LOCUS       NM_033520                374 bp    mRNA    linear   PRI 02-APR-2024
DEFINITION  Homo sapiens chromosome 19 open reading frame 33 (C19orf33),
            transcript variant 1, mRNA.
ACCESSION   NM_033520 XM_085984
VERSION     NM_033520.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 374)
  AUTHORS   Asadzadeh,Z., Hemmat,N., Hassanian,H., Alizadeh,N.,
            Mokhtarzadeh,A., Jafarlou,M. and Baradaran,B.
  TITLE     Unraveling dedifferentiation and metastasis traces in pancreatic
            ductal adenocarcinoma ductal cells: Insights from single-cell RNA
            sequencing analysis of ITGB4 and C19orf33
  JOURNAL   Pathol Res Pract 253, 155012 (2024)
   PUBMED   38071887
  REMARK    GeneRIF: Unraveling dedifferentiation and metastasis traces in
            pancreatic ductal adenocarcinoma ductal cells: Insights from
            single-cell RNA sequencing analysis of ITGB4 and C19orf33.
REFERENCE   2  (bases 1 to 374)
  AUTHORS   Luo,Q., Pan,Y., Fu,Q., Zhang,X., Zhou,S., Yu,P., Tian,H., Liu,P.,
            Chen,S., Zhang,H. and Qin,T.
  TITLE     Immortalization-upregulated protein promotes pancreatic cancer
            progression by regulating NPM1/FHL1-mediated cell-cycle-checkpoint
            protein activity
  JOURNAL   Cell Biol Toxicol 39 (5), 2069-2087 (2023)
   PUBMED   35142956
  REMARK    GeneRIF: Immortalization-upregulated protein promotes pancreatic
            cancer progression by regulating NPM1/FHL1-mediated
            cell-cycle-checkpoint protein activity.
REFERENCE   3  (bases 1 to 374)
  AUTHORS   Jeon,S.Y., Lee,H.J., Na,K.H., Cha,D.H., Kim,J.K., Park,J.W.,
            Yoon,T.K. and Kim,G.J.
  TITLE     Hypoxia-induced downregulation of XIAP in trophoblasts mediates
            apoptosis via interaction with IMUP-2: implications for placental
            development during pre-eclampsia
  JOURNAL   J Cell Biochem 114 (1), 89-98 (2013)
   PUBMED   22886722
  REMARK    GeneRIF: Hypoxia-induced down-regulation of XIAP mediates apoptosis
            in trophoblasts through interaction with increased IMUP-2; this
            mechanism underlies the pathogenesis of pre-eclampsia.
REFERENCE   4  (bases 1 to 374)
  AUTHORS   Jeon,S.Y., Lee,H.J., Park,J.M., Jung,H.M., Yoo,J.K., Lee,H.J.,
            Lee,J.S., Cha,D.H., Kim,J.K. and Kim,G.J.
  TITLE     Increased immortalization-upregulated protein 2 (IMUP-2) by hypoxia
            induces apoptosis of the trophoblast and pre-eclampsia
  JOURNAL   J Cell Biochem 110 (2), 522-530 (2010)
   PUBMED   20432246
  REMARK    GeneRIF: results suggest that IMUP-2 expression is specifically
            elevated in preterm pre-eclampsia and under hypoxic conditions, and
            that IMUP-2 induces apoptosis of the trophoblast
REFERENCE   5  (bases 1 to 374)
  AUTHORS   Kim,S.J., An,H.J., Kim,H.J., Jungs,H.M., Lee,S., Ko,J.J., Kim,I.H.,
            Sakuragi,N. and Kim,J.K.
  TITLE     Imup-1 and imup-2 overexpression in endometrial carcinoma in Korean
            and Japanese populations
  JOURNAL   Anticancer Res 28 (2A), 865-871 (2008)
   PUBMED   18507030
  REMARK    GeneRIF: These findings demonstrate the up-regulation of imup-1 and
            imup-2 in human endometrial carcinomas and indicate that these
            molecules play a role in endometrial carcinogenesis in both Korean
            and Japanese patients.
REFERENCE   6  (bases 1 to 374)
  AUTHORS   Naganuma,S., Itoh,H., Uchiyama,S., Nagaike,K., Tanaka,H.,
            Akiyama,Y., Chijiiwa,K. and Kataoka,H.
  TITLE     Nuclear translocation of H2RSP is impaired in regenerating
            intestinal epithelial cells of murine colitis model
  JOURNAL   Virchows Arch 448 (3), 354-360 (2006)
   PUBMED   16189703
  REMARK    GeneRIF: Nuclear translocation of H2RSP may be related to a
            signaling involved in the transition from cellular proliferation to
            differentiation in experimental murine colitis.
REFERENCE   7  (bases 1 to 374)
  AUTHORS   Kim,J.K., An,H.J., Kim,N.K., Ahn,J.Y., Kim,K.S., Kang,Y.J.,
            Ko,J.J., Oh,D., Lee,C., Kim,S.J. and Cha,K.Y.
  TITLE     IMUP-1 and IMUP-2 genes are up-regulated in human ovarian
            epithelial tumors
  JOURNAL   Anticancer Res 23 (6C), 4709-4713 (2003)
   PUBMED   14981917
  REMARK    GeneRIF: results showed the up-regulation of IMUP-1 and IMUP-2 in
            human ovarian epithelial tumors and suggested that the altered mRNA
            level of these molecules is possibly associated with ovarian
            tumorigenesis
REFERENCE   8  (bases 1 to 374)
  AUTHORS   Naganuma,S., Itoh,H., Uchiyama,S., Tanaka,H., Nagaike,K.,
            Miyata,S., Uchinokura,S., Nuki,Y., Akiyama,Y., Chijiiwa,K. and
            Kataoka,H.
  TITLE     Characterization of transcripts generated from mouse hepatocyte
            growth factor activator inhibitor type 2 (HAI-2) and HAI-2-related
            small peptide (H2RSP) genes: chimeric mRNA transcribed from both
            HAI-2 and H2RSP genes is detected in human but not in mouse
  JOURNAL   Biochem Biophys Res Commun 302 (2), 345-353 (2003)
   PUBMED   12604353
REFERENCE   9  (bases 1 to 374)
  AUTHORS   Itoh,H., Kataoka,H., Yamauchi,M., Naganuma,S., Akiyama,Y., Nuki,Y.,
            Shimomura,T., Miyazawa,K., Kitamura,N. and Koono,M.
  TITLE     Identification of hepatocyte growth factor activator inhibitor type
            2 (HAI-2)-related small peptide (H2RSP): its nuclear localization
            and generation of chimeric mRNA transcribed from both HAI-2 and
            H2RSP genes
  JOURNAL   Biochem Biophys Res Commun 288 (2), 390-399 (2001)
   PUBMED   11606055
  REMARK    GeneRIF: H2RSP and H2RSP/HAI-2 chimeric peptides might function as
            a transcriptional regulatory peptide at the nucleus.
REFERENCE   10 (bases 1 to 374)
  AUTHORS   Kim,J.K., Ryll,R., Ishizuka,Y. and Kato,S.
  TITLE     Identification of cDNAs encoding two novel nuclear proteins, IMUP-1
            and IMUP-2, upregulated in SV40-immortalized human fibroblasts
  JOURNAL   Gene 257 (2), 327-334 (2000)
   PUBMED   11080599
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AF213678.1 and CB109881.1.
            
            On Nov 22, 2018 this sequence version replaced NM_033520.2.
            
            Summary: The protein encoded by this gene has been shown to be
            upregulated in SV40-immortalized fibroblasts as well as in
            endometrial carcinoma cells. The encoded protein is found primarily
            in the nucleus. This protein may play a role in placental
            development and diseases such as pre-eclampsia. Two transcript
            variants encoding different isoforms have been found for this gene.
            [provided by RefSeq, Dec 2015].
            
            Transcript Variant: This variant (1) encodes the longer isoform
            (IMUP-1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB038317.1, BG287159.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1966682, SAMEA1968189
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000301246.10/ ENSP00000301246.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-5                 AF213678.1         91-95
            6-374               CB109881.1         1-369
FEATURES             Location/Qualifiers
     source          1..374
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19q13.2"
     gene            1..374
                     /gene="C19orf33"
                     /gene_synonym="H2RSP; IMUP; IMUP-1; IMUP-2"
                     /note="chromosome 19 open reading frame 33"
                     /db_xref="GeneID:64073"
                     /db_xref="HGNC:HGNC:16668"
                     /db_xref="MIM:619711"
     exon            1..33
                     /gene="C19orf33"
                     /gene_synonym="H2RSP; IMUP; IMUP-1; IMUP-2"
                     /inference="alignment:Splign:2.1.0"
     CDS             12..332
                     /gene="C19orf33"
                     /gene_synonym="H2RSP; IMUP; IMUP-1; IMUP-2"
                     /note="isoform IMUP-1 is encoded by transcript variant 1;
                     immortalization-upregulated protein; HAI-2 related small
                     protein; immortalization up-regulated protein; hepatocyte
                     growth factor activator inhibitor type 2-related small
                     protein"
                     /codon_start=1
                     /product="immortalization up-regulated protein isoform
                     IMUP-1"
                     /protein_id="NP_277055.1"
                     /db_xref="CCDS:CCDS12511.1"
                     /db_xref="GeneID:64073"
                     /db_xref="HGNC:HGNC:16668"
                     /db_xref="MIM:619711"
                     /translation="MEFDLGAALEPTSQKPGVGAGHGGDPKLSPHKVQGRSEAGAGPG
                     PKQGHHSSSDSSSSSSDSDTDVKSHAAGSKQHESIPGKAKKPKVKKKEKGKKEKGKKK
                     EAPH"
     exon            34..149
                     /gene="C19orf33"
                     /gene_synonym="H2RSP; IMUP; IMUP-1; IMUP-2"
                     /inference="alignment:Splign:2.1.0"
     exon            150..212
                     /gene="C19orf33"
                     /gene_synonym="H2RSP; IMUP; IMUP-1; IMUP-2"
                     /inference="alignment:Splign:2.1.0"
     exon            213..374
                     /gene="C19orf33"
                     /gene_synonym="H2RSP; IMUP; IMUP-1; IMUP-2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      352..357
                     /regulatory_class="polyA_signal_sequence"
                     /gene="C19orf33"
                     /gene_synonym="H2RSP; IMUP; IMUP-1; IMUP-2"
                     /note="hexamer: ATTAAA"
     polyA_site      374
                     /gene="C19orf33"
                     /gene_synonym="H2RSP; IMUP; IMUP-1; IMUP-2"
                     /note="major polyA site"
ORIGIN      
        1 ctcttaccgc catggagttc gacctgggag cagccctgga gcccacctcc cagaagcccg
       61 gtgtgggggc gggccacggg ggagatccca agctcagtcc ccacaaagtt cagggccggt
      121 cggaggcagg ggcaggtccg ggtccaaagc aaggacacca cagctcttcc gactccagca
      181 gcagctccag cgattcggac acggatgtga agtcccacgc tgctggctcc aagcagcacg
      241 agagcatccc gggcaaggcc aagaagccca aagtgaagaa gaaggagaag ggcaagaagg
      301 agaagggcaa gaagaaggag gctccccact gaagggccct ggacagggct cattaaacct
      361 tcctctctgc cttc
//
