LOCUS       NM_031909               1413 bp    mRNA    linear   PRI 27-MAY-2024
DEFINITION  Homo sapiens C1q and TNF related 4 (C1QTNF4), mRNA.
ACCESSION   NM_031909
VERSION     NM_031909.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1413)
  AUTHORS   Gao,J., Rouzi,M.R.Y., Zhang,H., Cai,X., Xu,B., Lu,J. and Lei,T.
  TITLE     Association of serum CTRP4 levels with vascular endothelial
            function in patients with type 2 diabetes mellitus: CTRP4
            ameliorating inflammation, proliferation and migration in human
            umbilical vein endothelial cells
  JOURNAL   Acta Diabetol 61 (5), 565-575 (2024)
   PUBMED   38286878
  REMARK    GeneRIF: Association of serum CTRP4 levels with vascular
            endothelial function in patients with type 2 diabetes mellitus:
            CTRP4 ameliorating inflammation, proliferation and migration in
            human umbilical vein endothelial cells.
REFERENCE   2  (bases 1 to 1413)
  AUTHORS   Sun,J.L., Ryu,J.H., Cho,W., Oh,H., Abd El-Aty,A.M., Ozkal
            Eminoglu,D., Jeong,J.H. and Jung,T.W.
  TITLE     CTRP4 ameliorates inflammation, thereby attenuating the interaction
            between HUVECs and THP-1 monocytes through SIRT6/Nrf2 signaling
  JOURNAL   Biochem Biophys Res Commun 691, 149293 (2024)
   PUBMED   38016337
  REMARK    GeneRIF: CTRP4 ameliorates inflammation, thereby attenuating the
            interaction between HUVECs and THP-1 monocytes through SIRT6/Nrf2
            signaling.
REFERENCE   3  (bases 1 to 1413)
  AUTHORS   Han,J., Fan,H., Dai,Y. and Cheng,X.
  TITLE     Serum C1q/TNF-Related Protein 4 Levels are Associated with
            Nonalcoholic Fatty Liver Disease in Type 2 Diabetic Patients
  JOURNAL   Metab Syndr Relat Disord 21 (3), 163-168 (2023)
   PUBMED   36787473
  REMARK    GeneRIF: Serum C1q/TNF-Related Protein 4 Levels are Associated with
            Nonalcoholic Fatty Liver Disease in Type 2 Diabetic Patients.
REFERENCE   4  (bases 1 to 1413)
  AUTHORS   Gao,J., Lu,J., Qiu,J., Sun,D., Xu,B., Wang,Z. and Lei,T.
  TITLE     C1q tumor necrosis factor-related protein 4 is associated with
            coronary artery disease in patients with type 2 diabetes
  JOURNAL   J Diabetes Investig 13 (10), 1723-1731 (2022)
   PUBMED   35598316
  REMARK    GeneRIF: C1q tumor necrosis factor-related protein 4 is associated
            with coronary artery disease in patients with type 2 diabetes.
REFERENCE   5  (bases 1 to 1413)
  AUTHORS   Dai,Y., Zhou,J., Niu,L., Hu,J. and Han,J.
  TITLE     Increased serum C1q/TNF-related protein 4 concentration in patients
            with acute coronary syndrome
  JOURNAL   Clin Chim Acta 524, 187-191 (2022)
   PUBMED   34801485
  REMARK    GeneRIF: Increased serum C1q/TNF-related protein 4 concentration in
            patients with acute coronary syndrome.
REFERENCE   6  (bases 1 to 1413)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   7  (bases 1 to 1413)
  AUTHORS   Biswas,P., Naeem,M.A., Ali,M.H., Assir,M.Z., Khan,S.N.,
            Riazuddin,S., Hejtmancik,J.F., Riazuddin,S.A. and Ayyagari,R.
  TITLE     Whole-Exome Sequencing Identifies Novel Variants that Co-segregates
            with Autosomal Recessive Retinal Degeneration in a Pakistani
            Pedigree
  JOURNAL   Adv Exp Med Biol 1074, 219-228 (2018)
   PUBMED   29721947
  REMARK    GeneRIF: In a Pakistani family with retinal degeneration,
            whole-exome sequencing identified 2 homozygous missense variants:
            c.1304G>A; p.Arg435Gln in ZNF408 (NM_024741) and c.902G>A;
            p.Gly301Asp in C1QTNF4 (NM_031909). Both segregated with the
            retinal phenotype in this family and were absent in ethnically
            matched control chromosomes.
REFERENCE   8  (bases 1 to 1413)
  AUTHORS   Byerly,M.S., Petersen,P.S., Ramamurthy,S., Seldin,M.M., Lei,X.,
            Provost,E., Wei,Z., Ronnett,G.V. and Wong,G.W.
  TITLE     C1q/TNF-related protein 4 (CTRP4) is a unique secreted protein with
            two tandem C1q domains that functions in the hypothalamus to
            modulate food intake and body weight
  JOURNAL   J Biol Chem 289 (7), 4055-4069 (2014)
   PUBMED   24366864
  REMARK    GeneRIF: These results establish CTRP4 as a novel
            nutrient-responsive central regulator of food intake and energy
            balance.
REFERENCE   9  (bases 1 to 1413)
  AUTHORS   Li,Q., Wang,L., Tan,W., Peng,Z., Luo,Y., Zhang,Y., Zhang,G., Na,D.,
            Jin,P., Shi,T., Ma,D. and Wang,L.
  TITLE     Identification of C1qTNF-related protein 4 as a potential cytokine
            that stimulates the STAT3 and NF-kappaB pathways and promotes cell
            survival in human cancer cells
  JOURNAL   Cancer Lett 308 (2), 203-214 (2011)
   PUBMED   21658842
  REMARK    GeneRIF: CTRP4 is a novel tumor-promoting inflammatory regulator.
REFERENCE   10 (bases 1 to 1413)
  AUTHORS   Tao,W.A., Wollscheid,B., O'Brien,R., Eng,J.K., Li,X.J.,
            Bodenmiller,B., Watts,J.D., Hood,L. and Aebersold,R.
  TITLE     Quantitative phosphoproteome analysis using a dendrimer conjugation
            chemistry and tandem mass spectrometry
  JOURNAL   Nat Methods 2 (8), 591-598 (2005)
   PUBMED   16094384
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC104942.5.
            
            On Nov 23, 2018 this sequence version replaced NM_031909.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: ERR279833.2223.1, ERR279863.649.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968540, SAMEA2142680
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000302514.4/ ENSP00000302274.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-264               AC104942.5         137530-137793
            265-1413            AC104942.5         141126-142274
FEATURES             Location/Qualifiers
     source          1..1413
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11p11.2"
     gene            1..1413
                     /gene="C1QTNF4"
                     /gene_synonym="CTRP4; ZACRP4"
                     /note="C1q and TNF related 4"
                     /db_xref="GeneID:114900"
                     /db_xref="HGNC:HGNC:14346"
                     /db_xref="MIM:614911"
     exon            1..264
                     /gene="C1QTNF4"
                     /gene_synonym="CTRP4; ZACRP4"
                     /inference="alignment:Splign:2.1.0"
     exon            265..1413
                     /gene="C1QTNF4"
                     /gene_synonym="CTRP4; ZACRP4"
                     /inference="alignment:Splign:2.1.0"
     CDS             270..1259
                     /gene="C1QTNF4"
                     /gene_synonym="CTRP4; ZACRP4"
                     /note="complement-c1q tumor necrosis factor-related
                     protein 4; complement C1q tumor necrosis factor-related
                     protein 4; C1q and tumor necrosis factor related protein
                     4; C1q/TNF-related protein 4"
                     /codon_start=1
                     /product="complement C1q tumor necrosis factor-related
                     protein 4 precursor"
                     /protein_id="NP_114115.2"
                     /db_xref="CCDS:CCDS7942.1"
                     /db_xref="GeneID:114900"
                     /db_xref="HGNC:HGNC:14346"
                     /db_xref="MIM:614911"
                     /translation="MLPLLLGLLGPAACWALGPTPGPGSSELRSAFSAARTTPLEGTS
                     EMAVTFDKVYVNIGGDFDVATGQFRCRVPGAYFFSFTAGKAPHKSLSVMLVRNRDEVQ
                     ALAFDEQRRPGARRAASQSAMLQLDYGDTVWLRLHGAPQYALGAPGATFSGYLVYADA
                     DADAPARGPPAPPEPRSAFSAARTRSLVGSDAGPGPRHQPLAFDTEFVNIGGDFDAAA
                     GVFRCRLPGAYFFSFTLGKLPRKTLSVKLMKNRDEVQAMIYDDGASRRREMQSQSVML
                     ALRRGDAVWLLSHDHDGYGAYSNHGKYITFSGFLVYPDLAPAAPPGLGASELL"
     regulatory      1373..1378
                     /regulatory_class="polyA_signal_sequence"
                     /gene="C1QTNF4"
                     /gene_synonym="CTRP4; ZACRP4"
                     /note="hexamer: AATAAA"
     polyA_site      1413
                     /gene="C1QTNF4"
                     /gene_synonym="CTRP4; ZACRP4"
                     /note="major polyA site"
ORIGIN      
        1 ctcttcgctc tcgctcggct ccctctctag ctgaccttcc ctttccctca cgcctcccca
       61 cgcccggccc ctggccccag caccctgtcc gctgccgcct cagagccggg aaaagcagcc
      121 ggagcccccg ccgcccctgc cgcagcgcgg gcggtcagcg cgcagcccgg cacccgcagc
      181 ctgcagcctg cagcccgcag cccgcagccc ggagccagat cgcgggctca gaccgaaccc
      241 gactcgaccg ccgcccccag ccaggcgcca tgctgccgct tctgctgggc ctgctgggcc
      301 cagcggcctg ctgggccctg ggcccgaccc ccggcccggg atcctctgag ctgcgctcgg
      361 ccttctcggc ggcacgcacc acccccctgg agggcacgtc ggagatggcg gtgaccttcg
      421 acaaggtgta cgtgaacatc gggggcgact tcgatgtggc caccggccag tttcgctgcc
      481 gcgtgcccgg cgcctacttc ttctccttca cggctggcaa ggccccgcac aagagcctgt
      541 cggtgatgct ggtgcgaaac cgcgacgagg tgcaggcgct ggccttcgac gagcagcggc
      601 ggccaggcgc gcggcgcgca gccagccaga gcgccatgct gcagctcgac tacggcgaca
      661 cagtgtggct gcggctgcat ggcgccccgc agtacgcgct aggcgcgccc ggcgccacct
      721 tcagcggcta cctagtctac gccgacgccg acgctgacgc gcctgcgcgc gggccgcccg
      781 cgccccccga gccgcgctcg gccttctcgg cggcgcgcac gcgcagcttg gtgggctcgg
      841 acgctggccc cgggccgcgg caccaaccac tcgccttcga caccgagttc gtcaacattg
      901 gcggcgactt cgacgcggcg gccggcgtgt tccgctgccg tctgcccggc gcctacttct
      961 tctccttcac gctgggcaag ctgccgcgta agacgctgtc ggttaagctg atgaagaacc
     1021 gcgacgaggt gcaggccatg atttacgacg acggcgcgtc gcggcgccgc gagatgcaga
     1081 gccagagcgt gatgctggcc ctgcggcgcg gcgacgccgt ctggctgctc agccacgacc
     1141 acgacggcta cggcgcctac agcaaccacg gcaagtacat caccttctcc ggcttcctgg
     1201 tgtaccccga cctcgccccc gccgccccgc cgggcctcgg ggcctcggag ctactgtgag
     1261 ccccgggcca gagaagagcc cgggagggcc aggggcgtgc atgccaggcc gggccggagg
     1321 ctcgaaagtc ccgcgcgagc gccacggcct ccgggcgcgc ctggactctg ccaataaagc
     1381 ggaaagcggg cacgcgcagc gcccggcagc cca
//
