LOCUS       NM_031908               2396 bp    mRNA    linear   PRI 08-JUN-2024
DEFINITION  Homo sapiens C1q and TNF related 2 (C1QTNF2), transcript variant 1,
            mRNA.
ACCESSION   NM_031908
VERSION     NM_031908.6
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2396)
  AUTHORS   Jerobin,J., Ramanjaneya,M., Bettahi,I., Parammal,R., Siveen,K.S.,
            Alkasem,M., Aye,M., Sathyapalan,T., Skarulis,M., Atkin,S.L. and
            Abou-Samra,A.B.
  TITLE     Regulation of circulating CTRP-2/CTRP-9 and GDF-8/GDF-15 by
            intralipids and insulin in healthy control and polycystic ovary
            syndrome women following chronic exercise training
  JOURNAL   Lipids Health Dis 20 (1), 34 (2021)
   PUBMED   33874963
  REMARK    GeneRIF: Regulation of circulating CTRP-2/CTRP-9 and GDF-8/GDF-15
            by intralipids and insulin in healthy control and polycystic ovary
            syndrome women following chronic exercise training.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2396)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 2396)
  AUTHORS   Ilbeigi,D., Khoshfetrat,M., Afrisham,R., Rahimi,B. and
            Gorgani-Firuzjaee,S.
  TITLE     Serum C1q/TNF-Related Protein-2 (CTRP2) Levels are Associated with
            Coronary Artery Disease
  JOURNAL   Arch Med Res 51 (2), 167-172 (2020)
   PUBMED   32147289
  REMARK    GeneRIF: Serum C1q/TNF-Related Protein-2 (CTRP2) Levels are
            Associated with Coronary Artery Disease.
REFERENCE   4  (bases 1 to 2396)
  AUTHORS   Lei,X. and Wong,G.W.
  TITLE     C1q/TNF-related protein 2 (CTRP2) deletion promotes adipose tissue
            lipolysis and hepatic triglyceride secretion
  JOURNAL   J Biol Chem 294 (43), 15638-15649 (2019)
   PUBMED   31439668
  REMARK    GeneRIF: CTRP2 regulates lipid metabolism in adipose tissue and
            liver.
REFERENCE   5  (bases 1 to 2396)
  AUTHORS   Hatoum,I.J., Greenawalt,D.M., Cotsapas,C., Daly,M.J., Reitman,M.L.
            and Kaplan,L.M.
  TITLE     Weight loss after gastric bypass is associated with a variant at
            15q26.1
  JOURNAL   Am J Hum Genet 92 (5), 827-834 (2013)
   PUBMED   23643386
REFERENCE   6  (bases 1 to 2396)
  AUTHORS   Clark,H.F., Gurney,A.L., Abaya,E., Baker,K., Baldwin,D., Brush,J.,
            Chen,J., Chow,B., Chui,C., Crowley,C., Currell,B., Deuel,B.,
            Dowd,P., Eaton,D., Foster,J., Grimaldi,C., Gu,Q., Hass,P.E.,
            Heldens,S., Huang,A., Kim,H.S., Klimowski,L., Jin,Y., Johnson,S.,
            Lee,J., Lewis,L., Liao,D., Mark,M., Robbie,E., Sanchez,C.,
            Schoenfeld,J., Seshagiri,S., Simmons,L., Singh,J., Smith,V.,
            Stinson,J., Vagts,A., Vandlen,R., Watanabe,C., Wieand,D., Woods,K.,
            Xie,M.H., Yansura,D., Yi,S., Yu,G., Yuan,J., Zhang,M., Zhang,Z.,
            Goddard,A., Wood,W.I., Godowski,P. and Gray,A.
  TITLE     The secreted protein discovery initiative (SPDI), a large-scale
            effort to identify novel human secreted and transmembrane proteins:
            a bioinformatics assessment
  JOURNAL   Genome Res 13 (10), 2265-2270 (2003)
   PUBMED   12975309
  REMARK    Erratum:[Genome Res. 2003 Dec;13(12):2759]
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AY358839.1 and AC112191.2.
            
            On May 17, 2019 this sequence version replaced NM_031908.5.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR3476690.224328.1, BC011699.2
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968189, SAMEA1968540
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000652664.2/ ENSP00000498651.1
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-519               AY358839.1         16-534
            520-2396            AC112191.2         20270-22146
FEATURES             Location/Qualifiers
     source          1..2396
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="5"
                     /map="5q33.3"
     gene            1..2396
                     /gene="C1QTNF2"
                     /gene_synonym="CTRP2; zacrp2"
                     /note="C1q and TNF related 2"
                     /db_xref="GeneID:114898"
                     /db_xref="HGNC:HGNC:14325"
                     /db_xref="MIM:618647"
     exon            1..115
                     /gene="C1QTNF2"
                     /gene_synonym="CTRP2; zacrp2"
                     /inference="alignment:Splign:2.1.0"
     exon            116..368
                     /gene="C1QTNF2"
                     /gene_synonym="CTRP2; zacrp2"
                     /inference="alignment:Splign:2.1.0"
     CDS             125..982
                     /gene="C1QTNF2"
                     /gene_synonym="CTRP2; zacrp2"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; complement-c1q tumor necrosis factor-related
                     protein 2; complement C1q tumor necrosis factor-related
                     protein 2; C1q and tumor necrosis factor related protein
                     2"
                     /codon_start=1
                     /product="complement C1q tumor necrosis factor-related
                     protein 2 isoform 1 precursor"
                     /protein_id="NP_114114.3"
                     /db_xref="CCDS:CCDS4351.3"
                     /db_xref="GeneID:114898"
                     /db_xref="HGNC:HGNC:14325"
                     /db_xref="MIM:618647"
                     /translation="MIPWVLLACALPCAADPLLGAFARRDFRKGSPQLVCSLPGPQGP
                     PGPPGAPGPSGMMGRMGFPGKDGQDGHDGDRGDSGEEGPPGRTGNRGKPGPKGKAGAI
                     GRAGPRGPKGVNGTPGKHGTPGKKGPKGKKGEPGLPGPCSCGSGHTKSAFSVAVTKSY
                     PRERLPIKFDKILMNEGGHYNASSGKFVCGVPGIYYFTYDITLANKHLAIGLVHNGQY
                     RIRTFDANTGNHDVASGSTILALKQGDEVWLQIFYSEQNGLFYDPYWTDSLFTGFLIY
                     ADQDDPNEV"
     exon            369..2396
                     /gene="C1QTNF2"
                     /gene_synonym="CTRP2; zacrp2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1130..1135
                     /regulatory_class="polyA_signal_sequence"
                     /gene="C1QTNF2"
                     /gene_synonym="CTRP2; zacrp2"
                     /note="hexamer: ATTAAA"
     polyA_site      1158
                     /gene="C1QTNF2"
                     /gene_synonym="CTRP2; zacrp2"
                     /note="major polyA site"
ORIGIN      
        1 atgcctgggg ccgacgctct gcccggctgc tgccgctgag gaaagccggg acgcggagcc
       61 ccgccgagag cttctttgct ccggacgccc ctggacgtgg cgggcagccg cgagggtaac
      121 caccatgatc ccctgggtgc tcctggcctg tgccctcccc tgtgctgctg acccactgct
      181 tggcgccttt gctcgcaggg acttccggaa aggctcccct caactggtct gcagcctgcc
      241 tggcccccag ggcccacccg gccccccagg agccccaggg ccctcaggaa tgatgggacg
      301 aatgggcttt cctggcaaag acggccaaga tggacacgac ggcgaccggg gggacagcgg
      361 agaggaaggt ccacctggcc ggacaggtaa ccggggaaag ccaggaccaa agggcaaagc
      421 cggggccatt gggcgggctg gcccccgtgg ccccaagggg gtcaacggta cccccgggaa
      481 gcatggcaca ccaggcaaga aggggcccaa gggcaagaag ggggagccag gcctcccagg
      541 cccctgcagc tgtggcagtg gccataccaa gtcagctttc tcggtggcag tgaccaagag
      601 ctacccacgg gagcggctgc ccatcaagtt tgacaagatt ctgatgaacg agggtggcca
      661 ctacaatgct tccagcggca agttcgtctg cggcgtgcct gggatctact acttcaccta
      721 cgacatcacg ctggccaaca agcacctggc catcggcctg gtgcacaacg gccagtaccg
      781 catccggacc tttgatgcca acaccggcaa ccacgatgtg gcctcaggct ccaccatcct
      841 ggctctcaag cagggtgacg aagtttggct gcagatcttc tactcagagc agaacgggct
      901 cttctatgac ccttactgga cagacagcct ctttacgggc ttcctaatct atgccgacca
      961 ggatgacccc aacgaggtat agacatgcca cggcggtcct ccaggcaggg aacaagcttc
     1021 tggacttggg cttacagagc aagaccccac aactgtaggc tgggggtggg gggtcgagtg
     1081 agcggttcta gcctcaggct cacctcctct gcctcttttt ttccccttca ttaaatccaa
     1141 acctttttat tcatccaacc atctatttat tcacttcttt ttaaagtatc tactgtgtaa
     1201 caggcactat gctattctct gaaagatgca gcagtggaca agacagagta tctgtcctca
     1261 tgcagcttac attctagcag gagatacaat ttacaaatat acaagcaaat aatataatat
     1321 tatgccagga tagaaatgaa catgccatgg ttgacagtaa taggaataac aggagacagg
     1381 gaagaggtgg aaatttgttt ctttttttaa gtttgcgttt ttaggtttac ttacatacag
     1441 tgactctcca gattttaagt tgacaactca gtgaataatt tttgcttatg tgcacactct
     1501 gaaacctcca tgtagatcaa agaacaagct atttccaact tctcacctcc cttccccaaa
     1561 agctctctta agacccctct aagtcagtac ctggaaaatt tccatttttg agctgagttc
     1621 caaagaagga aatagagcaa cacaaaggcc tcgaaaagag gtctccagca aaaggctctg
     1681 caagtgcaaa gaccttgaca ggaaagaggg aggggccaag gtaagaactg agaagggagg
     1741 catgaggcgt gaggctggaa gataatacag aatgtcccag gccatggcag agctcgttcc
     1801 attcacgaag gcttatcaga atacaaagtg acactgatag gcggatcatc ttgaatctgc
     1861 tcattgcatg agtcaagtcg gccacagact tgagcgcttt attattagtt aatcttttgc
     1921 aggcccgctt ctcaatgaat gagatacacc aggatatgca cgtgcatctg agaaccgctg
     1981 ctctgagatg gcaggaatgg atcccacgca aatgaatcgc accccaagca caggtgttgc
     2041 cagtatgcag ggatctgggg gcttaagaag ctgcagtaaa agtgccaggt gctggcggga
     2101 tgtggtagct catgcctata atcccaggac tttgggaagc tgaggtggac ggatcatttg
     2161 aggtcaggag ttcaagacca gcctgaccaa catggcaaaa catcgtctaa aaaaatacaa
     2221 aaattagaca ggcgtggtgt tgggtgcctg taatcccagc tactggggag gctgaggcgg
     2281 gagaatcgct tgaacccagg aggtggaggt tgcagttagc tgagatcctg ccactgcact
     2341 ccagcctggg caacagagtg agactatctc aaaaaaaaac aaaaaaaaaa aaaaaa
//
