LOCUS       NM_001288980            5703 bp    mRNA    linear   PRI 06-JUN-2024
DEFINITION  Homo sapiens chromosome 18 open reading frame 54 (C18orf54),
            transcript variant 1, mRNA.
ACCESSION   NM_001288980
VERSION     NM_001288980.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5703)
  AUTHORS   Ma,Y., Yan,D., Tian,F., Song,W., Sha,R., Shang,X., Lv,J.,
            Maimaiti,N., Kong,P. and Ma,X.
  TITLE     C18ORF54 promotes immune infiltration and poor prognosis as a
            potential biomarker for hepatocellular carcinoma
  JOURNAL   Am J Transl Res 15 (8), 5007-5034 (2023)
   PUBMED   37692934
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 5703)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   3  (bases 1 to 5703)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   4  (bases 1 to 5703)
  AUTHORS   Giotti,B., Chen,S.H., Barnett,M.W., Regan,T., Ly,T., Wiemann,S.,
            Hume,D.A. and Freeman,T.C.
  TITLE     Assembly of a parts list of the human mitotic cell cycle machinery
  JOURNAL   J Mol Cell Biol 11 (8), 703-718 (2019)
   PUBMED   30452682
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC093462.11, CN359540.1, AB353076.1 and AC087395.7.
            
            On Nov 22, 2018 this sequence version replaced NM_001288980.1.
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (a). Both variants 1 and
            2 encode the same isoform.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB353076.1 [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000620105.5/ ENSP00000477654.1
            RefSeq Select criteria :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-11                AC093462.11        10443-10453         c
            12-12               CN359540.1         5-5
            13-1939             AB353076.1         1-1927
            1940-5703           AC087395.7         12398-16161         c
FEATURES             Location/Qualifiers
     source          1..5703
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="18"
                     /map="18q21.2"
     gene            1..5703
                     /gene="C18orf54"
                     /gene_synonym="LAS2"
                     /note="chromosome 18 open reading frame 54"
                     /db_xref="GeneID:162681"
                     /db_xref="HGNC:HGNC:13796"
                     /db_xref="MIM:613258"
     exon            1..170
                     /gene="C18orf54"
                     /gene_synonym="LAS2"
                     /inference="alignment:Splign:2.1.0"
     exon            171..267
                     /gene="C18orf54"
                     /gene_synonym="LAS2"
                     /inference="alignment:Splign:2.1.0"
     exon            268..596
                     /gene="C18orf54"
                     /gene_synonym="LAS2"
                     /inference="alignment:Splign:2.1.0"
     CDS             314..1915
                     /gene="C18orf54"
                     /gene_synonym="LAS2"
                     /note="isoform a is encoded by transcript variant 1; lung
                     adenoma susceptibility protein 2"
                     /codon_start=1
                     /product="lung adenoma susceptibility protein 2 isoform a"
                     /protein_id="NP_001275909.1"
                     /db_xref="CCDS:CCDS74223.1"
                     /db_xref="GeneID:162681"
                     /db_xref="HGNC:HGNC:13796"
                     /db_xref="MIM:613258"
                     /translation="MAKSKTKHRLCSQESSVSALLASCTLSGSNSSNSDGSFHYKDKL
                     YRSASQALQAYIDDFDLGQIYPGASTGKINIDEDFTNMSQFCNYIYKPNNAFENLDHK
                     KHSNFISCRRHTVNDIDSMSLTTDDLLRLPADGSFSYTYVGPSHRTSKKNKKCRGRLG
                     SLDIEKNPHFQGPYTSMGKDNFVTPVIRSNINGKQCGRLKNPKLMNRTNNCISESSLS
                     FPKKSSFKDSSEHSLEKNYPRWLTSQKSDLNVSGITSIPDFKYPVWLHNQDLLPDANS
                     QRVYQIFKDDQCSPRHSHQAQGTSRLINKLDCFEYAFEPSNFSNSLSDDKELVNEYKC
                     DFEHSQCQCENPLLPGQSTKPFSGDKIELLILKAKRNLEQCTEELPKSMKKDDSPCSL
                     DKLEADRSWENIPVTFKSPVPVNSDDSPQQTSRAKSAKGVLEDFLNNDNQSCTLSGGK
                     HHGPVEALKQMLFNLQAVQERFNQNKTTDPKEEIKQVSEDDFSKLQLKESMIPITRSL
                     QKALHHLSRLRDLVDDTNGERSPKM"
     exon            597..1385
                     /gene="C18orf54"
                     /gene_synonym="LAS2"
                     /inference="alignment:Splign:2.1.0"
     exon            1386..1536
                     /gene="C18orf54"
                     /gene_synonym="LAS2"
                     /inference="alignment:Splign:2.1.0"
     exon            1537..1639
                     /gene="C18orf54"
                     /gene_synonym="LAS2"
                     /inference="alignment:Splign:2.1.0"
     exon            1640..1771
                     /gene="C18orf54"
                     /gene_synonym="LAS2"
                     /inference="alignment:Splign:2.1.0"
     exon            1772..1842
                     /gene="C18orf54"
                     /gene_synonym="LAS2"
                     /inference="alignment:Splign:2.1.0"
     exon            1843..5703
                     /gene="C18orf54"
                     /gene_synonym="LAS2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4732..4737
                     /regulatory_class="polyA_signal_sequence"
                     /gene="C18orf54"
                     /gene_synonym="LAS2"
                     /note="hexamer: ATTAAA"
     polyA_site      4754
                     /gene="C18orf54"
                     /gene_synonym="LAS2"
                     /note="major polyA site"
     regulatory      5659..5664
                     /regulatory_class="polyA_signal_sequence"
                     /gene="C18orf54"
                     /gene_synonym="LAS2"
                     /note="hexamer: TATAAA"
     regulatory      5678..5683
                     /regulatory_class="polyA_signal_sequence"
                     /gene="C18orf54"
                     /gene_synonym="LAS2"
                     /note="hexamer: GATAAA"
     polyA_site      5683
                     /gene="C18orf54"
                     /gene_synonym="LAS2"
     polyA_site      5703
                     /gene="C18orf54"
                     /gene_synonym="LAS2"
ORIGIN      
        1 gccatgttgg ggcggtttga aagcgagcgc gggtgtcgag ctctgctgtg actgcggagg
       61 aagctgcgag tgagccgagc ctgaggcggg gcggtgtccg ggttggggat gctttgtggt
      121 gtctcgcgtt gggtaacagg cctgagcttt cggcggagag ctgtggaagt ttagttaaaa
      181 tttgttgtca ataagtttaa cattctgttc ttccgcgtga tggattttct tttggagatt
      241 cgaactgaag cctgtacgga ggaaatgttg tttttaaggg aaatgaatag aaacaatcca
      301 ctttgaagaa gccatggcga aatcaaagac aaaacataga ctttgttctc aggaatcttc
      361 agtatctgcc ctgctggcaa gctgcaccct gagtggtagt aattcctcta attctgatgg
      421 ctcgtttcac tataaagata agctgtacag atctgcttct caagctctac aggcttatat
      481 tgatgatttt gatctaggcc aaatatatcc tggtgcaagc actggaaaaa ttaacattga
      541 tgaggatttt actaatatgt cacagttctg caactatatt tacaaaccaa acaatgcttt
      601 tgaaaacctt gatcacaaaa agcactcaaa cttcatatcc tgtagaagac acaccgttaa
      661 tgacatagac tccatgagcc taacaactga tgatctatta agactcccag cagatggatc
      721 attttcttat acttatgttg gaccgagtca ccgaacgagc aagaaaaaca agaaatgccg
      781 tggaagactg ggttcattgg acattgagaa gaatccacat tttcaaggac cctacacttc
      841 catgggcaag gataactttg ttactcctgt tatacgctca aatataaatg gaaagcaatg
      901 tggtaggctg aaaaacccaa aacttatgaa taggactaat aattgcattt ctgaatcatc
      961 tttgtctttt cccaagaaat cgtctttcaa ggacagttca gaacacagtc ttgaaaagaa
     1021 ttacccaaga tggctcacta gccagaaatc tgaccttaat gtttcaggga taactagtat
     1081 acctgatttc aaatacccag tctggctgca caatcaagac ttgctacctg atgcaaatag
     1141 tcaaagggtt tatcagatat ttaaagatga tcagtgttcc cctagacata gtcatcaggc
     1201 acaaggaact tctcggctta tcaataaatt agattgtttt gaatatgctt ttgaaccctc
     1261 aaacttttca aattccttga gtgatgataa agaattagtt aatgaataca aatgtgattt
     1321 tgaacatagc cagtgtcaat gtgagaatcc acttctccca ggacaatcca caaagccatt
     1381 cagtggtgac aaaattgaat tgcttatctt gaaggccaag agaaatctag agcagtgtac
     1441 tgaagaatta ccaaagtcca tgaaaaagga tgacagtcct tgctcattag ataaacttga
     1501 agcagacaga tcatgggaaa atattcctgt tactttcaaa tctcctgttc ccgttaactc
     1561 tgatgatagt cctcaacaaa cttcaagggc aaagagtgct aaaggggttc ttgaagactt
     1621 tctaaataat gataatcaga gctgtactct ctctggaggc aaacatcatg gtcctgttga
     1681 agccctgaaa caaatgttat ttaaccttca agcagtacaa gaacgtttta atcaaaataa
     1741 gaccacagat ccaaaagaag agattaaaca agtttcagaa gatgatttct ctaaattaca
     1801 gttgaaggaa agtatgattc ctattactag gtcacttcag aaggctttgc accatttatc
     1861 tcgcctgaga gacctggttg atgatacgaa tggagaacgg tcaccgaaaa tgtgaagagg
     1921 aaaatgaaac tgtcaccaca atgaatagtc accacagaac aaataggcat tttttctatt
     1981 acttaaactg acaaagtaaa tataagccat acattatttt gtggttggtt caaggattat
     2041 atatttctaa aacactaaac ttgaaaatac ccataggttt tgggacctat ctttattttg
     2101 tgccaacata ctagaatgtg aactgcaagg acccacaata tatcctgaag tcttactttc
     2161 gccttctggc cagcaaatgt ctaatattta aagatggatg acttctgttc ttgaagctta
     2221 cctggattta accttcttca gcatcctcaa cattttatta cctggttcag gatcattaag
     2281 aaacttactg gtttttatcc aaaatctttt acgttaaata gactttttta aagatatagt
     2341 tagcatcact tttaaacagc ttaaaggaat atcaaaattg ttattgtgta tctcatctat
     2401 aaggaagtct gttactttga aattttcata aatttaatat ttaagataca ttgtatttga
     2461 aaattgcatt aatagtgggg tgatactgtg ttaaaaggaa tgttgtgttg tgacattcaa
     2521 gagaacctcc tcatttaatt agtactttga ttctgtgtaa gataatcttg gtagtgcttg
     2581 acagtttcca aacctttttt tggagagata tttaagaatt taatattttg atattagatt
     2641 gtttcccaga ttttaatttt ggggttggct caaactagtg aaaactatga ctcaatggcc
     2701 aattgcttta tcaaatttga taactaaaac ttaaaatgaa tatggaaaat cagaaagcaa
     2761 ctctatttta gagctatttt gtaagagttg tgctttcttt aacaccatct gtagtcttaa
     2821 gtttgtctct agctagaact gaacaaagct ctataatttt taccaagcac ttattattaa
     2881 tacttcttat aagtagtaag catctttact aacacaactg agaattaagt cataaaacat
     2941 aactaataca gcacattact gcctgacaaa attaaagagt actgtgtgta tgtataacta
     3001 ctacaggtta acacttcacc caaatgatag cgtttttcct cagtagatta ttgtcaaata
     3061 ggaatttcta agcacattga gtcaaagcat tttttccaag ttaataaagt gttatttact
     3121 atctttgtta gaggtgacat gtcaaacact acagtgagct ctgtggggtt tttttttttt
     3181 ttttttgccc gtgagttttt taccatgctg ctctgaccag tttgagtggc aattaccaat
     3241 agatttgttt tctttattct atggagatgt ttttaccact gacactgttt tctgattata
     3301 gtctgcttca tagaaaatag cctgcataat caaacaagga gttactttga aattaaagta
     3361 tgcctggcta ttaaaaatgc agattttagg tgggtaaaca tcaggtaggt ctgggtgggt
     3421 catgttctag gcctagaaaa atacactatt agacaagttc taaagaaggc aaggagataa
     3481 aggcatcagg tggtaacttc taattgaata ttatatgttg atcatacata atatatacta
     3541 tgcctggaaa ttatgactga aaagcaccta ttcggttagt gctcctattc atgagaacat
     3601 atctccaata ctaaatgaga taagcctgtt ctaaaatctt atagccagta ttttaagaaa
     3661 cttgattata cttaccaaag gaacattgtt tgttttctct tgttttaaat atggagaggt
     3721 ttaatccttt acataacaaa ggaattaatt ttagcaaaat gattcattcc aaccttctta
     3781 taagaaatat ctaggagagt caagtaagaa aaataacgaa tctaagtgat aaacattcaa
     3841 gaaattctct aaataagaga tttatttata attttaatat ctcagggttc tttttaggtt
     3901 tccaggggaa aagagcagga taacagtgtg gagactgcta agttgagaat ttaaaacaaa
     3961 tgagaacata agatttttaa aattgcattg tgaatgtaaa atttttatca atcctttgct
     4021 ctcttttaga catattgaga aaatgttaaa tagaaaaaat taagaaattt taataagatg
     4081 tttcagatct ttgagtatga aaaacataac aaaaaaagcc taatttcaaa aaactatttg
     4141 agatcaaggg acaatggtgt gaccaatatg aagggtcaag actgaaatgt attgtcttta
     4201 ctatcaagaa ctctactttc agttgtttct cagacagtta atttcagctt catagagatt
     4261 tctgagcaaa ttaagaaaca ctgttttcct gggtttgttt tgggtatatg tcattatagt
     4321 tatgttattt cttgttgaaa tttataattg taggtttttt gtattgtttt agtatttaat
     4381 ggtgtataat gtgttattac attatatgta gttataccaa aatattgcct gaagataaat
     4441 catgacaagg tcccctgttt attcctgtgt tacagacgca tggaattgct cctgtagatt
     4501 tgaatttttg tttcattttt ttctgtccca cccttcactc tctctgtttc agaacatttt
     4561 tggtagaagt gctatccaga agtgaacttg tcaaaaggca agtagcatga aagaagacag
     4621 aagaagcaaa aggctaatac agtggataat ttctgagcac ttgaagtttc ttcaaatgtg
     4681 caagactgtg tgtcttccta ttagatgtat aaattggata tttcatgcct aattaaatgt
     4741 tgcgttggat tgcagtgcct atcatacagt gattggagta aattgaggcc taatcctgaa
     4801 cacatataga gcatattgtt agatattttt cctgtgacat ttgaagttat tattctccca
     4861 tttccttttt ctttttttgt ttataatcat atgtccctaa gattgttttc cttttttgga
     4921 ccaaaaaaaa gaaaaaaaaa atcttagctt ttcatcctcc cagtgtattc tgcattgtcc
     4981 ttaccctaga tcagcccctt ctgtgttaac agtttttctc acaatgtagc aacttttatc
     5041 cacccttcag gaccttcact gggactagtt cattcatttt caaatagcta tttcaacctt
     5101 taacatctac tgtcttagtc ttttacacag aagccagagt gactggtctt ggcaagactc
     5161 tgttgtgtat caccactcta accttactga tttgtttcag caaatttgct ttagttaaat
     5221 tgctttactc agattccccc aaactttata tgtgtattgt catctttgtg catattattt
     5281 ctcatgcatg aaatactcaa tttttattct tttatctaac gcttactctt acatttcttt
     5341 aaagctctgg ccaagtattt tatttcgtcc ctaaacattc taactatcca ccaaactggt
     5401 aagttggctt ttctttttcc tccccctgtc attcatttag ctgttatatt tcattttaat
     5461 gttttgggtg gtgcctctta tactatgttg tattcctaga caaggaaatg tatatcaaaa
     5521 tatgttagat gattgattgt tttatctcct tgatgatagc acctcttata ctgctttaca
     5581 gaatcaggaa aaagtaaact gcattttaca tagtggtttt aaatattgat tgattgatat
     5641 tctaaacctg gtttcctata taaagttgta agttcaagat aaagagacca cattctttac
     5701 tca
//
