LOCUS       NM_001014980            1036 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens C1q and TNF related 12 (C1QTNF12), mRNA.
ACCESSION   NM_001014980 XM_928940 XM_938281
VERSION     NM_001014980.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1036)
  AUTHORS   Nadimi Shahraki,Z., Azimi,H., Ilchi,N., Rohani Borj,M.,
            Pourghadamyari,H., Mosallanejad,S., Abbaszadeh-Goudarzi,K. and
            Sahebkar,A.
  TITLE     Circulating C1q/TNF-related protein-12 levels are associated with
            the severity of coronary artery disease
  JOURNAL   Cytokine 144, 155545 (2021)
   PUBMED   33965313
  REMARK    GeneRIF: Circulating C1q/TNF-related protein-12 levels are
            associated with the severity of coronary artery disease.
REFERENCE   2  (bases 1 to 1036)
  AUTHORS   Wang,G., Chen,J.J., Deng,W.Y., Ren,K., Yin,S.H. and Yu,X.H.
  TITLE     CTRP12 ameliorates atherosclerosis by promoting cholesterol efflux
            and inhibiting inflammatory response via the miR-155-5p/LXRalpha
            pathway
  JOURNAL   Cell Death Dis 12 (3), 254 (2021)
   PUBMED   33692340
  REMARK    GeneRIF: CTRP12 ameliorates atherosclerosis by promoting
            cholesterol efflux and inhibiting inflammatory response via the
            miR-155-5p/LXRalpha pathway.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1036)
  AUTHORS   Sobieh,B.H., Kassem,D.H., Zakaria,Z.M. and El-Mesallamy,H.O.
  TITLE     Potential emerging roles of the novel adipokines adipolin/CTRP12
            and meteorin-like/METRNL in obesity-osteoarthritis interplay
  JOURNAL   Cytokine 138, 155368 (2021)
   PUBMED   33248913
  REMARK    GeneRIF: Potential emerging roles of the novel adipokines
            adipolin/CTRP12 and meteorin-like/METRNL in obesity-osteoarthritis
            interplay.
REFERENCE   4  (bases 1 to 1036)
  AUTHORS   Omidifar,A., Toolabi,K., Rahimipour,A., Emamgholipour,S. and
            Shanaki,M.
  TITLE     The gene expression of CTRP12 but not CTRP13 is upregulated in both
            visceral and subcutaneous adipose tissue of obese subjects
  JOURNAL   Diabetes Metab Syndr 13 (4), 2593-2599 (2019)
   PUBMED   31405681
  REMARK    GeneRIF: High CTRP12 expression is associated with obesity.
REFERENCE   5  (bases 1 to 1036)
  AUTHORS   Kasabri,V., Al-Ghareeb,M.I., Saleh,M.I., Suyagh,M., Halaseh,L.,
            Al-Sarraf,I. and AlAlawi,S.
  TITLE     Proportional correlates of adipolin and cathepsin S in metabolic
            syndrome patients with and without prediabetes
  JOURNAL   Diabetes Metab Syndr 13 (4), 2403-2408 (2019)
   PUBMED   31405651
  REMARK    GeneRIF: High Serum adipolin levels are associated with metabolic
            syndrome and prediabetes.
REFERENCE   6  (bases 1 to 1036)
  AUTHORS   Tan,B.K., Chen,J., Hu,J., Amar,O., Mattu,H.S., Ramanjaneya,M.,
            Patel,V., Lehnert,H. and Randeva,H.S.
  TITLE     Circulatory changes of the novel adipokine adipolin/CTRP12 in
            response to metformin treatment and an oral glucose challenge in
            humans
  JOURNAL   Clin Endocrinol (Oxf) 81 (6), 841-846 (2014)
   PUBMED   24612181
  REMARK    GeneRIF: Serum adipolin concentrations were significantly lower in
            polycystic ovarian syndrome compared with control subjects.
REFERENCE   7  (bases 1 to 1036)
  AUTHORS   Tan,B.K., Lewandowski,K.C., O'Hare,J.P. and Randeva,H.S.
  TITLE     Insulin regulates the novel adipokine adipolin/CTRP12: in vivo and
            ex vivo effects
  JOURNAL   J Endocrinol 221 (1), 111-119 (2014)
   PUBMED   24492466
  REMARK    GeneRIF: In subcutaneous adipose tissue explants, insulin
            significantly increased CTRP12 protein expression and secretion.
            Publication Status: Online-Only
REFERENCE   8  (bases 1 to 1036)
  AUTHORS   Conde,J., Scotece,M., Lopez,V., Gomez,R., Lago,F., Pino,J.,
            Gomez-Reino,J.J. and Gualillo,O.
  TITLE     Expression and modulation of adipolin/C1qdc2: a novel adipokine in
            human and murine ATDC-5 chondrocyte cell line
  JOURNAL   Ann Rheum Dis 72 (1), 140-142 (2013)
   PUBMED   22736092
  REMARK    GeneRIF: we describe, for the first time, adipolin expression in
            human chondrocytes as well as the intracellular mechanism involved
            in its regulation
REFERENCE   9  (bases 1 to 1036)
  AUTHORS   Wei,Z., Lei,X., Seldin,M.M. and Wong,G.W.
  TITLE     Endopeptidase cleavage generates a functionally distinct isoform of
            C1q/tumor necrosis factor-related protein-12 (CTRP12) with an
            altered oligomeric state and signaling specificity
  JOURNAL   J Biol Chem 287 (43), 35804-35814 (2012)
   PUBMED   22942287
  REMARK    GeneRIF: Endopeptidase cleavage generates a functionally distinct
            isoform of C1q/tumor necrosis factor-related protein-12 (CTRP12)
            with an altered oligomeric state and signaling specificity.
REFERENCE   10 (bases 1 to 1036)
  AUTHORS   Enomoto,T., Ohashi,K., Shibata,R., Higuchi,A., Maruyama,S.,
            Izumiya,Y., Walsh,K., Murohara,T. and Ouchi,N.
  TITLE     Adipolin/C1qdc2/CTRP12 protein functions as an adipokine that
            improves glucose metabolism
  JOURNAL   J Biol Chem 286 (40), 34552-34558 (2011)
   PUBMED   21849507
  REMARK    GeneRIF: Reports cloning, expression, regulation and function of
            mouse adipolin (Fam132a)
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC089443.1.
            
            On May 17, 2019 this sequence version replaced NM_001014980.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC089443.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000330388.2/ ENSP00000329137.2
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1036              BC089443.1         1-1036
FEATURES             Location/Qualifiers
     source          1..1036
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1p36.33"
     gene            1..1036
                     /gene="C1QTNF12"
                     /gene_synonym="C1QDC2; CTRP12; FAM132A"
                     /note="C1q and TNF related 12"
                     /db_xref="GeneID:388581"
                     /db_xref="HGNC:HGNC:32308"
                     /db_xref="MIM:616593"
     exon            1..209
                     /gene="C1QTNF12"
                     /gene_synonym="C1QDC2; CTRP12; FAM132A"
                     /inference="alignment:Splign:2.1.0"
     CDS             33..941
                     /gene="C1QTNF12"
                     /gene_synonym="C1QDC2; CTRP12; FAM132A"
                     /note="C1q domain containing 2; adipose-derived
                     insulin-sensitizing factor; C1q/TNF-related protein 12;
                     adipolin; protein FAM132A; complement C1q tumor necrosis
                     factor-related protein 12; family with sequence similarity
                     132 member A; C1q and tumor necrosis factor related
                     protein 12; C1q and TNF related protein 12"
                     /codon_start=1
                     /product="adipolin precursor"
                     /protein_id="NP_001014980.1"
                     /db_xref="CCDS:CCDS30554.1"
                     /db_xref="GeneID:388581"
                     /db_xref="HGNC:HGNC:32308"
                     /db_xref="MIM:616593"
                     /translation="MRRWAWAAVVVLLGPQLVLLGGVGARREAQRTQQPGQRADPPNA
                     TASASSREGLPEAPKPSQASGPEFSDAHMTWLNFVRRPDDGALRKRCGSRDKKPRDLF
                     GPPGPPGAEVTAETLLHEFQELLKEATERRFSGLLDPLLPQGAGLRLVGEAFHCRLQG
                     PRRVDKRTLVELHGFQAPAAQGAFLRGSGLSLASGRFTAPVSGIFQFSASLHVDHSEL
                     QGKARLRARDVVCVLICIESLCQRHTCLEAVSGLESNSRVFTLQVQGLLQLQAGQYAS
                     VFVDNGSGAVLTIQAGSSFSGLLLGT"
     exon            210..326
                     /gene="C1QTNF12"
                     /gene_synonym="C1QDC2; CTRP12; FAM132A"
                     /inference="alignment:Splign:2.1.0"
     exon            327..411
                     /gene="C1QTNF12"
                     /gene_synonym="C1QDC2; CTRP12; FAM132A"
                     /inference="alignment:Splign:2.1.0"
     exon            412..563
                     /gene="C1QTNF12"
                     /gene_synonym="C1QDC2; CTRP12; FAM132A"
                     /inference="alignment:Splign:2.1.0"
     exon            564..672
                     /gene="C1QTNF12"
                     /gene_synonym="C1QDC2; CTRP12; FAM132A"
                     /inference="alignment:Splign:2.1.0"
     exon            673..763
                     /gene="C1QTNF12"
                     /gene_synonym="C1QDC2; CTRP12; FAM132A"
                     /inference="alignment:Splign:2.1.0"
     exon            764..842
                     /gene="C1QTNF12"
                     /gene_synonym="C1QDC2; CTRP12; FAM132A"
                     /inference="alignment:Splign:2.1.0"
     exon            843..1036
                     /gene="C1QTNF12"
                     /gene_synonym="C1QDC2; CTRP12; FAM132A"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1016..1021
                     /regulatory_class="polyA_signal_sequence"
                     /gene="C1QTNF12"
                     /gene_synonym="C1QDC2; CTRP12; FAM132A"
                     /note="hexamer: AATAAA"
     polyA_site      1036
                     /gene="C1QTNF12"
                     /gene_synonym="C1QDC2; CTRP12; FAM132A"
                     /note="major polyA site"
ORIGIN      
        1 ctcgccgcgc tgagccgcct cgggacggag ccatgcggcg ctgggcctgg gccgcggtcg
       61 tggtcctcct cgggccgcag ctcgtgctcc tcgggggcgt cggggcccgg cgggaggcac
      121 agaggacgca gcagcctggc cagcgcgcag atccccccaa cgccaccgcc agcgcgtcct
      181 cccgcgaggg gctgcccgag gcccccaagc catcccaggc ctcaggacct gagttctccg
      241 acgcccacat gacatggctg aactttgtcc ggcggccgga cgacggcgcc ttaaggaagc
      301 ggtgcggaag cagggacaag aagccgcggg atctcttcgg tcccccagga cctccaggtg
      361 cagaagtgac cgcggagact ctgcttcacg agtttcagga gctgctgaaa gaggccacgg
      421 agcgccggtt ctcagggctt ctggacccgc tgctgcccca gggggcgggc ctgcggctgg
      481 tgggcgaggc ctttcactgc cggctgcagg gtccccgccg ggtggacaag cggacgctgg
      541 tggagctgca tggtttccag gctcctgctg cccaaggtgc cttcctgcga ggctccggtc
      601 tgagcctggc ctcgggtcgg ttcacggccc ccgtgtccgg catcttccag ttctctgcca
      661 gtctgcacgt ggaccacagt gagctgcagg gcaaggcccg gctgcgggcc cgggacgtgg
      721 tgtgtgttct catctgtatt gagtccctgt gccagcgcca cacgtgcctg gaggccgtct
      781 caggcctgga gagcaacagc agggtcttca cgctacaggt gcaggggctg ctgcagctgc
      841 aggctggaca gtacgcttct gtgtttgtgg acaatggctc cggggccgtc ctcaccatcc
      901 aggcgggctc cagcttctcc gggctgctcc tgggcacgtg agggcgccca ggggggctgg
      961 cgaggagctg ccgccggatc ccggggaccc tcctactgat gcccgtggtc accacaataa
     1021 agagccctcc accctc
//
