE     A genome annotation-driven approach to cloning the human ORFeome
  JOURNAL   Genome Biol 5 (10), R84 (2004)
   PUBMED   15461802
REFERENCE   10 (bases 1 to 2893)
  AUTHORS   Clark,H.F., Gurney,A.L., Abaya,E., Baker,K., Baldwin,D., Brush,J.,
            Chen,J., Chow,B., Chui,C., Crowley,C., Currell,B., Deuel,B.,
            Dowd,P., Eaton,D., Foster,J., Grimaldi,C., Gu,Q., Hass,P.E.,
            Heldens,S., Huang,A., Kim,H.S., Klimowski,L., Jin,Y., Johnson,S.,
            Lee,J., Lewis,L., Liao,D., Mark,M., Robbie,E., Sanchez,C.,
            Schoenfeld,J., Seshagiri,S., Simmons,L., Singh,J., Smith,V.,
            Stinson,J., Vagts,A., Vandlen,R., Watanabe,C., Wieand,D., Woods,K.,
            Xie,M.H., Yansura,D., Yi,S., Yu,G., Yuan,J., Zhang,M., Zhang,Z.,
            Goddard,A., Wood,W.I., Godowski,P. and Gray,A.
  TITLE     The secreted protein discovery initiative (SPDI), a large-scale
            effort to identify novel human secreted and transmembrane proteins:
            a bioinformatics assessment
  JOURNAL   Genome Res 13 (10), 2265-2270 (2003)
   PUBMED   12975309
  REMARK    Erratum:[Genome Res. 2003 Dec;13(12):2759]
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BU147265.1, CB961508.1, BC020551.1, BU535692.1, BM722009.1,
            BQ674594.1, BU859813.1, BU542015.1 and BM678522.1.
            
            On Nov 22, 2018 this sequence version replaced NM_031910.3.
            
            Transcript Variant: This variant (1) represents the longer
            transcript.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK314060.1, BC020551.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000337843.7/ ENSP00000338812.2
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-95                BU147265.1         46-140
            96-642              CB961508.1         123-669
            643-884             BC020551.1         685-926
            885-1082            BU535692.1         514-711
            1083-1607           BM722009.1         7-531
            1608-1948           BQ674594.1         169-509
            1949-2409           BU859813.1         319-779
            2410-2703           BU542015.1         416-709
            2704-2740           BM678522.1         173-209             c
            2741-2893           BM678522.1         19-171              c
FEATURES             Location/Qualifiers
     source          1..2893
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="22"
                     /map="22q12.3"
     gene            1..2893
                     /gene="C1QTNF6"
                     /gene_synonym="CTFP6; CTRP6; ZACRP6"
                     /note="C1q and TNF related 6"
                     /db_xref="GeneID:114904"
                     /db_xref="HGNC:HGNC:14343"
                     /db_xref="MIM:614910"
     exon            1..85
                     /gene="C1QTNF6"
                     /gene_synonym="CTFP6; CTRP6; ZACRP6"
                     /inference="alignment:Splign:2.1.0"
     CDS             35..871
                     /gene="C1QTNF6"
                     /gene_synonym="CTFP6; CTRP6; ZACRP6"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; complement-c1q tumor necrosis factor-related
                     protein 6; complement C1q tumor necrosis factor-related
                     protein 6; C1q and tumor necrosis factor related protein
                     6"
                     /codon_start=1
                     /product="complement C1q tumor necrosis factor-related
                     protein 6 isoform 1 precursor"
                     /protein_id="NP_114116.3"
                     /db_xref="CCDS:CCDS13943.1"
                     /db_xref="GeneID:114904"
                     /db_xref="HGNC:HGNC:14343"
                     /db_xref="MIM:614910"
                     /translation="MQWLRVRESPGEATGHRVTMGTAALGPVWAALLLFLLMCEIPMV
                     ELTFDRAVASGCQRCCDSEDPLDPAHVSSASSSGRPHALPEIRPYINITILKGDKGDP
                     GPMGLPGYMGREGPQGEPGPQGSKGDKGEMGSPGAPCQKRFFAFSVGRKTALHSGEDF
                     QTLLFERVFVNLDGCFDMATGQFAAPLRGIYFFSLNVHSWNYKETYVHIMHNQKEAVI
                     LYAQPSERSIMQSQSVMLDLAYGDRVWVRLFKRQRENAIYSNDFDTYITFSGHLIKAE
                     DD"
     exon            86..323
                     /gene="C1QTNF6"
                     /gene_synonym="CTFP6; CTRP6; ZACRP6"
                     /inference="alignment:Splign:2.1.0"
     exon            324..2893
                     /gene="C1QTNF6"
                     /gene_synonym="CTFP6; CTRP6; ZACRP6"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1777..1782
                     /regulatory_class="polyA_signal_sequence"
                     /gene="C1QTNF6"
                     /gene_synonym="CTFP6; CTRP6; ZACRP6"
                     /note="hexamer: ATTAAA"
     polyA_site      1795
                     /gene="C1QTNF6"
                     /gene_synonym="CTFP6; CTRP6; ZACRP6"
                     /note="major polyA site"
     regulatory      2868..2873
                     /regulatory_class="polyA_signal_sequence"
                     /gene="C1QTNF6"
                     /gene_synonym="CTFP6; CTRP6; ZACRP6"
                     /note="hexamer: ATTAAA"
     polyA_site      2893
                     /gene="C1QTNF6"
                     /gene_synonym="CTFP6; CTRP6; ZACRP6"
ORIGIN      
        1 agtattgcag acatgggcca aggagccaga ggccatgcag tggctcaggg tccgtgagtc
       61 gcctggggag gccacaggac acagggtcac catggggaca gccgccctgg gtcccgtctg
      121 ggcagcgctc ctgctctttc tcctgatgtg tgagatccct atggtggagc tcacctttga
      181 cagagctgtg gccagcggct gccaacggtg ctgtgactct gaggaccccc tggatcctgc
      241 ccatgtatcc tcagcctctt cctccggccg cccccacgcc ctgcctgaga tcagacccta
      301 cattaatatc accatcctga agggtgacaa aggggaccca ggcccaatgg gcctgccagg
      361 gtacatgggc agggagggtc cccaagggga gcctggccct cagggcagca agggtgacaa
      421 gggggagatg ggcagccccg gcgccccgtg ccagaagcgc ttcttcgcct tctcagtggg
      481 ccgcaagacg gccctgcaca gcggcgagga cttccagacg ctgctcttcg aaagggtctt
      541 tgtgaacctt gatgggtgct ttgacatggc gaccggccag tttgctgctc ccctgcgtgg
      601 catctacttc ttcagcctca atgtgcacag ctggaattac aaggagacgt acgtgcacat
      661 tatgcataac cagaaagagg ctgtcatcct gtacgcgcag cccagcgagc gcagcatcat
      721 gcagagccag agtgtgatgc tggacctggc ctacggggac cgcgtctggg tgcggctctt
      781 caagcgccag cgcgagaacg ccatctacag caacgacttc gacacctaca tcaccttcag
      841 cggccacctc atcaaggccg aggacgactg agggcctctg ggccaccctc ccggctggag
      901 agctcaggtg ctggtcccgt cccctgcagg gctcagtttg cactgctgtg aagcaggaag
      961 gccagggagg tccccgggga cctggcattc tggggagacc ctgcttctat cttggctgcc
     1021 atcatccctc ccagcctatt tctgctcctc tcttctctct tggacctatt ttaagaagct
     1081 tgctaaccta aatattctag aactttccca gcctcgtagc ccagcacttc tcaaacttgg
     1141 aaatgcatgc gaatcacccg gggttcgtgt taaatgcaga ttctgactca gcaggtctga
     1201 gtgggtccag gattctgtgt ttctcatatg ttcctgggtg atgctgatgg ggtcagtcta
     1261 tgaaccacac tggagcaacc aggttctagg actttctcaa tattctagta ctttctgaac
     1321 attctggaat cctccccaca ttctagaatt ctcccaacat ttttttttct tgagacagag
     1381 tcttgctctg ttgcccaggc tagagtgcag tggtgcaatc tcagttcact gcaacctctg
     1441 cctcccgggt tcaagcgatt cttctgcctc agcctcccta gtggctggga ttacaggcgc
     1501 ctgctaccat gcctggctaa tttttgtatt tttagtagag atggggtttc accatattgg
     1561 ccaggctggt cttgaactcc tgacttcagg tgacccaccc gcctcggcct ctcaaaatgc
     1621 tgggattaca ggtgtgagcc accgtgcctg gccaattcca acattcttaa attctctcat
     1681 ccctccaggg ctccccgtgc tatgttctct ttaccccttc cccctcttct cttgctcagg
     1741 cctgcaccac tgcagccacc gttcatttat tcattcatta aacactgagc actcactctg
     1801 tgctgggtcc cgggaagggt gagggggtca gacacaggcc ctgcccctgc cctcagtgac
     1861 tggccagtcc agcccaggcg gggagagatg tgtacatagg ttttaaagca gacccagagc
     1921 tcatgggggc ctgtgttctg ggtgttcagg tgctgctggt cctccattac ccactgctcc
     1981 ccaaggctgg tgggacgggg tcccggtggc aggggcaggt atctccttcc cgttcctcat
     2041 ccacctgccc agtgctcatc gttacagcaa accccagggg gccttggcca ggtcaagggt
     2101 tctgtgagga gaggacccag gagtgtgggg gcatttgggg ggtgaagtgg cccccgaaga
     2161 atggaaccca cacccatagc tctccccaca gctgatacgg catcctgcga gaagacctgc
     2221 cctcctcact gggatcccct tcctgcctcc tcccagggct ctgccagggc cttgctcagt
     2281 cccttccacc aaagtcatct gaacttccgt ttccccaggg cctccagctg ccctcagaca
     2341 ctgatgtctg tccccaggtg ctctctgccc ctcatgcccc tctcaccggc ccagtgcccc
     2401 gactctccag gctttatcaa ggtgctaagg cccgggtggg cagctcctcg tctcagagcc
     2461 ctcctccggc ctggtgctgc ctttacaaac acctgcagga gaagggccac ggaagcccca
     2521 ggctttagag ccctcagcag gtctggggag ctagagcaaa ggagggacct caggccttcc
     2581 gtttcttctt ccagggtggg gtggcctggt gttcccctag ccttccaaac ccaggtggcc
     2641 tgcccttctc cccagaggga ggcggcctcc gcccattggt gctcatgcag actctggggc
     2701 tgaggtgccc cggggggtga tctctggtgc tcacagccga ggagccgtgg ctccatggcc
     2761 agatgacgga aacagggtct gaccaagtgc caggaagacc tgtgctataa accaccctgc
     2821 ctgatcctgc ccctgcctga ccccgccacg ccctgccgtc cagcatgatt aaagaatgct
     2881 gtctcctctt ggc
//
