LOCUS       NM_001371184            1251 bp    mRNA    linear   PRI 10-FEB-2025
DEFINITION  Homo sapiens complement C1q B chain (C1QB), transcript variant 1,
            mRNA.
ACCESSION   NM_001371184
VERSION     NM_001371184.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1251)
  AUTHORS   Hu,Y., Yu,Y., Dong,H. and Jiang,W.
  TITLE     Identifying C1QB, ITGAM, and ITGB2 as potential diagnostic
            candidate genes for diabetic nephropathy using bioinformatics
            analysis
  JOURNAL   PeerJ 11, e15437 (2023)
   PUBMED   37250717
  REMARK    GeneRIF: Identifying C1QB, ITGAM, and ITGB2 as potential diagnostic
            candidate genes for diabetic nephropathy using bioinformatics
            analysis.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1251)
  AUTHORS   Liang,Z., Pan,L., Shi,J. and Zhang,L.
  TITLE     C1QA, C1QB, and GZMB are novel prognostic biomarkers of skin
            cutaneous melanoma relating tumor microenvironment
  JOURNAL   Sci Rep 12 (1), 20460 (2022)
   PUBMED   36443341
  REMARK    GeneRIF: C1QA, C1QB, and GZMB are novel prognostic biomarkers of
            skin cutaneous melanoma relating tumor microenvironment.
            Erratum:[Sci Rep. 2023 Jul 6;13(1):10973. doi:
            10.1038/s41598-023-37876-6.. PMID: 37414837]
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1251)
  AUTHORS   Jiao,Y., Jiang,S., Wang,Y., Yu,T., Zou,G., Zhuo,L. and Li,W.
  TITLE     Activation of complement C1q and C3 in glomeruli might accelerate
            the progression of diabetic nephropathy: Evidence from
            transcriptomic data and renal histopathology
  JOURNAL   J Diabetes Investig 13 (5), 839-849 (2022)
   PUBMED   34932275
  REMARK    GeneRIF: Activation of complement C1q and C3 in glomeruli might
            accelerate the progression of diabetic nephropathy: Evidence from
            transcriptomic data and renal histopathology.
REFERENCE   4  (bases 1 to 1251)
  AUTHORS   Son,M., Diamond,B. and Santiago-Schwarz,F.
  TITLE     Fundamental role of C1q in autoimmunity and inflammation
  JOURNAL   Immunol Res 63 (1-3), 101-106 (2015)
   PUBMED   26410546
  REMARK    Review article
REFERENCE   5  (bases 1 to 1251)
  AUTHORS   Kouser,L., Madhukaran,S.P., Shastri,A., Saraon,A., Ferluga,J.,
            Al-Mozaini,M. and Kishore,U.
  TITLE     Emerging and Novel Functions of Complement Protein C1q
  JOURNAL   Front Immunol 6, 317 (2015)
   PUBMED   26175731
  REMARK    Review article
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1251)
  AUTHORS   Sellar,G.C., Cockburn,D. and Reid,K.B.
  TITLE     Localization of the gene cluster encoding the A, B, and C chains of
            human C1q to 1p34.1-1p36.3
  JOURNAL   Immunogenetics 35 (3), 214-216 (1992)
   PUBMED   1537612
REFERENCE   7  (bases 1 to 1251)
  AUTHORS   Sellar,G.C., Blake,D.J. and Reid,K.B.
  TITLE     Characterization and organization of the genes encoding the A-, B-
            and C-chains of human complement subcomponent C1q. The complete
            derived amino acid sequence of human C1q
  JOURNAL   Biochem J 274 (Pt 2) (Pt 2), 481-490 (1991)
   PUBMED   1706597
REFERENCE   8  (bases 1 to 1251)
  AUTHORS   Reid,K.B., Bentley,D.R. and Wood,K.J.
  TITLE     Cloning and characterization of the complementary DNA for the B
            chain of normal human serum C1q
  JOURNAL   Philos Trans R Soc Lond B Biol Sci 306 (1129), 345-354 (1984)
   PUBMED   6208566
REFERENCE   9  (bases 1 to 1251)
  AUTHORS   Reid,K.B.
  TITLE     Complete amino acid sequences of the three collagen-like regions
            present in subcomponent C1q of the first component of human
            complement
  JOURNAL   Biochem J 179 (2), 367-371 (1979)
   PUBMED   486087
REFERENCE   10 (bases 1 to 1251)
  AUTHORS   Reid,K.B.
  TITLE     Isolation, by partial pepsin digestion, of the three collagen-like
            regions present in subcomponent Clq of the first component of human
            complement
  JOURNAL   Biochem J 155 (1), 5-17 (1976)
   PUBMED   7240
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BQ711602.1, BI489644.1,
            X03084.1, AI125081.1 and AA838059.1.
            
            On Jan 30, 2020 this sequence version replaced NM_001371184.2.
            
            Summary: This gene encodes the B-chain polypeptide of serum
            complement subcomponent C1q, which associates with C1r and C1s to
            yield the first component of the serum complement system. C1q is
            composed of 18 polypeptide chains which include 6 A-chains, 6
            B-chains, and 6 C-chains. Each chain contains an N-terminal
            collagen-like region and a C-terminal C1q globular domain. C1q
            deficiency is associated with lupus erythematosus and
            glomerulonephritis. [provided by RefSeq, Dec 2016].
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes isoform 2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BQ711602.1, BI489644.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            CDS uses downstream in-frame AUG :: upstream AUG and CDS extension
                                                is not conserved
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-10                BQ711602.1         57-66
            11-560              BI489644.1         1-550
            561-1078            X03084.1           249-766
            1079-1150           AI125081.1         8-79                c
            1151-1251           AA838059.1         7-107               c
FEATURES             Location/Qualifiers
     source          1..1251
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1p36.12"
     gene            1..1251
                     /gene="C1QB"
                     /gene_synonym="C1QD2"
                     /note="complement C1q B chain"
                     /db_xref="GeneID:713"
                     /db_xref="HGNC:HGNC:1242"
                     /db_xref="MIM:120570"
     exon            1..68
                     /gene="C1QB"
                     /gene_synonym="C1QD2"
                     /inference="alignment:Splign:2.1.0"
     exon            69..221
                     /gene="C1QB"
                     /gene_synonym="C1QD2"
                     /inference="alignment:Splign:2.1.0"
     exon            222..425
                     /gene="C1QB"
                     /gene_synonym="C1QD2"
                     /inference="alignment:Splign:2.1.0"
     CDS             245..1000
                     /gene="C1QB"
                     /gene_synonym="C1QD2"
                     /note="isoform 2 precursor is encoded by transcript
                     variant 1; complement component C1q, B chain; complement
                     component 1, q subcomponent, beta polypeptide; complement
                     C1q subcomponent subunit B; complement component 1, q
                     subcomponent, B chain; complement C1q chain B; complement
                     subcomponent C1q chain B"
                     /codon_start=1
                     /product="complement C1q subcomponent subunit B isoform 2
                     precursor"
                     /protein_id="NP_001358113.2"
                     /db_xref="CCDS:CCDS90878.1"
                     /db_xref="GeneID:713"
                     /db_xref="HGNC:HGNC:1242"
                     /db_xref="MIM:120570"
                     /translation="MKIPWGSIPVLMLLLLLGLIDISQAQLSCTGPPAIPGIPGIPGT
                     PGPDGQPGTPGIKGEKGLPGLAGDHGEFGEKGDPGIPGNPGKVGPKGPMGPKGGPGAP
                     GAPGPKGESGDYKATQKIAFSATRTINVPLRRDQTIRFDHVITNMNNNYEPRSGKFTC
                     KVPGLYYFTYHASSRGNLCVNLMRGRERAQKVVTFCDYAYNTFQVTTGGMVLKLEQGE
                     NVFLQATDKNSLLGMEGANSIFSGFLLFPDMEA"
     exon            426..1251
                     /gene="C1QB"
                     /gene_synonym="C1QD2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1127..1132
                     /regulatory_class="polyA_signal_sequence"
                     /gene="C1QB"
                     /gene_synonym="C1QD2"
                     /note="hexamer: AATAAA"
     polyA_site      1146
                     /gene="C1QB"
                     /gene_synonym="C1QD2"
                     /note="major polyA site"
     regulatory      1230..1235
                     /regulatory_class="polyA_signal_sequence"
                     /gene="C1QB"
                     /gene_synonym="C1QD2"
                     /note="hexamer: AATGAA"
     polyA_site      1251
                     /gene="C1QB"
                     /gene_synonym="C1QD2"
ORIGIN      
        1 agtaggctct cggctcctgg tcccactgct gctcagccca gtggcctcac aggacaccag
       61 cttcccagcc ctgtcaggtt gaaatcagca ttgccaagag gctcagagag gttaaggcac
      121 ttgcctgagg ttatgcagcc ggtagcagat ggggctttaa agtcaagtgg gcctgactcc
      181 atgttgcgga aagggactgc tggaccgaag gagatggaaa ggaggcgtct gacacagtat
      241 gatgatgaag atcccatggg gcagcatccc agtactgatg ttgctcctgc tcctgggcct
      301 aatcgatatc tcccaggccc agctcagctg caccgggccc ccagccatcc ctggcatccc
      361 gggtatccct gggacacctg gccccgatgg ccaacctggg accccaggga taaaaggaga
      421 gaaagggctt ccagggctgg ctggagacca tggtgagttc ggagagaagg gagacccagg
      481 gattcctggg aatccaggaa aagtcggccc caagggcccc atgggcccta aaggtggccc
      541 aggggcccct ggagccccag gccccaaagg tgaatcggga gactacaagg ccacccagaa
      601 aatcgccttc tctgccacaa gaaccatcaa cgtccccctg cgccgggacc agaccatccg
      661 cttcgaccac gtgatcacca acatgaacaa caattatgag ccccgcagtg gcaagttcac
      721 ctgcaaggtg cccggtctct actacttcac ctaccacgcc agctctcgag ggaacctgtg
      781 cgtgaacctc atgcgtggcc gggagcgtgc acagaaggtg gtcaccttct gtgactatgc
      841 ctacaacacc ttccaggtca ccaccggtgg catggtcctc aagctggagc agggggagaa
      901 cgtcttcctg caggccaccg acaagaactc actactgggc atggagggtg ccaacagcat
      961 cttttccggg ttcctgctct ttccagatat ggaggcctga cctgtgggct gcttcacatc
     1021 caccccggct ccccctgcca gcaacgctca ctctaccccc aacaccaccc cttgcccaac
     1081 caatgcacac agtagggctt ggtgaatgct gctgagtgaa tgagtaaata aactcttcaa
     1141 ggccaaggga cagtggtcta attcaactct gtgtcccagc acctggcaca ccagaagtgc
     1201 catgctcaga aatgttggtt acatgaatga atgaaccatg aatgaatgaa a
//
