LOCUS       NM_001277378            1443 bp    mRNA    linear   PRI 10-FEB-2024
DEFINITION  Homo sapiens chromosome 19 open reading frame 67 (C19orf67), mRNA.
ACCESSION   NM_001277378 XM_929382
VERSION     NM_001277378.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1443)
  AUTHORS   Grimwood,J., Gordon,L.A., Olsen,A., Terry,A., Schmutz,J.,
            Lamerdin,J., Hellsten,U., Goodstein,D., Couronne,O.,
            Tran-Gyamfi,M., Aerts,A., Altherr,M., Ashworth,L., Bajorek,E.,
            Black,S., Branscomb,E., Caenepeel,S., Carrano,A., Caoile,C.,
            Chan,Y.M., Christensen,M., Cleland,C.A., Copeland,A., Dalin,E.,
            Dehal,P., Denys,M., Detter,J.C., Escobar,J., Flowers,D.,
            Fotopulos,D., Garcia,C., Georgescu,A.M., Glavina,T., Gomez,M.,
            Gonzales,E., Groza,M., Hammon,N., Hawkins,T., Haydu,L., Ho,I.,
            Huang,W., Israni,S., Jett,J., Kadner,K., Kimball,H., Kobayashi,A.,
            Larionov,V., Leem,S.H., Lopez,F., Lou,Y., Lowry,S., Malfatti,S.,
            Martinez,D., McCready,P., Medina,C., Morgan,J., Nelson,K.,
            Nolan,M., Ovcharenko,I., Pitluck,S., Pollard,M., Popkie,A.P.,
            Predki,P., Quan,G., Ramirez,L., Rash,S., Retterer,J., Rodriguez,A.,
            Rogers,S., Salamov,A., Salazar,A., She,X., Smith,D., Slezak,T.,
            Solovyev,V., Thayer,N., Tice,H., Tsai,M., Ustaszewska,A., Vo,N.,
            Wagner,M., Wheeler,J., Wu,K., Xie,G., Yang,J., Dubchak,I.,
            Furey,T.S., DeJong,P., Dickson,M., Gordon,D., Eichler,E.E.,
            Pennacchio,L.A., Richardson,P., Stubbs,L., Rokhsar,D.S.,
            Myers,R.M., Rubin,E.M. and Lucas,S.M.
  TITLE     The DNA sequence and biology of human chromosome 19
  JOURNAL   Nature 428 (6982), 529-535 (2004)
   PUBMED   15057824
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            HY028687.1, DR008137.1, DY655148.1, DN831393.1, HY212999.1 and
            AC022098.9.
            
            On May 17, 2019 this sequence version replaced NM_001277378.1.
            
            CCDS Note: This gene lacks full-length human transcript support,
            and therefore the exon combination represented in this CCDS ID is
            inferred; it is supported by tiled partial transcript alignments
            (human HY028687.1, DR008137.1, DN831393.1 and others) and by
            homologous transcript alignments (mouse BC147276.1 and others).
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMEA1968968,
                              SAMEA2148093 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            inferred exon combination :: based on alignments, homology
            MANE Ensembl match        :: ENST00000548523.6/ ENSP00000449137.1
            RefSeq Select criteria    :: based on conservation, expression,
                                         longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-465               HY028687.1         14-478
            466-581             DR008137.1         43-158
            582-582             DY655148.1         283-283             c
            583-817             DR008137.1         160-394
            818-1093            DN831393.1         184-459
            1094-1435           HY212999.1         1-342               c
            1436-1443           AC022098.9         119001-119008       c
FEATURES             Location/Qualifiers
     source          1..1443
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19p13.12"
     gene            1..1443
                     /gene="C19orf67"
                     /note="chromosome 19 open reading frame 67"
                     /db_xref="GeneID:646457"
                     /db_xref="HGNC:HGNC:34354"
     exon            1..491
                     /gene="C19orf67"
                     /inference="alignment:Splign:2.1.0"
     CDS             157..1233
                     /gene="C19orf67"
                     /codon_start=1
                     /product="UPF0575 protein C19orf67"
                     /protein_id="NP_001264307.1"
                     /db_xref="CCDS:CCDS59360.1"
                     /db_xref="GeneID:646457"
                     /db_xref="HGNC:HGNC:34354"
                     /translation="MATEQWFEGSLPLDPGETPPPDALEPGTPPCGDPSRSTPPGRPG
                     NPSEPDPEDAEGRLAEARASTSSPKPLVPRPGPAPPRLSLDTLFSPITQQLRYLLKKA
                     DDFQSYLLYSRDQVQKEQLAKAMPTFLQMCEPYFLYLEAAARSIPPIYGPLQELVRKG
                     LLEISQQLTLRLEQLVLMYASFGFVDLEEMNPLSISCFFCGRFSISLSHEVSIFRYCA
                     PTAYTASRFPRYLYKKMRWHLEATPEAPGRGQDSLVDYYFLCYRDTWEDTGQSPANSC
                     PQIQKLWSIGRWVPLGPAEDDLYSWILCPQPLGDYQQLLTIGFEEPTPTLATDLLVQI
                     LTGQAGQARPPSAAGPAGWAAQGS"
     exon            492..636
                     /gene="C19orf67"
                     /inference="alignment:Splign:2.1.0"
     exon            637..737
                     /gene="C19orf67"
                     /inference="alignment:Splign:2.1.0"
     exon            738..923
                     /gene="C19orf67"
                     /inference="alignment:Splign:2.1.0"
     exon            924..1058
                     /gene="C19orf67"
                     /inference="alignment:Splign:2.1.0"
     exon            1059..1443
                     /gene="C19orf67"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1424..1429
                     /regulatory_class="polyA_signal_sequence"
                     /gene="C19orf67"
                     /note="hexamer: AATAAA"
     polyA_site      1443
                     /gene="C19orf67"
                     /note="major polyA site"
ORIGIN      
        1 aaaagaggcg aacggccccc ggcgcggcgg cgcggctccg gtggagaggt caaggcaggg
       61 gccagtcgga ggctcccggg gcggggtcga acccgcggcc aacctgagca gcagcggaag
      121 cttaaagagc tcaggttccc gccccccggc cctaccatgg ctacagagca gtggttcgag
      181 gggtcgctcc ccctggaccc tggagaaaca ccgcctccag acgccttgga acctgggacg
      241 ccgccctgcg gagacccctc caggtcgacg ccccctggca ggcctgggaa cccatctgag
      301 ccggatcctg aagatgccga ggggcggctg gctgaggccc gggcctccac gtcttccccc
      361 aaacctctgg tcccccggcc tgggccagca cctccccgcc tatccctgga cactttgttc
      421 agccccatca cccaacagct gcgctaccta ctgaagaagg cagatgattt ccagagctac
      481 ttgctctaca gcagagacca agtacagaag gagcagctgg ccaaggccat gcccaccttc
      541 ttacagatgt gtgagcccta cttcctgtac ctggaggcag ccgcgagaag catacccccc
      601 atctatggac ccctgcagga gctggtccga aaggggctgt tagagatctc ccaacagctg
      661 accctgcgcc tggaacagct ggtcctcatg tacgcttcct ttgggttcgt ggacctggag
      721 gagatgaacc cccttagcat ctcctgtttc ttttgcggga ggttctccat cagcctgtcc
      781 catgaggtct ccatcttcag atactgtgcc ccaaccgcct acactgccag ccgcttcccc
      841 cgctacctct ataagaagat gcgctggcac ctggaagcca ccccagaggc ccctggtcgg
      901 ggacaagatt cccttgtgga ttactacttt ctgtgctatc gagatacttg ggaagacaca
      961 ggccagagtc cagccaattc gtgcccacag atccagaagc tgtggtccat cggccgatgg
     1021 gtgcccctag gaccagccga ggatgacctt tattcatgga ttttgtgccc gcagccgctt
     1081 ggggactacc agcagctgct gaccatcggc ttcgaggagc ccacgcccac gctggccacc
     1141 gacctgctgg tgcagatcct cacgggccag gcaggccagg cccggcctcc gagcgcagcc
     1201 gggcctgcgg ggtgggcagc gcaggggtct tgaacctggg gaagagggta ggagctggaa
     1261 cttgacagtt ccaaactcca gaataggggg caggggaggg gctcactcgt tctcgcagtg
     1321 cagcccggcc tcgccttcca aagggccagg ccgagctgac ctgtctgcac cgagtccggc
     1381 ttggccgtgg ggccctgaat gcggacacgt cagttttgtg ttaaataaaa gaaagaaaga
     1441 ggt
//
