LOCUS       NM_181435               3773 bp    mRNA    linear   PRI 09-JUL-2024
DEFINITION  Homo sapiens C1q and TNF related 3 (C1QTNF3), transcript variant 2,
            mRNA.
ACCESSION   NM_181435
VERSION     NM_181435.6
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3773)
  AUTHORS   Chen,Y., Wang,S., Li,J., Fu,Y., Chen,P., Liu,X., Zhang,J., Sun,L.,
            Zhang,R., Li,X. and Liu,L.
  TITLE     The relationships between biological novel biomarkers Lp-PLA2 and
            CTRP-3 and CVD in patients with type 2 diabetes mellitus
  JOURNAL   J Diabetes 16 (7), e13574 (2024)
   PUBMED   38924255
  REMARK    GeneRIF: The relationships between biological novel biomarkers
            Lp-PLA2 and CTRP-3 and CVD in patients with type 2 diabetes
            mellitus.
REFERENCE   2  (bases 1 to 3773)
  AUTHORS   Schmid,A., Pankuweit,S., Vlacil,A.K., Koch,S., Berge,B.,
            Gajawada,P., Richter,M., Troidl,K., Schieffer,B., Schaffler,A. and
            Grote,K.
  TITLE     Decreased circulating CTRP3 levels in acute and chronic
            cardiovascular patients
  JOURNAL   J Mol Med (Berl) 102 (5), 667-677 (2024)
   PUBMED   38436713
  REMARK    GeneRIF: Decreased circulating CTRP3 levels in acute and chronic
            cardiovascular patients.
REFERENCE   3  (bases 1 to 3773)
  AUTHORS   Shao,Q. and Sun,L.
  TITLE     Clinical Significance of Serum CTRP3 Level in the Prediction of
            Cardiac and Intestinal Mucosal Barrier Dysfunction in Patients with
            Severe Acute Pancreatitis
  JOURNAL   Crit Rev Immunol 44 (5), 99-111 (2024)
   PUBMED   38618732
  REMARK    GeneRIF: Clinical Significance of Serum CTRP3 Level in the
            Prediction of Cardiac and Intestinal Mucosal Barrier Dysfunction in
            Patients with Severe Acute Pancreatitis.
REFERENCE   4  (bases 1 to 3773)
  AUTHORS   Zou,C., Tang,X., Guo,T., Jiang,T., Zhang,W. and Zhang,J.
  TITLE     CTRP3 attenuates inflammation, oxidative and cell death in
            cisplatin induced HK-2 cells
  JOURNAL   PeerJ 11, e15890 (2023)
   PUBMED   37637169
  REMARK    GeneRIF: CTRP3 attenuates inflammation, oxidative and cell death in
            cisplatin induced HK-2 cells.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3773)
  AUTHORS   Zeng,Y., Xu,Y., Pan,Y. and Guo,H.
  TITLE     KLF10 knockdown negatively regulates CTRP3 to improve OGD/R-induced
            brain microvascular endothelial cell injury and barrier dysfunction
            through Nrf2/HO-1 signaling pathway
  JOURNAL   Tissue Cell 82, 102106 (2023)
   PUBMED   37210762
  REMARK    GeneRIF: KLF10 knockdown negatively regulates CTRP3 to improve
            OGD/R-induced brain microvascular endothelial cell injury and
            barrier dysfunction through Nrf2/HO-1 signaling pathway.
REFERENCE   6  (bases 1 to 3773)
  AUTHORS   Akiyama,H., Furukawa,S., Wakisaka,S. and Maeda,T.
  TITLE     CTRP3/cartducin promotes proliferation and migration of endothelial
            cells
  JOURNAL   Mol Cell Biochem 304 (1-2), 243-248 (2007)
   PUBMED   17534697
  REMARK    GeneRIF: CTRP3/cartducin may be involved as a novel angiogenic
            factor in the formation of neointima following angioplasty.
REFERENCE   7  (bases 1 to 3773)
  AUTHORS   Wurm,S., Neumeier,M., Weigert,J., Schaffler,A. and Buechler,C.
  TITLE     Plasma levels of leptin, omentin, collagenous repeat-containing
            sequence of 26-kDa protein (CORS-26) and adiponectin before and
            after oral glucose uptake in slim adults
  JOURNAL   Cardiovasc Diabetol 6, 7 (2007)
   PUBMED   17311679
  REMARK    GeneRIF: Blood level is determined by a glucose tolerance test in
            normal adults
            Publication Status: Online-Only
REFERENCE   8  (bases 1 to 3773)
  AUTHORS   Weigert,J., Neumeier,M., Schaffler,A., Fleck,M., Scholmerich,J.,
            Schutz,C. and Buechler,C.
  TITLE     The adiponectin paralog CORS-26 has anti-inflammatory properties
            and is produced by human monocytic cells
  JOURNAL   FEBS Lett 579 (25), 5565-5570 (2005)
   PUBMED   16213490
REFERENCE   9  (bases 1 to 3773)
  AUTHORS   Schaffler,A., Ehling,A., Neumann,E., Herfarth,H., Paul,G.,
            Tarner,I., Gay,S., Scholmerich,J. and Muller-Ladner,U.
  TITLE     Genomic organization, promoter, amino acid sequence, chromosomal
            localization, and expression of the human gene for CORS-26
            (collagenous repeat-containing sequence of 26-kDa protein)
  JOURNAL   Biochim Biophys Acta 1630 (2-3), 123-129 (2003)
   PUBMED   14654242
REFERENCE   10 (bases 1 to 3773)
  AUTHORS   Maeda,T., Abe,M., Kurisu,K., Jikko,A. and Furukawa,S.
  TITLE     Molecular cloning and characterization of a novel gene, CORS26,
            encoding a putative secretory protein and its possible involvement
            in skeletal development
  JOURNAL   J Biol Chem 276 (5), 3628-3634 (2001)
   PUBMED   11071891
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK295968.1, AC139783.3 and BX640995.1.
            
            On Jun 2, 2019 this sequence version replaced NM_181435.5.
            
            Transcript Variant: This variant (2) uses an alternate in-frame
            splice site that results in an additional segment in the 5' coding
            region, compared to variant 1. The encoded isoform (b) is longer
            than isoform a.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660809.244148.1,
                                           SRR1803615.5872.1 [ECO:0000332]
            RNAseq introns              :: mixed/partial sample support
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000350]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000382065.8/ ENSP00000371497.3
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1322              AK295968.1         54-1375
            1323-3712           AC139783.3         127768-130157       c
            3713-3773           BX640995.1         3366-3426
FEATURES             Location/Qualifiers
     source          1..3773
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="5"
                     /map="5p13.2"
     gene            1..3773
                     /gene="C1QTNF3"
                     /gene_synonym="C1ATNF3; CORCS; CORS; CORS-26; CORS26;
                     CTRP3"
                     /note="C1q and TNF related 3"
                     /db_xref="GeneID:114899"
                     /db_xref="HGNC:HGNC:14326"
                     /db_xref="MIM:612045"
     exon            1..391
                     /gene="C1QTNF3"
                     /gene_synonym="C1ATNF3; CORCS; CORS; CORS-26; CORS26;
                     CTRP3"
                     /inference="alignment:Splign:2.1.0"
     CDS             89..1048
                     /gene="C1QTNF3"
                     /gene_synonym="C1ATNF3; CORCS; CORS; CORS-26; CORS26;
                     CTRP3"
                     /EC_number="5.1.99.4"
                     /note="isoform b precursor is encoded by transcript
                     variant 2; cartonectin; complement C1q tumor necrosis
                     factor-related protein 3; collagenous repeat-containing
                     sequence of 26-kDa; secretory protein CORS26; collagenous
                     repeat-containing sequence 26 kDa protein; C1q and tumor
                     necrosis factor related protein 3"
                     /codon_start=1
                     /product="complement C1q tumor necrosis factor-related
                     protein 3 isoform b precursor"
                     /protein_id="NP_852100.3"
                     /db_xref="CCDS:CCDS34141.1"
                     /db_xref="GeneID:114899"
                     /db_xref="HGNC:HGNC:14326"
                     /db_xref="MIM:612045"
                     /translation="MLWRQLIYWQLLALFFLPFCLCQDEYMEVSGRTNKVVARIVQSH
                     QQTGRSGSRREKVRERSHPKTGTVDNNTSTDLKSLRPDELPHPEVDDLAQITTFWGQS
                     PQTGGLPPDCSKCCHGDYSFRGYQGPPGPPGPPGIPGNHGNNGNNGATGHEGAKGEKG
                     DKGDLGPRGERGQHGPKGEKGYPGIPPELQIAFMASLATHFSNQNSGIIFSSVETNIG
                     NFFDVMTGRFGAPVSGVYFFTFSMMKHEDVEEVYVYLMHNGNTVFSMYSYEMKGKSDT
                     SSNHAVLKLAKGDEVWLRMGNGALHGDHQRFSTFAGFLLFETK"
     exon            392..503
                     /gene="C1QTNF3"
                     /gene_synonym="C1ATNF3; CORCS; CORS; CORS-26; CORS26;
                     CTRP3"
                     /inference="alignment:Splign:2.1.0"
     exon            504..658
                     /gene="C1QTNF3"
                     /gene_synonym="C1ATNF3; CORCS; CORS; CORS-26; CORS26;
                     CTRP3"
                     /inference="alignment:Splign:2.1.0"
     exon            659..788
                     /gene="C1QTNF3"
                     /gene_synonym="C1ATNF3; CORCS; CORS; CORS-26; CORS26;
                     CTRP3"
                     /inference="alignment:Splign:2.1.0"
     exon            789..888
                     /gene="C1QTNF3"
                     /gene_synonym="C1ATNF3; CORCS; CORS; CORS-26; CORS26;
                     CTRP3"
                     /inference="alignment:Splign:2.1.0"
     exon            889..3773
                     /gene="C1QTNF3"
                     /gene_synonym="C1ATNF3; CORCS; CORS; CORS-26; CORS26;
                     CTRP3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1911..1916
                     /regulatory_class="polyA_signal_sequence"
                     /gene="C1QTNF3"
                     /gene_synonym="C1ATNF3; CORCS; CORS; CORS-26; CORS26;
                     CTRP3"
                     /note="hexamer: AATAAA"
     polyA_site      1935
                     /gene="C1QTNF3"
                     /gene_synonym="C1ATNF3; CORCS; CORS; CORS-26; CORS26;
                     CTRP3"
                     /note="major polyA site"
     regulatory      2157..2162
                     /regulatory_class="polyA_signal_sequence"
                     /gene="C1QTNF3"
                     /gene_synonym="C1ATNF3; CORCS; CORS; CORS-26; CORS26;
                     CTRP3"
                     /note="hexamer: AATAAA"
     polyA_site      2178
                     /gene="C1QTNF3"
                     /gene_synonym="C1ATNF3; CORCS; CORS; CORS-26; CORS26;
                     CTRP3"
     regulatory      3752..3757
                     /regulatory_class="polyA_signal_sequence"
                     /gene="C1QTNF3"
                     /gene_synonym="C1ATNF3; CORCS; CORS; CORS-26; CORS26;
                     CTRP3"
                     /note="hexamer: AATAAA"
     polyA_site      3773
                     /gene="C1QTNF3"
                     /gene_synonym="C1ATNF3; CORCS; CORS; CORS-26; CORS26;
                     CTRP3"
ORIGIN      
        1 agctccagtc ctggcatctg cccgaggaga ccacgctcct ggagctctgc tgtcttctca
       61 gggagactct gaggctctgt tgagaatcat gctttggagg cagctcatct attggcaact
      121 gctggctttg tttttcctcc ctttttgcct gtgtcaagat gaatacatgg aggtgagcgg
      181 aagaactaat aaagtggtgg caagaatagt gcaaagccac cagcagactg gccgtagcgg
      241 ctccaggagg gagaaagtga gagagcggag ccatcctaaa actgggactg tggataataa
      301 cacttctaca gacctaaaat ccctgagacc agatgagcta ccgcaccccg aggtagatga
      361 cctagcccag atcaccacat tctggggcca gtctccacaa accggaggac tacccccaga
      421 ctgcagtaag tgttgtcatg gagactacag ctttcgaggc taccaaggcc cccctgggcc
      481 accgggccct cctggcattc caggaaacca tggaaacaat ggcaacaatg gagccactgg
      541 tcatgaagga gccaaaggtg agaagggcga caaaggtgac ctggggcctc gaggggagcg
      601 ggggcagcat ggccccaaag gagagaaggg ctacccgggg attccaccag aacttcagat
      661 tgcattcatg gcttctctgg caacccactt cagcaatcag aacagtggga ttatcttcag
      721 cagtgttgag accaacattg gaaacttctt tgatgtcatg actggtagat ttggggcccc
      781 agtatcaggt gtgtatttct tcaccttcag catgatgaag catgaggatg ttgaggaagt
      841 gtatgtgtac cttatgcaca atggcaacac agtcttcagc atgtacagct atgaaatgaa
      901 gggcaaatca gatacatcca gcaatcatgc tgtgctgaag ctagccaaag gggatgaggt
      961 ttggctgcga atgggcaatg gcgctctcca tggggaccac caacgcttct ccacctttgc
     1021 aggattcctg ctctttgaaa ctaagtaaat atatgactag aatagctcca ctttggggaa
     1081 gacttgtagc tgagctgatt tgttacgatc tgaggaacat taaagttgag ggttttacat
     1141 tgctgtattc aaaaaattat tggttgcaat gttgttcacg ctacaggtac accaataatg
     1201 ttggacaatt caggggctca gaagaatcaa ccacaaaata gtcttctcag atgaccttga
     1261 ctaatatact cagcatcttt atcactcttt ccttggcacc taaaagataa ttctcctctg
     1321 acgcaggttg gaaatatttt tttctatcac agaagtcatt tgcaaagaat tttgactact
     1381 ctgcttttaa tttaatacca gttttcagga acccctgaag ttttaagttc attattcttt
     1441 ataacatttg agagaatcgg atgtagtgat atgacagggc tggggcaaga acaggggcac
     1501 tagctgcctt attagctaat ttagtgccct ccgtgttcag cttagccttt gaccctttcc
     1561 ttttgatcca caaaatacat taaaactctg aattcacata caatgctatt ttaaagtcaa
     1621 tagattttag ctataaagtg cttgaccagt aatgtggttg taattttgtg tatgttcccc
     1681 cacatcgccc ccaacttcgg atgtggggtc aggaggttga ggttcactat taacaaatgt
     1741 cataaatatc tcatagaggt acagtgccaa tagatattca aatgttgcat gttgaccaga
     1801 gggattttat atctgaagaa catacactat taataaatac cttagagaaa gattttgacc
     1861 tggctttaga taaaactgtg gcaagaaaaa tgtaatgagc aatatatgga aataaacaca
     1921 cctttgttaa agatactttc taaacttgtg tttaataaac tttaatagtc atagaattgt
     1981 aaatcactat ggttaacaga aagtgaaaat attttcatgc agatgatgtg aacagccatg
     2041 tgaataggtg acttgggcac acagcagggt catatgactt cagaaaactt cgcttttcag
     2101 ttattccatt gttataatgt caacccttta agacattgat gtttagaggg ctcacaaata
     2161 aaatctgaat acctgtaagg aaagaggttt tttatcacat accttaagtc tttgtaatgt
     2221 tcatgcttaa attctaagtt ttcaccttag tgacacacaa ggtttggttg taggcaacaa
     2281 gtcccaggtg tgtgggaaat tgattcacaa cagagatggg aaaaggtgca gataatttcc
     2341 aatgccttca caatttaccc atgaccagaa atatacttgg aagactgatt tcacaagtgt
     2401 cccaaaactg agatgctaaa aaggaaacag taggtaggtg tcataggaaa tttacatgta
     2461 ccatctaata aacaaacttg caaattctaa atcttttttt tttttgagac agtttcacgc
     2521 tgctgcccag gctggagtgc agtggcatga tctcagctca ccgcagcctc cgcctcctgg
     2581 gttcaagtga ctctcctacc tcagcctcct gagtagctgg gactacaggc gcccaccacc
     2641 aggaccagct aatttttaat gtttctaata gagatggggt ttcaccatgt tgaccaggcc
     2701 ggtctggaac tcctgacctc aggtgatctg cctgcctcgg tcttccaaag tgctgggatt
     2761 acaggcgtga gcccccgcac ccagccgcaa attctaaatc ttaaaacaac tctgcaaacg
     2821 aagcacttga gtttctgctt gcttcaggga tgtaatatgg tgtagaactg tttcacataa
     2881 tgatcagcct tggtaatttt ccagtgtaga aaacattata tttgaccctt ggacaacaaa
     2941 gagattatat tgaaggaatt ttattgattg tatcatgaat aaaagctgaa gtcaaaatta
     3001 aaatgtaaaa aaataattca gaggatggaa tatgcaaatg taaactccaa atgatgtggc
     3061 tggaattcat aaacatttac tttatgcaag atactgtgct attccaggca ctcctatggc
     3121 atttaaagta caattcttac cttccctaat ttttcaacct agtagaggac aataggctaa
     3181 agggaataag tacatggata acaaaacata aagtagaatg tttttacagc catagaaggc
     3241 aaagggctag gaattcacag gagagagaaa cagtatctag ctgagagcat aagaaaagct
     3301 tgtggaaaag ataatatctg atggccagag acaatttctt gctttggtat gtttgaagtg
     3361 ttatatttaa atatatatat ttttatttaa aaaactcact atagaaaatt tataaaattc
     3421 cccaaaatat ttagtataaa attaatcatc ccatcaaata ttaaataata ttactatttt
     3481 aaagtgttta tttcagtctt ttcctgcatg tatttatggc ttttattttt aaatatagta
     3541 ataaaataat ttgaaattag ctttttatat atttttgtat cttgctctaa tgggttggac
     3601 taaacatatt aagaacactc tcaaatgcta ctaaggacaa tttgaaaaca taattttaat
     3661 gactgcataa tttatttaac tttcctgttt tggaaaatat tatttttttt ttattacaaa
     3721 taatatgtca tgagcattct ctttttaaaa aaataaacta tgtgtgcata taa
//
