LOCUS       NM_001193623            1335 bp    mRNA    linear   PRI 16-FEB-2025
DEFINITION  Homo sapiens chromosome 19 open reading frame 84 (C19orf84),
            transcript variant 1, mRNA.
ACCESSION   NM_001193623 XM_001134195 XM_001134326 XM_001726058
VERSION     NM_001193623.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1335)
  AUTHORS   Zoch,A., Konieczny,G., Auchynnikava,T., Stallmeyer,B., Rotte,N.,
            Heep,M., Berrens,R.V., Schito,M., Kabayama,Y., Schopp,T.,
            Kliesch,S., Houston,B., Nagirnaja,L., O'Bryan,M.K., Aston,K.I.,
            Conrad,D.F., Rappsilber,J., Allshire,R.C., Cook,A.G., Tuttelmann,F.
            and O'Carroll,D.
  TITLE     C19ORF84 connects piRNA and DNA methylation machineries to defend
            the mammalian germ line
  JOURNAL   Mol Cell 84 (6), 1021-1035 (2024)
   PUBMED   38359823
  REMARK    GeneRIF: C19ORF84 connects piRNA and DNA methylation machineries to
            defend the mammalian germ line.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC008750.9 and BC043532.1.
            
            On Nov 23, 2018 this sequence version replaced NM_001193623.1.
            
            Transcript Variant: This variant (1) encodes the supported protein.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC043532.1, BI827168.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1966682, SAMEA1968540
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000574814.2/ ENSP00000458772.1
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-17                AC008750.9         63525-63541         c
            18-1335             BC043532.1         1-1318
FEATURES             Location/Qualifiers
     source          1..1335
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19q13.41"
     gene            1..1335
                     /gene="C19orf84"
                     /note="chromosome 19 open reading frame 84"
                     /db_xref="GeneID:147646"
                     /db_xref="HGNC:HGNC:27112"
     exon            1..114
                     /gene="C19orf84"
                     /inference="alignment:Splign:2.1.0"
     CDS             80..640
                     /gene="C19orf84"
                     /note="uncharacterized protein C19orf84"
                     /codon_start=1
                     /product="piRNA-mediated silencing protein C19orf84"
                     /protein_id="NP_001180552.1"
                     /db_xref="CCDS:CCDS58676.1"
                     /db_xref="GeneID:147646"
                     /db_xref="HGNC:HGNC:27112"
                     /translation="MEQPKDGAGPEGNNLSLPSSGTEPWPPAPLPAPPPLLLNSTDPT
                     HLGLPESVASVTVPIRLDTLSCLLHSALLGAYTFQQALPSCPCCSQAGHSQPGAVRRP
                     PRGRGGWEVRHRPGWGRGLHRRGLGRAEQPERGRAGGPGAGPRTPPMTLPSPPTLPAQ
                     DGKKEARGPEPPLETPLAAEDWETEY"
     exon            115..1335
                     /gene="C19orf84"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1312..1317
                     /regulatory_class="polyA_signal_sequence"
                     /gene="C19orf84"
                     /note="hexamer: AATAAA"
     polyA_site      1335
                     /gene="C19orf84"
                     /note="major polyA site"
ORIGIN      
        1 ccctccccaa ccttcccggg cccccgaagg atctcggagg cgaagttgct agaagatacg
       61 taagagggcc ccagtggaga tggaacaacc aaaggacggg gctgggcctg aagggaacaa
      121 cctgtccctg ccgtcatctg ggaccgagcc atggccccct gcgcctctcc cagcccctcc
      181 acccttgctc ctgaactcca cagaccccac ccacctgggg ctcccggaga gcgtggcctc
      241 tgtcaccgtg cccatacgcc tggacaccct ctcctgcctc ctgcacagcg ccctgctggg
      301 ggcctacacc ttccaacagg ccttgccctc ttgcccctgc tgctcccagg caggccactc
      361 ccagccgggg gcagttagga ggcctcccag gggacgcgga ggctgggaag tcaggcacag
      421 gccaggctgg ggccgaggcc tgcatcgacg gggccttggg agagctgagc agccagagag
      481 gggccgggcg gggggccctg gggctggccc caggacccca ccaatgacac tgccatcacc
      541 accaacactg cctgcccagg atgggaagaa agaagctcga ggtccagagc cacccctgga
      601 aacaccactg gctgctgagg actgggagac agagtactag gaccttggag ggtcaggcac
      661 ctgagattgc agtcacccag gagggttttc ctggggccca gagtgatctc agccctgtca
      721 gaagaacccc aagaaacatc ttccatcctc ccctctcccc aaaaccacaa tcccaggagt
      781 agctcctgtg aggcacttgg tgaacctgac ctaagtcacc tgaatcccaa gtgagaagaa
      841 aatcctaaac ctcgtaccca aacctgtctc cttgatggcc tcaaccccat tcccaatgcc
      901 atccccaacc acaaccacaa tccttacctc attctcaacc cccagggctc ctccaacccc
      961 attccctatc ctctccctaa tcccaaagcc actcctacct gcctctctct tccccactct
     1021 caataccctg ttcccaaacc cattcattcc catccctgtc accagtccca gctccacttc
     1081 tgcgcctcaa ccctaaccca ccctctttac caaccccttt ctcctcattg cctgtgtacc
     1141 tcagcccatc tttaatgtcc tctgaatcta cagccccaaa gagctccatc ctcaacctca
     1201 gccacagccc tgtgtccatc cccacaaaga accgcattgg ccccacatac ccagacacct
     1261 gtgactcccc accccactgc ctgctcttca ggtagaaagc cctggttgaa caataaacgc
     1321 atgactctcc ctgaa
//
