LOCUS       NM_173625               1920 bp    mRNA    linear   PRI 12-JAN-2025
DEFINITION  Homo sapiens chromosome 17 open reading frame 78 (C17orf78),
            transcript variant 1, mRNA.
ACCESSION   NM_173625
VERSION     NM_173625.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1920)
  AUTHORS   Long,A., Liu,Y., Fang,X., Jia,L., Li,Z., Hu,J., Wu,S., Chen,C.,
            Huang,P. and Wang,Y.
  TITLE     Famsin, a novel gut-secreted hormone, contributes to metabolic
            adaptations to fasting via binding to its receptor OLFR796
  JOURNAL   Cell Res 33 (4), 273-287 (2023)
   PUBMED   36806353
REFERENCE   2  (bases 1 to 1920)
  AUTHORS   Garner,C., Ahn,R., Ding,Y.C., Steele,L., Stoven,S., Green,P.H.,
            Fasano,A., Murray,J.A. and Neuhausen,S.L.
  TITLE     Genome-wide association study of celiac disease in North America
            confirms FRMD4B as new celiac locus
  JOURNAL   PLoS One 9 (7), e101428 (2014)
   PUBMED   24999842
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1920)
  AUTHORS   Pharoah,P.D., Tsai,Y.Y., Ramus,S.J., Phelan,C.M., Goode,E.L.,
            Lawrenson,K., Buckley,M., Fridley,B.L., Tyrer,J.P., Shen,H.,
            Weber,R., Karevan,R., Larson,M.C., Song,H., Tessier,D.C., Bacot,F.,
            Vincent,D., Cunningham,J.M., Dennis,J., Dicks,E., Aben,K.K.,
            Anton-Culver,H., Antonenkova,N., Armasu,S.M., Baglietto,L.,
            Bandera,E.V., Beckmann,M.W., Birrer,M.J., Bloom,G., Bogdanova,N.,
            Brenton,J.D., Brinton,L.A., Brooks-Wilson,A., Brown,R., Butzow,R.,
            Campbell,I., Carney,M.E., Carvalho,R.S., Chang-Claude,J.,
            Chen,Y.A., Chen,Z., Chow,W.H., Cicek,M.S., Coetzee,G., Cook,L.S.,
            Cramer,D.W., Cybulski,C., Dansonka-Mieszkowska,A., Despierre,E.,
            Doherty,J.A., Dork,T., du Bois,A., Durst,M., Eccles,D., Edwards,R.,
            Ekici,A.B., Fasching,P.A., Fenstermacher,D., Flanagan,J., Gao,Y.T.,
            Garcia-Closas,M., Gentry-Maharaj,A., Giles,G., Gjyshi,A., Gore,M.,
            Gronwald,J., Guo,Q., Halle,M.K., Harter,P., Hein,A., Heitz,F.,
            Hillemanns,P., Hoatlin,M., Hogdall,E., Hogdall,C.K., Hosono,S.,
            Jakubowska,A., Jensen,A., Kalli,K.R., Karlan,B.Y., Kelemen,L.E.,
            Kiemeney,L.A., Kjaer,S.K., Konecny,G.E., Krakstad,C.,
            Kupryjanczyk,J., Lambrechts,D., Lambrechts,S., Le,N.D., Lee,N.,
            Lee,J., Leminen,A., Lim,B.K., Lissowska,J., Lubinski,J.,
            Lundvall,L., Lurie,G., Massuger,L.F., Matsuo,K., McGuire,V.,
            McLaughlin,J.R., Menon,U., Modugno,F., Moysich,K.B., Nakanishi,T.,
            Narod,S.A., Ness,R.B., Nevanlinna,H., Nickels,S., Noushmehr,H.,
            Odunsi,K., Olson,S., Orlow,I., Paul,J., Pejovic,T., Pelttari,L.M.,
            Permuth-Wey,J., Pike,M.C., Poole,E.M., Qu,X., Risch,H.A.,
            Rodriguez-Rodriguez,L., Rossing,M.A., Rudolph,A., Runnebaum,I.,
            Rzepecka,I.K., Salvesen,H.B., Schwaab,I., Severi,G., Shen,H.,
            Shridhar,V., Shu,X.O., Sieh,W., Southey,M.C., Spellman,P.,
            Tajima,K., Teo,S.H., Terry,K.L., Thompson,P.J., Timorek,A.,
            Tworoger,S.S., van Altena,A.M., van den Berg,D., Vergote,I.,
            Vierkant,R.A., Vitonis,A.F., Wang-Gohrke,S., Wentzensen,N.,
            Whittemore,A.S., Wik,E., Winterhoff,B., Woo,Y.L., Wu,A.H.,
            Yang,H.P., Zheng,W., Ziogas,A., Zulkifli,F., Goodman,M.T., Hall,P.,
            Easton,D.F., Pearce,C.L., Berchuck,A., Chenevix-Trench,G.,
            Iversen,E., Monteiro,A.N., Gayther,S.A., Schildkraut,J.M. and
            Sellers,T.A.
  CONSRTM   Australian Cancer Study; Australian Ovarian Cancer Study Group
  TITLE     GWAS meta-analysis and replication identifies three new
            susceptibility loci for ovarian cancer
  JOURNAL   Nat Genet 45 (4), 362-370 (2013)
   PUBMED   23535730
REFERENCE   4  (bases 1 to 1920)
  AUTHORS   Bailey,S.D., Xie,C., Do,R., Montpetit,A., Diaz,R., Mohan,V.,
            Keavney,B., Yusuf,S., Gerstein,H.C., Engert,J.C. and Anand,S.
  CONSRTM   DREAM investigators
  TITLE     Variation at the NFATC2 locus increases the risk of
            thiazolidinedione-induced edema in the Diabetes REduction
            Assessment with ramipril and rosiglitazone Medication (DREAM) study
  JOURNAL   Diabetes Care 33 (10), 2250-2253 (2010)
   PUBMED   20628086
  REMARK    GeneRIF: Observational study of gene-disease association,
            gene-environment interaction, and pharmacogenomic / toxicogenomic.
            (HuGE Navigator)
REFERENCE   5  (bases 1 to 1920)
  AUTHORS   Talmud,P.J., Drenos,F., Shah,S., Shah,T., Palmen,J., Verzilli,C.,
            Gaunt,T.R., Pallas,J., Lovering,R., Li,K., Casas,J.P., Sofat,R.,
            Kumari,M., Rodriguez,S., Johnson,T., Newhouse,S.J., Dominiczak,A.,
            Samani,N.J., Caulfield,M., Sever,P., Stanton,A., Shields,D.C.,
            Padmanabhan,S., Melander,O., Hastie,C., Delles,C., Ebrahim,S.,
            Marmot,M.G., Smith,G.D., Lawlor,D.A., Munroe,P.B., Day,I.N.,
            Kivimaki,M., Whittaker,J., Humphries,S.E. and Hingorani,A.D.
  CONSRTM   ASCOT investigators; NORDIL investigators; BRIGHT Consortium
  TITLE     Gene-centric association signals for lipids and apolipoproteins
            identified via the HumanCVD BeadChip
  JOURNAL   Am J Hum Genet 85 (5), 628-642 (2009)
   PUBMED   19913121
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC243654.3, AK096966.1, BC034672.1 and EG328593.1.
            
            On May 17, 2019 this sequence version replaced NM_173625.4.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC034672.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2144835, SAMEA2152474
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000615133.2/ ENSP00000478886.1
            RefSeq Select criteria :: based on manual assertion, longest
                                      protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1                 AC243654.3         92459-92459
            2-58                AK096966.1         2-58
            59-562              BC034672.1         1-504
            563-563             EG328593.1         365-365
            564-1920            BC034672.1         506-1862
FEATURES             Location/Qualifiers
     source          1..1920
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17q12"
     gene            1..1920
                     /gene="C17orf78"
                     /note="chromosome 17 open reading frame 78"
                     /db_xref="GeneID:284099"
                     /db_xref="HGNC:HGNC:26831"
     exon            1..166
                     /gene="C17orf78"
                     /inference="alignment:Splign:2.1.0"
     CDS             109..936
                     /gene="C17orf78"
                     /note="isoform 1 is encoded by transcript variant 1;
                     uncharacterized protein C17orf78; famsin"
                     /codon_start=1
                     /product="uncharacterized protein C17orf78 isoform 1"
                     /protein_id="NP_775896.3"
                     /db_xref="CCDS:CCDS45655.1"
                     /db_xref="GeneID:284099"
                     /db_xref="HGNC:HGNC:26831"
                     /translation="MDTILVFSLIIASYDANKKDLRDSSCRLEQLPGIFPKDVRSIRE
                     LQMQETHTETKRTTFIQNRTIATLQCLGSDSKVKVNLVYLERRPKVKHILKNLRIIAA
                     PRRNSSASSSCHLIPTSKFQTGSLLKGKAFLPGISQCKVLGASSETFPTTAPSITPGN
                     KEGEKTTSTDTDENLEKRQKWSIVVKILIAVTLLLSGVAIIVFVIFEVPCPYQCLGAR
                     KLCQCQWLWRWQKKGGQPPGTAESKPDSQPQKVGQDAANSSNPKKAAEITVIHQTYF"
     exon            167..253
                     /gene="C17orf78"
                     /inference="alignment:Splign:2.1.0"
     exon            254..499
                     /gene="C17orf78"
                     /inference="alignment:Splign:2.1.0"
     exon            500..616
                     /gene="C17orf78"
                     /inference="alignment:Splign:2.1.0"
     exon            617..741
                     /gene="C17orf78"
                     /inference="alignment:Splign:2.1.0"
     exon            742..858
                     /gene="C17orf78"
                     /inference="alignment:Splign:2.1.0"
     exon            859..1920
                     /gene="C17orf78"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 caaacttggt tccagctgcg tgtggtgaaa gcaactagag gcagagctat caagggctgt
       61 gacagatgag cagtggtctg tctgcaatga gcatgtgctc aagctaacat ggataccatc
      121 ttggtcttca gcctaatcat tgcatcctat gatgccaaca agaaagacct cagagatagc
      181 agttgccgac tggaacagct gcctgggatc ttcccaaaag acgtgagaag catcagagaa
      241 ttgcaaatgc aagaaactca cacagaaacc aaaaggacaa cattcattca aaaccggact
      301 atagctaccc tgcagtgcct tggctctgac agcaaagtaa aagtcaacct tgtatatttg
      361 gagagaaggc caaaggtcaa gcatattttg aagaacctga gaatcattgc tgctccccgc
      421 agaaacagct ctgcctcctc aagctgtcac ctaatcccca catccaagtt tcagactgga
      481 tctcttctaa aaggcaaagc ttttttacca gggatctcac aatgtaaagt cctgggggct
      541 tcatcagaga cttttcccac cactgcccct tctataactc ctgggaataa agaaggagag
      601 aaaactacaa gtaccgacac agatgagaac ctagagaaga gacagaaatg gagtattgtg
      661 gtcaaaattc tgattgctgt caccctgttg ctcagtggag ttgccattat agtatttgta
      721 atttttgaag tcccatgtcc ttatcaatgc ctaggagcca ggaagctgtg ccaatgccag
      781 tggttgtgga gatggcaaaa gaagggaggc cagccacctg ggacagctga atccaagcct
      841 gactctcagc cccagaaggt tggacaagat gctgccaatt catcaaaccc aaagaaagct
      901 gcagagatca ctgttatcca ccagacatac ttctgaaaag ttctgctcta tctcaaagac
      961 tgaatgatac tacacagtcc tctccctatt aatatgggca cattcttgcc aatttcacac
     1021 ttgtatcttc agcagggaca ttacaatcaa acaccaattc ctggttaatg aagggagagt
     1081 gtgggcttag cagagttacc ctcatgcccc tatctgagcc acaaccttct gtaattcact
     1141 tcatacatcc atctaaatgg atacctttcc atcccctcaa acgagaacaa aaagtattcc
     1201 ctgcaagcac tatgaatgga ccttactact ctctttgaca gaagactcaa acacagcctc
     1261 taagaaacaa ggcagctgtt agtgtgacat agcttccagc tcctctgtta tcttcacagc
     1321 tgacttcaca ctcactggcc ctcaatagct tagagtggga ctcctgatct ccctggttga
     1381 cgtttataag gttttgtaat ttagcttctg gtactacatg tatctatcca cacactgctg
     1441 aagggaactt gaccctacgc attccaaaag ccttcctcat aagttatccc caaggggttc
     1501 agggactaca gaccattagt acccaagtga agtcttctga cgatccagaa ttcctaaggt
     1561 ggctctgata ttatatcata ctttaataga gagttgcata ccttttggac aaagattcca
     1621 gagcaaaata attatgataa tgctgtttct cacaggagaa tagctatgag tcaaatctaa
     1681 cctgcttaaa taagagtttg gtgagaaagt gaaaccacct gatcttgaat caatgttgag
     1741 gtgaaaaagg aaatgtcagg agggataaga cagggtgagg ccctgcttct tttcctaaga
     1801 gtctgaaacc attccatttc attttggtga aatgtgtctg tttctaagaa attctgtttt
     1861 cttagttctc tggttaaaaa aaaaaataca taaactgtat ccttctttct ttcacttcaa
//
