LOCUS       NM_001163075            1072 bp    mRNA    linear   PRI 05-AUG-2024
DEFINITION  Homo sapiens chromosome 17 open reading frame 99 (C17orf99), mRNA.
ACCESSION   NM_001163075 XM_002343545 XM_002345081 XM_002347812
VERSION     NM_001163075.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1072)
  AUTHORS   Cerezo,L.A., Navratilova,A., Kuklova,M., Prokopcova,A., Baloun,J.,
            Kropackova,T., Veigl,D., Popelka,S., Fulin,P., Ballay,R.,
            Pavelka,K., Vencovsky,J. and Senolt,L.
  TITLE     IL-40 is up-regulated in the synovial fluid and cartilage of
            osteoarthritis patients and contributes to the alteration of
            chondrocytes phenotype in vitro
  JOURNAL   Arthritis Res Ther 26 (1), 146 (2024)
   PUBMED   39080724
  REMARK    GeneRIF: IL-40 is up-regulated in the synovial fluid and cartilage
            of osteoarthritis patients and contributes to the alteration of
            chondrocytes phenotype in vitro.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1072)
  AUTHORS   Bashi,M.A. and Ad'hiah,A.H.
  TITLE     Molecular landscape of the interleukin-40 encoding gene, C17orf99,
            in patients with acute myeloid leukemia
  JOURNAL   Gene 904, 148214 (2024)
   PUBMED   38286266
  REMARK    GeneRIF: Molecular landscape of the interleukin-40 encoding gene,
            C17orf99, in patients with acute myeloid leukemia.
REFERENCE   3  (bases 1 to 1072)
  AUTHORS   Bani-Wais,D.F.N. and Ad'hiah,A.H.
  TITLE     A novel intergenic variant, rs2004339 A/G, of the gene encoding
            interleukin-40, C17orf99, is associated with risk of rheumatoid
            arthritis in Iraqi women
  JOURNAL   Mol Immunol 164, 39-46 (2023)
   PUBMED   37951185
  REMARK    GeneRIF: A novel intergenic variant, rs2004339 A/G, of the gene
            encoding interleukin-40, C17orf99, is associated with risk of
            rheumatoid arthritis in Iraqi women.
REFERENCE   4  (bases 1 to 1072)
  AUTHORS   Catalan-Dibene,J., Vazquez,M.I., Luu,V.P., Nuccio,S.P.,
            Karimzadeh,A., Kastenschmidt,J.M., Villalta,S.A., Ushach,I.,
            Pone,E.J., Casali,P., Raffatellu,M., Burkhardt,A.M.,
            Hernandez-Ruiz,M., Heller,G., Hevezi,P.A. and Zlotnik,A.
  TITLE     Identification of IL-40, a Novel B Cell-Associated Cytokine
  JOURNAL   J Immunol 199 (9), 3326-3335 (2017)
   PUBMED   28978694
  REMARK    GeneRIF: these observations indicate that C17orf99 encodes a novel
            B cell-associated cytokine, which we have called IL-40, that plays
            an important role in humoral immune responses and may also play a
            role in B cell development.
REFERENCE   5  (bases 1 to 1072)
  AUTHORS   Zhang,Z. and Henzel,W.J.
  TITLE     Signal peptide prediction based on analysis of experimentally
            verified cleavage sites
  JOURNAL   Protein Sci 13 (10), 2819-2824 (2004)
   PUBMED   15340161
REFERENCE   6  (bases 1 to 1072)
  AUTHORS   Clark,H.F., Gurney,A.L., Abaya,E., Baker,K., Baldwin,D., Brush,J.,
            Chen,J., Chow,B., Chui,C., Crowley,C., Currell,B., Deuel,B.,
            Dowd,P., Eaton,D., Foster,J., Grimaldi,C., Gu,Q., Hass,P.E.,
            Heldens,S., Huang,A., Kim,H.S., Klimowski,L., Jin,Y., Johnson,S.,
            Lee,J., Lewis,L., Liao,D., Mark,M., Robbie,E., Sanchez,C.,
            Schoenfeld,J., Seshagiri,S., Simmons,L., Singh,J., Smith,V.,
            Stinson,J., Vagts,A., Vandlen,R., Watanabe,C., Wieand,D., Woods,K.,
            Xie,M.H., Yansura,D., Yi,S., Yu,G., Yuan,J., Zhang,M., Zhang,Z.,
            Goddard,A., Wood,W.I., Godowski,P. and Gray,A.
  TITLE     The secreted protein discovery initiative (SPDI), a large-scale
            effort to identify novel human secreted and transmembrane proteins:
            a bioinformatics assessment
  JOURNAL   Genome Res 13 (10), 2265-2270 (2003)
   PUBMED   12975309
  REMARK    Erratum:[Genome Res. 2003 Dec;13(12):2759]
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AY358510.1 and AC021593.15.
            
            On Jun 2, 2019 this sequence version replaced NM_001163075.1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY358510.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2149004, SAMEA2154529
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000340363.10/ ENSP00000343493.4
            RefSeq Select criteria :: based on conservation
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-323               AY358510.1         40-362
            324-324             AC021593.15        25424-25424         c
            325-952             AY358510.1         364-991
            953-1072            AC021593.15        20312-20431         c
FEATURES             Location/Qualifiers
     source          1..1072
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17q25.3"
     gene            1..1072
                     /gene="C17orf99"
                     /gene_synonym="IL-40; UNQ464"
                     /note="chromosome 17 open reading frame 99"
                     /db_xref="GeneID:100141515"
                     /db_xref="HGNC:HGNC:34490"
     exon            1..60
                     /gene="C17orf99"
                     /gene_synonym="IL-40; UNQ464"
                     /inference="alignment:Splign:2.1.0"
     CDS             24..821
                     /gene="C17orf99"
                     /gene_synonym="IL-40; UNQ464"
                     /note="GLPG464; uncharacterized protein C17orf99;
                     interleukin-40; protein IL-40"
                     /codon_start=1
                     /product="protein IL-40 precursor"
                     /protein_id="NP_001156547.1"
                     /db_xref="CCDS:CCDS54171.1"
                     /db_xref="GeneID:100141515"
                     /db_xref="HGNC:HGNC:34490"
                     /translation="MGLPGLFCLAVLAASSFSKAREEEITPVVSIAYKVLEVFPKGRW
                     VLITCCAPQPPPPITYSLCGTKNIKVAKKVVKTHEPASFNLNVTLKSSPDLLTYFCWA
                     SSTSGAHVDSARLQMHWELWSKPVSELRANFTLQDRGAGPRVEMICQASSGSPPITNS
                     LIGKDGQVHLQQRPCHRQPANFSFLPSQTSDWFWCQAANNANVQHSALTVVPPGGDQK
                     MEDWQGPLESPILALPLYRSTRRLSEEEFGGFRIGNGEVRGRKAAAM"
     exon            61..93
                     /gene="C17orf99"
                     /gene_synonym="IL-40; UNQ464"
                     /inference="alignment:Splign:2.1.0"
     exon            94..393
                     /gene="C17orf99"
                     /gene_synonym="IL-40; UNQ464"
                     /inference="alignment:Splign:2.1.0"
     exon            394..663
                     /gene="C17orf99"
                     /gene_synonym="IL-40; UNQ464"
                     /inference="alignment:Splign:2.1.0"
     exon            664..1072
                     /gene="C17orf99"
                     /gene_synonym="IL-40; UNQ464"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agaggcccta cacccaccga ggcatggggc tccctgggct gttctgcttg gccgtgctgg
       61 ctgccagcag cttctccaag gcacgggagg aagaaattac ccctgtggtc tccattgcct
      121 acaaagtcct ggaagttttc cccaaaggcc gctgggtgct cataacctgc tgtgcacccc
      181 agccaccacc gcccatcacc tattccctct gtggaaccaa gaacatcaag gtggccaaga
      241 aggtggtgaa gacccacgag ccggcctcct tcaacctcaa cgtcacactc aagtccagtc
      301 cagacctgct cacctacttc tgctgggcgt cctccacctc aggtgcccat gtggacagtg
      361 ccaggctaca gatgcactgg gagctgtggt ccaagccagt gtctgagctg cgggccaact
      421 tcactctgca ggacagaggg gcaggcccca gggtggagat gatctgccag gcgtcctcgg
      481 gcagcccacc tatcaccaac agcctgatcg ggaaggatgg gcaggtccac ctgcagcaga
      541 gaccatgcca caggcagcct gccaacttct ccttcctgcc gagccagaca tcggactggt
      601 tctggtgcca ggctgcaaac aacgccaatg tccagcacag cgccctcaca gtggtgcccc
      661 caggtggtga ccagaagatg gaggactggc agggtcccct ggagagcccc atccttgcct
      721 tgccgctcta caggagcacc cgccgtctga gtgaagagga gtttgggggg ttcaggatag
      781 ggaatgggga ggtcagagga cgcaaagcag cagccatgta gaatgaaccg tccagagagc
      841 caagcacggc agaggactgc aggccatcag cgtgcactgt tcgtatttgg agttcatgca
      901 aaatgagtgt gttttagctg ctcttgccac aaaaaaaaaa aaaaaaaaaa aagggtaact
      961 atgagagatg gtggatatgt taacttgctt cgctatagga acctttgtgc tatctatatt
     1021 atctatatga atcccatcat atcaggttgt ctaccttaaa tatacacaaa aa
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