LOCUS       NM_152482               2243 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens chromosome 19 open reading frame 25 (C19orf25), mRNA.
ACCESSION   NM_152482
VERSION     NM_152482.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2243)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   2  (bases 1 to 2243)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   3  (bases 1 to 2243)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   4  (bases 1 to 2243)
  AUTHORS   Pan,J., Meyers,R.M., Michel,B.C., Mashtalir,N., Sizemore,A.E.,
            Wells,J.N., Cassel,S.H., Vazquez,F., Weir,B.A., Hahn,W.C.,
            Marsh,J.A., Tsherniak,A. and Kadoch,C.
  TITLE     Interrogation of Mammalian Protein Complex Structure, Function, and
            Membership Using Genome-Scale Fitness Screens
  JOURNAL   Cell Syst 6 (5), 555-568 (2018)
   PUBMED   29778836
REFERENCE   5  (bases 1 to 2243)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Paulo,J.A., Cannon,J.R., Ting,L.,
            Baltier,K., Colby,G., Gebreab,F., Gygi,M.P., Parzen,H., Szpyt,J.,
            Tam,S., Zarraga,G., Pontano-Vaites,L., Swarup,S., White,A.E.,
            Schweppe,D.K., Rad,R., Erickson,B.K., Obar,R.A., Guruharsha,K.G.,
            Li,K., Artavanis-Tsakonas,S., Gygi,S.P. and Harper,J.W.
  TITLE     Architecture of the human interactome defines protein communities
            and disease networks
  JOURNAL   Nature 545 (7655), 505-509 (2017)
   PUBMED   28514442
REFERENCE   6  (bases 1 to 2243)
  AUTHORS   Bailey,S.D., Xie,C., Do,R., Montpetit,A., Diaz,R., Mohan,V.,
            Keavney,B., Yusuf,S., Gerstein,H.C., Engert,J.C. and Anand,S.
  CONSRTM   DREAM investigators
  TITLE     Variation at the NFATC2 locus increases the risk of
            thiazolidinedione-induced edema in the Diabetes REduction
            Assessment with ramipril and rosiglitazone Medication (DREAM) study
  JOURNAL   Diabetes Care 33 (10), 2250-2253 (2010)
   PUBMED   20628086
  REMARK    GeneRIF: Observational study of gene-disease association,
            gene-environment interaction, and pharmacogenomic / toxicogenomic.
            (HuGE Navigator)
REFERENCE   7  (bases 1 to 2243)
  AUTHORS   Talmud,P.J., Drenos,F., Shah,S., Shah,T., Palmen,J., Verzilli,C.,
            Gaunt,T.R., Pallas,J., Lovering,R., Li,K., Casas,J.P., Sofat,R.,
            Kumari,M., Rodriguez,S., Johnson,T., Newhouse,S.J., Dominiczak,A.,
            Samani,N.J., Caulfield,M., Sever,P., Stanton,A., Shields,D.C.,
            Padmanabhan,S., Melander,O., Hastie,C., Delles,C., Ebrahim,S.,
            Marmot,M.G., Smith,G.D., Lawlor,D.A., Munroe,P.B., Day,I.N.,
            Kivimaki,M., Whittaker,J., Humphries,S.E. and Hingorani,A.D.
  CONSRTM   ASCOT investigators; NORDIL investigators; BRIGHT Consortium
  TITLE     Gene-centric association signals for lipids and apolipoproteins
            identified via the HumanCVD BeadChip
  JOURNAL   Am J Hum Genet 85 (5), 628-642 (2009)
   PUBMED   19913121
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   8  (bases 1 to 2243)
  AUTHORS   Kops,G.J., Kim,Y., Weaver,B.A., Mao,Y., McLeod,I., Yates,J.R. 3rd,
            Tagaya,M. and Cleveland,D.W.
  TITLE     ZW10 links mitotic checkpoint signaling to the structural
            kinetochore
  JOURNAL   J Cell Biol 169 (1), 49-60 (2005)
   PUBMED   15824131
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BP210473.1, BC018441.1 and AL122089.1.
            
            On Jun 2, 2019 this sequence version replaced NM_152482.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AL122089.1, SRR1803617.94391.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA2142586,
                                           SAMEA2151358 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000585675.6/ ENSP00000468688.2
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-16                BP210473.1         15-30
            17-1276             BC018441.1         1-1260
            1277-2243           AL122089.1         1262-2228
FEATURES             Location/Qualifiers
     source          1..2243
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19p13.3"
     gene            1..2243
                     /gene="C19orf25"
                     /note="chromosome 19 open reading frame 25"
                     /db_xref="GeneID:148223"
                     /db_xref="HGNC:HGNC:26711"
     exon            1..53
                     /gene="C19orf25"
                     /inference="alignment:Splign:2.1.0"
     exon            54..185
                     /gene="C19orf25"
                     /inference="alignment:Splign:2.1.0"
     CDS             56..412
                     /gene="C19orf25"
                     /codon_start=1
                     /product="UPF0449 protein C19orf25"
                     /protein_id="NP_689695.2"
                     /db_xref="CCDS:CCDS45898.1"
                     /db_xref="GeneID:148223"
                     /db_xref="HGNC:HGNC:26711"
                     /translation="MGSKAKKRVLLPTRPAPPTVEQILEDVRGAPAEDPVFTILAPED
                     PPVPFRMMEDAEAPGEQLYQQSRAYVAANQRLQQAGNVLRQRCELLQRAGEDLEREVA
                     QMKQAALPAAEAASSG"
     exon            186..2243
                     /gene="C19orf25"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1252..1257
                     /regulatory_class="polyA_signal_sequence"
                     /gene="C19orf25"
                     /note="hexamer: CATAAA"
     polyA_site      1276
                     /gene="C19orf25"
                     /note="major polyA site"
     regulatory      2221..2226
                     /regulatory_class="polyA_signal_sequence"
                     /gene="C19orf25"
                     /note="hexamer: ATTAAA"
     polyA_site      2243
                     /gene="C19orf25"
                     /note="major polyA site"
ORIGIN      
        1 ggaatcggaa gtggctgcgt cgtcgacgct gggctttcgg gtcccgcgcc cagagatggg
       61 ctccaaggca aagaagcgcg tgctgctgcc cacccgccca gcgcccccca cggtggagca
      121 gatcctggag gatgtgcggg gtgcgccggc agaggatcca gtgttcacca tcctggcccc
      181 ggaagacccc ccagttccct tcaggatgat ggaggatgcg gaggccccgg gagagcagct
      241 ctaccagcaa agccgggcct acgtggctgc caaccagcgg ctgcagcagg cgggcaacgt
      301 gctgaggcag aggtgtgagc tcctgcagcg agccggcgag gacctggagc gggaggtggc
      361 ccagatgaag caggcagcat taccggcagc cgaggctgcc tcctcaggct gacctctcgg
      421 ggcctgcagg cttgggcagc gcacaaggtg gcctgcaccc aggctttccc tgggggtccg
      481 tcggccccag actggcattc acggggtccc agcccacgtg ggtgttgaca caggcgcccc
      541 tcctgatgct ggggctgcgg ttcatccgtc gtctcattca tgccgagttg gtgggaccca
      601 cccagctggc tccgtcctgc gtgacctgag ggccccactg gggttctgga agaggatagg
      661 gacattattg ctgtactgtg attctgtcgt cagctcacag tggccgtgct ctgcagtggg
      721 gcccctggga gcaggtgcca cctccttcct ctcccggggc aggcactcgc ctgtccactt
      781 ctgagtccag gtgttgggat cgaggtgtta actgtgattc catccagcga gtgcccaccc
      841 aatgtcagag cagcccgagg gccagcctga gcccctgacc ccacttcctt ctgggccccg
      901 ggctcctccc acaagccacg ttgatcttca caacgaccct gggccgctgg ggtcacccaa
      961 gagaagcagc cctgagaccc agccaggctg ggcctagctc cacggcacgg gtgtctccca
     1021 gccactgccc ttgctggagg accgctgtga gtcactggcc aggagcccag ggtgtcctga
     1081 gtctcatagc caccctgcca gctgcagcag gtcctgggcc tgcttccctg cgggttctgg
     1141 ccctggggga gggggcgtta gtgcggcgga gggtcttgcc aaaggctttt catcctaaat
     1201 agcaacttga gtggaaacct gggcaaggcg gcccagaggc tgggccctgc acataaagct
     1261 ttcgtgtgtg tctggccgtc tgaatggtgc ctctgtgagc ggctccgtcc cggggccccg
     1321 gaagctgggg agggatgggt accggcgacc ccgggaaccc tgctcagtcc tgccgggcac
     1381 tgcatgcagg gaccgtccgc ctgacccaga gacctggggc tgcctcaccc tctctccaga
     1441 cccacagcca gctttgtttc ttgaatgtgg aagatgtttc ttattccctg aagaaagggg
     1501 gcctgccaca cacagcctgg gaggcgcctc atccagaaac tgggacttgg ctagcccggc
     1561 ctgggcccta gggacttctc actggtcatg cttctgaagc tgctcacctg gccgagggag
     1621 gtcccggcag tgtcccaggg tggaaggtgg ggagggggcc ggctcctgcc atcccttccc
     1681 accctgcact tctgtgctgc ttgcagtcat agctttcctt gtccccccag ctgggccagg
     1741 gctgtgctcc ctgaagtggc tttgacgtgg ggccgtccca gctcccgcag cccctgtcca
     1801 ccattgactc tccccggtag tggctgctgt ggctgcccca tcccagctgt tgcaccagcc
     1861 acagctccta gtggctcatg ggtgcctcct gccccacact ggggcctgcc ataataactg
     1921 gcccaggtac caatgcccag gttggacccc ctgtctgggg tgctgtgcac cccctggagc
     1981 ctgccctccc ttgggaccag ggggagactc ctggcctcag ccagtgcctc cccggcccat
     2041 ctgggtgggg tgcccacaaa ccctgtgccc ccagtttctg ctttctggct ctgcttccag
     2101 ggatctaacc tggggggtct cagcaattct gtggcagcac atagacagcg atgaacctac
     2161 ccgcccacag cccattttga ggaagaggtg atggcggcag gcaatgcaag agctcagttt
     2221 attaaatgtg tgcgagtcgg aca
//
