LOCUS       NM_001010908            2376 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens complement C1q like 3 (C1QL3), mRNA.
ACCESSION   NM_001010908 XM_372305
VERSION     NM_001010908.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2376)
  AUTHORS   Zhu,W., Yang,G., Chen,N., Zhang,W., Gao,Q., Li,T., Yuan,N. and
            Jin,H.
  TITLE     CTRP13 alleviates palmitic acid-induced inflammation, oxidative
            stress, apoptosis and endothelial cell dysfunction in HUVECs
  JOURNAL   Tissue Cell 86, 102232 (2024)
   PUBMED   37976900
  REMARK    GeneRIF: CTRP13 alleviates palmitic acid-induced inflammation,
            oxidative stress, apoptosis and endothelial cell dysfunction in
            HUVECs.
REFERENCE   2  (bases 1 to 2376)
  AUTHORS   Du,J., Wu,J., Zhang,Y., Liu,Q., Luo,X., Huang,X., Wang,X., Yang,F.
            and Hou,J.
  TITLE     CTRP13 Mitigates Endothelial Cell Ferroptosis via the AMPK/KLF4
            Pathway: Implications for Atherosclerosis Protection
  JOURNAL   Med Sci Monit 30, e942733 (2024)
   PUBMED   38273650
  REMARK    GeneRIF: CTRP13 Mitigates Endothelial Cell Ferroptosis via the
            AMPK/KLF4 Pathway: Implications for Atherosclerosis Protection.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2376)
  AUTHORS   Chen,F., Sarver,D.C., Saqib,M., Zhou,M., Aja,S., Seldin,M.M. and
            Wong,G.W.
  TITLE     CTRP13 ablation improves systemic glucose and lipid metabolism
  JOURNAL   Mol Metab 78, 101824 (2023)
   PUBMED   37844630
  REMARK    GeneRIF: CTRP13 ablation improves systemic glucose and lipid
            metabolism.
REFERENCE   4  (bases 1 to 2376)
  AUTHORS   Erbas,I.M., Paketci,A., Turan,S., Sisman,A.R., Demir,K., Bober,E.
            and Abaci,A.
  TITLE     Low Complement C1q/TNF-related Protein-13 Levels are Associated
            with Childhood Obesity But not Binge Eating Disorder
  JOURNAL   J Clin Res Pediatr Endocrinol 14 (2), 179-187 (2022)
   PUBMED   35014243
  REMARK    GeneRIF: Low Complement C1q/TNF-related Protein-13 Levels are
            Associated with Childhood Obesity But not Binge Eating Disorder
REFERENCE   5  (bases 1 to 2376)
  AUTHORS   Wang,C., Chao,Y., Xu,W., Liang,M., Deng,S., Zhang,D. and Huang,K.
  TITLE     CTRP13 Preserves Endothelial Function by Targeting GTP
            Cyclohydrolase 1 in Diabetes
  JOURNAL   Diabetes 69 (1), 99-111 (2020)
   PUBMED   31676569
  REMARK    GeneRIF: CTRP13 preserves endothelial function in diabetic mice by
            regulating GCH1/BH4 axis-dependent eNOS coupling, suggesting the
            therapeutic potential of CTRP13 against diabetic vasculopathy.
REFERENCE   6  (bases 1 to 2376)
  AUTHORS   Afrookhteh,A., Emamgholipour,S., Alipoor,B., Moradi,N.,
            Meshkani,R., Nasli-Esfahani,E., Rahimipour,A. and Shanaki,M.
  TITLE     The Circulating Levels of Complement-C1q/TNF-Related Protein 13
            (CTRP13) in Patients with Type 2 Diabetes and its Association with
            Insulin Resistance
  JOURNAL   Clin Lab 63 (2), 327-333 (2017)
   PUBMED   28182339
  REMARK    GeneRIF: CTRP13 is a novel adipokine that is down-regulated in the
            serum of type 2 diabetics.
REFERENCE   7  (bases 1 to 2376)
  AUTHORS   Fadaei,R., Moradi,N., Baratchian,M., Aghajani,H., Malek,M.,
            Fazaeli,A.A. and Fallah,S.
  TITLE     Association of C1q/TNF-Related Protein-3 (CTRP3) and CTRP13 Serum
            Levels with Coronary Artery Disease in Subjects with and without
            Type 2 Diabetes Mellitus
  JOURNAL   PLoS One 11 (12), e0168773 (2016)
   PUBMED   28033351
  REMARK    GeneRIF: decreased levels of CTRP3 and especially CTRP13 were
            associated with increased risk of T2DM and CAD
            Publication Status: Online-Only
REFERENCE   8  (bases 1 to 2376)
  AUTHORS   Wei,Z., Peterson,J.M. and Wong,G.W.
  TITLE     Metabolic regulation by C1q/TNF-related protein-13 (CTRP13):
            activation OF AMP-activated protein kinase and suppression of fatty
            acid-induced JNK signaling
  JOURNAL   J Biol Chem 286 (18), 15652-15665 (2011)
   PUBMED   21378161
  REMARK    GeneRIF: CTRP13 reduces glucose output in hepatocytes by inhibiting
            the mRNA expression of gluconeogenic enzymes, glucose-6-phosphatase
            and the cytosolic form of phosphoenolpyruvate carboxykinase.
REFERENCE   9  (bases 1 to 2376)
  AUTHORS   Deloukas,P., Earthrowl,M.E., Grafham,D.V., Rubenfield,M.,
            French,L., Steward,C.A., Sims,S.K., Jones,M.C., Searle,S.,
            Scott,C., Howe,K., Hunt,S.E., Andrews,T.D., Gilbert,J.G.,
            Swarbreck,D., Ashurst,J.L., Taylor,A., Battles,J., Bird,C.P.,
            Ainscough,R., Almeida,J.P., Ashwell,R.I., Ambrose,K.D.,
            Babbage,A.K., Bagguley,C.L., Bailey,J., Banerjee,R., Bates,K.,
            Beasley,H., Bray-Allen,S., Brown,A.J., Brown,J.Y., Burford,D.C.,
            Burrill,W., Burton,J., Cahill,P., Camire,D., Carter,N.P.,
            Chapman,J.C., Clark,S.Y., Clarke,G., Clee,C.M., Clegg,S., Corby,N.,
            Coulson,A., Dhami,P., Dutta,I., Dunn,M., Faulkner,L., Frankish,A.,
            Frankland,J.A., Garner,P., Garnett,J., Gribble,S., Griffiths,C.,
            Grocock,R., Gustafson,E., Hammond,S., Harley,J.L., Hart,E.,
            Heath,P.D., Ho,T.P., Hopkins,B., Horne,J., Howden,P.J., Huckle,E.,
            Hynds,C., Johnson,C., Johnson,D., Kana,A., Kay,M., Kimberley,A.M.,
            Kershaw,J.K., Kokkinaki,M., Laird,G.K., Lawlor,S., Lee,H.M.,
            Leongamornlert,D.A., Laird,G., Lloyd,C., Lloyd,D.M., Loveland,J.,
            Lovell,J., McLaren,S., McLay,K.E., McMurray,A.,
            Mashreghi-Mohammadi,M., Matthews,L., Milne,S., Nickerson,T.,
            Nguyen,M., Overton-Larty,E., Palmer,S.A., Pearce,A.V., Peck,A.I.,
            Pelan,S., Phillimore,B., Porter,K., Rice,C.M., Rogosin,A.,
            Ross,M.T., Sarafidou,T., Sehra,H.K., Shownkeen,R., Skuce,C.D.,
            Smith,M., Standring,L., Sycamore,N., Tester,J., Thorpe,A.,
            Torcasso,W., Tracey,A., Tromans,A., Tsolas,J., Wall,M., Walsh,J.,
            Wang,H., Weinstock,K., West,A.P., Willey,D.L., Whitehead,S.L.,
            Wilming,L., Wray,P.W., Young,L., Chen,Y., Lovering,R.C.,
            Moschonas,N.K., Siebert,R., Fechtel,K., Bentley,D., Durbin,R.,
            Hubbard,T., Doucette-Stamm,L., Beck,S., Smith,D.R. and Rogers,J.
  TITLE     The DNA sequence and comparative analysis of human chromosome 10
  JOURNAL   Nature 429 (6990), 375-381 (2004)
   PUBMED   15164054
REFERENCE   10 (bases 1 to 2376)
  AUTHORS   Koide,T., Aso,A., Yorihuzi,T. and Nagata,K.
  TITLE     Conformational requirements of collagenous peptides for recognition
            by the chaperone protein HSP47
  JOURNAL   J Biol Chem 275 (36), 27957-27963 (2000)
   PUBMED   10862616
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL353576.18 and AL360230.20.
            
            On Nov 22, 2018 this sequence version replaced NM_001010908.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803615.186834.1,
                                           SRR1803611.209128.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1968540
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000298943.4/ ENSP00000298943.3
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1402              AL353576.18        3296-4697           c
            1403-2367           AL360230.20        157160-158124       c
            2368-2376           AL360230.20        157151-157159       c
FEATURES             Location/Qualifiers
     source          1..2376
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="10"
                     /map="10p13"
     gene            1..2376
                     /gene="C1QL3"
                     /gene_synonym="C1ql; C1QTNF13; CTRP13; K100"
                     /note="complement C1q like 3"
                     /db_xref="GeneID:389941"
                     /db_xref="HGNC:HGNC:19359"
                     /db_xref="MIM:615227"
     exon            1..1402
                     /gene="C1QL3"
                     /gene_synonym="C1ql; C1QTNF13; CTRP13; K100"
                     /inference="alignment:Splign:2.1.0"
     CDS             815..1582
                     /gene="C1QL3"
                     /gene_synonym="C1ql; C1QTNF13; CTRP13; K100"
                     /note="complement C1q-like protein 3; complement component
                     1, q subcomponent-like 3; C1q/TNF-related protein 13; C1q
                     and tumor necrosis factor-related protein 13"
                     /codon_start=1
                     /product="complement C1q-like protein 3 precursor"
                     /protein_id="NP_001010908.1"
                     /db_xref="CCDS:CCDS31156.1"
                     /db_xref="GeneID:389941"
                     /db_xref="HGNC:HGNC:19359"
                     /db_xref="MIM:615227"
                     /translation="MVLLLVILIPVLVSSAGTSAHYEMLGTCRMVCDPYGGTKAPSTA
                     ATPDRGLMQSLPTFIQGPKGEAGRPGKAGPRGPPGEPGPPGPMGPPGEKGEPGRQGLP
                     GPPGAPGLNAAGAISAATYSTVPKIAFYAGLKRQHEGYEVLKFDDVVTNLGNHYDPTT
                     GKFTCSIPGIYFFTYHVLMRGGDGTSMWADLCKNNQVRASAIAQDADQNYDYASNSVV
                     LHLEPGDEVYIKLDGGKAHGGNNNKYSTFSGFIIYAD"
     exon            1403..2376
                     /gene="C1QL3"
                     /gene_synonym="C1ql; C1QTNF13; CTRP13; K100"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2050..2055
                     /regulatory_class="polyA_signal_sequence"
                     /gene="C1QL3"
                     /gene_synonym="C1ql; C1QTNF13; CTRP13; K100"
                     /note="hexamer: AATAAT"
     polyA_site      2071
                     /gene="C1QL3"
                     /gene_synonym="C1ql; C1QTNF13; CTRP13; K100"
     regulatory      2353..2358
                     /regulatory_class="polyA_signal_sequence"
                     /gene="C1QL3"
                     /gene_synonym="C1ql; C1QTNF13; CTRP13; K100"
                     /note="hexamer: AATACA"
     polyA_site      2376
                     /gene="C1QL3"
                     /gene_synonym="C1ql; C1QTNF13; CTRP13; K100"
                     /note="major polyA site"
ORIGIN      
        1 ctcctcttct cctggcaggt ggtacccagg cagaattctg ccttcagtct ctctctcgct
       61 ccgctcccgg ccgtgaggcg ctcgccgctg ctcgctcgct cctccgcccc agctctgagc
      121 ctcgccgtgc cgaccgtgcc cgccgccgcc gccgctgggc gcacccgggg gacgcccggg
      181 cccacgcggg gctttggggt gcgcgtctat tcgagttgtg gtggtggcaa aggaggaaga
      241 gagaaaggag gcaataaaaa aaaaaggcag cggacgggcg aactgagcga gcgaaagaag
      301 aggaggagga ggcagaaaaa ggcaacttca gacggaaagt tggtgcgaac aggcgcagtc
      361 tgcaaaaacg gaaaagtcga tcgcaggcgg cggcggcata aaagtgtgag ctgcccgggc
      421 gagctcagga ggcggcggct ggctctgccc tcccggtggc cgcgccggcg ccggctgcag
      481 ccacaggtgc gaaggagctc gcggggggcg agggcgcccc gcgcacccct cccccggccc
      541 ccaccccggg ctcgggactt cggctcaagt cactgggcgc ccgcgctccc tccccagccg
      601 cagcctccgc ggggggagca ggagtcggca gcagcggccg gcgcacgcac gcccagggga
      661 gttggggttc gcagggggtt gttttcggct ctgaagaggt ccccgcccaa ccttcaaaat
      721 tctgtccaaa agcagacaag aggatcgccc cgcgctgagc cggctggtgg gcagcaggag
      781 gcgcctgatc gccgccgggg cgctgggggt ggtgatggtg ctgctgctgg tgatcctcat
      841 cccggtgctg gtgagctcgg ccggcacgtc ggcgcactac gagatgctgg gcacctgccg
      901 catggtctgc gacccctacg ggggcaccaa ggcgcccagc accgctgcca cgcccgaccg
      961 cggcctcatg cagtccctgc ccaccttcat ccagggcccc aaaggcgagg ccggcaggcc
     1021 cgggaaggcg ggtccgcgcg ggccccccgg agagcccggg ccacccggcc ccatggggcc
     1081 cccgggcgag aagggcgagc cgggccgcca aggcctgccg ggcccgcccg gggcgcccgg
     1141 cctgaacgcg gccggggcca tcagcgccgc cacctacagc acggtgccca agatcgcctt
     1201 ctacgccggc ctcaagcggc agcatgaagg ctacgaggtg ctcaagttcg acgacgtggt
     1261 caccaacctc ggaaaccact acgaccccac caccggcaag ttcacctgct ccatcccggg
     1321 catctacttc ttcacctacc acgtcctgat gcgcggaggg gacggcacca gcatgtgggc
     1381 tgatctctgc aaaaacaacc aggtgcgtgc tagtgcaatt gcccaagatg ctgatcagaa
     1441 ttacgactat gccagtaaca gtgtggttct tcatttggag ccgggagatg aagtctatat
     1501 caaattagat ggcgggaaag cccatggagg aaacaacaac aaatacagca cgttttctgg
     1561 atttattatt tatgctgact gataatgcag aaactaagct tattattctg agtttgaaca
     1621 ctggattcgt atggctaacg tcagtgaatc aaggatccca ggggatgcca atggcagggc
     1681 acctcagttg tgtatatgtg gggaaatcaa atgctacctg actcacatct gtatcactca
     1741 gaaacattat gtaaaaaata tcaaagcaag ataagcagat gtgtgatcca ctaccgccaa
     1801 agcaaatact ccttatcgtt agtgtccatg tgaatgaagt cctatataga tcacaaattt
     1861 ttatagacaa atctaagaca ttgaattatt tcttctatat atatgatact ttggtgtact
     1921 gtgatcttgc tgcttttatc catatgtcag ctttggttct tgtgagttta cctgcttatt
     1981 atgatacttg gagtccattc atagtgtggg gaagaatgat ttttgccctg caggagaagg
     2041 tctaattgaa ataatgctgc ttgtccccaa agaaattgtt tgccttgtac tcttgttaac
     2101 cttagagcta gacctgggaa tgattcaact tcaagcctta acctggaatt ttctggattt
     2161 gagggaattc ccaagcctat gatctttttc acattttctt tttcttatat gaattttctt
     2221 ttctctcttt tctggtgata gtctttaaaa atagagattg acagtgtatc ataggattac
     2281 cctctaagtg tgaaaatgtg taattatgta cggtatttag aaaaagccct tatgtgtcca
     2341 ttttgtcaac tgaatacatt tagattcact gggaaa
//
