LOCUS       NM_001212               1169 bp    mRNA    linear   PRI 18-NOV-2024
DEFINITION  Homo sapiens complement C1q binding protein (C1QBP), mRNA; nuclear
            gene for mitochondrial product.
ACCESSION   NM_001212
VERSION     NM_001212.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1169)
  AUTHORS   Kim,S., Tan,S., Ku,J., Widowati,T.A., Ku,D., Lee,K., You,K. and
            Kim,Y.
  TITLE     RNA 5-methylcytosine marks mitochondrial double-stranded RNAs for
            degradation and cytosolic release
  JOURNAL   Mol Cell 84 (15), 2935-2948 (2024)
   PUBMED   39019044
REFERENCE   2  (bases 1 to 1169)
  AUTHORS   Egusquiza-Alvarez,C.A., Moreno-Londono,A.P., Alvarado-Ortiz,E.,
            Ramos-Godinez,M.D.P., Sarabia-Sanchez,M.A., Castaneda-Patlan,M.C.
            and Robles-Flores,M.
  TITLE     Inhibition of Multifunctional Protein p32/C1QBP Promotes Cytostatic
            Effects in Colon Cancer Cells by Altering Mitogenic Signaling
            Pathways and Promoting Mitochondrial Damage
  JOURNAL   Int J Mol Sci 25 (5), 2712 (2024)
   PUBMED   38473963
  REMARK    GeneRIF: Inhibition of Multifunctional Protein p32/C1QBP Promotes
            Cytostatic Effects in Colon Cancer Cells by Altering Mitogenic
            Signaling Pathways and Promoting Mitochondrial Damage.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1169)
  AUTHORS   Tio,M., Wen,R., Choo,C.N., Tan,J.B., Chua,A., Xiao,B.,
            Sundaram,J.R., Chan,C.H.S. and Tan,E.K.
  TITLE     Genetic and pharmacologic p32-inhibition rescue CHCHD2-linked
            Parkinson's disease phenotypes in vivo and in cell models
  JOURNAL   J Biomed Sci 31 (1), 24 (2024)
   PUBMED   38395904
  REMARK    GeneRIF: Genetic and pharmacologic p32-inhibition rescue
            CHCHD2-linked Parkinson's disease phenotypes in vivo and in cell
            models.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1169)
  AUTHORS   Scully,O.J., Shyamasundar,S., Matsumoto,K., Dheen,S.T., Yip,G.W.
            and Bay,B.H.
  TITLE     C1QBP Mediates Breast Cancer Cell Proliferation and Growth via
            Multiple Potential Signalling Pathways
  JOURNAL   Int J Mol Sci 24 (2), 1343 (2023)
   PUBMED   36674861
  REMARK    GeneRIF: C1QBP Mediates Breast Cancer Cell Proliferation and Growth
            via Multiple Potential Signalling Pathways.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1169)
  AUTHORS   Freda,C.T., Yin,W., Ghebrehiwet,B. and Rubenstein,D.A.
  TITLE     Complement component C1q initiates extrinsic coagulation via the
            receptor for the globular head of C1q in adventitial fibroblasts
            and vascular smooth muscle cells
  JOURNAL   Immun Inflamm Dis 11 (1), e769 (2023)
   PUBMED   36705413
  REMARK    GeneRIF: Complement component C1q initiates extrinsic coagulation
            via the receptor for the globular head of C1q in adventitial
            fibroblasts and vascular smooth muscle cells.
REFERENCE   6  (bases 1 to 1169)
  AUTHORS   Fridell,R.A., Harding,L.S., Bogerd,H.P. and Cullen,B.R.
  TITLE     Identification of a novel human zinc finger protein that
            specifically interacts with the activation domain of lentiviral Tat
            proteins
  JOURNAL   Virology 209 (2), 347-357 (1995)
   PUBMED   7778269
REFERENCE   7  (bases 1 to 1169)
  AUTHORS   Ghebrehiwet,B., Lim,B.L., Peerschke,E.I., Willis,A.C. and Reid,K.B.
  TITLE     Isolation, cDNA cloning, and overexpression of a 33-kD cell surface
            glycoprotein that binds to the globular 'heads' of C1q
  JOURNAL   J Exp Med 179 (6), 1809-1821 (1994)
   PUBMED   8195709
REFERENCE   8  (bases 1 to 1169)
  AUTHORS   Luo,Y., Yu,H. and Peterlin,B.M.
  TITLE     Cellular protein modulates effects of human immunodeficiency virus
            type 1 Rev
  JOURNAL   J Virol 68 (6), 3850-3856 (1994)
   PUBMED   8189522
REFERENCE   9  (bases 1 to 1169)
  AUTHORS   Krainer,A.R., Mayeda,A., Kozak,D. and Binns,G.
  TITLE     Functional expression of cloned human splicing factor SF2: homology
            to RNA-binding proteins, U1 70K, and Drosophila splicing regulators
  JOURNAL   Cell 66 (2), 383-394 (1991)
   PUBMED   1830244
REFERENCE   10 (bases 1 to 1169)
  AUTHORS   Busby,T.F. and Ingham,K.C.
  TITLE     NH2-terminal calcium-binding domain of human complement C1s-
            mediates the interaction of C1r- with C1q
  JOURNAL   Biochemistry 29 (19), 4613-4618 (1990)
   PUBMED   2372546
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC004148.1 and L04636.1.
            
            On Nov 23, 2018 this sequence version replaced NM_001212.3.
            
            Summary: The human complement subcomponent C1q associates with C1r
            and C1s in order to yield the first component of the serum
            complement system. The protein encoded by this gene is known to
            bind to the globular heads of C1q molecules and inhibit C1
            activation. This protein has also been identified as the p32
            subunit of pre-mRNA splicing factor SF2, as well as a hyaluronic
            acid-binding protein. [provided by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1163655.675649.1,
                                           SRR1163655.239161.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN03267753, SAMN03267760
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: reported by MitoCarta
            MANE Ensembl match                 :: ENST00000225698.8/
                                                  ENSP00000225698.4
            RefSeq Select criteria             :: based on single
                                                  protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-4                 AC004148.1         66691-66694         c
            5-1167              L04636.1           1-1163
            1168-1169           AC004148.1         60316-60317         c
FEATURES             Location/Qualifiers
     source          1..1169
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17p13.2"
     gene            1..1169
                     /gene="C1QBP"
                     /gene_synonym="COXPD33; gC1Q-R; GC1QBP; gC1qR; HABP1; p32;
                     SF2AP32; SF2p32"
                     /note="complement C1q binding protein"
                     /db_xref="GeneID:708"
                     /db_xref="HGNC:HGNC:1243"
                     /db_xref="MIM:601269"
     exon            1..314
                     /gene="C1QBP"
                     /gene_synonym="COXPD33; gC1Q-R; GC1QBP; gC1qR; HABP1; p32;
                     SF2AP32; SF2p32"
                     /inference="alignment:Splign:2.1.0"
     exon            315..465
                     /gene="C1QBP"
                     /gene_synonym="COXPD33; gC1Q-R; GC1QBP; gC1qR; HABP1; p32;
                     SF2AP32; SF2p32"
                     /inference="alignment:Splign:2.1.0"
     exon            466..559
                     /gene="C1QBP"
                     /gene_synonym="COXPD33; gC1Q-R; GC1QBP; gC1qR; HABP1; p32;
                     SF2AP32; SF2p32"
                     /inference="alignment:Splign:2.1.0"
     exon            560..658
                     /gene="C1QBP"
                     /gene_synonym="COXPD33; gC1Q-R; GC1QBP; gC1qR; HABP1; p32;
                     SF2AP32; SF2p32"
                     /inference="alignment:Splign:2.1.0"
     exon            659..781
                     /gene="C1QBP"
                     /gene_synonym="COXPD33; gC1Q-R; GC1QBP; gC1qR; HABP1; p32;
                     SF2AP32; SF2p32"
                     /inference="alignment:Splign:2.1.0"
     exon            782..1169
                     /gene="C1QBP"
                     /gene_synonym="COXPD33; gC1Q-R; GC1QBP; gC1qR; HABP1; p32;
                     SF2AP32; SF2p32"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1145..1150
                     /regulatory_class="polyA_signal_sequence"
                     /gene="C1QBP"
                     /gene_synonym="COXPD33; gC1Q-R; GC1QBP; gC1qR; HABP1; p32;
                     SF2AP32; SF2p32"
                     /note="hexamer: CATAAA"
     polyA_site      1169
                     /gene="C1QBP"
                     /gene_synonym="COXPD33; gC1Q-R; GC1QBP; gC1qR; HABP1; p32;
                     SF2AP32; SF2p32"
                     /note="major polyA site"
ORIGIN      
        1 gcttccggcg gcgcctcagg tcgcggggcg cctaggcctg ggttgtcctt tgcatctgca
       61 cgtgttcgca gtcgtttccg cgatgctgcc tctgctgcgc tgcgtgcccc gtgtgctggg
      121 ctcctccgtc gccggcctcc gcgctgccgc gcccgcctcg cctttccggc agctcctgca
      181 gccggcaccc cggctgtgca cccggccctt cgggctgctc agcgtgcgcg caggttccga
      241 gcggcggccg ggcctcctgc ggcctcgcgg accctgcgcc tgtggctgtg gctgcggctc
      301 gctgcacacc gacggagaca aagcttttgt tgatttcctg agtgatgaaa ttaaggagga
      361 aagaaaaatt cagaagcata aaaccctccc taagatgtct ggaggttggg agctggaact
      421 gaatgggaca gaagcgaaat tagtgcggaa agttgccggg gaaaaaatca cggtcacttt
      481 caacattaac aacagcatcc caccaacatt tgatggtgag gaggaaccct cgcaagggca
      541 gaaggttgaa gaacaggagc ctgaactgac atcaactccc aatttcgtgg ttgaagttat
      601 aaagaatgat gatggcaaga aggcccttgt gttggactgt cattatccag aggatgaggt
      661 tggacaagaa gacgaggctg agagtgacat cttctctatc agggaagtta gctttcagtc
      721 cactggcgag tctgaatgga aggatactaa ttatacactc aacacagatt ccttggactg
      781 ggccttatat gaccacctaa tggatttcct tgccgaccga ggggtggaca acacttttgc
      841 agatgagctg gtggagctca gcacagccct ggagcaccag gagtacatta cttttcttga
      901 agacctcaag agttttgtca agagccagta gagcagacag atgctgaaag ccatagtttc
      961 atggcaggct ttggccagtg aacaaatcct actctgaagc tagacatgtg ctttgaaatg
     1021 attatcatcc taatatcatg ggggaaaaaa taccaaattt aaattatatg ttttgtgttc
     1081 tcatttatta tcattttttt ctgtacaaat ctattatttc tagatttttg tataacatga
     1141 tagacataaa attggtttat ctcctccaa
//
