LOCUS       NM_006688               1527 bp    mRNA    linear   PRI 06-JUN-2024
DEFINITION  Homo sapiens complement C1q like 1 (C1QL1), mRNA.
ACCESSION   NM_006688
VERSION     NM_006688.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1527)
  AUTHORS   Celestino,R., Nome,T., Pestana,A., Hoff,A.M., Goncalves,A.P.,
            Pereira,L., Cavadas,B., Eloy,C., Bjoro,T., Sobrinho-Simoes,M.,
            Skotheim,R.I. and Soares,P.
  TITLE     CRABP1, C1QL1 and LCN2 are biomarkers of differentiated thyroid
            carcinoma, and predict extrathyroidal extension
  JOURNAL   BMC Cancer 18 (1), 68 (2018)
   PUBMED   29321030
  REMARK    GeneRIF: We conclude that the underexpression of CRABP1 and the
            overexpression of LCN2 may be useful diagnostic biomarkers in
            thyroid tumours with questionable malignity, and the overexpression
            of LCN2 and C1QL1 may be useful for prognostic purposes.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1527)
  AUTHORS   Renteria,M.E., Coolen,M.W., Statham,A.L., Choi,R.S., Qu,W.,
            Campbell,M.J., Smith,S., Henders,A.K., Montgomery,G.W., Clark,S.J.,
            Martin,N.G. and Medland,S.E.
  TITLE     GWAS of DNA methylation variation within imprinting control regions
            suggests parent-of-origin association
  JOURNAL   Twin Res Hum Genet 16 (4), 767-781 (2013)
   PUBMED   23725790
REFERENCE   3  (bases 1 to 1527)
  AUTHORS   Davila,S., Froeling,F.E., Tan,A., Bonnard,C., Boland,G.J.,
            Snippe,H., Hibberd,M.L. and Seielstad,M.
  TITLE     New genetic associations detected in a host response study to
            hepatitis B vaccine
  JOURNAL   Genes Immun 11 (3), 232-238 (2010)
   PUBMED   20237496
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   4  (bases 1 to 1527)
  AUTHORS   Peterson,J.M., Wei,Z. and Wong,G.W.
  TITLE     CTRP8 and CTRP9B are novel proteins that hetero-oligomerize with
            C1q/TNF family members
  JOURNAL   Biochem Biophys Res Commun 388 (2), 360-365 (2009)
   PUBMED   19666007
REFERENCE   5  (bases 1 to 1527)
  AUTHORS   Sie,C.P. and Maas,S.
  TITLE     Conserved recoding RNA editing of vertebrate C1q-related factor
            C1QL1
  JOURNAL   FEBS Lett 583 (7), 1171-1174 (2009)
   PUBMED   19275900
  REMARK    GeneRIF: Conserved recoding RNA editing of vertebrate C1q-related
            factor C1QL1.
REFERENCE   6  (bases 1 to 1527)
  AUTHORS   Berube,N.G., Swanson,X.H., Bertram,M.J., Kittle,J.D., Didenko,V.,
            Baskin,D.S., Smith,J.R. and Pereira-Smith,O.M.
  TITLE     Cloning and characterization of CRF, a novel C1q-related factor,
            expressed in areas of the brain involved in motor function
  JOURNAL   Brain Res Mol Brain Res 63 (2), 233-240 (1999)
   PUBMED   9878755
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC015936.14 and BC008798.2.
            
            On Nov 23, 2018 this sequence version replaced NM_006688.4.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC008798.2, BI603927.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968189, SAMEA1968540
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000253407.4/ ENSP00000253407.2
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-27                AC015936.14        142598-142624       c
            28-1396             BC008798.2         1-1369
            1397-1397           AC015936.14        134144-134144       c
            1398-1527           BC008798.2         1371-1500
FEATURES             Location/Qualifiers
     source          1..1527
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17q21.31"
     gene            1..1527
                     /gene="C1QL1"
                     /gene_synonym="C1QRF; C1QTNF14; CRF; CTRP14"
                     /note="complement C1q like 1"
                     /db_xref="GeneID:10882"
                     /db_xref="HGNC:HGNC:24182"
                     /db_xref="MIM:611586"
     exon            1..852
                     /gene="C1QL1"
                     /gene_synonym="C1QRF; C1QTNF14; CRF; CTRP14"
                     /inference="alignment:Splign:2.1.0"
     CDS             256..1032
                     /gene="C1QL1"
                     /gene_synonym="C1QRF; C1QTNF14; CRF; CTRP14"
                     /note="C1q-related factor; complement component 1, q
                     subcomponent-like 1; C1q/TNF-related protein 14; C1q and
                     tumor necrosis factor-related protein 14"
                     /codon_start=1
                     /product="C1q-related factor precursor"
                     /protein_id="NP_006679.1"
                     /db_xref="CCDS:CCDS11492.1"
                     /db_xref="GeneID:10882"
                     /db_xref="HGNC:HGNC:24182"
                     /db_xref="MIM:611586"
                     /translation="MLLVLVVLIPVLVSSGGPEGHYEMLGTCRMVCDPYPARGPGAGA
                     RTDGGDALSEQSGAPPPSTLVQGPQGKPGRTGKPGPPGPPGDPGPPGPVGPPGEKGEP
                     GKPGPPGLPGAGGSGAISTATYTTVPRVAFYAGLKNPHEGYEVLKFDDVVTNLGNNYD
                     AASGKFTCNIPGTYFFTYHVLMRGGDGTSMWADLCKNGQVRASAIAQDADQNYDYASN
                     SVILHLDAGDEVFIKLDGGKAHGGNSNKYSTFSGFIIYSD"
     exon            853..1527
                     /gene="C1QL1"
                     /gene_synonym="C1QRF; C1QTNF14; CRF; CTRP14"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1505..1510
                     /regulatory_class="polyA_signal_sequence"
                     /gene="C1QL1"
                     /gene_synonym="C1QRF; C1QTNF14; CRF; CTRP14"
                     /note="hexamer: AATAAA"
     polyA_site      1527
                     /gene="C1QL1"
                     /gene_synonym="C1QRF; C1QTNF14; CRF; CTRP14"
                     /note="major polyA site"
ORIGIN      
        1 agtccggcag cgcagcagga gggaggcgcg aggcaggagc cggcggctgg gctccgcagc
       61 gcagccagcg cagcgcggcg ccccgggccc ggccccatgc ccgcagcccc gccggaccgt
      121 ccttgagcgc gggcgcctag cccgcgcccc ctgcccgccg gcaccattgc cccgacggcg
      181 cggccgggcg gcccggcgct ccccaggctc cgcgcgggcc gaaagacgct gctagcggcc
      241 gccgcgggtg tggtgatgct gctggtgctg gtggtgctca tccccgtgct ggtgagctcg
      301 ggcggcccgg aaggccacta tgagatgctg ggcacctgcc gcatggtgtg cgacccctac
      361 cccgcgcggg gccccggcgc cggcgcgcgg accgacggcg gcgacgccct gagcgagcag
      421 agcggcgcgc ccccgccttc cacgctggtg cagggccccc aggggaagcc gggccgcacc
      481 ggcaagcccg gccctccggg gcctcccggg gacccaggtc ctcccggccc tgtggggccg
      541 ccgggggaga agggtgagcc aggcaagccg ggccctccgg ggctgccggg cgcggggggc
      601 agcggcgcca tcagcactgc cacctacacc acggtgccgc gcgtggcctt ctacgccggc
      661 ctcaagaacc cccacgaggg ttacgaggta ctcaagtttg acgacgtggt caccaaccta
      721 ggcaacaact acgacgcggc cagcggcaag tttacgtgca acattcccgg cacctacttt
      781 ttcacctacc atgtcctcat gcgcggcggc gacggcacca gtatgtgggc agacctctgc
      841 aagaatggcc aggtgcgggc cagtgctatt gcccaggacg cggaccagaa ctacgactac
      901 gccagcaaca gcgtgatcct gcacctggac gccggcgacg aggtcttcat caagctggat
      961 ggaggcaaag cacacggcgg caacagcaac aaatacagca cgttctctgg cttcatcatc
     1021 tactccgact gagctcccca cgtctccctc cacccacgtc cctcacccgc cggggtcccc
     1081 tccgggcggg gcagacgatg actcgcccct cgcccacccg ctcgctgccc ggccctcccc
     1141 ggctatgacg cccccggccc gtgctcaaca ccgcctgggc cacagctagg ccctcccacc
     1201 ggctcgctgc agagccgggc ccagcgcgcc ctgtccccgt gccagggaac cggggttgac
     1261 cgcccccgcc cagcccgcgc tatatatttg tacaatagga ctgtttactg cccacctccg
     1321 cctgccagcc caccccagcc tggggagagg tcgcggcggc gggtttgctt cctgcgctct
     1381 gagatgagct gccctccgct ccctccgggg tggcgcgccc gggggagggg ggagttgggg
     1441 gctggatagc ttcccagcac cctcagagcc cccgcccggc tgtgccccgt ctgaccaaag
     1501 ttataataaa aacattttca ccccgca
//
