LOCUS       NM_173177               2241 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens C1D nuclear receptor corepressor (C1D), transcript
            variant 2, mRNA.
ACCESSION   NM_173177
VERSION     NM_173177.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2241)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   2  (bases 1 to 2241)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   3  (bases 1 to 2241)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   4  (bases 1 to 2241)
  AUTHORS   Tomita,T., Ieguchi,K., Takita,M., Tsukahara,F., Yamada,M.,
            Egly,J.M. and Maru,Y.
  TITLE     C1D is not directly involved in the repair of UV-damaged DNA but
            protects cells from oxidative stress by regulating gene expressions
            in human cell lines
  JOURNAL   J Biochem 164 (6), 415-426 (2018)
   PUBMED   30165670
  REMARK    GeneRIF: Data confirm that C1D is not directly involved in repair
            of UV-damaged DNA; C1D appears to protects cells from oxidative
            stress (induced by UV irradiation or hydrogen peroxide oxidation)
            by regulating expression of DNA repair/transcription enzymes such
            as APEX1 or DDIT3. (C1D = nuclear receptor corepressor C1D; APEX1 =
            apurinic/apyrimidinic endodeoxyribonuclease-1; DDIT3 = DNA damage
            inducible transcript-3)
REFERENCE   5  (bases 1 to 2241)
  AUTHORS   Li,G., Liu,J., Abu-Asab,M., Masabumi,S. and Maru,Y.
  TITLE     XPB induces C1D expression to counteract UV-induced apoptosis
  JOURNAL   Mol Cancer Res 8 (6), 885-895 (2010)
   PUBMED   20530579
  REMARK    GeneRIF: C1D is associated with the DNA repair complex and may
            promote repair of ultraviolet irradiation-induced DNA damage.
REFERENCE   6  (bases 1 to 2241)
  AUTHORS   Rothbarth,K., Spiess,E., Juodka,B., Yavuzer,U., Nehls,P.,
            Stammer,H. and Werner,D.
  TITLE     Induction of apoptosis by overexpression of the DNA-binding and
            DNA-PK-activating protein C1D
  JOURNAL   J Cell Sci 112 (Pt 13), 2223-2232 (1999)
   PUBMED   10362552
REFERENCE   7  (bases 1 to 2241)
  AUTHORS   Yavuzer,U., Smith,G.C., Bliss,T., Werner,D. and Jackson,S.P.
  TITLE     DNA end-independent activation of DNA-PK mediated via association
            with the DNA-binding protein C1D
  JOURNAL   Genes Dev 12 (14), 2188-2199 (1998)
   PUBMED   9679063
  REMARK    GeneRIF: The C1D protein interacts with the catalytic subunit of
            DNA-PK and is a very effective substrate for DNA-PK in vitro.
            Moreover, C1D directs the activation of DNA-PK in a manner that
            does not require DNA termini, suggesting a role for C1D in DNA
            repair.
REFERENCE   8  (bases 1 to 2241)
  AUTHORS   Haataja,L., Groffen,J. and Heisterkamp,N.
  TITLE     Identification of a novel Rac3-interacting protein C1D
  JOURNAL   Int J Mol Med 1 (4), 665-670 (1998)
   PUBMED   9852280
REFERENCE   9  (bases 1 to 2241)
  AUTHORS   Nehls,P., Keck,T., Greferath,R., Spiess,E., Glaser,T.,
            Rothbarth,K., Stammer,H. and Werner,D.
  TITLE     cDNA cloning, recombinant expression and characterization of
            polypetides with exceptional DNA affinity
  JOURNAL   Nucleic Acids Res 26 (5), 1160-1166 (1998)
   PUBMED   9469821
REFERENCE   10 (bases 1 to 2241)
  AUTHORS   Zamir,I., Dawson,J., Lavinsky,R.M., Glass,C.K., Rosenfeld,M.G. and
            Lazar,M.A.
  TITLE     Cloning and characterization of a corepressor and potential
            component of the nuclear hormone receptor repression complex
  JOURNAL   Proc Natl Acad Sci U S A 94 (26), 14400-14405 (1997)
   PUBMED   9405624
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BG505686.1, BC009589.1,
            CN342947.1, BM354091.1 and AC079112.4.
            
            On Jun 2, 2019 this sequence version replaced NM_173177.2.
            
            Summary: The protein encoded by this gene is a DNA binding and
            apoptosis-inducing protein and is localized in the nucleus. It is
            also a Rac3-interacting protein which acts as a corepressor for the
            thyroid hormone receptor. This protein is thought to regulate
            TRAX/Translin complex formation. Alternate splicing results in
            multiple transcript variants that encode the same protein. Multiple
            pseudogenes of this gene are found on chromosome 10.[provided by
            RefSeq, Jun 2010].
            
            Transcript Variant: This variant (2) differs in the 5' UTR compared
            to variant 1. Variants 1, 2, 3 and 4 encode the same protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR14038194.759128.1, BC009589.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000410067.8/ ENSP00000386468.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-7                 BG505686.1         24-30
            8-540               BC009589.1         1-533
            541-935             CN342947.1         278-672
            936-1167            BC009589.1         927-1158
            1168-1171           BM354091.1         392-395
            1172-2241           AC079112.4         114529-115598       c
FEATURES             Location/Qualifiers
     source          1..2241
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2p14"
     gene            1..2241
                     /gene="C1D"
                     /gene_synonym="hC1D; LRP1; Rrp47; SUN-CoR; SUNCOR"
                     /note="C1D nuclear receptor corepressor"
                     /db_xref="GeneID:10438"
                     /db_xref="HGNC:HGNC:29911"
                     /db_xref="MIM:606997"
     exon            1..47
                     /gene="C1D"
                     /gene_synonym="hC1D; LRP1; Rrp47; SUN-CoR; SUNCOR"
                     /inference="alignment:Splign:2.1.0"
     exon            48..194
                     /gene="C1D"
                     /gene_synonym="hC1D; LRP1; Rrp47; SUN-CoR; SUNCOR"
                     /inference="alignment:Splign:2.1.0"
     CDS             57..482
                     /gene="C1D"
                     /gene_synonym="hC1D; LRP1; Rrp47; SUN-CoR; SUNCOR"
                     /note="C1D nuclear receptor co-repressor; small unique
                     nuclear receptor co-repressor; nuclear DNA-binding
                     protein; small unique nuclear receptor corepressor; C1D
                     DNA-binding protein"
                     /codon_start=1
                     /product="nuclear nucleic acid-binding protein C1D"
                     /protein_id="NP_775269.1"
                     /db_xref="CCDS:CCDS1883.1"
                     /db_xref="GeneID:10438"
                     /db_xref="HGNC:HGNC:29911"
                     /db_xref="MIM:606997"
                     /translation="MAGEEINEDYPVEIHEYLSAFENSIGAVDEMLKTMMSVSRNELL
                     QKLDPLEQAKVDLVSAYTLNSMFWVYLATQGVNPKEHPVKQELERIRVYMNRVKEITD
                     KKKAGKLDRGAASRFVKNALWEPKSKNASKVANKGKSKS"
     exon            195..261
                     /gene="C1D"
                     /gene_synonym="hC1D; LRP1; Rrp47; SUN-CoR; SUNCOR"
                     /inference="alignment:Splign:2.1.0"
     exon            262..317
                     /gene="C1D"
                     /gene_synonym="hC1D; LRP1; Rrp47; SUN-CoR; SUNCOR"
                     /inference="alignment:Splign:2.1.0"
     exon            318..2241
                     /gene="C1D"
                     /gene_synonym="hC1D; LRP1; Rrp47; SUN-CoR; SUNCOR"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1143..1148
                     /regulatory_class="polyA_signal_sequence"
                     /gene="C1D"
                     /gene_synonym="hC1D; LRP1; Rrp47; SUN-CoR; SUNCOR"
                     /note="hexamer: AATAAA"
     polyA_site      1171
                     /gene="C1D"
                     /gene_synonym="hC1D; LRP1; Rrp47; SUN-CoR; SUNCOR"
                     /note="major polyA site"
     regulatory      1661..1666
                     /regulatory_class="polyA_signal_sequence"
                     /gene="C1D"
                     /gene_synonym="hC1D; LRP1; Rrp47; SUN-CoR; SUNCOR"
                     /note="hexamer: AATAAA"
     polyA_site      1690
                     /gene="C1D"
                     /gene_synonym="hC1D; LRP1; Rrp47; SUN-CoR; SUNCOR"
     regulatory      2163..2168
                     /regulatory_class="polyA_signal_sequence"
                     /gene="C1D"
                     /gene_synonym="hC1D; LRP1; Rrp47; SUN-CoR; SUNCOR"
                     /note="hexamer: AATAAA"
     polyA_site      2185
                     /gene="C1D"
                     /gene_synonym="hC1D; LRP1; Rrp47; SUN-CoR; SUNCOR"
ORIGIN      
        1 atcgttgccc gaccgctttc cgggagactg gagtcgaagg ccgtgagtca gccataatgg
       61 caggtgaaga aattaatgaa gactatccag tagaaattca cgagtatttg tcagcgtttg
      121 agaattccat tggtgctgtg gatgagatgc tgaagaccat gatgtctgtt tctagaaatg
      181 agttgttgca gaagttggat ccacttgaac aagcaaaagt ggatttggtt tctgcataca
      241 cattaaattc aatgttttgg gtttatttgg caacccaagg agttaatcct aaggaacatc
      301 cagtaaaaca ggaattggaa agaatcagag tatatatgaa cagagtcaag gaaataacag
      361 acaagaaaaa ggctggcaag ctggacagag gtgcagcttc aagatttgta aaaaatgccc
      421 tctgggaacc aaaatcgaaa aatgcatcaa aagttgccaa taaaggaaaa agtaaaagtt
      481 aactttttgg ttttgatgta cacatattca aaaagtacat cttccccccc cccccccccc
      541 ccgcaaaata attctgtggc agggcaaggt ttaaatgtgt ttcttattaa tatgtaaatt
      601 cacagtaaat atgtaaagct aaatactttc ctctccaaag atcattatct ttattgatta
      661 gcactgagga ttttaacatt gtgatatatt atatatttat aatttaccat ctcttgatga
      721 gactcttatt tctttatata ggtcagtctt gcaagtacca ttttataagc agctgtgaaa
      781 tttaagtgaa atgttctttg taaacatttg tactatttta aatgaataat gaccttatga
      841 agtatgctat ctgtaggctg aaattatagg tacatctgtt ttcactatat gatattaaga
      901 aagcgtgaaa tgacttaaat gttcattttt ttctgtatag atactttatc atgttttcat
      961 gattttagga attactgctt tgttgatatt caaagtgtga aactaaaact ttatggttgt
     1021 actttaattc ttggcatgtt gcctctatgt cccatttaaa ataaaataca ttctcattaa
     1081 ctttagatgg gaaataaggt tgtatgttga tggatgaatt ttggcatgat gactgtactc
     1141 tcaataaagg ctgaaaatgt tgtataactg acctgtgtat ttttatcttt tgagtaaatt
     1201 tgccttccaa attaggaaga taggttttag aagtcatcac aaatagagaa attcttgagt
     1261 ttttgttcct gatgcatggt gtccacagtt cttttcatct catttttttt cagatttttt
     1321 ttatttcatg tttttgaggc tgtatcaagt acatacaagt gttttggaac aacttcttaa
     1381 gttacctaat gccacttaag cagatgagaa gtccaaagga gattacactg tgtttgtatt
     1441 gtggtttatt tttctggaat attagttaca gagagtacta catagtaaac ctttttttaa
     1501 atgtctaagc ccatgaattt taattatatg cccttaatgc tttcagtgtt tgaatccata
     1561 tcattatgtg taggaatgcc aagtatagta aagtacttta atttttgaaa aaggagttgt
     1621 taaaattttc tgtgtgatta attctccata agtaaccttg aataaatgga tttcttgatt
     1681 tatgatagca gatattggaa atggtcttaa aatgtaatgg attttgtaaa gcatgttgaa
     1741 ctctttctat gacacatgaa gaggaagtca ctgatagacg cagaaggtct tttctgtctc
     1801 tgatgtcagt ttttgaagtg gaagaacatt agtgaacatt tatagttatt ttactccttt
     1861 ttttgccttt gtctccaaat ttctagctat ttttaaaaat aacctcttca tgagagaaat
     1921 gtgttactgt taagatcaag tgtagtgtac ctgtctttgt gttatttatt gcaaagaaat
     1981 ttatttggat ttctgtatat tttctaattt cataaaagaa aaacagctta aatgaaaaat
     2041 gttatacaat tgcagaaaat cattattggt tttagctaag ttattggttt atgaaagtgc
     2101 acctctacgt tctgttaaat tgtgtaactt ttaagtgagt aattctttca ttattaggta
     2161 gaaataaaag tttgagtata ttccatttta ttatgtataa ttttaaatac ttagcacgta
     2221 ataaggagct gaatggctgt a
//
