LOCUS       NM_001256441            3611 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens chromosome 19 open reading frame 47 (C19orf47),
            transcript variant 2, mRNA.
ACCESSION   NM_001256441
VERSION     NM_001256441.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3611)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BI916290.1, BM459040.1, AL834131.1, AI394044.1 and AC118344.2.
            
            On Jun 2, 2019 this sequence version replaced NM_001256441.1.
            
            Transcript Variant: This variant (2) differs in the 5' UTR, lacks a
            portion of the 5' coding region and initiates translation at a
            downstream, in-frame start codon, compared to variant 1. The
            encoded isoform (2) has a shorter N-terminus, compared to isoform
            1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR11853559.17087.1,
                                           SRR14038192.2988104.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000683109.1/ ENSP00000508349.1
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-38                BI916290.1         13-50
            39-812              BM459040.1         1-774
            813-2084            AL834131.1         855-2126
            2085-2087           AI394044.1         3-5                 c
            2088-3611           AC118344.2         47396-48919
FEATURES             Location/Qualifiers
     source          1..3611
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19q13.2"
     gene            1..3611
                     /gene="C19orf47"
                     /note="chromosome 19 open reading frame 47"
                     /db_xref="GeneID:126526"
                     /db_xref="HGNC:HGNC:26723"
     exon            1..74
                     /gene="C19orf47"
                     /inference="alignment:Splign:2.1.0"
     exon            75..126
                     /gene="C19orf47"
                     /inference="alignment:Splign:2.1.0"
     CDS             108..1265
                     /gene="C19orf47"
                     /note="isoform 2 is encoded by transcript variant 2;
                     uncharacterized protein C19orf47"
                     /codon_start=1
                     /product="uncharacterized protein C19orf47 isoform 2"
                     /protein_id="NP_001243370.1"
                     /db_xref="CCDS:CCDS92619.1"
                     /db_xref="GeneID:126526"
                     /db_xref="HGNC:HGNC:26723"
                     /translation="MVSVTMATSEWIQFFKEAGIPPGPAVNYAVMFVDNRIQKSMLLD
                     LNKEIMNELGVTVVGDIIAILKHAKVVHRQDMCKAATESVPCSPSPLAGEIRRGTSAA
                     SRMITNSLNHDSPPSTPPRRPDTSTSKISVTVSNKMAAKSAKATAALARREEESLAVP
                     AKRRRVTAEMEGKYVINMPKGTTPRTRKILEQQQAAKGLHRTSVFDRLGAETKADTTT
                     GSKPTGVFSRLGATPETDEDLAWDSDNDSSSSVLQYAGVLKKLGRGPAKASPQPALTV
                     KAKATSSATTAAAPTLRRLALSSRSGLERKPESLSKVSIIKRLGAAALVPEAQDSQVT
                     STKSKSSAEVKVTIKRTLVGPRGSSSSEGLGAQMDHAGTVSVFKRLGRRTF"
     exon            127..214
                     /gene="C19orf47"
                     /inference="alignment:Splign:2.1.0"
     exon            215..329
                     /gene="C19orf47"
                     /inference="alignment:Splign:2.1.0"
     exon            330..408
                     /gene="C19orf47"
                     /inference="alignment:Splign:2.1.0"
     exon            409..546
                     /gene="C19orf47"
                     /inference="alignment:Splign:2.1.0"
     exon            547..699
                     /gene="C19orf47"
                     /inference="alignment:Splign:2.1.0"
     exon            700..770
                     /gene="C19orf47"
                     /inference="alignment:Splign:2.1.0"
     exon            771..3611
                     /gene="C19orf47"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2062..2067
                     /regulatory_class="polyA_signal_sequence"
                     /gene="C19orf47"
                     /note="hexamer: AATATA"
     polyA_site      2067
                     /gene="C19orf47"
     polyA_site      2084
                     /gene="C19orf47"
                     /note="major polyA site"
ORIGIN      
        1 gaggagtgtc tgacagttgg cgccgccggg agggagggcg ggcggcgcga gtgggcgcgg
       61 gcccggtggg ccaggctcca gggagcagtg tcagggccag ggagacgatg gtctccgtga
      121 ctatggccac ttccgagtgg atccagttct ttaaggaagc cggcattcct ccaggacctg
      181 ccgtcaatta tgccgtgatg tttgtggata ataggattca gaagagcatg ctgctggatc
      241 tcaataagga gataatgaat gagctgggcg tgaccgtggt gggtgacatc atcgccattc
      301 tcaagcatgc caaagtggtg caccgtcagg acatgtgcaa agctgccact gagtcagtac
      361 cctgcagccc tagccccctt gcaggcgaaa ttcgccgtgg caccagtgct gcctcccgaa
      421 tgatcaccaa cagcctgaac catgactctc cacccagcac accccccagg cgcccggaca
      481 ccagcacctc caagatctcg gtcactgtgt ccaacaagat ggcagcaaag agtgccaagg
      541 ccactgcagc cctggcccgc cgggaggagg agagcctggc tgttcctgcc aagcggcgcc
      601 gggtcactgc tgagatggag gggaagtacg tcatcaacat gcccaaaggc accacacccc
      661 gcacccgcaa gatcctggag cagcagcagg ctgcaaaagg tctccatagg acgtctgtgt
      721 ttgaccgcct cggcgccgag accaaggcag acaccacgac agggagtaaa cccacaggag
      781 tcttcagccg cctgggggcc accccagaaa cggacgagga tctggcttgg gacagcgaca
      841 atgacagcag cagctctgtc ttgcagtatg ccggggtcct gaagaagcta ggacggggcc
      901 cagccaaggc cagtccccag ccagcactga ctgtcaaagc caaggccaca agctcagcga
      961 caacggctgc tgccccgaca ctgcggcgcc tggcgctttc ctcacggtct gggcttgaga
     1021 ggaagccgga gtccttgtct aaagtcagca tcatcaagag actgggcgca gctgcccttg
     1081 tgcccgaggc ccaggacagc caggtcacca gcaccaagag taagtcctca gccgaggtca
     1141 aggtcaccat taagaggact ctggtggggc cccgggggag cagctccagc gagggccttg
     1201 gtgcccagat ggaccacgcg ggcactgtga gcgtgttcaa aagactgggc cgcaggacct
     1261 tctagcccac ctgtgggcgg ggtgcaggca gcagagcctg cgggcatctg ccctggccgc
     1321 cccaggctcc tggcttcatc acgcctccca ccagctcctg gatgacacag cttgtctccc
     1381 tcgggctcta gagctaggcc cgagcattcg ggggatcacc ccatttctcc tagcctggga
     1441 tggtcgtcgc agctggcctg gcctgctcca ggactcccct tctctcatgt cctctgtgct
     1501 ttcttctctg gctgtggcct tggcagaacc cacttttcta cctctcccaa gtgccagggg
     1561 gcttcttcct ctcctacatt ccccttcttc ccctgagcag ggtctgctgc ctcagacccc
     1621 agctcatcag cctccctgtc cccctcaact aagtgggtgt cacctggtgg gcctcccttc
     1681 ccccactccc cactgacctc cctcactcct ctgcgcctcc ccccactgct gtgacttctc
     1741 tctctccctg tcttcacttt gttcatttct cttctgtttt ctgtccccgt ggcaaggccc
     1801 gactgtccgc tgcgtcctgc ccgaccctcc tgtacctccg gcctcccagc ggccccctcg
     1861 tcggcggtgg cgtcgagcct gttgagactg ttagccgccc tctactccca ggctggaggg
     1921 acctctccag accctgggct gcggctgagg cgcatccgtt ttcctgccct gggcatctgt
     1981 ctctgaaagt gtatggcggg tggtgggcaa ggggcactgg gaagggaggc cagtgcctag
     2041 agtgaagaca gctgctgttt taatatattt ttgtgacttt caaatcattt cccccactcc
     2101 ttcagggtga gttgcaggac tgtttcacac tatgcgcagc tgggctgggg atggtggcag
     2161 aggattgggc tgtgtctcta aaggtcaggc ttcctgcaca cacatggtcc atgtccctgc
     2221 tgcaagccct gagtcagggg gagtaatggc cacagtcacc attcagttag gccgccccct
     2281 gcccccaata agccgtagtg gttttgtcac tctatcccct ccccccatgg atttcacctg
     2341 cctgctggca cctttccaaa tgatgggctc cgtttgtgag accatgagtt tccactggtt
     2401 tggtcgccca cccctccctg ctgcacagcg cccctgagcc aggcctgtcc taggagctgg
     2461 tagcaggtag tgagcagggc ctctccaggg atggggtgta ggtaaagcgg tggtgctggc
     2521 caaggaatct gaggagtggg agaaagtggc cagggccgct tcagtggttg tggataggaa
     2581 ggccttgcag aaggggtgac atggaggcca agttgggaat gtggcttcat gaagttcagg
     2641 aggagagctt tcagacagag ggacagccag gggcagaggt gctgaggtgg gacaaggaac
     2701 aggaagaagg ctggtggctg tgggtgaggg tgggccctgc ctccagcatg aggcagaggt
     2761 gggtgggcag gggctaggtg gctgggggtg ttgtgatcaa ggaggaggaa tgtgcacagt
     2821 gacccgggag tgctggatcg ggaggatttg gagctgggat gtgctgagct gagtttcatt
     2881 taggatcatc gctctggctt ctgtgaggag aaggaatggc tgggagggct ggggtggatg
     2941 ccactgcagc agtccaggca ggaagccagg atggctgcga gggcatggca gtggggagca
     3001 gggaagaggg ccgcttgggc tgcttagggt gtgctttgga ggaagagctg tgggatgtgc
     3061 tgatgggttg gaagttgggg ctagagaaga tgagaatcat agggcccgcc tagatgttag
     3121 accggagcat ctgggggaac ggctgttaac agagaagggg agacgggagg aaggtcaagg
     3181 aagagggagc tgtgttctga ctgcattgcg cctgttaggg tccccgctgg ggctcaggcg
     3241 gacacctggg ctgggggttc atggctgctg acagtgcgca gggtacagct ggaatcaaag
     3301 ccaagggcct tggctgggcg tggtggctta cgcttgtaat cccagcagtt tgggaggcca
     3361 aggcgggtgg atcacaaggt caggagttcg agaccagcct ggccaagatg gtgaaacccc
     3421 gtctctacta aaaatacaaa aattagccgg gtgtggtgac aggtgcctgt aatcccggct
     3481 acttaggagg ctgaggcagg aggatcgctt gaacccggga ggtggaggtt gcagtgagct
     3541 gagatcgtgc cactgcactc cagcctaggc aacaagagcg agactccatc tcaaaaaaaa
     3601 aaaaaaaaaa a
//
