LOCUS       NM_000491               1098 bp    mRNA    linear   PRI 09-FEB-2025
DEFINITION  Homo sapiens complement C1q B chain (C1QB), transcript variant 2,
            mRNA.
ACCESSION   NM_000491
VERSION     NM_000491.5
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1098)
  AUTHORS   Hu,Y., Yu,Y., Dong,H. and Jiang,W.
  TITLE     Identifying C1QB, ITGAM, and ITGB2 as potential diagnostic
            candidate genes for diabetic nephropathy using bioinformatics
            analysis
  JOURNAL   PeerJ 11, e15437 (2023)
   PUBMED   37250717
  REMARK    GeneRIF: Identifying C1QB, ITGAM, and ITGB2 as potential diagnostic
            candidate genes for diabetic nephropathy using bioinformatics
            analysis.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1098)
  AUTHORS   Liang,Z., Pan,L., Shi,J. and Zhang,L.
  TITLE     C1QA, C1QB, and GZMB are novel prognostic biomarkers of skin
            cutaneous melanoma relating tumor microenvironment
  JOURNAL   Sci Rep 12 (1), 20460 (2022)
   PUBMED   36443341
  REMARK    GeneRIF: C1QA, C1QB, and GZMB are novel prognostic biomarkers of
            skin cutaneous melanoma relating tumor microenvironment.
            Erratum:[Sci Rep. 2023 Jul 6;13(1):10973. doi:
            10.1038/s41598-023-37876-6.. PMID: 37414837]
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1098)
  AUTHORS   Jiao,Y., Jiang,S., Wang,Y., Yu,T., Zou,G., Zhuo,L. and Li,W.
  TITLE     Activation of complement C1q and C3 in glomeruli might accelerate
            the progression of diabetic nephropathy: Evidence from
            transcriptomic data and renal histopathology
  JOURNAL   J Diabetes Investig 13 (5), 839-849 (2022)
   PUBMED   34932275
  REMARK    GeneRIF: Activation of complement C1q and C3 in glomeruli might
            accelerate the progression of diabetic nephropathy: Evidence from
            transcriptomic data and renal histopathology.
REFERENCE   4  (bases 1 to 1098)
  AUTHORS   Son,M., Diamond,B. and Santiago-Schwarz,F.
  TITLE     Fundamental role of C1q in autoimmunity and inflammation
  JOURNAL   Immunol Res 63 (1-3), 101-106 (2015)
   PUBMED   26410546
  REMARK    Review article
REFERENCE   5  (bases 1 to 1098)
  AUTHORS   Kouser,L., Madhukaran,S.P., Shastri,A., Saraon,A., Ferluga,J.,
            Al-Mozaini,M. and Kishore,U.
  TITLE     Emerging and Novel Functions of Complement Protein C1q
  JOURNAL   Front Immunol 6, 317 (2015)
   PUBMED   26175731
  REMARK    Review article
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1098)
  AUTHORS   Sellar,G.C., Cockburn,D. and Reid,K.B.
  TITLE     Localization of the gene cluster encoding the A, B, and C chains of
            human C1q to 1p34.1-1p36.3
  JOURNAL   Immunogenetics 35 (3), 214-216 (1992)
   PUBMED   1537612
REFERENCE   7  (bases 1 to 1098)
  AUTHORS   Sellar,G.C., Blake,D.J. and Reid,K.B.
  TITLE     Characterization and organization of the genes encoding the A-, B-
            and C-chains of human complement subcomponent C1q. The complete
            derived amino acid sequence of human C1q
  JOURNAL   Biochem J 274 (Pt 2) (Pt 2), 481-490 (1991)
   PUBMED   1706597
REFERENCE   8  (bases 1 to 1098)
  AUTHORS   Reid,K.B., Bentley,D.R. and Wood,K.J.
  TITLE     Cloning and characterization of the complementary DNA for the B
            chain of normal human serum C1q
  JOURNAL   Philos Trans R Soc Lond B Biol Sci 306 (1129), 345-354 (1984)
   PUBMED   6208566
REFERENCE   9  (bases 1 to 1098)
  AUTHORS   Reid,K.B.
  TITLE     Complete amino acid sequences of the three collagen-like regions
            present in subcomponent C1q of the first component of human
            complement
  JOURNAL   Biochem J 179 (2), 367-371 (1979)
   PUBMED   486087
REFERENCE   10 (bases 1 to 1098)
  AUTHORS   Reid,K.B.
  TITLE     Isolation, by partial pepsin digestion, of the three collagen-like
            regions present in subcomponent Clq of the first component of human
            complement
  JOURNAL   Biochem J 155 (1), 5-17 (1976)
   PUBMED   7240
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL158086.32.
            
            On Nov 23, 2018 this sequence version replaced NM_000491.4.
            
            Summary: This gene encodes the B-chain polypeptide of serum
            complement subcomponent C1q, which associates with C1r and C1s to
            yield the first component of the serum complement system. C1q is
            composed of 18 polypeptide chains which include 6 A-chains, 6
            B-chains, and 6 C-chains. Each chain contains an N-terminal
            collagen-like region and a C-terminal C1q globular domain. C1q
            deficiency is associated with lupus erythematosus and
            glomerulonephritis. [provided by RefSeq, Dec 2016].
            
            Transcript Variant: This variant (2) differs in the 5' UTR,
            compared to variant 1. Variants 1 and 2 encode the same protein.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR3476690.525733.1,
                                           SRR3476690.1172121.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-68                AL158086.32        25953-26020
            69-272              AL158086.32        32157-32360
            273-1098            AL158086.32        33529-34354
FEATURES             Location/Qualifiers
     source          1..1098
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1p36.12"
     gene            1..1098
                     /gene="C1QB"
                     /gene_synonym="C1QD2"
                     /note="complement C1q B chain"
                     /db_xref="GeneID:713"
                     /db_xref="HGNC:HGNC:1242"
                     /db_xref="MIM:120570"
     exon            1..68
                     /gene="C1QB"
                     /gene_synonym="C1QD2"
                     /inference="alignment:Splign:2.1.0"
     exon            69..272
                     /gene="C1QB"
                     /gene_synonym="C1QD2"
                     /inference="alignment:Splign:2.1.0"
     CDS             86..847
                     /gene="C1QB"
                     /gene_synonym="C1QD2"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 2; complement component C1q, B chain; complement
                     component 1, q subcomponent, beta polypeptide; complement
                     C1q subcomponent subunit B; complement component 1, q
                     subcomponent, B chain; complement C1q chain B; complement
                     subcomponent C1q chain B"
                     /codon_start=1
                     /product="complement C1q subcomponent subunit B isoform 1
                     precursor"
                     /protein_id="NP_000482.3"
                     /db_xref="GeneID:713"
                     /db_xref="HGNC:HGNC:1242"
                     /db_xref="MIM:120570"
                     /translation="MMMKIPWGSIPVLMLLLLLGLIDISQAQLSCTGPPAIPGIPGIP
                     GTPGPDGQPGTPGIKGEKGLPGLAGDHGEFGEKGDPGIPGNPGKVGPKGPMGPKGGPG
                     APGAPGPKGESGDYKATQKIAFSATRTINVPLRRDQTIRFDHVITNMNNNYEPRSGKF
                     TCKVPGLYYFTYHASSRGNLCVNLMRGRERAQKVVTFCDYAYNTFQVTTGGMVLKLEQ
                     GENVFLQATDKNSLLGMEGANSIFSGFLLFPDMEA"
     exon            273..1098
                     /gene="C1QB"
                     /gene_synonym="C1QD2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      974..979
                     /regulatory_class="polyA_signal_sequence"
                     /gene="C1QB"
                     /gene_synonym="C1QD2"
                     /note="hexamer: AATAAA"
     polyA_site      993
                     /gene="C1QB"
                     /gene_synonym="C1QD2"
                     /note="major polyA site"
     regulatory      1077..1082
                     /regulatory_class="polyA_signal_sequence"
                     /gene="C1QB"
                     /gene_synonym="C1QD2"
                     /note="hexamer: AATGAA"
     polyA_site      1098
                     /gene="C1QB"
                     /gene_synonym="C1QD2"
ORIGIN      
        1 agtaggctct cggctcctgg tcccactgct gctcagccca gtggcctcac aggacaccag
       61 cttcccagga ggcgtctgac acagtatgat gatgaagatc ccatggggca gcatcccagt
      121 actgatgttg ctcctgctcc tgggcctaat cgatatctcc caggcccagc tcagctgcac
      181 cgggccccca gccatccctg gcatcccggg tatccctggg acacctggcc ccgatggcca
      241 acctgggacc ccagggataa aaggagagaa agggcttcca gggctggctg gagaccatgg
      301 tgagttcgga gagaagggag acccagggat tcctgggaat ccaggaaaag tcggccccaa
      361 gggccccatg ggccctaaag gtggcccagg ggcccctgga gccccaggcc ccaaaggtga
      421 atcgggagac tacaaggcca cccagaaaat cgccttctct gccacaagaa ccatcaacgt
      481 ccccctgcgc cgggaccaga ccatccgctt cgaccacgtg atcaccaaca tgaacaacaa
      541 ttatgagccc cgcagtggca agttcacctg caaggtgccc ggtctctact acttcaccta
      601 ccacgccagc tctcgaggga acctgtgcgt gaacctcatg cgtggccggg agcgtgcaca
      661 gaaggtggtc accttctgtg actatgccta caacaccttc caggtcacca ccggtggcat
      721 ggtcctcaag ctggagcagg gggagaacgt cttcctgcag gccaccgaca agaactcact
      781 actgggcatg gagggtgcca acagcatctt ttccgggttc ctgctctttc cagatatgga
      841 ggcctgacct gtgggctgct tcacatccac cccggctccc cctgccagca acgctcactc
      901 tacccccaac accacccctt gcccaaccaa tgcacacagt agggcttggt gaatgctgct
      961 gagtgaatga gtaaataaac tcttcaaggc caagggacag tggtctaatt caactctgtg
     1021 tcccagcacc tggcacacca gaagtgccat gctcagaaat gttggttaca tgaatgaatg
     1081 aaccatgaat gaatgaaa
//
