LOCUS       NM_014047                897 bp    mRNA    linear   PRI 05-DEC-2024
DEFINITION  Homo sapiens chromosome 19 open reading frame 53 (C19orf53), mRNA.
ACCESSION   NM_014047
VERSION     NM_014047.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 897)
  AUTHORS   Lam,A.Y.W., Tsuboyama,K., Tadakuma,H. and Tomari,Y.
  TITLE     DNAJA2 and Hero11 mediate similar conformational extension and
            aggregation suppression of TDP-43
  JOURNAL   RNA 30 (11), 1422-1436 (2024)
   PUBMED   39117455
  REMARK    GeneRIF: DNAJA2 and Hero11 mediate similar conformational extension
            and aggregation suppression of TDP-43.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 897)
  AUTHORS   Zhang,Y., Liang,X., Luo,S., Chen,Y., Li,Y., Ma,C., Li,N. and Gao,N.
  TITLE     Visualizing the nucleoplasmic maturation of human pre-60S ribosomal
            particles
  JOURNAL   Cell Res 33 (11), 867-878 (2023)
   PUBMED   37491604
REFERENCE   3  (bases 1 to 897)
  AUTHORS   Andersen,J.S., Lam,Y.W., Leung,A.K., Ong,S.E., Lyon,C.E.,
            Lamond,A.I. and Mann,M.
  TITLE     Nucleolar proteome dynamics
  JOURNAL   Nature 433 (7021), 77-83 (2005)
   PUBMED   15635413
REFERENCE   4  (bases 1 to 897)
  AUTHORS   Jouen-Beades,F., Halary,F., Drouot,L., Peyrat,M.A., Paris,E.,
            Joly,P., Gilbert,D., Bonneville,M. and Tron,F.
  TITLE     Expansion of circulating V gamma 9/V delta 1 T cells in a patient
            with a syndrome of recurrent fever: evidence for an unusual
            antigen-driven process leading to selection of recurrent motifs
            within TCR junctional loops of diverse lengths
  JOURNAL   Eur J Immunol 29 (10), 3338-3349 (1999)
   PUBMED   10540346
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DA768829.1, BC015465.2, AC008686.8 and AI689503.1.
            
            On Nov 23, 2018 this sequence version replaced NM_014047.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1163658.211894.1,
                                           SRR1660807.96227.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000588234.6/ ENSP00000465432.1
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-12                DA768829.1         15-26
            13-585              BC015465.2         1-573
            586-852             AC008686.8         140495-140761
            853-897             AI689503.1         25-69               c
FEATURES             Location/Qualifiers
     source          1..897
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19p13.13"
     gene            1..897
                     /gene="C19orf53"
                     /gene_synonym="Hero11; HSPC023; L10K; LYDG10"
                     /note="chromosome 19 open reading frame 53"
                     /db_xref="GeneID:28974"
                     /db_xref="HGNC:HGNC:24991"
                     /db_xref="MIM:620685"
     exon            1..119
                     /gene="C19orf53"
                     /gene_synonym="Hero11; HSPC023; L10K; LYDG10"
                     /inference="alignment:Splign:2.1.0"
     CDS             23..322
                     /gene="C19orf53"
                     /gene_synonym="Hero11; HSPC023; L10K; LYDG10"
                     /codon_start=1
                     /product="leydig cell tumor 10 kDa protein homolog"
                     /protein_id="NP_054766.1"
                     /db_xref="CCDS:CCDS12298.1"
                     /db_xref="GeneID:28974"
                     /db_xref="HGNC:HGNC:24991"
                     /db_xref="MIM:620685"
                     /translation="MAQGQRKFQAHKPAKSKTAAAASEKNRGPRKGGRVIAPKKARVV
                     QQQKLKKNLEVGIRKKIEHDVVMKASSSLPKKLALLKAPAKKKGAAAATSSKTPS"
     exon            120..175
                     /gene="C19orf53"
                     /gene_synonym="Hero11; HSPC023; L10K; LYDG10"
                     /inference="alignment:Splign:2.1.0"
     exon            176..897
                     /gene="C19orf53"
                     /gene_synonym="Hero11; HSPC023; L10K; LYDG10"
                     /inference="alignment:Splign:2.1.0"
     regulatory      565..570
                     /regulatory_class="polyA_signal_sequence"
                     /gene="C19orf53"
                     /gene_synonym="Hero11; HSPC023; L10K; LYDG10"
                     /note="hexamer: AATAAA"
     polyA_site      585
                     /gene="C19orf53"
                     /gene_synonym="Hero11; HSPC023; L10K; LYDG10"
                     /note="major polyA site"
     regulatory      874..879
                     /regulatory_class="polyA_signal_sequence"
                     /gene="C19orf53"
                     /gene_synonym="Hero11; HSPC023; L10K; LYDG10"
                     /note="hexamer: ATTAAA"
     polyA_site      897
                     /gene="C19orf53"
                     /gene_synonym="Hero11; HSPC023; L10K; LYDG10"
ORIGIN      
        1 ctcttccgct gcgtgccgga ccatggcgca ggggcagcgc aagtttcagg cgcacaaacc
       61 cgcaaagagt aagacggcag cggcagcctc tgaaaagaat cggggcccaa gaaaaggcgg
      121 tcgtgttatc gctcccaaga aggcgcgcgt cgtgcagcag caaaagctca agaagaacct
      181 agaagtcgga atccggaaga agatcgaaca tgacgtggtg atgaaagcca gcagcagcct
      241 gcccaagaag ctggcactgc tgaaggcccc agccaagaag aaaggggcag ctgccgccac
      301 ctcctccaag acaccttcct gaggacgctg gccccagtgc aggccaacat cccaccccct
      361 acctccatat gggaccttgc aagtcatccc acaggctgca ctgtcaggaa gaggaccctg
      421 tcccccagca ctgggcttca cctagaactt cagtgggggc caagggtgct gagaacccag
      481 caatgaccag gaagatacag tcactaactt catctgtccc cgtgcccctt cccaggtcct
      541 gcctccacag gtttaaccca gaacaataaa cctggctttg tcatccctct tgcagtcctg
      601 tgttcgggtg agcaggccag gtgagcccac aagtctccat gagtgacgtg gcctggcgtg
      661 ctccacccca ccccaccgcc tttagcaacc atgtgcccag gggacagctg ggcttctaca
      721 cctctggccc tgagcctgag agccgggaaa gagtcttttc tccatttaac cccgggtgac
      781 tcactccctg gccagtcctc acccctgggg acacaaccag agtcaagctg gacatcagta
      841 ggtcagatgc cacctcacag gaccaaggtg ccgattaaac cggaatacat tcagaaa
//
