LOCUS       NM_001085430            2037 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens chromosome 17 open reading frame 67 (C17orf67), mRNA.
ACCESSION   NM_001085430 XM_378687 XM_939391
VERSION     NM_001085430.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2037)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   2  (bases 1 to 2037)
  AUTHORS   He,M., Xu,M., Zhang,B., Liang,J., Chen,P., Lee,J.Y., Johnson,T.A.,
            Li,H., Yang,X., Dai,J., Liang,L., Gui,L., Qi,Q., Huang,J., Li,Y.,
            Adair,L.S., Aung,T., Cai,Q., Cheng,C.Y., Cho,M.C., Cho,Y.S.,
            Chu,M., Cui,B., Gao,Y.T., Go,M.J., Gu,D., Gu,W., Guo,H., Hao,Y.,
            Hong,J., Hu,Z., Hu,Y., Huang,J., Hwang,J.Y., Ikram,M.K., Jin,G.,
            Kang,D.H., Khor,C.C., Kim,B.J., Kim,H.T., Kubo,M., Lee,J., Lee,J.,
            Lee,N.R., Li,R., Li,J., Liu,J., Longe,J., Lu,W., Lu,X., Miao,X.,
            Okada,Y., Ong,R.T., Qiu,G., Seielstad,M., Sim,X., Song,H.,
            Takeuchi,F., Tanaka,T., Taylor,P.R., Wang,L., Wang,W., Wang,Y.,
            Wu,C., Wu,Y., Xiang,Y.B., Yamamoto,K., Yang,H., Liao,M., Yokota,M.,
            Young,T., Zhang,X., Kato,N., Wang,Q.K., Zheng,W., Hu,F.B., Lin,D.,
            Shen,H., Teo,Y.Y., Mo,Z., Wong,T.Y., Lin,X., Mohlke,K.L., Ning,G.,
            Tsunoda,T., Han,B.G., Shu,X.O., Tai,E.S., Wu,T. and Qi,L.
  TITLE     Meta-analysis of genome-wide association studies of adult height in
            East Asians identifies 17 novel loci
  JOURNAL   Hum Mol Genet 24 (6), 1791-1800 (2015)
   PUBMED   25429064
REFERENCE   3  (bases 1 to 2037)
  AUTHORS   Laurell,T., Lundin,J., Anderlid,B.M., Gorski,J.L.,
            Grigelioniene,G., Knight,S.J., Krepischi,A.C., Nordenskjold,A.,
            Price,S.M., Rosenberg,C., Turnpenny,P.D., Vianna-Morgante,A.M. and
            Nordgren,A.
  TITLE     Molecular and clinical delineation of the 17q22 microdeletion
            phenotype
  JOURNAL   Eur J Hum Genet 21 (10), 1085-1092 (2013)
   PUBMED   23361222
REFERENCE   4  (bases 1 to 2037)
  AUTHORS   Mao,S., Xu,L., Zhu,Z., Qian,B., Qiao,J., Yi,L. and Qiu,Y.
  TITLE     Association between genetic determinants of peak height velocity
            during puberty and predisposition to adolescent idiopathic
            scoliosis
  JOURNAL   Spine (Phila Pa 1976) 38 (12), 1034-1039 (2013)
   PUBMED   23354108
REFERENCE   5  (bases 1 to 2037)
  AUTHORS   Sovio,U., Bennett,A.J., Millwood,I.Y., Molitor,J., O'Reilly,P.F.,
            Timpson,N.J., Kaakinen,M., Laitinen,J., Haukka,J., Pillas,D.,
            Tzoulaki,I., Molitor,J., Hoggart,C., Coin,L.J., Whittaker,J.,
            Pouta,A., Hartikainen,A.L., Freimer,N.B., Widen,E., Peltonen,L.,
            Elliott,P., McCarthy,M.I. and Jarvelin,M.R.
  TITLE     Genetic determinants of height growth assessed longitudinally from
            infancy to adulthood in the northern Finland birth cohort 1966
  JOURNAL   PLoS Genet 5 (3), e1000409 (2009)
   PUBMED   19266077
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC106858.12, BC041467.1 and BU075516.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_001085430.3.
            
            CCDS Note: The coding region has been updated to shorten the
            N-terminus to one that is more supported by the available protein
            and conservation data.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC041467.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            CDS uses downstream in-frame AUG :: downstream AUG is associated
                                                with N-terminal localization
                                                signal
            MANE Ensembl match               :: ENST00000397861.7/
                                                ENSP00000380959.2
            RefSeq Select criteria           :: based on single protein-coding
                                                transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-25                AC106858.12        4972-4996
            26-253              BC041467.1         1-228
            254-304             BU075516.1         111-161
            305-979             BC041467.1         280-954
            980-980             AC106858.12        13802-13802
            981-1286            BC041467.1         956-1261
            1287-1287           AC106858.12        23064-23064
            1288-2037           BC041467.1         1263-2012
FEATURES             Location/Qualifiers
     source          1..2037
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17q22"
     gene            1..2037
                     /gene="C17orf67"
                     /note="chromosome 17 open reading frame 67"
                     /db_xref="GeneID:339210"
                     /db_xref="HGNC:HGNC:27900"
     exon            1..303
                     /gene="C17orf67"
                     /inference="alignment:Splign:2.1.0"
     exon            304..748
                     /gene="C17orf67"
                     /inference="alignment:Splign:2.1.0"
     exon            749..989
                     /gene="C17orf67"
                     /inference="alignment:Splign:2.1.0"
     exon            990..1104
                     /gene="C17orf67"
                     /inference="alignment:Splign:2.1.0"
     exon            1105..1359
                     /gene="C17orf67"
                     /inference="alignment:Splign:2.1.0"
     CDS             1305..1577
                     /gene="C17orf67"
                     /note="uncharacterized protein C17orf67"
                     /codon_start=1
                     /product="uncharacterized protein C17orf67 precursor"
                     /protein_id="NP_001078899.2"
                     /db_xref="CCDS:CCDS42364.2"
                     /db_xref="GeneID:339210"
                     /db_xref="HGNC:HGNC:27900"
                     /translation="MKTLPVLVLSLTLLTVFSETSPILTEKQAKQLLRSRRQDRPSKP
                     GFPDEPMREYMHHLLALEHRAEEQFLEHWLNPHCKPHCDRNRIHPV"
     exon            1360..1460
                     /gene="C17orf67"
                     /inference="alignment:Splign:2.1.0"
     exon            1461..1597
                     /gene="C17orf67"
                     /inference="alignment:Splign:2.1.0"
     exon            1598..2037
                     /gene="C17orf67"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2015..2020
                     /regulatory_class="polyA_signal_sequence"
                     /gene="C17orf67"
                     /note="hexamer: AATAAA"
     polyA_site      2037
                     /gene="C17orf67"
                     /note="major polyA site"
ORIGIN      
        1 ggagtaacag tggggcgttt gagaggatgg agggttgaat gccaaaactt cgtaatcgta
       61 gaaaattctg gaaagccgcc ggcggggcaa ggccacgagg atcctcctcg cagcaccgcg
      121 ccgcgcgggg cccaggggcc gcgctcacgc ccgccgctcg gcgcagacac gagtgccccc
      181 gacttgagcc gaacctctag ccgatgccgg cgccgccgcc gccggggatg cgtaagccga
      241 ctgggaagcg agggggggag gcggcctgcg cggcaccgcc cgacctggcc gcggcgggct
      301 gagccccagg ttccggagga atgctcgctc cccgctggag tcctaccagc ccaacacgga
      361 cctgagccgc gaccacgcgg gctgcagcct gcagcacatc agctacccgg agaacgcgga
      421 cgcggaagca ccgctgctca gcacccccga agaaacacgg aatccagaga ggcacaggca
      481 ccgccccggc gcgcacagct gcactcagcg gcttccttcc tactacatac atacatagga
      541 gtgggagccg aggaccactt gttgcttgcg gacttcctct agcataaaag atggaaagaa
      601 aacacacacc gaagcaaggg accaaaggaa cagaaaagaa acgcagagat cataggaaaa
      661 ctgcaaagaa atacttgata atatcttcca aacgattaga gaagacataa cattcattaa
      721 gaatacacat atagatgtat atatacgtat gaagaaaacc tgcttgatat cacacagtca
      781 ggagtcaact gagttggggc tttgaactta ggtttatctg atgccaaagt ttgtgatgct
      841 cttcaaccat ttagggtacc gcagagtgtg gattttgaat cacctgcatc agcatcattt
      901 taaaatatag attctgtggt cctgaccagg tctctgaagt cagaatatga agtggagcta
      961 ggaatctaac ttcttaacaa gttccctaga tgcctaaggg tatccctgaa tgatacagtt
     1021 ttgtttgaaa gactgaaaag cccaaagctg gcccttttgg gaaatagcag taaatcattg
     1081 atatgtgaag gttcccagca ggaggatgaa aatttacagg aattcggagg aaaatatttc
     1141 agtggtcatt actaaaacgc tcagagtcag atacattcag catcataccg taagtcccgt
     1201 tagtcaaagc ataaacaagc gcagggcctg gcatggcttc cttcaagttg gctgactcag
     1261 tctgggagga ttcactcagc aagaggcaga ggaaccaagg caggatgaag acattgcctg
     1321 tgctcgtgct gtctcttacc ttactgactg tcttctcaga gacctccccg attttgacag
     1381 agaagcaggc caaacagctc ctaagatctc ggcgacagga tagaccaagc aaacccggat
     1441 tccccgatga gccaatgcgg gaatacatgc accacctgct cgccctggag catcgcgctg
     1501 aggagcagtt cctggagcac tggctgaacc ctcactgcaa accccactgt gacaggaaca
     1561 ggattcatcc tgtgtaaggg gatcaggacc agcctcgcaa gcattttaat agacaacaag
     1621 ctggataatg tcgaagcaag acaaggctgc ttctttcact tgtttttaaa ttgcagaaat
     1681 ggatgtcttc agacctcgtg aactgtgggc atatcaaaga ttgccttgga aatggcaaat
     1741 atatatactg cttcatttta ctaacctgca tagatcacta aaaccaatag cttaaagcat
     1801 agacacctcc caaaggtctt cccatcagtt tgcaagagtg ggaacaacca gaatcttacc
     1861 tggggttgat ggagctggaa ctcccagacc aggagttggg gcaggctgcc tgccctaagg
     1921 aatttgggga atccttgttc agagtagtga agcataccac ttggggttgc tgagttgttt
     1981 tgtcctctat ttttttcctc ttcttttctg ccctaataaa cattggtatt aaattta
//
