LOCUS       NM_030968               2886 bp    mRNA    linear   PRI 03-APR-2024
DEFINITION  Homo sapiens C1q and TNF related 1 (C1QTNF1), transcript variant 1,
            mRNA.
ACCESSION   NM_030968
VERSION     NM_030968.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2886)
  AUTHORS   Wang,Y., Li,H., Yu,X.H. and Tang,C.K.
  TITLE     CTRP1: A novel player in cardiovascular and metabolic diseases
  JOURNAL   Cytokine 164, 156162 (2023)
   PUBMED   36812667
  REMARK    GeneRIF: CTRP1: A novel player in cardiovascular and metabolic
            diseases.
            Review article
REFERENCE   2  (bases 1 to 2886)
  AUTHORS   Bai,G., Xie,X., Liu,H., Qiang,D., He,Y., Zhang,L. and Zhang,X.
  TITLE     The association between complement C1q tumour necrosis
            factor-related protein-1 (CTRP-1) level and metabolic syndrome
  JOURNAL   Endokrynol Pol 74 (3), 271-276 (2023)
   PUBMED   37155309
  REMARK    GeneRIF: The association between complement C1q tumour necrosis
            factor-related protein-1 (CTRP-1) level and metabolic syndrome.
REFERENCE   3  (bases 1 to 2886)
  AUTHORS   Ren,M., Pan,J., Yu,X., Chang,K., Yuan,X. and Zhang,C.
  TITLE     CTRP1 prevents high fat diet-induced obesity and improves glucose
            homeostasis in obese and STZ-induced diabetic mice
  JOURNAL   J Transl Med 20 (1), 449 (2022)
   PUBMED   36195912
  REMARK    GeneRIF: CTRP1 prevents high fat diet-induced obesity and improves
            glucose homeostasis in obese and STZ-induced diabetic mice.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2886)
  AUTHORS   Raeisy,H., Bayati,P., Noorbakhsh,F., Hakim Shooshtari,M., Eftekhar
            Ardebili,M., Shekarabi,M. and Mojtabavi,N.
  TITLE     C1q/TNF-related protein-1: Potential biomarker for early diagnosis
            of autism spectrum disorder
  JOURNAL   Int J Immunopathol Pharmacol 36, 3946320221079471 (2022)
   PUBMED   35202556
  REMARK    GeneRIF: C1q/TNF-related protein-1: Potential biomarker for early
            diagnosis of autism spectrum disorder.
REFERENCE   5  (bases 1 to 2886)
  AUTHORS   Arking,A., Sarver,D.C., Magge,S.N., Wong,G.W. and Wolf,R.M.
  TITLE     Novel Adipokines CTRP1, CTRP9, and FGF21 in Pediatric Type 1 and
            Type 2 Diabetes: A Cross-Sectional Analysis
  JOURNAL   Horm Res Paediatr 95 (1), 43-50 (2022)
   PUBMED   35172300
  REMARK    GeneRIF: Novel Adipokines CTRP1, CTRP9, and FGF21 in Pediatric Type
            1 and Type 2 Diabetes: A Cross-Sectional Analysis.
REFERENCE   6  (bases 1 to 2886)
  AUTHORS   Kim,K.Y., Kim,H.Y., Kim,J.H., Lee,C.H., Kim,D.H., Lee,Y.H.,
            Han,S.H., Lim,J.S., Cho,D.H., Lee,M.S., Yoon,S., Kim,K.I.,
            Yoon,D.Y. and Yang,Y.
  TITLE     Tumor necrosis factor-alpha and interleukin-1beta increases CTRP1
            expression in adipose tissue
  JOURNAL   FEBS Lett 580 (16), 3953-3960 (2006)
   PUBMED   16806199
  REMARK    GeneRIF: These findings indicate that CTRP1 expression may be
            associated with a low-grade chronic inflammation status in adipose
            tissues.
REFERENCE   7  (bases 1 to 2886)
  AUTHORS   Innamorati,G., Bianchi,E. and Whang,M.I.
  TITLE     An intracellular role for the C1q-globular domain
  JOURNAL   Cell Signal 18 (6), 761-770 (2006)
   PUBMED   16386877
  REMARK    GeneRIF: The review describes the potential role of C1qTNF1 as an
            intracellular regulator of signal transduction
            Review article
REFERENCE   8  (bases 1 to 2886)
  AUTHORS   Lasser,G., Guchhait,P., Ellsworth,J.L., Sheppard,P., Lewis,K.,
            Bishop,P., Cruz,M.A., Lopez,J.A. and Fruebis,J.
  TITLE     C1qTNF-related protein-1 (CTRP-1): a vascular wall protein that
            inhibits collagen-induced platelet aggregation by blocking VWF
            binding to collagen
  JOURNAL   Blood 107 (2), 423-430 (2006)
   PUBMED   16195328
REFERENCE   9  (bases 1 to 2886)
  AUTHORS   Clark,H.F., Gurney,A.L., Abaya,E., Baker,K., Baldwin,D., Brush,J.,
            Chen,J., Chow,B., Chui,C., Crowley,C., Currell,B., Deuel,B.,
            Dowd,P., Eaton,D., Foster,J., Grimaldi,C., Gu,Q., Hass,P.E.,
            Heldens,S., Huang,A., Kim,H.S., Klimowski,L., Jin,Y., Johnson,S.,
            Lee,J., Lewis,L., Liao,D., Mark,M., Robbie,E., Sanchez,C.,
            Schoenfeld,J., Seshagiri,S., Simmons,L., Singh,J., Smith,V.,
            Stinson,J., Vagts,A., Vandlen,R., Watanabe,C., Wieand,D., Woods,K.,
            Xie,M.H., Yansura,D., Yi,S., Yu,G., Yuan,J., Zhang,M., Zhang,Z.,
            Goddard,A., Wood,W.I., Godowski,P. and Gray,A.
  TITLE     The secreted protein discovery initiative (SPDI), a large-scale
            effort to identify novel human secreted and transmembrane proteins:
            a bioinformatics assessment
  JOURNAL   Genome Res 13 (10), 2265-2270 (2003)
   PUBMED   12975309
  REMARK    Erratum:[Genome Res. 2003 Dec;13(12):2759]
REFERENCE   10 (bases 1 to 2886)
  AUTHORS   Innamorati,G., Whang,M.I., Molteni,R., Le Gouill,C. and
            Birnbaumer,M.
  TITLE     GIP, a G-protein-coupled receptor interacting protein
  JOURNAL   Regul Pept 109 (1-3), 173-179 (2002)
   PUBMED   12409230
  REMARK    GeneRIF: molecular cloning, gene expression, and subcellular
            localization of GIP
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC073624.28 and AY358424.2.
            
            On Nov 22, 2018 this sequence version replaced NM_030968.4.
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes isoform 1. Variants 1-3 encode the same
            protein.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY358424.2, ERR279849.5106.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000579760.6/ ENSP00000463922.1
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-36                AC073624.28        79008-79043         c
            37-1993             AY358424.2         65-2021
            1994-2886           AY358424.2         2023-2915
FEATURES             Location/Qualifiers
     source          1..2886
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17q25.3"
     gene            1..2886
                     /gene="C1QTNF1"
                     /gene_synonym="CTRP1; GIP; ZSIG37"
                     /note="C1q and TNF related 1"
                     /db_xref="GeneID:114897"
                     /db_xref="HGNC:HGNC:14324"
                     /db_xref="MIM:610365"
     exon            1..326
                     /gene="C1QTNF1"
                     /gene_synonym="CTRP1; GIP; ZSIG37"
                     /inference="alignment:Splign:2.1.0"
     exon            327..495
                     /gene="C1QTNF1"
                     /gene_synonym="CTRP1; GIP; ZSIG37"
                     /inference="alignment:Splign:2.1.0"
     CDS             341..1186
                     /gene="C1QTNF1"
                     /gene_synonym="CTRP1; GIP; ZSIG37"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; complement C1q tumor necrosis factor-related
                     protein 1; G protein coupled receptor interacting protein;
                     g protein-coupled receptor-interacting protein; C1q and
                     tumor necrosis factor related protein 1"
                     /codon_start=1
                     /product="complement C1q tumor necrosis factor-related
                     protein 1 isoform 1 precursor"
                     /protein_id="NP_112230.1"
                     /db_xref="CCDS:CCDS11761.1"
                     /db_xref="GeneID:114897"
                     /db_xref="HGNC:HGNC:14324"
                     /db_xref="MIM:610365"
                     /translation="MGSRGQGLLLAYCLLLAFASGLVLSRVPHVQGEQQEWEGTEELP
                     SPPDHAERAEEQHEKYRPSQDQGLPASRCLRCCDPGTSMYPATAVPQINITILKGEKG
                     DRGDRGLQGKYGKTGSAGARGHTGPKGQKGSMGAPGERCKSHYAAFSVGRKKPMHSNH
                     YYQTVIFDTEFVNLYDHFNMFTGKFYCYVPGLYFFSLNVHTWNQKETYLHIMKNEEEV
                     VILFAQVGDRSIMQSQSLMLELREQDQVWVRLYKGERENAIFSEELDTYITFSGYLVK
                     HATEP"
     exon            496..635
                     /gene="C1QTNF1"
                     /gene_synonym="CTRP1; GIP; ZSIG37"
                     /inference="alignment:Splign:2.1.0"
     exon            636..2886
                     /gene="C1QTNF1"
                     /gene_synonym="CTRP1; GIP; ZSIG37"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2860..2865
                     /regulatory_class="polyA_signal_sequence"
                     /gene="C1QTNF1"
                     /gene_synonym="CTRP1; GIP; ZSIG37"
                     /note="hexamer: ATTAAA"
     polyA_site      2886
                     /gene="C1QTNF1"
                     /gene_synonym="CTRP1; GIP; ZSIG37"
                     /note="major polyA site"
ORIGIN      
        1 acatctggct gggcttcgct ccttgcgcgt ctgtcccact ttctccctct cttcctttac
       61 tttcgagaaa ccgcgcttcc gcttctggtc gcagagacct cggagaccgc gccggggaga
      121 cggaggtgct gtgggtgggg gggacctgtg gctgctcgta ccgcccccca ccctcctctt
      181 ctgcactgcc gtcctccgga agaccttttc ccctgctctg tttccttcac cgagtctgtg
      241 catcgccccg gacctggccg ggaggaggct tggccggcgg gagatgctct aggggcggcg
      301 cgggaggagc ggccggcggg acggagggcc cggcaggaag atgggctccc gtggacaggg
      361 actcttgctg gcgtactgcc tgctccttgc ctttgcctct ggcctggtcc tgagtcgtgt
      421 gccccatgtc cagggggaac agcaggagtg ggaggggact gaggagctgc cgtcgcctcc
      481 ggaccatgcc gagagggctg aagaacaaca tgaaaaatac aggcccagtc aggaccaggg
      541 gctccctgct tcccggtgct tgcgctgctg tgaccccggt acctccatgt acccggcgac
      601 cgccgtgccc cagatcaaca tcactatctt gaaaggggag aagggtgacc gcggagatcg
      661 aggcctccaa gggaaatatg gcaaaacagg ctcagcaggg gccaggggcc acactggacc
      721 caaagggcag aagggctcca tgggggcccc tggggagcgg tgcaagagcc actacgccgc
      781 cttttcggtg ggccggaaga agcccatgca cagcaaccac tactaccaga cggtgatctt
      841 cgacacggag ttcgtgaacc tctacgacca cttcaacatg ttcaccggca agttctactg
      901 ctacgtgccc ggcctctact tcttcagcct caacgtgcac acctggaacc agaaggagac
      961 ctacctgcac atcatgaaga acgaggagga ggtggtgatc ttgttcgcgc aggtgggcga
     1021 ccgcagcatc atgcaaagcc agagcctgat gctggagctg cgagagcagg accaggtgtg
     1081 ggtacgcctc tacaagggcg aacgtgagaa cgccatcttc agcgaggagc tggacaccta
     1141 catcaccttc agtggctacc tggtcaagca cgccaccgag ccctagctgg ccggccacct
     1201 cctttcctct cgccaccttc cacccctgcg ctgtgctgac cccaccgcct cttccccgat
     1261 ccctggactc cgactccctg gctttggcat tcagtgagac gccctgcaca cacagaaagc
     1321 caaagcgatc ggtgctccca gatcccgcag cctctggaga gagctgacgg cagatgaaat
     1381 caccagggcg gggcacccgc gagaaccctc tgggaccttc cgcggccctc tctgcacaca
     1441 tcctcaagtg accccgcacg gcgagacgcg ggtggcggca gggcgtccca gggtgcggca
     1501 ccgcggctcc agtccttgga aataattagg caaattctaa aggtctcaaa aggagcaaag
     1561 taaaccgtgg aggacaaaga aaagggttgt tatttttgtc tttccagcca gcctgctggc
     1621 tcccaagaga gaggcctttt cagttgagac tctgcttaag agaagatcca aagttaaagc
     1681 tctggggtca ggggaggggc cgggggcagg aaactacctc tggcttaatt cttttaagcc
     1741 acgtaggaac tttcttgagg gataggtgga ccctgacatc cctgtggcct tgcccaaggg
     1801 ctctgctggt ctttctgagt cacagctgcg aggtgatggg ggctggggcc ccaggcgtca
     1861 gcctcccaga gggacagctg agccccctgc cttggctcca ggttggtaga agcagccgaa
     1921 gggctcctga cagtggccag ggacccctgg gtcccccagg cctgcagatg tttctatgag
     1981 gggcagagct cctggtacat ccatgtgtgg ctctgctcca cccctgtgcc accccagagc
     2041 cctggggggt ggtctccatg cctgccaccc tggcatcggc tttctgtgcc gcctcccaca
     2101 caaatcagcc ccagaaggcc ccggggcctt ggcttctgtt ttttataaaa cacctcaagc
     2161 agcactgcag tctcccatct cctcgtgggc taagcatcac cgcttccacg tgtgttgtgt
     2221 tggttggcag caaggctgat ccagacccct tctgccccca ctgccctcat ccaggcctct
     2281 gaccagtagc ctgagagggg ctttttctag gcttcagagc aggggagagc tggaaggggc
     2341 tagaaagctc ccgcttgtct gtttctcagg ctcctgtgag cctcagtcct gagaccagag
     2401 tcaagaggaa gtacacgtcc caatcacccg tgtcaggatt cactctcagg agctgggtgg
     2461 caggagaggc aatagcccct gtggcaattg caggaccagc tggagcaggg ttgcggtgtc
     2521 tccacggtgc tctcgccctg cccatggcca ccccagactc tgatctccag gaaccccata
     2581 gcccctctcc acctcacccc atgttgatgc ccagggtcac tcttgctacc cgctgggccc
     2641 ccaaaccccc gctgcctctc ttccttcccc ccatccccca cctggttttg actaatcctg
     2701 cttccctctc tgggcctggc tgccgggatc tggggtccct aagtccctct ctttaaagaa
     2761 cttctgcggg tcagactctg aagccgagtt gctgtgggcg tgcccggaag cagagcgcca
     2821 cactcgctgc ttaagctccc ccagctcttt ccagaaaaca ttaaactcag aattgtgttt
     2881 tcagca
//
