LOCUS       NM_022344               4547 bp    mRNA    linear   PRI 07-FEB-2025
DEFINITION  Homo sapiens chromosome 17 open reading frame 75 (C17orf75), mRNA.
ACCESSION   NM_022344
VERSION     NM_022344.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4547)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   2  (bases 1 to 4547)
  AUTHORS   Navarro Negredo,P., Edgar,J.R., Manna,P.T., Antrobus,R. and
            Robinson,M.S.
  TITLE     The WDR11 complex facilitates the tethering of AP-1-derived
            vesicles
  JOURNAL   Nat Commun 9 (1), 596 (2018)
   PUBMED   29426865
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4547)
  AUTHORS   Shin,J.J.H., Gillingham,A.K., Begum,F., Chadwick,J. and Munro,S.
  TITLE     TBC1D23 is a bridging factor for endosomal vesicle capture by
            golgins at the trans-Golgi
  JOURNAL   Nat Cell Biol 19 (12), 1424-1432 (2017)
   PUBMED   29084197
  REMARK    Erratum:[Nat Cell Biol. 2018 Feb;20(2):222. doi:
            10.1038/s41556-017-0026-7.. PMID: 29311657]
REFERENCE   4  (bases 1 to 4547)
  AUTHORS   Bassik,M.C., Kampmann,M., Lebbink,R.J., Wang,S., Hein,M.Y.,
            Poser,I., Weibezahn,J., Horlbeck,M.A., Chen,S., Mann,M.,
            Hyman,A.A., Leproust,E.M., McManus,M.T. and Weissman,J.S.
  TITLE     A systematic mammalian genetic interaction map reveals pathways
            underlying ricin susceptibility
  JOURNAL   Cell 152 (4), 909-922 (2013)
   PUBMED   23394947
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BP308900.1, AC005899.1, BC026017.2 and CA444740.1.
            
            On Nov 23, 2018 this sequence version replaced NM_022344.3.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803617.25402.1,
                                           SRR1803617.185463.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000577809.6/ ENSP00000464275.1
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-9                 BP308900.1         37-45
            10-18               AC005899.1         51797-51805         c
            19-1626             BC026017.2         1-1608
            1627-4342           AC005899.1         38287-41002         c
            4343-4547           CA444740.1         17-221              c
FEATURES             Location/Qualifiers
     source          1..4547
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17q11.2"
     gene            1..4547
                     /gene="C17orf75"
                     /gene_synonym="NJMU-R1; SRI2"
                     /note="chromosome 17 open reading frame 75"
                     /db_xref="GeneID:64149"
                     /db_xref="HGNC:HGNC:30173"
     exon            1..174
                     /gene="C17orf75"
                     /gene_synonym="NJMU-R1; SRI2"
                     /inference="alignment:Splign:2.1.0"
     CDS             35..1225
                     /gene="C17orf75"
                     /gene_synonym="NJMU-R1; SRI2"
                     /note="spermatogenesis-related protein; sensitization to
                     ricin complex subunit 2"
                     /codon_start=1
                     /product="protein Njmu-R1"
                     /protein_id="NP_071739.2"
                     /db_xref="CCDS:CCDS58537.1"
                     /db_xref="GeneID:64149"
                     /db_xref="HGNC:HGNC:30173"
                     /translation="MLPSLQESMDGDEKELESSEEGGSAEERRLEPPSSSHYCLYSYR
                     GSRLAQQRGDSEDGSPSGTNAETPSGDDFSLSLADTNLPSEVEPELRSFIAKRLSRGA
                     VFEGLGNVASVELKIPGYRVGCYYCLFQNEKLLPETVTIDSERNPSEYVVCFLGGSEK
                     GLELFRLELDKYIQGLKNNMNCEARGLESHIKSYLSSWFEDVVCPIQRVVLLFQEKLT
                     FLLHAALSYTPVEVKESDEKTKRDINRFLSVASLQGLIHEGTMTSLCMAMTEEQHKSV
                     VIDCSSSQPQFCNAGSNRFCEDWMQAFLNGAKGGNPFLFRQVLENFKLKAIQDTNNLK
                     RFIRQAEMNHYALFKCYMFLKNCGSGDILLKIVKVEHEEMPEAKNVIAVLEEFMKEAL
                     DQSF"
     exon            175..255
                     /gene="C17orf75"
                     /gene_synonym="NJMU-R1; SRI2"
                     /inference="alignment:Splign:2.1.0"
     exon            256..381
                     /gene="C17orf75"
                     /gene_synonym="NJMU-R1; SRI2"
                     /inference="alignment:Splign:2.1.0"
     exon            382..525
                     /gene="C17orf75"
                     /gene_synonym="NJMU-R1; SRI2"
                     /inference="alignment:Splign:2.1.0"
     exon            526..583
                     /gene="C17orf75"
                     /gene_synonym="NJMU-R1; SRI2"
                     /inference="alignment:Splign:2.1.0"
     exon            584..703
                     /gene="C17orf75"
                     /gene_synonym="NJMU-R1; SRI2"
                     /inference="alignment:Splign:2.1.0"
     exon            704..768
                     /gene="C17orf75"
                     /gene_synonym="NJMU-R1; SRI2"
                     /inference="alignment:Splign:2.1.0"
     exon            769..905
                     /gene="C17orf75"
                     /gene_synonym="NJMU-R1; SRI2"
                     /inference="alignment:Splign:2.1.0"
     exon            906..1009
                     /gene="C17orf75"
                     /gene_synonym="NJMU-R1; SRI2"
                     /inference="alignment:Splign:2.1.0"
     exon            1010..4547
                     /gene="C17orf75"
                     /gene_synonym="NJMU-R1; SRI2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1374..1379
                     /regulatory_class="polyA_signal_sequence"
                     /gene="C17orf75"
                     /gene_synonym="NJMU-R1; SRI2"
                     /note="hexamer: AATAAA"
     polyA_site      1392
                     /gene="C17orf75"
                     /gene_synonym="NJMU-R1; SRI2"
                     /note="major polyA site"
     regulatory      4525..4530
                     /regulatory_class="polyA_signal_sequence"
                     /gene="C17orf75"
                     /gene_synonym="NJMU-R1; SRI2"
                     /note="hexamer: AATAAA"
     polyA_site      4547
                     /gene="C17orf75"
                     /gene_synonym="NJMU-R1; SRI2"
ORIGIN      
        1 ggcggagaca cagggccgct cagaggccgc cgcaatgctc ccctctttgc aggagtcgat
       61 ggatggagat gaaaaggaac tagagagcag cgaagaggga ggctcagccg aggagcggag
      121 actcgagccg ccgtccagca gccactactg tctttacagc tatcgcggaa gcagattggc
      181 acagcaacga ggggacagtg aggacggaag cccaagtggc acaaatgcag aaactccctc
      241 tggtgatgat ttcagcctct ccttggcaga tactaatcta ccatccgaag tggagccaga
      301 gctgcgcagt ttcattgcta agcgtctttc aagaggtgca gtctttgaag ggctgggtaa
      361 tgttgcatct gtggagctaa aaattccagg ttaccgagtt ggttgttatt actgcctttt
      421 ccaaaatgaa aaactgcttc ctgaaacagt aacgatagac tctgaacgta acccttcaga
      481 atatgtggtc tgttttttag gagggtctga aaaaggactt gagcttttca ggcttgaatt
      541 ggacaagtac attcaagggc tgaaaaataa catgaattgt gaggcaaggg gcctggagag
      601 tcacataaaa tcctatctga gcagctggtt tgaggatgtt gtatgcccaa tccaaagggt
      661 tgttcttctc tttcaggaaa agcttacctt tctgctacat gctgctttga gttacactcc
      721 tgttgaagtt aaagaatcag atgaaaaaac aaagagagac attaacaggt ttctgagtgt
      781 ggccagtctt caaggactta ttcatgaagg caccatgact tctttgtgca tggccatgac
      841 agaggagcag cataagtctg tggtcatcga ttgcagcagc tcccagcctc agttctgcaa
      901 tgcaggaagt aaccggtttt gtgaggattg gatgcaagct tttttaaatg gtgccaaagg
      961 aggtaaccct tttcttttcc gacaagtact ggagaacttt aaactaaagg ccatacaaga
     1021 cacaaacaat ttgaagagat ttatccgaca ggcagaaatg aatcattatg ctttgtttaa
     1081 atgttacatg ttcctaaaga actgtggtag tggagatata cttttgaaga ttgttaaagt
     1141 ggaacatgaa gaaatgcctg aagccaaaaa tgtgatagct gtccttgaag aattcatgaa
     1201 agaagctctt gaccaaagtt tttgatcata tgttttgaga taattgtatg atcaagttgt
     1261 atatttaagt cttagtgttt gaaattgcag ttataattgt tcataggatt gctatttaag
     1321 atgatttgaa actcaatcca gattttcttt ttgtatttta ccaatttaac ttaaataaaa
     1381 atctgaagaa catcttcact gagtcctaga tagataatgt atgtgagagt tgtgaaattt
     1441 tagtgtctca ctggccccat aaattccacg cttcaggaag ttgttgctta aaaaatttca
     1501 gagatgattt tgtttgtggc ttttctcagg aaaagcctga gtttgctgca gtatttagca
     1561 acttttcttc tcagaaaaac cataatactt ccttttcagt ggactgtagc ttcttaaaaa
     1621 aaaaaatgta attctagtct tagaacagat taataccact acaccagttc agagatagat
     1681 ctgtgcatcc tgtgggtgct tgatacattt ttttgtctag ttgataacgg catggatgat
     1741 aaagtcagat tttaagtcaa tatgcaaatc ctgagtatgt agaaaattaa atgagcttta
     1801 caaatcgatg cactagcttc aagataaaat attatctttg agctgggcgc agtggctcaa
     1861 gcctgtaatc ccagcacttt gggaggctga ggcgggcaga tcatgaggtc aggagatcga
     1921 gaccatcctg gctaacacag tgaaagcccg tctctactaa aatacaaaaa attagccggg
     1981 catggtggcg ggcgcctgta gtcccagcta ctctggaggc tgaggcagga gagtggcgtg
     2041 aacccaggag gtggagcttg cagtgagccg agatcgcgcc actgcactcc agcctgggcg
     2101 acagagcgag actctgtctc aaaaaaaaaa ataattatct ctgagagaaa gctactgcag
     2161 aaatcgcctt cagtcaccat ttcatttatt tgttcacagg tatttatgaa gagcctgtgt
     2221 tttcttttag gtgaaaatgc tggagtttta aaacagtgtt gagaaaagaa acaaagtaca
     2281 tacagtttac aagcaaactg taacataagg aatgcaaaca gtttcttcct attagagtta
     2341 ctcattgatt ttagtttttt gtacatttgt tacaagcctc agattgtttt actctgaatc
     2401 aattgaaagt gccctcagct agccatttac aattcccatg gaagcctatg tagctacata
     2461 catacaattg caatttgctc gggatagctc tttaataaat tcatttgata atgatttttg
     2521 cttagaagaa cagaagtctt gtgttctcac ttccctgagg atgctcagag gagcacaaac
     2581 ccataaaact gaggaatcct ctcttaaatg gatctaaatt cacattaagt gctgagtttt
     2641 aactttcaaa atgactgaca atggccttct gctttctcct ctacataagc ctcgggacat
     2701 gactcacatt tcttttcttt taatgagaaa tacaattcag aatcttcata aatgctttca
     2761 tacggtttta aactttaata acttggaatg taggcagtat agaaaaaaat ctaagtagca
     2821 tttttcatag tattaaagtg agagtggctg ggcacgatgg ctcatgcctg taatcccagc
     2881 actttgagag gccgaggcag gtggatcacc tgaggtcagg agttccagac cagcctgacc
     2941 aatatggtga aaccctgtct ctactaaaat tacaaaaatt agctgggaac tgtggcatgt
     3001 gcctgtagtc ccagctactt gggaggctga ggcaggagaa tcgcttgaac ccgggaggca
     3061 gagattgcgg tgagccgaga tcgcgccact gcattccaac ctgagtgaca gagcgagact
     3121 ctgtctcaaa aaaataaagt cagggtgact aaggaaaacc agcaatttta tgacactgtc
     3181 cttgaatctg actgtctttt cccaatgtag ttggttcccc acttggaaat cattttttaa
     3241 agtaagctac attagcacat caacgtttta agtctgaaaa aatacttcat tttcaaattc
     3301 atgtcattca agagtctatg ttgtaaatgg catttaaaag caaatgtgtt acctgcttca
     3361 aatcatttat ggatataggc aaggtgtaat tacatattct ctgtgtggtt gtatatattt
     3421 ttgtaatgta ggctcactac attacacagc tctatatgat agtcttattt tatctttttt
     3481 tttttttaat gaaatggggt ctcactatgt tgctcagact ggtcttaaac tcttggactc
     3541 aagcaatcct cccaccttgg cctcccaaac tgagccactg cacccggcct ctggtagtct
     3601 tattttaaaa aaagtaagtc tgggctgggt gtggtggctc atgcctgtaa tcccagcact
     3661 ttgggaggcc taggcgggca gatcatgagg tcaggagatc gagaccatcc tggctaacac
     3721 ggtgaaaccc cgtctctact aaaagtacaa aaaattagcc gggcgtggtg gcaggcgtct
     3781 gtagttccag ctactcggga ggctgaggca ggagaatggc gtgaacccgg gaggcggagc
     3841 ttgcagtgag tcgagatcac accactgcac tcaagcctgg gcgacagagc gagactccgt
     3901 ctcaaaaaaa aaaaaaaagt ctgacaaact ctgtatcact actgtagaca aggaaaatgg
     3961 tgtcatggaa ctgaatatct tggtcatgag aagaaaccac agagttcatg actagaaaca
     4021 tgtactgtat tcaaatttta ataagctact atcttggctt ttaaagttgt tttttttttt
     4081 gtttttgttt tattttttaa gacagaatct cgctctgtca cccaggctgg agtgtggtgg
     4141 tgcaatcttg gctcactgca acctctgcct cccaggttca agtgattctc cttcctcagc
     4201 ctccccagta gctgggacta caggcatgtg ccaccatgca tggctaattt tttgtatttt
     4261 tagtagagac ggggtttcac cgtgttagcc aggatggtct cgatcttctc accttgtgat
     4321 ccacccgcct tggcctccca aagtgccggg attacaggcg tgagccactg tgcccagcca
     4381 gcttttaaag ttttaaaaag gatttgttca gacatggaat atatttgtgt atattacttg
     4441 tgtgctgtac acacagagga aatgtatgtt tgtcatgtat gaagaatggc ttcagtttct
     4501 ctgtaattaa tttgtaatta taataataaa acttagcttc tcatcaa
//
