LOCUS       NM_031446                985 bp    mRNA    linear   PRI 10-JUL-2024
DEFINITION  Homo sapiens chromosome 18 open reading frame 21 (C18orf21),
            transcript variant 1, mRNA.
ACCESSION   NM_031446
VERSION     NM_031446.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 985)
  AUTHORS   Palukuri,M.V., Patil,R.S. and Marcotte,E.M.
  TITLE     Molecular complex detection in protein interaction networks through
            reinforcement learning
  JOURNAL   BMC Bioinformatics 24 (1), 306 (2023)
   PUBMED   37532987
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 985)
  AUTHORS   Behr,E.R., Ritchie,M.D., Tanaka,T., Kaab,S., Crawford,D.C.,
            Nicoletti,P., Floratos,A., Sinner,M.F., Kannankeril,P.J.,
            Wilde,A.A., Bezzina,C.R., Schulze-Bahr,E., Zumhagen,S.,
            Guicheney,P., Bishopric,N.H., Marshall,V., Shakir,S.,
            Dalageorgou,C., Bevan,S., Jamshidi,Y., Bastiaenen,R.,
            Myerburg,R.J., Schott,J.J., Camm,A.J., Steinbeck,G., Norris,K.,
            Altman,R.B., Tatonetti,N.P., Jeffery,S., Kubo,M., Nakamura,Y.,
            Shen,Y., George,A.L. Jr. and Roden,D.M.
  TITLE     Genome wide analysis of drug-induced torsades de pointes: lack of
            common variants with large effect sizes
  JOURNAL   PLoS One 8 (11), e78511 (2013)
   PUBMED   24223155
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 985)
  AUTHORS   Beausoleil,S.A., Villen,J., Gerber,S.A., Rush,J. and Gygi,S.P.
  TITLE     A probability-based approach for high-throughput protein
            phosphorylation analysis and site localization
  JOURNAL   Nat Biotechnol 24 (10), 1285-1292 (2006)
   PUBMED   16964243
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC108730.1 and AA648431.1.
            
            On Nov 22, 2018 this sequence version replaced NM_031446.4.
            
            Transcript Variant: This variant (1) encodes the longest isoform
            (a).
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR3476690.423295.1,
                                           SRR5189667.318016.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000592875.6/ ENSP00000465517.1
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-981               BC108730.1         15-995
            982-985             AA648431.1         19-22               c
FEATURES             Location/Qualifiers
     source          1..985
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="18"
                     /map="18q12.2"
     gene            1..985
                     /gene="C18orf21"
                     /gene_synonym="HsT3108; PNAS-124; PNAS-131; XTP13"
                     /note="chromosome 18 open reading frame 21"
                     /db_xref="GeneID:83608"
                     /db_xref="HGNC:HGNC:28802"
     exon            1..127
                     /gene="C18orf21"
                     /gene_synonym="HsT3108; PNAS-124; PNAS-131; XTP13"
                     /inference="alignment:Splign:2.1.0"
     CDS             51..713
                     /gene="C18orf21"
                     /gene_synonym="HsT3108; PNAS-124; PNAS-131; XTP13"
                     /note="isoform a is encoded by transcript variant 1; HBV
                     X-transactivated protein 13; HBV XAg-transactivated
                     protein 13; HBV X-transactivated gene 13 protein; UPF0711
                     protein C18orf21"
                     /codon_start=1
                     /product="UPF0711 protein C18orf21 isoform a"
                     /protein_id="NP_113634.3"
                     /db_xref="CCDS:CCDS11916.2"
                     /db_xref="GeneID:83608"
                     /db_xref="HGNC:HGNC:28802"
                     /translation="MRQKHYLEAAARGLHDSCPGQARYLLWAYTSSHDDKSTFEETCP
                     YCFQLLVLDNSRVRLKPKARLTPKIQKLLNREARNYTLSFKEAKMVKKFKDSKSVLLI
                     TCKTCNRTVKHHGKSRSFVSTLKSNPATPTSKLSLKTPERRTANPNHDMSGSKGKSPA
                     SVFRTPTSGQSVSTCSSKNTSKTKKHFSQLKMLLSQNESQKIPKVDFRNFLSSLKGGL
                     LK"
     exon            128..150
                     /gene="C18orf21"
                     /gene_synonym="HsT3108; PNAS-124; PNAS-131; XTP13"
                     /inference="alignment:Splign:2.1.0"
     exon            151..350
                     /gene="C18orf21"
                     /gene_synonym="HsT3108; PNAS-124; PNAS-131; XTP13"
                     /inference="alignment:Splign:2.1.0"
     exon            351..541
                     /gene="C18orf21"
                     /gene_synonym="HsT3108; PNAS-124; PNAS-131; XTP13"
                     /inference="alignment:Splign:2.1.0"
     exon            542..985
                     /gene="C18orf21"
                     /gene_synonym="HsT3108; PNAS-124; PNAS-131; XTP13"
                     /inference="alignment:Splign:2.1.0"
     regulatory      738..743
                     /regulatory_class="polyA_signal_sequence"
                     /gene="C18orf21"
                     /gene_synonym="HsT3108; PNAS-124; PNAS-131; XTP13"
                     /note="hexamer: ACTAAA"
     polyA_site      756
                     /gene="C18orf21"
                     /gene_synonym="HsT3108; PNAS-124; PNAS-131; XTP13"
                     /note="major polyA site"
     regulatory      962..967
                     /regulatory_class="polyA_signal_sequence"
                     /gene="C18orf21"
                     /gene_synonym="HsT3108; PNAS-124; PNAS-131; XTP13"
                     /note="hexamer: TATAAA"
     polyA_site      985
                     /gene="C18orf21"
                     /gene_synonym="HsT3108; PNAS-124; PNAS-131; XTP13"
                     /note="major polyA site"
ORIGIN      
        1 ctattttctc acctggttcc cgcggcgagc cagcggcagc ggcggcggcg atgagacaga
       61 agcactacct tgaggctgca gcgcggggac tgcacgacag ctgcccgggc caagcccgct
      121 acctcctctg ggcctacact tcgtcgcacg atgataagag cacttttgaa gaaacgtgtc
      181 catactgttt ccagctgttg gttctggata actctcgagt gcgtctcaaa cccaaagcca
      241 ggttgacacc caaaatacag aaacttctta atcgagaagc gagaaactat acactcagtt
      301 ttaaagaagc aaaaatggtg aaaaagttca aagactccaa aagtgtattg ttgatcactt
      361 gtaaaacatg caacagaaca gtgaaacatc atggtaaaag tagaagcttt gtgtcaacat
      421 tgaagagcaa tcctgccact cctacaagta aactcagcct gaagacacca gagagaagga
      481 ctgcaaaccc aaatcatgac atgtctggct cgaaaggcaa gagcccagca tcggttttca
      541 gaacacctac atctggacag tcagtatcta cttgctcctc aaagaacacc agcaaaacaa
      601 agaaacactt ctctcaacta aaaatgttac ttagtcagaa tgaatcccaa aagattccaa
      661 aggtggactt cagaaatttc ttatcttctc tgaagggtgg acttttaaaa taagaaatgc
      721 ctgatgtcaa ttctgaaact aaagttggta aaacaacttt ttaaactctt attcattttt
      781 tgaatacatg gaaactagat ctgaatgcaa acttttcttg gcatccttca gtgtttatgg
      841 ggaaaatacc tcattagtgt gaatacctga aacctgccta cctcatagga cagctgtgag
      901 gatcaaaaaa tatatgaaag ttccttgtag atacatatct atagatatat atgtgtatgt
      961 atataaagat agatatatac attga
//
