LOCUS       NM_032207               3346 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens chromosome 19 open reading frame 44 (C19orf44),
            transcript variant 1, mRNA.
ACCESSION   NM_032207
VERSION     NM_032207.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3346)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   2  (bases 1 to 3346)
  AUTHORS   Nalls,M.A., Couper,D.J., Tanaka,T., van Rooij,F.J., Chen,M.H.,
            Smith,A.V., Toniolo,D., Zakai,N.A., Yang,Q., Greinacher,A.,
            Wood,A.R., Garcia,M., Gasparini,P., Liu,Y., Lumley,T., Folsom,A.R.,
            Reiner,A.P., Gieger,C., Lagou,V., Felix,J.F., Volzke,H.,
            Gouskova,N.A., Biffi,A., Doring,A., Volker,U., Chong,S.,
            Wiggins,K.L., Rendon,A., Dehghan,A., Moore,M., Taylor,K.,
            Wilson,J.G., Lettre,G., Hofman,A., Bis,J.C., Pirastu,N., Fox,C.S.,
            Meisinger,C., Sambrook,J., Arepalli,S., Nauck,M., Prokisch,H.,
            Stephens,J., Glazer,N.L., Cupples,L.A., Okada,Y., Takahashi,A.,
            Kamatani,Y., Matsuda,K., Tsunoda,T., Tanaka,T., Kubo,M.,
            Nakamura,Y., Yamamoto,K., Kamatani,N., Stumvoll,M., Tonjes,A.,
            Prokopenko,I., Illig,T., Patel,K.V., Garner,S.F., Kuhnel,B.,
            Mangino,M., Oostra,B.A., Thein,S.L., Coresh,J., Wichmann,H.E.,
            Menzel,S., Lin,J., Pistis,G., Uitterlinden,A.G., Spector,T.D.,
            Teumer,A., Eiriksdottir,G., Gudnason,V., Bandinelli,S.,
            Frayling,T.M., Chakravarti,A., van Duijn,C.M., Melzer,D.,
            Ouwehand,W.H., Levy,D., Boerwinkle,E., Singleton,A.B.,
            Hernandez,D.G., Longo,D.L., Soranzo,N., Witteman,J.C., Psaty,B.M.,
            Ferrucci,L., Harris,T.B., O'Donnell,C.J. and Ganesh,S.K.
  TITLE     Multiple loci are associated with white blood cell phenotypes
  JOURNAL   PLoS Genet 7 (6), e1002113 (2011)
   PUBMED   21738480
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC008764.9 and AK025395.1.
            
            On Nov 23, 2018 this sequence version replaced NM_032207.3.
            
            Transcript Variant: This variant (1) encodes the longer isoform
            (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660805.179031.1,
                                           SRR1660805.222521.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968189, SAMEA1968540
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000221671.8/ ENSP00000221671.2
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-29                AC008764.9         43636-43664
            30-2175             AK025395.1         11-2156
            2176-3346           AC008764.9         67424-68594
FEATURES             Location/Qualifiers
     source          1..3346
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19p13.11"
     gene            1..3346
                     /gene="C19orf44"
                     /note="chromosome 19 open reading frame 44"
                     /db_xref="GeneID:84167"
                     /db_xref="HGNC:HGNC:26141"
     exon            1..72
                     /gene="C19orf44"
                     /inference="alignment:Splign:2.1.0"
     exon            73..832
                     /gene="C19orf44"
                     /inference="alignment:Splign:2.1.0"
     CDS             74..2047
                     /gene="C19orf44"
                     /note="isoform 1 is encoded by transcript variant 1;
                     uncharacterized protein C19orf44"
                     /codon_start=1
                     /product="uncharacterized protein C19orf44 isoform 1"
                     /protein_id="NP_115583.1"
                     /db_xref="CCDS:CCDS12345.1"
                     /db_xref="GeneID:84167"
                     /db_xref="HGNC:HGNC:26141"
                     /translation="MASARKASRPMRDVFGDFSDVSLEDSTMEEIRNFQISRNLTKIA
                     PGHSRFLKRNQTLDEKHLLLKENPVLGSGPRLASCRPPTTASRIRANAALMKLAQLET
                     RIMNRKLQRNLSDTESDSMTADAGLPKRADRILSGGALELASQNTDKTSQNQARELPV
                     TENNAQNAKVSRFLKKKQAPVENISPEAPAGKERTLQTPKQKEPARTFDSPDSDEEEM
                     KVLLGSLMDSSREKNTNQGFSSANVSEEEERKLFSVPSQLRAFTVPSVELSSAKPSQT
                     SHLPTSLAADRTLHSTRSRADYPQSHVSSDTASHTPSVSITGAFSNSVSLKMGHVKLV
                     SSPGRSEAETVDEPVSEGADDSLDEFRINILSLDGLAPAVSENSDLEQEEESAQRQKT
                     AGKIFRAEASTGQDAPRQAQARSWASQGKAASAEGDESEVSEHLSASSASAIQQDSTS
                     SMQPPSEAPMVNTVSSAYSEDFENSPSLTASEPTAHSKESLDRTLDALSESSSSVKTD
                     LPQTAESRKKSGRHVTRVLVKDTAVQTPDPAFTYEWTKVASMAAMGPALGGAYVDPTP
                     IANHVISADAIEALTAYSPAVLALHDVLKQQLSLTQQFIQASRHLHASLLRSLDADSF
                     HYHTLEEAKEYIRCHRPAPLTMEDALEEVNKEL"
     exon            833..1148
                     /gene="C19orf44"
                     /inference="alignment:Splign:2.1.0"
     exon            1149..1222
                     /gene="C19orf44"
                     /inference="alignment:Splign:2.1.0"
     exon            1223..1712
                     /gene="C19orf44"
                     /inference="alignment:Splign:2.1.0"
     exon            1713..1808
                     /gene="C19orf44"
                     /inference="alignment:Splign:2.1.0"
     exon            1809..1975
                     /gene="C19orf44"
                     /inference="alignment:Splign:2.1.0"
     exon            1976..2087
                     /gene="C19orf44"
                     /inference="alignment:Splign:2.1.0"
     exon            2088..3346
                     /gene="C19orf44"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3325..3330
                     /regulatory_class="polyA_signal_sequence"
                     /gene="C19orf44"
                     /note="hexamer: ATTAAA"
     polyA_site      3346
                     /gene="C19orf44"
                     /note="major polyA site"
ORIGIN      
        1 gttgcccagg gcaaccgctc cttcaggcgt gaatgtggcg gctgcctctg cgaatggacg
       61 gcgtgggaag agaatggctt ctgcaaggaa agccagccgt cccatgcgtg atgtttttgg
      121 tgacttcagt gatgtttcct tggaagattc aacaatggaa gaaatcagaa acttccagat
      181 cagtagaaat cttaccaaaa tagcacctgg tcatagcaga tttctaaaaa gaaaccaaac
      241 tctagatgag aaacacttac tcctgaaaga gaaccctgtg ctcgggagtg gacccaggct
      301 tgcctcatgt agaccgccca ccactgcctc caggatccga gccaatgccg cactcatgaa
      361 gctggcccag ctggaaaccc ggatcatgaa tcggaagctg cagaggaatt tgtctgacac
      421 ggaatctgac tcaatgaccg ccgatgctgg tcttccaaag agagctgaca gaatcctctc
      481 tgggggtgca ctcgaactcg cgtcccagaa cacagacaaa acttcccaga atcaagcccg
      541 tgaacttcct gtcaccgaaa ataatgcaca gaacgcgaag gtcagtaggt ttctaaagaa
      601 gaaacaagca cctgttgaaa acatatcccc tgaagcacct gctgggaaag agaggacttt
      661 gcaaaccccc aaacagaaag aacctgctag aacatttgat tctccagaca gtgacgaaga
      721 agaaatgaaa gtattgctag gaagcttgat ggactcttct agagaaaaaa acacgaatca
      781 aggcttcagc agcgctaacg tcagcgagga agaagaaaga aaactatttt cggtcccatc
      841 tcaactgaga gcatttactg tacccagcgt ggaactctcc agcgcaaagc cttctcagac
      901 atcacacctg ccaacctccc tggcagcaga cagaaccctt cacagcactc gctcaagagc
      961 agactaccca cagagtcacg tttccagtga caccgcctcc cacacgccgt cagtttccat
     1021 cacaggcgcc ttttcaaact cagtgtcttt aaagatgggg catgtcaagc ttgtgtcctc
     1081 cccgggaagg agtgaggctg agactgtgga cgagccagtc tcagaaggtg ctgatgacag
     1141 cctcgacgag tttagaataa atattttatc gcttgacggt ctggctccag ctgtcagtga
     1201 gaactccgat ttggaacagg aagaggaaag tgctcagaga caaaaaacag ctggcaaaat
     1261 cttcagagcc gaggcgtcca ctgggcagga tgccccgagg caggcccagg cgaggagctg
     1321 ggcatcacag ggaaaggccg cctctgcaga gggggatgag agcgaggtct cggagcatct
     1381 cagtgccagc tcggcttctg ccatccagca ggacagcact tccagcatgc agccaccatc
     1441 tgaagccccc atggtgaaca cagtcagctc agcttattcg gaggattttg aaaactctcc
     1501 aagtctgaca gcatctgagc caaccgccca ttccaaggag tctcttgaca gaacactgga
     1561 cgctttgtct gaatcctctt caagtgtgaa gacagacctt ccacaaacag ccgagtctag
     1621 gaaaaagtcg ggcaggcacg tgacaagagt gcttgtgaag gacacagctg tgcagacgcc
     1681 agatcctgcc ttcacctacg agtggaccaa ggtggccagc atggcagcca tggggcctgc
     1741 cctgggaggc gcctacgtgg acccgacacc catcgccaat catgttatca gtgcagatgc
     1801 aatagaagcc ctgaccgctt acagcccggc cgtgctggca ctccatgatg tgctgaagca
     1861 gcagctgagc ctgacgcagc agttcatcca ggccagccgg cacctgcacg cctccctcct
     1921 gcgctccctg gacgcggact ccttccacta ccacaccctg gaggaagcca aagagtacat
     1981 taggtgccac agacctgccc cactgaccat ggaggatgcc ctggaggagg tgaacaagga
     2041 gctgtgagcg ccagcaggtg gagcttgacg tgacgtctta acaaaagcaa agcaccgcag
     2101 cttcccagag ttaccagcgc agcacttaag acaggatctt acggcggggt ggggctcctg
     2161 gaccgtgacc ggcgtcttct tcctggggag tacgacttgg accgggaccg cgactgggac
     2221 cgggagcggc ttctggagga gcgcgacctg ctccgacttc tgcagggaag ggtgcccaag
     2281 ggtcagcagc agccaggcgt cgtggggagg ccacaggaag aggcctcagg cactgccctg
     2341 aggcagcctc tgcctaccta gatctggagc gggagtagga acgggagcag gagcgcgacc
     2401 ttgaccttga gtacgagcct gaagacttgg aggatcttga gttggagcgg gaggaagaac
     2461 gccctcgact cttggatctg ctccgagacc tcgagggtcc gctgtgggga gaggcctgat
     2521 gatcaggtgc cccagtggat gggctgcacc cagcccaccc tggccctcag gttcctagac
     2581 caccccagat gcaggggctc tggctgtgga tgtggcgcca tagccacagc aacggtacca
     2641 agttcctaaa tagtgtggcc gagcctgctg ctgtgtgaat tcaggccttg tggaaaacac
     2701 cgccccatag gcacaggctg tgtgagggtg gacgtgatga gtgtatctgg ggtctgctcc
     2761 cacccatcac aagctgtgga ccctggcccc ccggccactg cagacatctg cgcttttacc
     2821 tgttcctctt ctcctggcct ttcctccgcc gggcccgcat ttttgctcgg aagaactcat
     2881 agaggccgtt ctgctcccag ccttcactgt aagacacggc attccgtgtg tgaccacgtg
     2941 acacccaccc acaaggaagt cgtgaaaaag tcatcaggag ttaatccaca gaaccttgga
     3001 gagtacatgg ccctgtggct gtgggctccg agcatgggcg cagtagagct tggttcagtg
     3061 ttcccacagg gctgtcctcc tgcagcccag tggctcctct ggtgcccacg cccttgccac
     3121 cctgctgttc cgctgaggtg gtggggaccc atggtctgtg gaactgggaa acaggaacac
     3181 tgactcatgg gtggacaggc ctgcagccca gcacaggaag gaggggtgac cactgggaag
     3241 ggtgggctga gggccctgtg gcagccggct gcttgagacg tgccgccgtg ccacaccttc
     3301 cctaacttct tctgatgtgt ctccattaaa acgcccttca ttgagg
//
